JP2017503849A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017503849A5 JP2017503849A5 JP2016550686A JP2016550686A JP2017503849A5 JP 2017503849 A5 JP2017503849 A5 JP 2017503849A5 JP 2016550686 A JP2016550686 A JP 2016550686A JP 2016550686 A JP2016550686 A JP 2016550686A JP 2017503849 A5 JP2017503849 A5 JP 2017503849A5
- Authority
- JP
- Japan
- Prior art keywords
- protein transduction
- transduction reagent
- modified
- modification
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361895562P | 2013-10-25 | 2013-10-25 | |
| US61/895,562 | 2013-10-25 | ||
| PCT/US2014/062400 WO2015061779A1 (en) | 2013-10-25 | 2014-10-27 | Methods, systems and compositions relating to cell conversion via protein induced in-vivo cell reprogramming |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018187189A Division JP6577112B2 (ja) | 2013-10-25 | 2018-10-02 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503849A JP2017503849A (ja) | 2017-02-02 |
| JP2017503849A5 true JP2017503849A5 (enExample) | 2017-09-14 |
| JP6415582B2 JP6415582B2 (ja) | 2018-10-31 |
Family
ID=52993686
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550686A Active JP6415582B2 (ja) | 2013-10-25 | 2014-10-27 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
| JP2018187189A Active JP6577112B2 (ja) | 2013-10-25 | 2018-10-02 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
| JP2019151759A Active JP6880125B2 (ja) | 2013-10-25 | 2019-08-22 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018187189A Active JP6577112B2 (ja) | 2013-10-25 | 2018-10-02 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
| JP2019151759A Active JP6880125B2 (ja) | 2013-10-25 | 2019-08-22 | タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10076574B2 (enExample) |
| EP (2) | EP3954381A1 (enExample) |
| JP (3) | JP6415582B2 (enExample) |
| KR (2) | KR102113829B1 (enExample) |
| CN (2) | CN106170295B (enExample) |
| AU (3) | AU2014339843B2 (enExample) |
| CA (2) | CA3194454A1 (enExample) |
| DK (1) | DK3060237T3 (enExample) |
| ES (1) | ES2896021T3 (enExample) |
| IL (3) | IL245300B (enExample) |
| PL (1) | PL3060237T3 (enExample) |
| PT (1) | PT3060237T (enExample) |
| SG (1) | SG11201603230UA (enExample) |
| WO (1) | WO2015061779A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| JP6530206B2 (ja) * | 2015-03-17 | 2019-06-12 | 学校法人同志社 | 上皮間葉転換阻害剤及び癌転移治療剤 |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CN106110297B (zh) * | 2016-07-05 | 2019-12-17 | 南通大学 | Gfi1截短体的应用 |
| CN110536685A (zh) * | 2016-12-23 | 2019-12-03 | 昆士兰大学 | Sox18蛋白活性的抑制剂用于治疗血管生成相关疾病和/或淋巴管生成相关疾病 |
| JP2018132365A (ja) * | 2017-02-14 | 2018-08-23 | 株式会社神戸製鋼所 | マーキング装置 |
| AU2018375192B2 (en) | 2017-12-01 | 2023-11-09 | Encoded Therapeutics, Inc. | Engineered DNA binding proteins |
| US10785574B2 (en) | 2017-12-14 | 2020-09-22 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
| US11001618B2 (en) | 2018-03-02 | 2021-05-11 | Northwestern University | Overexpression of FOXC1 to treat corneal vascularization |
| US11340226B2 (en) * | 2018-03-02 | 2022-05-24 | The Chinese University Of Hong Kong | Squalene epoxidase in the diagnosis and treatment of non-alcoholic fatty liver diseases |
| JP7217542B2 (ja) * | 2018-03-29 | 2023-02-03 | 国立大学法人 琉球大学 | 分化コントロール化合物を用いて造腫瘍性をもつおそれのある未分化ｉＰＳ細胞等の混入を除去する方法 |
| US12274733B2 (en) | 2018-09-28 | 2025-04-15 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| AU2019347666B2 (en) | 2018-09-28 | 2025-10-02 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| EP3942018A4 (en) * | 2019-03-17 | 2022-12-07 | Baylor College of Medicine | Direct reprogramming of cardiac fibroblasts into cardiomyocytes using an endothelial cell transdifferentiation strategy |
| CN113710285A (zh) * | 2019-03-26 | 2021-11-26 | 宾州研究基金会 | 用于治疗癌症的方法和材料 |
| KR102150489B1 (ko) * | 2019-04-09 | 2020-09-01 | 고려대학교 산학협력단 | 소변세포로부터 신장전구세포로의 직접 역분화를 유도하는 방법 및 이의 방법으로 역분화된 신장전구세포를 포함하는 신장세포 손상 질환 예방 또는 치료용 약학 조성물 |
| US20210162002A1 (en) * | 2019-10-17 | 2021-06-03 | The Penn State Research Foundation | Regenerating functional neurons for treatment of spinal cord injury and als |
| JP2022552002A (ja) * | 2019-10-17 | 2022-12-14 | ザ・ペン・ステイト・リサーチ・ファウンデイション | 出血性脳卒中の治療のための機能的ニューロンの再生 |
| CN114630699A (zh) * | 2019-10-17 | 2022-06-14 | 宾州研究基金会 | 再生功能神经元以用于治疗神经病症 |
| WO2021108609A1 (en) * | 2019-11-25 | 2021-06-03 | The Penn State Research Foundation | Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion |
| CN112877364B (zh) * | 2019-11-29 | 2023-07-28 | 中国医学科学院药物研究所 | 软骨下骨细胞向关节软骨细胞直接转化的重编程诱导方案 |
| JPWO2021149823A1 (enExample) * | 2020-01-24 | 2021-07-29 | ||
| CN111214660B (zh) * | 2020-02-25 | 2022-01-18 | 北京大学第三医院（北京大学第三临床医学院） | Pax4基因表达抑制剂在制备抑制纤维化的药物中的应用 |
| US11091524B1 (en) | 2020-04-22 | 2021-08-17 | Houston Gene Therapeutics Llc | Compositions for treatment of vascular disease |
| CN114231489A (zh) * | 2020-09-08 | 2022-03-25 | 纽伦捷生物医药科技（苏州）有限公司 | 用于重编程的功能性片段、组合及其应用 |
| JP2023543360A (ja) * | 2020-09-29 | 2023-10-13 | ニューエクセル・セラピューティクス・インコーポレイテッド | Ｄｌｘ２ベクター |
| CA3197178A1 (en) * | 2020-09-29 | 2022-04-07 | NeuExcell Therapeutics Inc. | Neurod1 combination vector |
| EP4221836A4 (en) * | 2020-09-29 | 2025-02-19 | Neuexcell Therapeutics Inc. | NEUROD1 AND DLX2 VECTOR |
| JP2022104813A (ja) * | 2020-12-29 | 2022-07-11 | アイ ピース，インコーポレイテッド | リプログラミング因子を導入された細胞の培養方法 |
| CN113563428B (zh) * | 2021-06-22 | 2022-08-02 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 特定空间结构多肽及其在制备iPSC中的应用 |
| CN117070477A (zh) * | 2022-05-10 | 2023-11-17 | 纽伦捷生物医药科技（上海）有限公司 | 重组溶瘤病毒的重编程的功能性片段、组合及其应用 |
| WO2024112118A1 (ko) * | 2022-11-25 | 2024-05-30 | 고려대학교 산학협력단 | 방사선 치료에 의하여 손상된 근육 재생을 위한 고기능성 세포 치료제 조성물 |
| US12252518B2 (en) | 2023-01-06 | 2025-03-18 | Life Biosciences, Inc. | Methods of treating non-arteritic anterior ischemic optic neuropathy |
| WO2025106947A1 (en) * | 2023-11-17 | 2025-05-22 | Exir, Inc. | Compositions and methods for induced stem cell differentiation to neuronal lineage |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| EP0671926B1 (en) | 1992-08-11 | 2002-11-13 | President And Fellows Of Harvard College | Immunomodulatory peptides |
| FR2766195A1 (fr) | 1997-07-21 | 1999-01-22 | Transgene Sa | Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique |
| DE19839491A1 (de) | 1998-08-29 | 2000-03-02 | Hermann Heumann | Verfahren zur Markierung von Biopolymeren mit Isotopen |
| US20040142474A1 (en) | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| US6696038B1 (en) | 2000-09-14 | 2004-02-24 | Expression Genetics, Inc. | Cationic lipopolymer as biocompatible gene delivery agent |
| DE60230147D1 (de) | 2001-07-06 | 2009-01-15 | Merck Patent Gmbh | Verfahren zur überwachung und modulierung von proteinfaltung |
| WO2003046160A2 (en) | 2001-11-30 | 2003-06-05 | Applied Research Systems Ars Holding N.V. | Methods of increasing protein expression levels |
| US20030134352A1 (en) | 2002-01-04 | 2003-07-17 | Freimuth Paul I. | Facilitating protein folding and solubility by use of peptide extensions |
| CA2471178A1 (en) | 2002-01-07 | 2003-07-17 | European Molecular Biology Laboratory | Recombinant protein expression |
| WO2005026196A2 (en) | 2003-09-12 | 2005-03-24 | Novexin Limited | Methods for folding proteins and reducing protein aggregation |
| CA2548202C (en) | 2003-11-25 | 2013-05-14 | The Government Of The United States, As Represented By The Secretary Of The Army | Use of shigella invaplex to transport functional proteins and transcriptionally active nucleic acids across mammalian cell membranes in vitro and in vivo |
| CN101528267A (zh) | 2006-10-25 | 2009-09-09 | 皇家飞利浦电子股份有限公司 | 用于检测前列腺癌的造影剂 |
| SG10202103401QA (en) | 2008-03-17 | 2021-05-28 | Scripps Research Inst | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| US8722348B2 (en) | 2008-05-28 | 2014-05-13 | Wayne State University | Method and composition for a protein transduction technology and its applications |
| CN102272142A (zh) * | 2008-12-23 | 2011-12-07 | 帷幄生物技术公司 | 非遗传修饰性重编程细胞的组合物和方法 |
| EP2414510A4 (en) | 2009-04-03 | 2013-04-17 | Mclean Hospital Corp | INDUCED PLURIPOTENTIAL STEM CELLS |
| US20120115225A1 (en) | 2009-04-23 | 2012-05-10 | Xu C W | Reprogramming of somatic cells with purified proteins |
| EP2253700A1 (en) | 2009-05-13 | 2010-11-24 | Helmholtz-Zentrum für Infektionsforschung GmbH | A method for producing test systems from donors suffering from adverse effects of medicaments and /or medical treatments, and uses of said systems |
| JP2013510563A (ja) | 2009-11-13 | 2013-03-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 操作された微小胞を用いた真核細胞のリプログラミング |
| JP2011135864A (ja) * | 2009-12-30 | 2011-07-14 | Korea Univ Research & Business Foundation | Ｏｃｔ４及びＢｍｉ１、またはその上位調節子を用いて体細胞から胚幹細胞類似細胞への逆分化を誘導する組成物及びこれを用いた胚幹細胞類似細胞の製造方法 |
| JP2013518587A (ja) * | 2010-02-04 | 2013-05-23 | ヴィヴォスクリプト，インコーポレイテッド | 神経学的障害を治療するために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| KR101788903B1 (ko) * | 2010-08-19 | 2017-10-23 | 에프. 호프만-라 로슈 아게 | 체세포의 유도된 재프로그래밍된 신경 줄기 세포 (ｉｒｎｓｃｓ) 로의 전환 |
| WO2012116064A1 (en) * | 2011-02-22 | 2012-08-30 | The Board Of Regents Of The University Of Texas | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
| WO2012151234A2 (en) | 2011-05-02 | 2012-11-08 | Wayne State University | A protein-induced pluripotent cell technology uses thereof |
| US20140289882A1 (en) * | 2011-07-19 | 2014-09-25 | Oregon Health And Science University | Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage |
| JP6298405B2 (ja) | 2011-08-30 | 2018-03-20 | ザ ジェイ． デヴィッド グラッドストーン インスティテューツ | 心筋細胞を生成するための方法 |
| US20180223260A1 (en) * | 2011-10-21 | 2018-08-09 | Stemgenics, Inc. | Functionalized nanoparticles for the intracellular delivery of biologically active molecules and methods for their manufacture and use |
-
2014
- 2014-10-27 PT PT148550403T patent/PT3060237T/pt unknown
- 2014-10-27 EP EP21187708.9A patent/EP3954381A1/en not_active Withdrawn
- 2014-10-27 CN CN201480071293.0A patent/CN106170295B/zh active Active
- 2014-10-27 ES ES14855040T patent/ES2896021T3/es active Active
- 2014-10-27 CA CA3194454A patent/CA3194454A1/en active Pending
- 2014-10-27 US US15/031,839 patent/US10076574B2/en active Active
- 2014-10-27 JP JP2016550686A patent/JP6415582B2/ja active Active
- 2014-10-27 KR KR1020167013867A patent/KR102113829B1/ko active Active
- 2014-10-27 WO PCT/US2014/062400 patent/WO2015061779A1/en not_active Ceased
- 2014-10-27 EP EP14855040.3A patent/EP3060237B1/en active Active
- 2014-10-27 DK DK14855040.3T patent/DK3060237T3/da active
- 2014-10-27 PL PL14855040T patent/PL3060237T3/pl unknown
- 2014-10-27 KR KR1020207014071A patent/KR20200057108A/ko not_active Ceased
- 2014-10-27 CA CA2934065A patent/CA2934065C/en active Active
- 2014-10-27 SG SG11201603230UA patent/SG11201603230UA/en unknown
- 2014-10-27 CN CN202011127974.8A patent/CN112245592A/zh active Pending
- 2014-10-27 AU AU2014339843A patent/AU2014339843B2/en active Active
-
2016
- 2016-04-25 IL IL245300A patent/IL245300B/en active IP Right Grant
-
2018
- 2018-09-04 US US16/120,829 patent/US10548983B2/en active Active
- 2018-10-02 JP JP2018187189A patent/JP6577112B2/ja active Active
-
2019
- 2019-05-19 IL IL266705A patent/IL266705B/en active IP Right Grant
- 2019-06-28 AU AU2019204630A patent/AU2019204630C1/en active Active
- 2019-08-22 JP JP2019151759A patent/JP6880125B2/ja active Active
-
2020
- 2020-01-28 IL IL272324A patent/IL272324B/en unknown
-
2021
- 2021-06-29 AU AU2021204485A patent/AU2021204485B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017503849A5 (enExample) | ||
| JP2020007330A5 (enExample) | ||
| Luz-Madrigal et al. | Reprogramming of the chick retinal pigmented epithelium after retinal injury | |
| BR112022001460A2 (pt) | Moléculas de ligação ao antígeno biespecíficas, um ou mais polinucleotídeos isolados, célula hospedeira, método para produzir uma molécula de ligação ao antígeno biespecífica e para tratar uma doença em um indivíduo, composição farmacêutica, uso da molécula de ligação ao antígeno biespecífica e invenção | |
| NZ739499A (en) | Single domain antibody for programmed death-ligand (pd-l1) and derived protein thereof | |
| PH12020500643A1 (en) | Anti-ngf antibodies and methods thereof | |
| FI3515487T3 (fi) | Bispesifisiä anti-MUC16-CD3-vasta-aineita ja anti-MUC16-lääkekonjugaatteja | |
| WO2018091740A3 (en) | Novel anti_cd137 antibodies and uses thereof | |
| MX2016012716A (es) | Compuestos y metodos para suministro trans-membrana de moleculas. | |
| WO2018083538A8 (en) | Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof | |
| BRPI0906786A2 (pt) | Composto, processo para a preparação de um composto, uso de um composto, método para o tratamento de uma doença ou condição, composição farmacêutica, processo para a preparação de uma composição farmacêutica, produto, e, kit. | |
| BR112017012621A2 (pt) | peptídeos cíclicos com seletividade de ligação nervosa melhorada, nanopartículas ligadas com os referidos peptídeos cíclicos, e o uso dos mesmos para a produção de imagens de tecido nervoso in vivo em tempo real | |
| MX2012004638A (es) | Modulacion de degeneracion de axones. | |
| MX359570B (es) | Proteinas de union que inhiben la interaccion en el receptor de vegf-a. | |
| WO2010048446A3 (en) | Modulation of axon degeneration | |
| AU2017242867A8 (en) | Vortioxetine pamoic acid salt and crystal form thereof | |
| EP2915818A3 (en) | Dual variable domain immunoglobulins and uses thereof | |
| WO2016065349A3 (en) | Short non-coding protein regulatory rnas (sprrnas) and methods of use | |
| BR112015033069A2 (pt) | moduladores de receptor do hormônio de crescimento | |
| MX358991B (es) | Uso de moleculas de enlace a la semaforina-4d para promover la neurogenesis despues de la apoplejia. | |
| EP4321165A3 (en) | Method for diagnosis of alzheimer's disease and frontotemporal lobar degeneration, diagnostic agent, therapeutic agent, and screening method for said agents | |
| WO2019236750A3 (en) | Targeted treatment of autism spectrum disorder and other neurological or psychiatric disorders | |
| BR112012024786A2 (pt) | anticorpos humanizados il-25 | |
| EP4069288A4 (en) | TREATMENT METHODS USING ILT7 BINDING PROTEINS | |
| WO2011135332A3 (en) | Nmn modulators for the treatment of neurodegenerative disorders |