DK3060237T3 - Modificeret omprogrammeringsprotein til anvendelse i behandling af cancer - Google Patents

Modificeret omprogrammeringsprotein til anvendelse i behandling af cancer Download PDF

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Publication number
DK3060237T3
DK3060237T3 DK14855040.3T DK14855040T DK3060237T3 DK 3060237 T3 DK3060237 T3 DK 3060237T3 DK 14855040 T DK14855040 T DK 14855040T DK 3060237 T3 DK3060237 T3 DK 3060237T3
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protein
cancer treatment
modified programming
programming
modified
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DK14855040.3T
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Danish (da)
English (en)
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Jianjun Wang
Qianqian Li
Michael Chopp
Feng Jiang
Guojun Wu
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Univ Wayne State
Qurgen Inc
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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DK14855040.3T 2013-10-25 2014-10-27 Modificeret omprogrammeringsprotein til anvendelse i behandling af cancer DK3060237T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361895562P 2013-10-25 2013-10-25
PCT/US2014/062400 WO2015061779A1 (en) 2013-10-25 2014-10-27 Methods, systems and compositions relating to cell conversion via protein induced in-vivo cell reprogramming

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DK3060237T3 true DK3060237T3 (da) 2021-10-25

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US (2) US10076574B2 (enExample)
EP (2) EP3060237B1 (enExample)
JP (3) JP6415582B2 (enExample)
KR (2) KR20200057108A (enExample)
CN (2) CN106170295B (enExample)
AU (3) AU2014339843B2 (enExample)
CA (2) CA2934065C (enExample)
DK (1) DK3060237T3 (enExample)
ES (1) ES2896021T3 (enExample)
IL (3) IL245300B (enExample)
PL (1) PL3060237T3 (enExample)
PT (1) PT3060237T (enExample)
SG (1) SG11201603230UA (enExample)
WO (1) WO2015061779A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
EP3092049A1 (en) 2014-01-08 2016-11-16 Flodesign Sonics Inc. Acoustophoresis device with dual acoustophoretic chamber
JP6530206B2 (ja) * 2015-03-17 2019-06-12 学校法人同志社 上皮間葉転換阻害剤及び癌転移治療剤
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CN106110297B (zh) * 2016-07-05 2019-12-17 南通大学 Gfi1截短体的应用
CN110536685A (zh) 2016-12-23 2019-12-03 昆士兰大学 Sox18蛋白活性的抑制剂用于治疗血管生成相关疾病和/或淋巴管生成相关疾病
JP2018132365A (ja) * 2017-02-14 2018-08-23 株式会社神戸製鋼所 マーキング装置
AU2018375192B2 (en) 2017-12-01 2023-11-09 Encoded Therapeutics, Inc. Engineered DNA binding proteins
JP2021507561A (ja) 2017-12-14 2021-02-22 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響トランスデューサドライバ及びコントローラ
US11340226B2 (en) * 2018-03-02 2022-05-24 The Chinese University Of Hong Kong Squalene epoxidase in the diagnosis and treatment of non-alcoholic fatty liver diseases
WO2019168697A1 (en) * 2018-03-02 2019-09-06 Northwestern University Overexpression of foxc1 to treat corneal vascularization
JP7217542B2 (ja) * 2018-03-29 2023-02-03 国立大学法人 琉球大学 分化コントロール化合物を用いて造腫瘍性をもつおそれのある未分化ｉＰＳ細胞等の混入を除去する方法
US12274733B2 (en) 2018-09-28 2025-04-15 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
CA3113472A1 (en) 2018-09-28 2020-04-02 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
WO2020190940A1 (en) * 2019-03-17 2020-09-24 Baylor College Of Medicine Direct reprogramming of cardiac fibroblasts into cardiomyocytes using an endothelial cell transdifferentiation strategy
EP3946469A4 (en) * 2019-03-26 2022-12-28 The Penn State Research Foundation METHODS AND MATERIALS FOR THE TREATMENT OF CANCER
KR102150489B1 (ko) * 2019-04-09 2020-09-01 고려대학교 산학협력단 소변세포로부터 신장전구세포로의 직접 역분화를 유도하는 방법 및 이의 방법으로 역분화된 신장전구세포를 포함하는 신장세포 손상 질환 예방 또는 치료용 약학 조성물
CA3157523A1 (en) * 2019-10-17 2021-04-22 Gong Chen Regenerating functional neurons for treatment of spinal cord injury and als
EP4045526A4 (en) * 2019-10-17 2023-11-15 The Penn State Research Foundation REGENERATION OF FUNCTIONAL NEURONS FOR THE TREATMENT OF HEMORRHAGIC STROKE
WO2021076947A1 (en) * 2019-10-17 2021-04-22 The Penn State Research Foundation Regenerating functional neurons for treatment of neurological disorders
CN115135382A (zh) * 2019-11-25 2022-09-30 宾州研究基金会 通过neurod1介导的星形胶质细胞到神经元转化进行创伤性脑损伤后的脑修复
CN112877364B (zh) * 2019-11-29 2023-07-28 中国医学科学院药物研究所 软骨下骨细胞向关节软骨细胞直接转化的重编程诱导方案
US20230061798A1 (en) * 2020-01-24 2023-03-02 I Peace, Inc. Method for culturing factor-introduced cells
CN111214660B (zh) * 2020-02-25 2022-01-18 北京大学第三医院（北京大学第三临床医学院） Pax4基因表达抑制剂在制备抑制纤维化的药物中的应用
US11091524B1 (en) 2020-04-22 2021-08-17 Houston Gene Therapeutics Llc Compositions for treatment of vascular disease
CN114231489A (zh) * 2020-09-08 2022-03-25 纽伦捷生物医药科技（苏州）有限公司 用于重编程的功能性片段、组合及其应用
AU2021352917A1 (en) * 2020-09-29 2023-05-25 NeuExcell Therapeutics Inc. Dlx2 vector
US20220098254A1 (en) * 2020-09-29 2022-03-31 NeuExcell Therapeutics Inc. NEUROD1 and DLX2 VECTOR
WO2022072325A1 (en) * 2020-09-29 2022-04-07 NeuExcell Therapeutics Inc. Neurod1 combination vector
JP2022104813A (ja) 2020-12-29 2022-07-11 アイ ピース，インコーポレイテッド リプログラミング因子を導入された細胞の培養方法
CN113563428B (zh) * 2021-06-22 2022-08-02 呈诺再生医学科技(珠海横琴新区)有限公司 特定空间结构多肽及其在制备iPSC中的应用
CN117070477A (zh) * 2022-05-10 2023-11-17 纽伦捷生物医药科技（上海）有限公司 重组溶瘤病毒的重编程的功能性片段、组合及其应用
WO2024112118A1 (ko) * 2022-11-25 2024-05-30 고려대학교 산학협력단 방사선 치료에 의하여 손상된 근육 재생을 위한 고기능성 세포 치료제 조성물
US12252518B2 (en) 2023-01-06 2025-03-18 Life Biosciences, Inc. Methods of treating non-arteritic anterior ischemic optic neuropathy
WO2025106947A1 (en) * 2023-11-17 2025-05-22 Exir, Inc. Compositions and methods for induced stem cell differentiation to neuronal lineage

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
EP0671926B1 (en) 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunomodulatory peptides
FR2766195A1 (fr) 1997-07-21 1999-01-22 Transgene Sa Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique
DE19839491A1 (de) 1998-08-29 2000-03-02 Hermann Heumann Verfahren zur Markierung von Biopolymeren mit Isotopen
US6696038B1 (en) 2000-09-14 2004-02-24 Expression Genetics, Inc. Cationic lipopolymer as biocompatible gene delivery agent
US20040142474A1 (en) 2000-09-14 2004-07-22 Expression Genetics, Inc. Novel cationic lipopolymer as a biocompatible gene delivery agent
WO2003004698A2 (en) 2001-07-06 2003-01-16 Merck Patent Gmbh Method for monitoring and modulating protein folding
US7258997B2 (en) 2001-11-30 2007-08-21 Applied Research Systems Ars Holding N.V. Methods of increasing protein expression levels
US20030134352A1 (en) 2002-01-04 2003-07-17 Freimuth Paul I. Facilitating protein folding and solubility by use of peptide extensions
EP1468105A2 (en) 2002-01-07 2004-10-20 European Molecular Biology Laboratory Recombinant protein expression
WO2005026196A2 (en) 2003-09-12 2005-03-24 Novexin Limited Methods for folding proteins and reducing protein aggregation
DE602004025144D1 (de) 2003-11-25 2010-03-04 Us Gov Sec Army Verwendung von shigella invaplex für den transportven nukleinsäuren durch säugetier-zellmembranen in vitro und in vivo
US20100215581A1 (en) 2006-10-25 2010-08-26 Koninklijke Philips Electronics N.V. Contrast agents for detecting prostate cancer
WO2009117439A2 (en) 2008-03-17 2009-09-24 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
US8722348B2 (en) * 2008-05-28 2014-05-13 Wayne State University Method and composition for a protein transduction technology and its applications
EP2379577A4 (en) * 2008-12-23 2012-08-29 Vivoscript Inc COMPOSITIONS AND METHODS FOR CELL REPROGRAMMING WITHOUT GENETIC MODIFICATION
KR20110134939A (ko) 2009-04-03 2011-12-15 더 맥클린 하스피털 코퍼레이션 유도된 다능성 줄기 세포
WO2010124143A1 (en) 2009-04-23 2010-10-28 Nevada Cancer Institute Reprogramming of somatic cells with purified proteins
EP2253700A1 (en) 2009-05-13 2010-11-24 Helmholtz-Zentrum für Infektionsforschung GmbH A method for producing test systems from donors suffering from adverse effects of medicaments and /or medical treatments, and uses of said systems
JP2013510563A (ja) 2009-11-13 2013-03-28 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 操作された微小胞を用いた真核細胞のリプログラミング
JP2011135864A (ja) * 2009-12-30 2011-07-14 Korea Univ Research & Business Foundation Ｏｃｔ４及びＢｍｉ１、またはその上位調節子を用いて体細胞から胚幹細胞類似細胞への逆分化を誘導する組成物及びこれを用いた胚幹細胞類似細胞の製造方法
EP2531599A4 (en) * 2010-02-04 2014-01-08 Vivoscript Inc COMPOSITIONS AND METHODS OF RENEWING CELLS WITHOUT GENETIC MODIFICATION FOR THE TREATMENT OF NEUROLOGICAL SUFFERING
BR112013003031A2 (pt) * 2010-08-19 2016-06-14 Hoffmann La Roche método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nscs
AU2012220702B2 (en) * 2011-02-22 2016-12-15 The Board Of Regents Of The University Of Texas System Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes
CN107012118A (zh) * 2011-05-02 2017-08-04 韦恩州立大学 蛋白质诱导的多能细胞技术及其用途
JP6113160B2 (ja) 2011-07-19 2017-04-12 ヴィヴォスクリプト，インコーポレイテッド 軟骨損傷を修復するために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法
WO2013033213A1 (en) * 2011-08-30 2013-03-07 The J. David Gladstone Institutes Methods for generating cardiomyocytes
US20180223260A1 (en) * 2011-10-21 2018-08-09 Stemgenics, Inc. Functionalized nanoparticles for the intracellular delivery of biologically active molecules and methods for their manufacture and use

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