BR112012018278A2 - métodos e dispositivos para ativar o tecido adiposo marrom usando energia elétrica - Google Patents

métodos e dispositivos para ativar o tecido adiposo marrom usando energia elétrica

Info

Publication number
BR112012018278A2
BR112012018278A2 BR112012018278A BR112012018278A BR112012018278A2 BR 112012018278 A2 BR112012018278 A2 BR 112012018278A2 BR 112012018278 A BR112012018278 A BR 112012018278A BR 112012018278 A BR112012018278 A BR 112012018278A BR 112012018278 A2 BR112012018278 A2 BR 112012018278A2
Authority
BR
Brazil
Prior art keywords
bat
methods
devices
adipose tissue
brown adipose
Prior art date
Application number
BR112012018278A
Other languages
English (en)
Inventor
Anthony Diubaldi
David N Plescia
James W Voegele
Jason L Harris
Jeyakumar Subbaroyan
Lee M Kaplan
Mark S Ortiz
Nicholas Stylopoulos
Tamara C Baynham
Taylor Aronhalt
Theodore L Stephens
Original Assignee
Ethicon Endo Surgery Inc
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Endo Surgery Inc, Gen Hospital Corp filed Critical Ethicon Endo Surgery Inc
Publication of BR112012018278A2 publication Critical patent/BR112012018278A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0504—Subcutaneous electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36175—Pulse width or duty cycle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36196—Frequency modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/378—Electrical supply
    • A61N1/3787—Electrical supply from an external energy source
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36192—Amplitude modulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Electrotherapy Devices (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

métodos e dispositivos para ativar o tecido adiposo marrom usando energia elétrica. trat-ase de métodos e dispositivos que são fornecidos para ativar o tecido adiposo marrom (bat). geralmente, os métodos e os dispositivos podem ativar o bat para aumentar a termogênese, por exemplo, aumentar a produção de calor no paciente, que, com o tempo, pode levar a uam perda de peso. em uma modalidade, um dispositivo médico é fornecido que ativa o bat ao estimular eletricamente os nervos que ativam o bat e/ou estimular eletricamente os adipócitos marrons diretamente, desse modo, aumentando a termog~enese no bat e induzindo à perda de peso através do gasto de energia.
BR112012018278A 2010-01-22 2010-12-30 métodos e dispositivos para ativar o tecido adiposo marrom usando energia elétrica BR112012018278A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29740510P 2010-01-22 2010-01-22
US12/980,659 US9044606B2 (en) 2010-01-22 2010-12-29 Methods and devices for activating brown adipose tissue using electrical energy
PCT/US2010/062464 WO2011090764A1 (en) 2010-01-22 2010-12-30 Methods and devices for activating brown adipose tissue usnig electrical energy

Publications (1)

Publication Number Publication Date
BR112012018278A2 true BR112012018278A2 (pt) 2016-05-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012018278A BR112012018278A2 (pt) 2010-01-22 2010-12-30 métodos e dispositivos para ativar o tecido adiposo marrom usando energia elétrica

Country Status (9)

Country Link
US (4) US9044606B2 (pt)
EP (1) EP2525869A4 (pt)
JP (1) JP6087150B2 (pt)
CN (2) CN102946941A (pt)
AU (1) AU2010343059B2 (pt)
BR (1) BR112012018278A2 (pt)
CA (1) CA2787028A1 (pt)
RU (1) RU2580293C2 (pt)
WO (1) WO2011090764A1 (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9044606B2 (en) 2010-01-22 2015-06-02 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue using electrical energy
US9566765B2 (en) 2010-10-08 2017-02-14 Guardian Industries Corp. Radiation curable adhesives for reflective laminated solar panels, laminated solar panels including radiation curable adhesives, and/or associated methods
WO2012092056A1 (en) * 2010-12-29 2012-07-05 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue with targeted substance delivery
US10441459B2 (en) 2010-12-29 2019-10-15 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue with cooling
WO2012092057A1 (en) * 2010-12-29 2012-07-05 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue with light
US9238133B2 (en) * 2011-05-09 2016-01-19 The Invention Science Fund I, Llc Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
US9011510B2 (en) * 2011-05-09 2015-04-21 The Invention Science Fund I, Llc Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
US20120296402A1 (en) * 2011-05-17 2012-11-22 Rebecca Kotter Device and method for brown adipose tissue activation
US9402999B2 (en) * 2012-05-04 2016-08-02 Ethicon Endo-Surgery, Inc. Transdermal medical patch
US8812100B2 (en) * 2012-05-10 2014-08-19 Ethicon Endo-Surgery, Inc. Device and method for self-positioning of a stimulation device to activate brown adipose tissue depot in a supraclavicular fossa region
JP2014036742A (ja) * 2012-08-16 2014-02-27 Sony Corp 刺激発生装置
WO2014047388A1 (en) 2012-09-21 2014-03-27 Ethicon Endo-Surgery, Inc. Systems and methods for predicting metabolic and bariatric surgery outcomes
US10242756B2 (en) 2012-09-21 2019-03-26 Ethicon Endo-Surgery, Inc. Systems and methods for predicting metabolic and bariatric surgery outcomes
WO2014047432A1 (en) 2012-09-21 2014-03-27 Ethicon Endo-Surgery, Inc. Clinical predictors of weight loss
US9168000B2 (en) 2013-03-13 2015-10-27 Ethicon Endo-Surgery, Inc. Meal detection devices and methods
US9604060B2 (en) * 2014-03-11 2017-03-28 Oregon Health & Science University Deep brain electrode placement and stimulation based on brown adipose tissue temperature
AU2015321559B2 (en) * 2014-09-23 2018-09-13 Boston Scientific Neuromodulation Corporation Neuromodulation specific to objective function of modulation field for targeted tissue
US10080884B2 (en) * 2014-12-29 2018-09-25 Ethicon Llc Methods and devices for activating brown adipose tissue using electrical energy
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue
CN115227969A (zh) 2015-02-24 2022-10-25 伊莱拉股份有限公司 使用电极皮肤贴实现食欲调节或改善饮食依从性的方法
US10463854B2 (en) 2015-02-24 2019-11-05 Elira, Inc. Systems and methods for managing symptoms associated with dysmenorrhea using an electro-dermal patch
US10765863B2 (en) 2015-02-24 2020-09-08 Elira, Inc. Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy
US20220062621A1 (en) 2015-02-24 2022-03-03 Elira, Inc. Electrical Stimulation-Based Weight Management System
US10376145B2 (en) 2015-02-24 2019-08-13 Elira, Inc. Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch
US10335302B2 (en) 2015-02-24 2019-07-02 Elira, Inc. Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions
US10864367B2 (en) 2015-02-24 2020-12-15 Elira, Inc. Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions
WO2017075359A2 (en) * 2015-10-29 2017-05-04 Elira Therapeutics Llc Systems and methods for managing symptoms associated with dysmenorrhea using an electro-dermal patch
WO2017205047A2 (en) * 2016-05-26 2017-11-30 Elira, Inc. Systems and methods for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch
EP3532148A4 (en) * 2016-10-26 2020-07-08 Elira, Inc. SYSTEMS AND METHODS FOR USING A TRANSCUTANEOUS ELECTRICAL STIMULATION DEVICE TO DELIVER TITRATED THERAPY
US20180292478A1 (en) * 2017-04-05 2018-10-11 Howard Hughes Medical Institute Magnetic apparatus
WO2019074634A1 (en) * 2017-10-12 2019-04-18 Oregon Health & Science University MANAGEMENT OF ACTIVITY OF ADIPOSE BROWN FABRIC
WO2022125571A1 (en) * 2020-12-08 2022-06-16 The Regents Of The University Of California Bioelectric neuromodulation for hematopoiesis regulation during chemotherapy
EP4271295A1 (en) 2021-09-29 2023-11-08 Cilag GmbH International Surgical devices, systems, and methods for control of one visualization with another
WO2023052943A1 (en) 2021-09-29 2023-04-06 Cilag Gmbh International Surgical devices, systems, and methods for control of one visualization with another
EP4221613A1 (en) 2021-09-29 2023-08-09 Cilag GmbH International Surgical system for altering the body's sensing of food
US20230100698A1 (en) 2021-09-29 2023-03-30 Cilag Gmbh International Methods for Controlling Cooperative Surgical Instruments
WO2023052935A1 (en) 2021-09-29 2023-04-06 Cilag Gmbh International Surgical devices, systems, and methods for control of one visualization with another
WO2023052941A1 (en) 2021-09-29 2023-04-06 Cilag Gmbh International Surgical system for delivering energy to tissue in an anatomic space and monitoring a tissue parameter in a different anatomic space
WO2023052947A1 (en) 2021-09-29 2023-04-06 Cilag Gmbh International Surgical devices, systems, and methods for control of one visualization with another

Family Cites Families (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596792A (en) 1981-09-04 1986-06-24 The Regents Of The University Of California Safe vaccine for hepatitis containing polymerized serum albumin
US4498843A (en) 1982-08-02 1985-02-12 Schneider Philip H Insulin infusion pump
JPS5938877A (ja) 1982-08-30 1984-03-02 Musashi Eng Kk 紙葉判別方法
GB2138013A (en) 1983-04-01 1984-10-17 Gen Electric Cure accelerator for RTV composition
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599230A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4608251A (en) 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
GB8519154D0 (en) 1985-07-30 1985-09-04 Ici Plc Aromatic ethers
GB8607312D0 (en) 1986-03-25 1986-04-30 Ici Plc Therapeutic agents
GB8714901D0 (en) 1986-07-23 1987-07-29 Ici Plc Amide derivatives
US4978338A (en) 1988-04-21 1990-12-18 Therex Corp. Implantable infusion apparatus
CH676164A5 (pt) 1988-05-28 1990-12-14 Sc Techn Dipl Ing Peter A Neuk
CN2045308U (zh) 1988-10-12 1989-10-04 路雪清 电子减肥机
DK339289D0 (da) 1989-07-07 1989-07-07 Dak Lab As Farmaceutisk praeparat
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
GB9111426D0 (en) 1991-05-28 1991-07-17 Ici Plc Chemical compounds
JPH0521940A (ja) 1991-07-11 1993-01-29 Hitachi Telecom Technol Ltd プリント基板及びその製造方法
US5453270A (en) 1992-03-30 1995-09-26 Hypermetabolic Therapies, Inc. Pharmaceutical composition and method for hypermetabolic weight loss
GB9209076D0 (en) 1992-04-27 1992-06-10 Ici Plc Chemical compounds
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
AU7717894A (en) 1993-08-30 1995-03-22 Lipocyte, Inc. Method and composition for weight reduction
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5731408A (en) 1995-04-10 1998-03-24 Arizona Board Of Regents On Behalf Of The University Of Arizona Peptides having potent antagonist and agonist bioactivities at melanocortin receptors
US5837670A (en) 1995-04-18 1998-11-17 Hartshorn; Richard Timothy Detergent compositions having suds suppressing properties
FR2733513B1 (fr) 1995-04-25 1997-07-18 Centre Nat Rech Scient Lignees immortalisees de cellules issues du tissu adipeux humain, leur procede de preparation et leurs applications
US5540730A (en) * 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US6033397A (en) * 1996-03-05 2000-03-07 Vnus Medical Technologies, Inc. Method and apparatus for treating esophageal varices
US5789654A (en) 1996-05-09 1998-08-04 Beth Israel Hospital Association Transgenic animals deficient in endogenous β3 -adrenergic receptor and uses thereof
US6246912B1 (en) * 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
IT1286236B1 (it) * 1996-09-24 1998-07-08 Galaxy Top International Spa Procedimento per la stimolazione controllata di regioni predefinite del corpo umano tramite l'applicazione di segnali elettrici variabili
CA2248854C (en) 1996-09-30 2004-03-30 Dennis Jones The regulation of appetite, body weight and athletic function with materials derived from citrus varieties
US6224873B1 (en) 1996-09-30 2001-05-01 Zhishin, Llc Regulation of appetite, body weight and athletic function with materials derived from citrus varieties
WO1998031396A1 (en) 1997-01-15 1998-07-23 Duke University Respiration uncoupling protein
WO1998045313A1 (en) 1997-04-04 1998-10-15 Amylin Pharmaceuticals, Inc. Novel uncoupling protein and methods of use
JP2001526538A (ja) 1997-05-07 2001-12-18 ノバルティス アクチエンゲゼルシャフト 脱共役タンパク質相同物：ｕｃｐ３
US6426411B1 (en) 1997-05-30 2002-07-30 Dana-Farber Cancer Institute PGC-1, a novel brown fat pparγ coactivator
US5911992A (en) 1997-06-12 1999-06-15 A. Glenn Braswell Method for controlling weight with hypericum perforatum and garcinia cambogia
SE9702457D0 (sv) 1997-06-26 1997-06-26 Pharmacia & Upjohn Ab Screening
US6072100A (en) 1998-01-28 2000-06-06 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
WO1999039677A1 (fr) 1998-02-05 1999-08-12 Miwa Science Laboratory Inc. Appareil de rayonnement d'ondes ultrasoniques
DE19815411A1 (de) 1998-04-06 1999-10-07 Solvay Pharm Gmbh Thermogenese stimulierend wirksame Arzneimittel
WO2000004037A1 (en) 1998-07-14 2000-01-27 Amylin Pharmaceuticals, Inc. Uncoupling protein 4 (ucp-4) and methods of use
US7599736B2 (en) 2001-07-23 2009-10-06 Dilorenzo Biomedical, Llc Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease
ATE280615T1 (de) 1998-08-31 2004-11-15 Johnson & Johnson Consumer Elektrotransportvorrichtung mit klingen
US6605297B2 (en) 1998-09-01 2003-08-12 Janiftec, Inc. Substances having antiobese and visceral fat-reducing functions and utilization thereof
FR2788438B1 (fr) 1999-01-14 2003-10-03 Arkopharma Laboratoires Composition pour le traitement de l'obesite et procede de traitement esthetique
US6197580B1 (en) 1999-02-01 2001-03-06 American Home Products Corporation Transcriptional regulation of the human β3-adrenergic receptor gene
WO2000062797A1 (fr) 1999-04-16 2000-10-26 Sumitomo Pharmaceuticals Company, Limited Remedes pour le traitement des neuropathies automatiques
JP3207823B2 (ja) 1999-04-28 2001-09-10 リノール油脂株式会社 共役リノール酸を有効成分とする褐色脂肪増加剤
US7060437B1 (en) 1999-05-05 2006-06-13 Ohio University Growth hormone-regulatable brown adipose tissue genes and proteins and uses thereof
JP4155669B2 (ja) 1999-06-14 2008-09-24 独立行政法人科学技術振興機構 植物の発熱関連遺伝子と発熱関連タンパク質
US6548739B2 (en) 1999-06-18 2003-04-15 City Of Hope Method for activating peroxisome proliferator activated receptor-γ
US6607500B2 (en) * 1999-07-08 2003-08-19 Cyclotec Advanced Medical Technologies, Inc. Integrated cast and muscle stimulation system
US6445955B1 (en) 1999-07-08 2002-09-03 Stephen A. Michelson Miniature wireless transcutaneous electrical neuro or muscular-stimulation unit
US6381496B1 (en) * 1999-10-01 2002-04-30 Advanced Bionics Corporation Parameter context switching for an implanted device
US6207878B1 (en) 1999-10-21 2001-03-27 University Of Iowa Research Foundation Sarcospan-deficient mouse as a model for clinical disorders associated with sarcospan mutations
US6983753B1 (en) 1999-11-17 2006-01-10 Smithkline Beecham Corporation Infrared thermography
JP4723707B2 (ja) * 1999-12-22 2011-07-13 パナソニック電工株式会社 痩身器具
GB0002059D0 (en) 2000-01-28 2000-03-22 Melacure Therapeutics Ab Novel aromatic amines
JP2001259047A (ja) 2000-03-22 2001-09-25 Matsushita Seiko Co Ltd 体脂肪燃焼方法
JP2003528088A (ja) 2000-03-23 2003-09-24 メルク エンド カムパニー インコーポレーテッド メラノコルチン受容体作働薬としての置換ピペリジン類
US6472398B1 (en) 2000-03-23 2002-10-29 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
US6475530B1 (en) 2000-05-31 2002-11-05 Eric H. Kuhrts Methods and compositions for producing weight loss
AU2001283199A1 (en) 2000-08-08 2002-02-18 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of brown adipose cell disorders
EP1320366A4 (en) 2000-08-23 2005-04-06 Merck & Co Inc SUBSTITUTED PIPERIDINES AS AGONISTS OF MELANOCORTIN RECEPTORS
DZ3415A1 (fr) 2000-08-31 2002-03-07 Chiron Corp Guanidinobenzamides comme mc4-r agonistes.
WO2002032499A1 (en) * 2000-09-14 2002-04-25 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method and apparatus to treat disorders of gastrointestinal peristalsis
US7440806B1 (en) 2000-11-21 2008-10-21 Boston Scientific Neuromodulation Corp. Systems and methods for treatment of diabetes by electrical brain stimulation and/or drug infusion
US6922590B1 (en) 2000-11-21 2005-07-26 Advanced Bionics Corporation Systems and methods for treatment of diabetes by electrical brain stimulation and/or drug infusion
WO2002068619A2 (en) 2001-01-22 2002-09-06 Curagen Corporation Bfit (brown fat inducible thioesterase) polypeptides and polynucleotides and their use
EP1368339A1 (en) 2001-01-23 2003-12-10 Eli Lilly & Company Substituted piperidines/piperazines as melanocortin receptor agonists
DE60205727T2 (de) 2001-01-23 2006-06-29 Eli Lilly And Co., Indianapolis Piperazin- und piperidinderivate als agonisten des melanocortin-rezeptors
CA2432988A1 (en) 2001-01-23 2002-08-01 Cristina Garcia-Paredes Melanocortin receptor agonists
GEP20053710B (en) 2001-02-28 2005-12-26 Merck & Co Inc Acylated Piperidine Derivatives as Melanocortin-4 Receptor Agonists
AU2002250343B2 (en) 2001-02-28 2006-05-25 Merck Sharp & Dohme Corp. Acylated piperidine derivatives as melanocortin-4 receptor agonists
US7015235B2 (en) 2001-02-28 2006-03-21 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
WO2002081443A1 (en) 2001-04-09 2002-10-17 Chiron Corporation Novel guanidino compounds
US6911447B2 (en) 2001-04-25 2005-06-28 The Procter & Gamble Company Melanocortin receptor ligands
AU2002320301A1 (en) 2001-07-05 2003-01-21 Dana-Farber Cancer Institute, Inc. Novel pgc-1 isoforms and uses therefor
IL159797A0 (en) 2001-07-11 2004-06-20 Palatin Technologies Inc Linear and cyclic melanocortin receptor-specific peptides
DE60234348D1 (de) 2001-07-17 2009-12-24 Teijin Ltd Selektionsverfahren für eine durch das austesten einer ppard aktivierenden wirkung charakterisierten substanz und arzneistoff
ATE411021T1 (de) 2001-07-18 2008-10-15 Merck & Co Inc Überbrückte piperidinderivate als melanocortin- rezeptor-agonisten
US20070162085A1 (en) * 2001-07-23 2007-07-12 Dilorenzo Biomedical, Llc Method, apparatus, surgical technique, and stimulation parameters for autonomic neuromodulation for the treatment of obesity
US20090118780A1 (en) * 2001-07-23 2009-05-07 Dilorenzo Daniel John Method and apparatus for conformal electrodes for autonomic neuromodulation for the treatment of obesity and other conditions
US7115607B2 (en) 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
US6977264B2 (en) 2001-07-25 2005-12-20 Amgen Inc. Substituted piperidines and methods of use
PL368977A1 (en) * 2001-08-08 2005-04-04 Kevin R. Orton Apparatus and method for electrically conductive weight reduction
AU2002331898A1 (en) 2001-09-24 2003-04-07 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Induction of brown adipocytes by transcription factor nfe2l2
US20030082168A1 (en) 2001-10-22 2003-05-01 Inna Yegorova Compositions and methods for facilitating weight loss
US20050080026A1 (en) 2001-10-29 2005-04-14 Arnd Steuernagel Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
WO2003042362A2 (en) 2001-11-09 2003-05-22 Dana-Farber Cancer Institute, Inc. PGC-1β, A NOVEL PGC-1 HOMOLOGUE AND USES THEREFOR
CN2520883Y (zh) 2001-12-11 2002-11-20 中国人民解放军海军潜艇学院 电疗仪
EP1476080A4 (en) * 2002-02-20 2010-06-02 Medicis Technologies Corp ULTRASOUND TREATMENT AND COMPOSITE EXPLANATION OF FAT FABRICS
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
DE60319207T2 (de) 2002-03-15 2009-02-12 The General Hospital Corp., Boston Vorrichtungen für die selektive zerstörung von fettgewebe durch kontrollierte kühlung
US7689277B2 (en) * 2002-03-22 2010-03-30 Leptos Biomedical, Inc. Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
US7239912B2 (en) * 2002-03-22 2007-07-03 Leptos Biomedical, Inc. Electric modulation of sympathetic nervous system
US20040077556A1 (en) 2002-04-22 2004-04-22 Robert Chinery Compositions and methods for promoting weight loss, thermogenesis, appetite suppression, lean muscle mass, increasing metabolism and boosting energy levels, and use as a dietary supplement in mammals
US20040077566A9 (en) 2002-05-09 2004-04-22 Millennium Pharmaceuticals, Inc. Methods and compositions for the treatment and diagnosis of body weight disorders
US6565847B1 (en) 2002-07-03 2003-05-20 Vitacost.Com, Inc. Thermogenic weight management composition
US7236830B2 (en) * 2002-12-10 2007-06-26 Northstar Neuroscience, Inc. Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders
US7025791B2 (en) 2002-12-02 2006-04-11 Gi Dynamics, Inc. Bariatric sleeve
WO2004063354A2 (en) 2003-01-10 2004-07-29 The Regents Of The University Of Michigan Compositions and methods for characterizing and regulating wnt pathways
WO2004078716A1 (en) 2003-03-03 2004-09-16 Merck & Co. Inc. Acylated piperazine derivatives as melanocortin-4 receptor agonists
HUE035374T2 (hu) 2003-03-13 2018-05-02 Real Aesthetics Ltd Ultrahangos cellulitis kezelés
AU2004226452B2 (en) 2003-03-26 2008-07-24 Merck Sharp & Dohme Corp. Bicyclic piperidine derivatives as melanocortin-4 receptor agonists
US7463928B2 (en) 2003-04-25 2008-12-09 Medtronic, Inc. Identifying combinations of electrodes for neurostimulation therapy
CN1809288A (zh) 2003-06-04 2006-07-26 雀巢技术公司 体重管理饮料
WO2005002527A2 (en) 2003-07-03 2005-01-13 Massachusetts Institute Of Technology Sirt1 modulation of adipogenesis and adipose function
US7825235B2 (en) 2003-08-18 2010-11-02 Isis Pharmaceuticals, Inc. Modulation of diacylglycerol acyltransferase 2 expression
US20050045498A1 (en) 2003-08-25 2005-03-03 Kimberly-Clark Worldwide, Inc. Cold pack
US7565198B2 (en) * 2004-02-12 2009-07-21 Medtronic Urinary Solutions, Inc. Systems and methods for bilateral stimulation of left and right branches of the dorsal genital nerves to treat dysfunctions, such as urinary incontinence
JP3951271B2 (ja) 2003-09-30 2007-08-01 小林製薬株式会社 体脂肪燃焼促進剤
WO2005037232A2 (en) 2003-10-17 2005-04-28 Joslin Diabetes Center, Inc. Methods and compositions for modulating adipocyte function
US20050192286A1 (en) 2003-10-22 2005-09-01 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
US8620402B2 (en) 2003-10-30 2013-12-31 Halthion Medical Technologies, Inc. Physiological sensor device
US7989634B2 (en) 2003-11-12 2011-08-02 Lg Life Sciences Ltd. Melanocortin receptor agonists
GB0402492D0 (en) 2004-02-04 2004-03-10 Pfizer Ltd Pharmaceutically active compounds
US7647112B2 (en) 2004-02-11 2010-01-12 Ethicon, Inc. System and method for selectively stimulating different body parts
US8751003B2 (en) 2004-02-11 2014-06-10 Ethicon, Inc. Conductive mesh for neurostimulation
JP2007521914A (ja) 2004-02-11 2007-08-09 エシコン・インコーポレイテッド 超小型電子機械システムを用いた尿力学評価方法および評価システム
US7979137B2 (en) * 2004-02-11 2011-07-12 Ethicon, Inc. System and method for nerve stimulation
US8165695B2 (en) 2004-02-11 2012-04-24 Ethicon, Inc. System and method for selectively stimulating different body parts
US7691823B2 (en) 2004-03-05 2010-04-06 University Of Massachusetts RIP140 regulation of glucose transport
US7476406B1 (en) 2004-05-17 2009-01-13 Nse Products, Inc. Multifaceted weight control system
US20060014178A1 (en) 2004-05-26 2006-01-19 Whitson Robert H Use of Mrf-2 for screening and therapies
HUP0401177A2 (en) 2004-06-14 2007-09-28 N Gene Res Lab Inc Pharmaceutical composition for increasing the mitochondrial genesis
US20050288740A1 (en) 2004-06-24 2005-12-29 Ethicon Endo-Surgery, Inc. Low frequency transcutaneous telemetry to implanted medical device
US7191007B2 (en) 2004-06-24 2007-03-13 Ethicon Endo-Surgery, Inc Spatially decoupled twin secondary coils for optimizing transcutaneous energy transfer (TET) power transfer characteristics
US7599744B2 (en) 2004-06-24 2009-10-06 Ethicon Endo-Surgery, Inc. Transcutaneous energy transfer primary coil with a high aspect ferrite core
US7599743B2 (en) 2004-06-24 2009-10-06 Ethicon Endo-Surgery, Inc. Low frequency transcutaneous energy transfer to implanted medical device
US20060008540A1 (en) 2004-07-08 2006-01-12 Rulin Xiu Herbal compositions comprising portaluca
AU2005275232A1 (en) 2004-07-16 2006-02-23 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
EP1773338B1 (en) 2004-07-19 2010-01-06 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
US20060084637A1 (en) 2004-10-18 2006-04-20 Maria Alemany Methods of using fatty-acid esters of estrogens and thermogenic compounds for reducing the body weight of a mammal and compositions containing the same
DE102005000666B3 (de) 2005-01-04 2006-10-05 Sanofi-Aventis Deutschland Gmbh Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US20060204599A1 (en) 2005-03-14 2006-09-14 Wheat Jared R Dietary supplement and method of using same
CA2602292A1 (en) 2005-03-15 2006-09-21 The Regents Of The University Of California Method and system for modulating energy expenditure and neurotrophic factors
EP1888094B1 (en) 2005-03-31 2009-08-12 Amylin Pharmaceuticals, Inc. Amylin and amylin agonists for treating psychiatric diseases and disorders
US7825098B2 (en) 2005-04-04 2010-11-02 Joslin Diabetes Center, Inc. Methods and compositions for modulating Necdin function
US7300409B2 (en) 2005-05-12 2007-11-27 S.C. Johnson & Son, Inc. Therapy patch
US8588930B2 (en) 2005-06-07 2013-11-19 Ethicon, Inc. Piezoelectric stimulation device
JP2008545799A (ja) 2005-06-10 2008-12-18 ボード オブ スーパーバイザーズ オブ ルイジアナ ステイト ユニバーシティー アンド アグリカルチュラル アンド メカニカル カレッジ 脂肪組織における末梢時計の調節
CA2615209A1 (en) 2005-08-01 2007-02-08 Pfizer Limited Mc4r-ag0nists for the treatment of urinary tract dysfunction
CA2617654A1 (en) 2005-08-04 2007-02-08 Pfizer Limited Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
US20100222734A1 (en) 2005-09-01 2010-09-02 Dalia Jayes Double-sided patch
EP1762976B1 (en) 2005-09-08 2011-05-18 Aloka Co., Ltd. Computerized tomography device and image processing method for identifying brown adipose tissue
RU2008116844A (ru) 2005-09-29 2009-11-10 Мерк энд Ко., Инк. (US) Ацилированные производные спиропиперидина как модуляторы рецептора меланокортина-4
AU2006297452A1 (en) 2005-09-30 2007-04-12 Merck Sharp & Dohme Corp. Acylated piperidine derivatives as melanocortin-4 receptor agonists
EP1940401B1 (en) 2005-10-18 2012-07-11 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
US9061146B2 (en) * 2005-10-28 2015-06-23 Medtronic, Inc. Impedance-based bladder sensing
JP5021940B2 (ja) 2006-02-21 2012-09-12 公立大学法人大阪府立大学 全固体アルカリ二次電池用無機ヒドロゲル電解質の製法
US20070282318A1 (en) * 2006-05-16 2007-12-06 Spooner Gregory J Subcutaneous thermolipolysis using radiofrequency energy
CN2899835Y (zh) 2006-05-18 2007-05-16 陕西秦明医学仪器股份有限公司 植入式减肥刺激器
US20080262411A1 (en) 2006-06-02 2008-10-23 Dobak John D Dynamic nerve stimulation in combination with other eating disorder treatment modalities
US7264602B1 (en) 2006-06-28 2007-09-04 Longsworth Sheryl M Bandage assembly
US7623278B2 (en) 2006-09-26 2009-11-24 Xerox Corporation MEMS Fabry-Perot inline color scanner for printing applications using stationary membranes
EP2076183A4 (en) 2006-10-04 2009-09-16 Ndo Surgical Inc DEVICES AND METHODS FOR ENDOLUMINAL MANIPULATION OF TISSUE DURING GASTRIC RESTRICTION AND DRUG DELIVERY
US9074012B2 (en) 2006-10-18 2015-07-07 Dana-Farber Cancer Institute, Inc. Molecular control of brown fat differentiation and energy expenditure
US20080132962A1 (en) * 2006-12-01 2008-06-05 Diubaldi Anthony System and method for affecting gatric functions
US20080138449A1 (en) 2006-12-06 2008-06-12 H3 Formulations Ltd. Composition and method for supporting thermogenesis and lipid oxidation
US8128576B2 (en) 2006-12-07 2012-03-06 Ethicon, Inc. System and method for urodynamic evaluation utilizing micro electro-mechanical system technology
US8175718B2 (en) 2006-12-19 2012-05-08 Ethicon, Inc. Electrode patch and method for neurostimulation
WO2008085290A2 (en) 2006-12-28 2008-07-17 Vibrynt, Inc. Devices and methods for treatment of obesity
EP2101822A2 (en) 2007-01-18 2009-09-23 Novo Nordisk A/S Use of peptides in combination with surgical intervention for the treatment of obesity
JP2010516653A (ja) 2007-01-18 2010-05-20 ノボ・ノルデイスク・エー／エス 肥満の治療に使用される新規ペプチド
US7815895B2 (en) 2007-05-21 2010-10-19 Tohoku University Method for activating efferent sympathetic nerves innervating adipose tissues to improve obesity and symptoms associated therewith
US20100130597A1 (en) 2007-07-06 2010-05-27 The United State Of America, As Represented By The Secretary Of The Dept Of Health And Human Service Dna-pkcs modulates energy regulation and brain function
US8103355B2 (en) * 2007-07-16 2012-01-24 Invasix Ltd Method and device for minimally invasive skin and fat treatment
US20090024144A1 (en) 2007-07-18 2009-01-22 Zeiner Mark S Hybrid endoscopic/laparoscopic device for forming serosa to serosa plications in a gastric cavity
US20090081715A1 (en) 2007-09-07 2009-03-26 Cobalt Technologies, Inc., A Delaware Corporation Engineered Light-Emitting Reporter Genes
US9529972B2 (en) * 2007-09-24 2016-12-27 Medtronic, Inc. Patient event indication
US8352026B2 (en) 2007-10-03 2013-01-08 Ethicon, Inc. Implantable pulse generators and methods for selective nerve stimulation
US8260439B2 (en) 2007-11-16 2012-09-04 Ethicon, Inc. Nerve stimulation patches and methods for stimulating selected nerves
WO2009067501A2 (en) 2007-11-19 2009-05-28 Joslin Diabetes Center, Inc. Infrared thermography for monitoring brown adipose tissue
US20090149918A1 (en) 2007-12-06 2009-06-11 Peter Krulevitch Implantable antenna
US8527064B2 (en) * 2007-12-12 2013-09-03 Cardiac Pacemakers, Inc. System for stimulating autonomic targets from pulmonary artery
US8170683B2 (en) 2007-12-14 2012-05-01 Ethicon, Inc. Dermatome stimulation devices and methods
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8565885B2 (en) 2008-01-30 2013-10-22 The Board Of Regents Of The University Of Texas System Ileal electrical stimulation
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US20120040342A1 (en) 2008-03-17 2012-02-16 Geisinger Clinic Genetic Indicators Of Weight Loss
WO2010025146A1 (en) 2008-08-26 2010-03-04 Centocor Ortho Biotech Inc. Stimulation of satiety hormone release
US7818060B2 (en) * 2008-10-31 2010-10-19 Medtronic, Inc. Determination of stimulation output capabilities throughout power source voltage range
US7970478B2 (en) 2008-12-19 2011-06-28 Ethicon, Inc. Optimizing stimulation therapy of an external stimulating device based on firing of action potential in target nerve
US8897885B2 (en) 2008-12-19 2014-11-25 Ethicon, Inc. Optimizing the stimulus current in a surface based stimulation device
WO2010088533A1 (en) * 2009-01-30 2010-08-05 Medtronic, Inc. Closed-loop neurostimulation to treat pulmonary edema
CN101579120A (zh) * 2009-03-18 2009-11-18 北京惠中铭捷生物科技有限公司 一种具有减肥功能的营养食品及其制备方法
US8303982B2 (en) 2009-03-20 2012-11-06 Ethicon, Inc Self-locating, multiple application, and multiple location medical patch systems and methods therefor
US8340772B2 (en) * 2009-05-08 2012-12-25 Advanced Neuromodulation Systems, Inc. Brown adipose tissue utilization through neuromodulation
US8126530B2 (en) 2009-10-26 2012-02-28 Ethicon, Inc. Offset electrode
US20110144490A1 (en) * 2009-12-10 2011-06-16 General Electric Company Devices and methods for adipose tissue reduction and skin contour irregularity smoothing
US9220885B2 (en) 2009-12-18 2015-12-29 Ethicon, Inc. Placement devices that enable patients to accurately position medical patches at target locations and methods therefor
US8476227B2 (en) 2010-01-22 2013-07-02 Ethicon Endo-Surgery, Inc. Methods of activating a melanocortin-4 receptor pathway in obese subjects
US9044606B2 (en) 2010-01-22 2015-06-02 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue using electrical energy
WO2012092057A1 (en) 2010-12-29 2012-07-05 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue with light
US8696616B2 (en) 2010-12-29 2014-04-15 Ethicon Endo-Surgery, Inc. Obesity therapy and heart rate variability
US10441459B2 (en) 2010-12-29 2019-10-15 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue with cooling
US20120172783A1 (en) 2010-12-29 2012-07-05 Ethicon Endo-Surgery, Inc. Obesity therapy and heart rate variability
FR2972942B1 (fr) 2011-03-21 2017-11-24 Arkema France Procede de fabrication de nanotubes de carbone et appareil pour la mise en oeuvre du procede.
US9011510B2 (en) * 2011-05-09 2015-04-21 The Invention Science Fund I, Llc Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
US9314609B2 (en) 2011-10-28 2016-04-19 Martin Brown Device for providing electrical stimulation of a human knee
JP2013126486A (ja) 2011-12-19 2013-06-27 Panasonic Corp 電気刺激装置
US20130289650A1 (en) * 2012-04-25 2013-10-31 Pacesetter, Inc. Neuromodulation for Hypertension Control
US8812100B2 (en) 2012-05-10 2014-08-19 Ethicon Endo-Surgery, Inc. Device and method for self-positioning of a stimulation device to activate brown adipose tissue depot in a supraclavicular fossa region
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue

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