RU2012136125A - Способы и устройства для активации бурой жировой ткани с использованием электрической энергии - Google Patents

Способы и устройства для активации бурой жировой ткани с использованием электрической энергии Download PDF

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RU2012136125A
RU2012136125A RU2012136125/14A RU2012136125A RU2012136125A RU 2012136125 A RU2012136125 A RU 2012136125A RU 2012136125/14 A RU2012136125/14 A RU 2012136125/14A RU 2012136125 A RU2012136125 A RU 2012136125A RU 2012136125 A RU2012136125 A RU 2012136125A
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signal
patient
electrical signal
range
signal generator
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Джейсон Л. ХАРРИС
Николас СТИЛОПОУЛОС
Ли М. КАПЛАН
Тамара К. БЕЙНХАМ
Джейакумар СУББАРОЯН
Джеймс В. ВЕГЕЛЕ
Тэйлор АРОНХОЛТ
Энтони ДЬЮБАЛДИ
Дэвид Н. ПЛЕШИА
Марк С. ОРТИЗ
Теодор Л. СТЕФЕНС
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Этикон Эндо-Серджери, Инк.
ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН д/б/а МАССАЧУСЕТС ДЖЕНЕРАЛ ХОСПИТАЛ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0504—Subcutaneous electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36175—Pulse width or duty cycle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36196—Frequency modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/378—Electrical supply
    • A61N1/3787—Electrical supply from an external energy source
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36192—Amplitude modulation

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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Radiology & Medical Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Electrotherapy Devices (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Медицинское устройство, которое содержит:корпус, выполненный с возможностью размещения в непосредственном контакте с телом пациента близко к депо бурой жировой ткани; игенератор сигнала, соединенный с корпусом и выполненный с возможностью генерации электрического сигнала и подачи электрического сигнала в тело пациента близко к бурой жировой ткани для активации бурой жировой ткани и увеличения потребления энергии бурой жировой тканью, при этом электрический сигнал имеет модулирующий сигнал и несущий сигнал.2. Устройство по п.1, где корпус выполнен с возможностью наложения на внешнюю поверхность кожи пациента.3. Устройство по п.1, где корпус выполнен с возможностью по меньшей мере частичной имплантации внутрь пациента.4. Устройство по п.3, где корпус выполнен с возможностью имплантации целиком внутрь пациента.5. Устройство по п.1, где корпус выполнен с возможностью нахождения в непрерывном непосредственном контакте с телом пациента в течение предварительно определенного количества времени, причем генератор сигнала генерирует электрический сигнал и непрерывно подает электрический сигнал в тело пациента.6. Устройство по п.5, где предварительно определенное количество времени составляет по меньшей мере один день.7. Устройство по п.5, где предварительно определенное количество времени составляет по меньшей мере одну неделю.8. Устройство по п.5, где предварительно определенное количество времени составляет по меньшей мере четыре недели.9. Устройство по п.1, где корпус содержит корпус накладки, прикрепляемой к пациенту.10. Устройство по п.1, где генератор сигнала размещен внутри корпуса.11. Устройство по п.1, которое д

Claims (20)

1. Медицинское устройство, которое содержит:
корпус, выполненный с возможностью размещения в непосредственном контакте с телом пациента близко к депо бурой жировой ткани; и
генератор сигнала, соединенный с корпусом и выполненный с возможностью генерации электрического сигнала и подачи электрического сигнала в тело пациента близко к бурой жировой ткани для активации бурой жировой ткани и увеличения потребления энергии бурой жировой тканью, при этом электрический сигнал имеет модулирующий сигнал и несущий сигнал.
2. Устройство по п.1, где корпус выполнен с возможностью наложения на внешнюю поверхность кожи пациента.
3. Устройство по п.1, где корпус выполнен с возможностью по меньшей мере частичной имплантации внутрь пациента.
4. Устройство по п.3, где корпус выполнен с возможностью имплантации целиком внутрь пациента.
5. Устройство по п.1, где корпус выполнен с возможностью нахождения в непрерывном непосредственном контакте с телом пациента в течение предварительно определенного количества времени, причем генератор сигнала генерирует электрический сигнал и непрерывно подает электрический сигнал в тело пациента.
6. Устройство по п.5, где предварительно определенное количество времени составляет по меньшей мере один день.
7. Устройство по п.5, где предварительно определенное количество времени составляет по меньшей мере одну неделю.
8. Устройство по п.5, где предварительно определенное количество времени составляет по меньшей мере четыре недели.
9. Устройство по п.1, где корпус содержит корпус накладки, прикрепляемой к пациенту.
10. Устройство по п.1, где генератор сигнала размещен внутри корпуса.
11. Устройство по п.1, которое дополнительно содержит контроллер, выполненный с возможностью включения генератора сигнала, чтобы генератор сигнала начал генерировать электрический сигнал, выключения генератора сигнала, чтобы генератор сигнала закончил генерировать электрический сигнал, или и того и другого.
12. Устройство по п.11, где контроллер выполнен с возможностью размещения удаленно от пациента и нахождения в электронной связи с генератором сигнала.
13. Устройство по п.11, где контроллер выполнен с возможностью имплантации целиком внутрь пациента.
14. Устройство по п.1, где несущий сигнал имеет несущую частоту в диапазоне приблизительно от 10 до 400 кГц.
15. Устройство по п.1, где модулирующий сигнал имеет частоту активации в диапазоне приблизительно от 0,1 до 100 Гц.
16. Устройство по п.1, где модулирующий сигнал имеет частоту активации в диапазоне приблизительно от 0,1 до 100 Гц, и несущий сигнал имеет несущую частоту в диапазоне приблизительно от 10 до 400 кГц.
17. Устройство по п.16, где модулирующий сигнал имеет частоту активации менее чем приблизительно 10 Гц, и несущий сигнал имеет несущую частоту в диапазоне приблизительно от 200 до 250 кГц.
18. Устройство по п.1, где электрический сигнал имеет ширину импульса в диапазоне приблизительно от 10 мкс до 10 мс.
19. Устройство по п.1, где электрический сигнал имеет напряжение, имеющее амплитуду в диапазоне приблизительно от 1 до 20 В.
20. Устройство по п.1, где электрический сигнал имеет ток, имеющий амплитуду в диапазоне приблизительно от 2 до 6 мА.
RU2012136125/14A 2010-01-22 2010-12-30 Способы и устройствоа для активации бурой жировой ткани с использованием электрической энергии RU2580293C2 (ru)

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US29740510P 2010-01-22 2010-01-22
US61/297,405 2010-01-22
US12/980,659 2010-12-29
US12/980,659 US9044606B2 (en) 2010-01-22 2010-12-29 Methods and devices for activating brown adipose tissue using electrical energy
PCT/US2010/062464 WO2011090764A1 (en) 2010-01-22 2010-12-30 Methods and devices for activating brown adipose tissue usnig electrical energy

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EP2525869A1 (en) 2012-11-28
RU2580293C2 (ru) 2016-04-10
US20150258326A1 (en) 2015-09-17
WO2011090764A1 (en) 2011-07-28
JP6087150B2 (ja) 2017-03-01
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US9662486B2 (en) 2017-05-30
US20190083774A1 (en) 2019-03-21
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US11040196B2 (en) 2021-06-22
US10201695B2 (en) 2019-02-12
AU2010343059A1 (en) 2012-07-26
US9044606B2 (en) 2015-06-02
WO2011090764A8 (en) 2012-08-23
BR112012018278A2 (pt) 2016-05-03
CA2787028A1 (en) 2011-07-28
CN102946941A (zh) 2013-02-27
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US20110270360A1 (en) 2011-11-03
US20170232254A1 (en) 2017-08-17

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