BR112012014558A2 - nova composição dexibuprofeno hidrogel transdérmica - Google Patents
nova composição dexibuprofeno hidrogel transdérmicaInfo
- Publication number
- BR112012014558A2 BR112012014558A2 BR112012014558A BR112012014558A BR112012014558A2 BR 112012014558 A2 BR112012014558 A2 BR 112012014558A2 BR 112012014558 A BR112012014558 A BR 112012014558A BR 112012014558 A BR112012014558 A BR 112012014558A BR 112012014558 A2 BR112012014558 A2 BR 112012014558A2
- Authority
- BR
- Brazil
- Prior art keywords
- dexibuprofen
- hydrogel
- transdermal
- prepared
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
nova composição dexibuprofeno hidrogel transdérmica a presente invenção refere-se a um hidrogel não alcóolica estável transdérmica de dexibuprofeno foi preparado usando um processo de fabrico simples, e os ensaios experimentais mostraram que o ph modificando antioxidante agente, e solvente miscível com água são os excipientes essenciais para a obtenção de hidrogel não alcóolica estável transdérmica de dexibuprofeno. o hidrogel dexibuprofeno preparados utilizando carbopol como uma gelificação do polímero produzindo um gel opaco, enquanto que hidrogel preparados utilizando hyroxupropyl metilcelulose (hpmc) como um gelificante polímero produzido um gel transparente. não houve alterações siginificativas observadas com respeito à descrição física, ph ensaio, e particularmente para os valores de subsutâncias afins, quando os hidrogéis foram submetidos ao estudo de estabilidade a condição acelerada (40<198>c hr/75%) durante 3 meses em tubos laminados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3121CH2009 | 2009-12-16 | ||
IN3121/CHE/2009 | 2009-12-16 | ||
PCT/IN2010/000795 WO2011073998A1 (en) | 2009-12-16 | 2010-12-09 | Composition of dexibuprofen transdermal hydrogel |
Publications (4)
Publication Number | Publication Date |
---|---|
BR112012014558A2 true BR112012014558A2 (pt) | 2017-12-19 |
BR112012014558A8 BR112012014558A8 (pt) | 2018-04-10 |
BR112012014558B1 BR112012014558B1 (pt) | 2021-02-02 |
BR112012014558B8 BR112012014558B8 (pt) | 2021-05-25 |
Family
ID=54200209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012014558A BR112012014558B8 (pt) | 2009-12-16 | 2010-12-09 | nova composição de hidrogel transdérmico de dexibuprofeno |
Country Status (15)
Country | Link |
---|---|
US (2) | US20120259018A1 (pt) |
EP (1) | EP2512446B1 (pt) |
JP (1) | JP2013514347A (pt) |
KR (1) | KR101884951B1 (pt) |
CN (1) | CN102665681A (pt) |
AU (1) | AU2010331761B2 (pt) |
BR (1) | BR112012014558B8 (pt) |
CA (1) | CA2784827C (pt) |
DK (1) | DK2512446T3 (pt) |
ES (1) | ES2541483T3 (pt) |
MX (1) | MX352187B (pt) |
PE (1) | PE20130245A1 (pt) |
PL (1) | PL2512446T3 (pt) |
RU (1) | RU2012129527A (pt) |
WO (1) | WO2011073998A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101894891B1 (ko) * | 2012-11-30 | 2018-09-04 | 동아에스티주식회사 | 흡수가 증가된 덱시부프로펜 에멀젼 함유 겔 제형 |
US10583036B2 (en) * | 2013-01-17 | 2020-03-10 | Kanae Technos Co., Ltd. | Topical adhesive skin patch |
SG11201505541VA (en) * | 2013-02-14 | 2015-08-28 | Sanofi Sa | Chewable composition for oral administration and process for preparing thereof |
US9855211B2 (en) | 2013-02-28 | 2018-01-02 | Novan, Inc. | Topical compositions and methods of using the same |
US10206947B2 (en) | 2013-08-08 | 2019-02-19 | Novan, Inc. | Topical compositions and methods of using the same |
US11813284B2 (en) | 2013-08-08 | 2023-11-14 | Novan, Inc. | Topical compositions and methods of using the same |
US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
WO2016007834A1 (en) | 2014-07-11 | 2016-01-14 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
JP6865159B2 (ja) * | 2014-08-20 | 2021-04-28 | スリーエム イノベイティブ プロパティズ カンパニー | 硫酸塩還元微生物用の内蔵型嫌気性培養デバイス |
CN104188899A (zh) * | 2014-09-26 | 2014-12-10 | 天津市聚星康华医药科技有限公司 | 一种洛索洛芬钠凝胶及其制备方法 |
CN105168117B (zh) * | 2015-10-04 | 2018-08-07 | 临沂大学 | 一种右旋布洛芬微乳凝胶及其制备方法 |
JP7090549B2 (ja) | 2016-03-02 | 2022-06-24 | ノヴァン,インコーポレイテッド | 炎症のための治療用組成物およびその治療方法 |
CN105935445B (zh) * | 2016-03-28 | 2019-02-01 | 赤峰赛林泰药业有限公司 | 含2-(-4-异丁基苯基)丙酸右旋物的药物组合物及其制备方法 |
CN109310630A (zh) | 2016-04-13 | 2019-02-05 | 诺万公司 | 用于治疗感染的组合物、系统、试剂盒和方法 |
CN106074459A (zh) * | 2016-07-11 | 2016-11-09 | 雷春生 | 一种持久保水型水凝胶贴支持层材料的制备方法 |
CN112206222A (zh) * | 2018-11-09 | 2021-01-12 | 北京德默高科医药技术有限公司 | 含有布洛芬结构类似物的多层经皮给药系统 |
CN111388409B (zh) * | 2020-03-25 | 2023-01-31 | 牡丹江医学院 | 一种皮肤止痒抑菌贴剂用水凝胶材料的制备方法 |
EP4308088A1 (en) | 2021-11-08 | 2024-01-24 | Weiyong Li | Transdermal drug delivery system for delivering a drug to a patient |
KR102419076B1 (ko) * | 2022-01-17 | 2022-07-08 | 장보경 | 마취제 조성물 및 이의 제조방법 |
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GB8401965D0 (en) * | 1984-01-25 | 1984-02-29 | Beecham Group Plc | Composition |
US4684666A (en) * | 1986-08-19 | 1987-08-04 | Haas Pharmaceuticals, Inc. | Stabilized liquid analgesic compositions |
DE4024801A1 (de) * | 1990-08-04 | 1992-02-06 | Porsche Ag | Abgasanlage einer brennkraftmaschine |
HU219242B (en) * | 1991-05-13 | 2001-03-28 | Boots Co Plc | S(+)-ibuprofen sodium salt dihydrate, pharmaceutical composition comprising this compound and process for production of them |
CZ112496A3 (en) * | 1993-10-20 | 1997-04-16 | Boots Co Plc | Application of ibuprofen and flurbiprofen as agents relieving itching and pharmaceutical preparations for such application |
AT408067B (de) * | 1995-03-17 | 2001-08-27 | Gebro Pharma Gmbh | Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung |
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US20020102301A1 (en) * | 2000-01-13 | 2002-08-01 | Joseph Schwarz | Pharmaceutical solid self-emulsifying composition for sustained delivery of biologically active compounds and the process for preparation thereof |
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KR20060037320A (ko) * | 2003-07-02 | 2006-05-03 | 알자 코포레이션 | 미세돌출부 어레이 면역화 패치 및 방법 |
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JP4128521B2 (ja) * | 2003-12-19 | 2008-07-30 | 信越化学工業株式会社 | ゲル状シート及びその製造方法 |
WO2006122183A2 (en) * | 2005-05-10 | 2006-11-16 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
JP4969812B2 (ja) * | 2005-07-22 | 2012-07-04 | 久光製薬株式会社 | ハイドロゲル組成物 |
US20070083147A1 (en) * | 2005-09-30 | 2007-04-12 | Transcutaneous Technologies Inc. | Iontophoresis apparatus and method to deliver antibiotics to biological interfaces |
GB0718435D0 (en) * | 2007-09-21 | 2007-10-31 | Northern Health And Social Car | Wpund care formulation |
CN101455654B (zh) * | 2007-12-13 | 2013-03-06 | 天津医科大学 | 精氨酸布洛芬凝胶剂及其制备方法 |
US8383614B2 (en) * | 2008-01-31 | 2013-02-26 | The Trustees Of The University Of Pennsylvania | Hypercholestrolemia and tendinous injuries |
CA2726726A1 (en) * | 2008-09-10 | 2010-03-18 | Thrubit B.V. | Ibuprofen for topical administration |
-
2010
- 2010-12-09 WO PCT/IN2010/000795 patent/WO2011073998A1/en active Application Filing
- 2010-12-09 AU AU2010331761A patent/AU2010331761B2/en active Active
- 2010-12-09 CN CN2010800577381A patent/CN102665681A/zh active Pending
- 2010-12-09 KR KR1020127017992A patent/KR101884951B1/ko active IP Right Grant
- 2010-12-09 RU RU2012129527/15A patent/RU2012129527A/ru not_active Application Discontinuation
- 2010-12-09 EP EP10837172.5A patent/EP2512446B1/en active Active
- 2010-12-09 PL PL10837172T patent/PL2512446T3/pl unknown
- 2010-12-09 BR BR112012014558A patent/BR112012014558B8/pt active IP Right Grant
- 2010-12-09 PE PE2012000848A patent/PE20130245A1/es not_active Application Discontinuation
- 2010-12-09 ES ES10837172.5T patent/ES2541483T3/es active Active
- 2010-12-09 DK DK10837172.5T patent/DK2512446T3/en active
- 2010-12-09 JP JP2012543996A patent/JP2013514347A/ja active Pending
- 2010-12-09 CA CA2784827A patent/CA2784827C/en active Active
- 2010-12-09 MX MX2012007062A patent/MX352187B/es active IP Right Grant
-
2012
- 2012-06-18 US US13/525,432 patent/US20120259018A1/en not_active Abandoned
-
2015
- 2015-08-12 US US14/824,787 patent/US10085939B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2784827A1 (en) | 2011-06-23 |
BR112012014558B1 (pt) | 2021-02-02 |
EP2512446B1 (en) | 2015-04-08 |
WO2011073998A1 (en) | 2011-06-23 |
EP2512446A1 (en) | 2012-10-24 |
JP2013514347A (ja) | 2013-04-25 |
EP2512446A4 (en) | 2012-10-24 |
CN102665681A (zh) | 2012-09-12 |
PL2512446T3 (pl) | 2015-08-31 |
BR112012014558A8 (pt) | 2018-04-10 |
KR101884951B1 (ko) | 2018-08-02 |
DK2512446T3 (en) | 2015-06-29 |
PE20130245A1 (es) | 2013-03-08 |
RU2012129527A (ru) | 2014-01-27 |
MX2012007062A (es) | 2012-10-03 |
BR112012014558B8 (pt) | 2021-05-25 |
KR20120092700A (ko) | 2012-08-21 |
MX352187B (es) | 2017-11-13 |
US20120259018A1 (en) | 2012-10-11 |
AU2010331761A1 (en) | 2012-07-12 |
AU2010331761B2 (en) | 2015-09-24 |
US10085939B2 (en) | 2018-10-02 |
ES2541483T3 (es) | 2015-07-21 |
CA2784827C (en) | 2018-10-23 |
US20150342879A1 (en) | 2015-12-03 |
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