MX352187B - Composición novedosa de hidrogel transdérmico de dexibuprofeno. - Google Patents

Composición novedosa de hidrogel transdérmico de dexibuprofeno.

Info

Publication number
MX352187B
MX352187B MX2012007062A MX2012007062A MX352187B MX 352187 B MX352187 B MX 352187B MX 2012007062 A MX2012007062 A MX 2012007062A MX 2012007062 A MX2012007062 A MX 2012007062A MX 352187 B MX352187 B MX 352187B
Authority
MX
Mexico
Prior art keywords
dexibuprofen
hydrogel
prepared
polymer produced
stable non
Prior art date
Application number
MX2012007062A
Other languages
English (en)
Other versions
MX2012007062A (es
Inventor
Stuart Bergman Jeffrey
Devarajan Sampathkumar
Ramalingam Selvakumar
Vel Palanisamy Anandsenthil
Original Assignee
Shasun Pharmaceuticals Ltd Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shasun Pharmaceuticals Ltd Star filed Critical Shasun Pharmaceuticals Ltd Star
Publication of MX2012007062A publication Critical patent/MX2012007062A/es
Publication of MX352187B publication Critical patent/MX352187B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Hidrogel transdermico estable no-alcohólico de dexibuprofeno, se preparó mediante un proceso de fabricación simple, y los ensayos experimentales mostraron que el agente modificador de pH, antioxidante y disolvente miscible en agua son los excipientes esenciales para obtener hidrogel transdermico estable no-alcohólico. El hidrogel de dexibuprofeno preparado usando carbopol como un polímero gelificante produjo gel opaco, mientras que el hidrogel preparado utilizando hidroxipropil merlcelulosa (HPMC) como un polímero gelificante produjo un gel transparente. No se observaron cambios significativos con respecto a la descripción física, pH, ensayo y particularmente los valores relacionados con sustancias cuando los hidrogeles fueron sometidos al estudio de estanbilidad en condiciones aceleradas (40°C /75% RH) durante 3 meses en tubos laminados.
MX2012007062A 2009-12-16 2010-12-09 Composición novedosa de hidrogel transdérmico de dexibuprofeno. MX352187B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3121CH2009 2009-12-16
PCT/IN2010/000795 WO2011073998A1 (en) 2009-12-16 2010-12-09 Composition of dexibuprofen transdermal hydrogel

Publications (2)

Publication Number Publication Date
MX2012007062A MX2012007062A (es) 2012-10-03
MX352187B true MX352187B (es) 2017-11-13

Family

ID=54200209

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007062A MX352187B (es) 2009-12-16 2010-12-09 Composición novedosa de hidrogel transdérmico de dexibuprofeno.

Country Status (15)

Country Link
US (2) US20120259018A1 (es)
EP (1) EP2512446B1 (es)
JP (1) JP2013514347A (es)
KR (1) KR101884951B1 (es)
CN (1) CN102665681A (es)
AU (1) AU2010331761B2 (es)
BR (1) BR112012014558B8 (es)
CA (1) CA2784827C (es)
DK (1) DK2512446T3 (es)
ES (1) ES2541483T3 (es)
MX (1) MX352187B (es)
PE (1) PE20130245A1 (es)
PL (1) PL2512446T3 (es)
RU (1) RU2012129527A (es)
WO (1) WO2011073998A1 (es)

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EP2910244B1 (en) * 2013-01-17 2017-03-01 Kanae Technos Co., Ltd. Topical adhesive skin patch
WO2014124981A1 (en) * 2013-02-14 2014-08-21 Sanofi Chewable composition for oral administration and process for preparing thereof
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
US11813284B2 (en) 2013-08-08 2023-11-14 Novan, Inc. Topical compositions and methods of using the same
WO2016022170A1 (en) 2014-08-08 2016-02-11 Novan, Inc. Topical emulsions
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
US10322081B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
US10808215B2 (en) * 2014-08-20 2020-10-20 3M Innovative Properties Company Self-contained anaerobic culture device for sulfate-reducing microorganisms
CN104188899A (zh) * 2014-09-26 2014-12-10 天津市聚星康华医药科技有限公司 一种洛索洛芬钠凝胶及其制备方法
CN105168117B (zh) * 2015-10-04 2018-08-07 临沂大学 一种右旋布洛芬微乳凝胶及其制备方法
EP3423100A4 (en) 2016-03-02 2019-10-16 Novan, Inc. COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION AND METHOD FOR THE TREATMENT THEREOF
CN105935445B (zh) * 2016-03-28 2019-02-01 赤峰赛林泰药业有限公司 含2-(-4-异丁基苯基)丙酸右旋物的药物组合物及其制备方法
EP3442502A4 (en) 2016-04-13 2019-11-06 Novan, Inc. COMPOSITIONS, SYSTEMS, KITS AND METHODS FOR TREATING INFECTION
CN106074459A (zh) * 2016-07-11 2016-11-09 雷春生 一种持久保水型水凝胶贴支持层材料的制备方法
DE102017127433A1 (de) * 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag TTS auf Basis von klebenden Weichmacher-Polymer-Matrices
CN109432061B (zh) * 2018-11-09 2020-10-30 北京德默高科医药技术有限公司 含有布洛芬或其结构类似物的多层经皮给药系统
CN111388409B (zh) * 2020-03-25 2023-01-31 牡丹江医学院 一种皮肤止痒抑菌贴剂用水凝胶材料的制备方法
WO2023081539A1 (en) 2021-11-08 2023-05-11 Weiyong Li Transdermal drug delivery system for delivering a drug to a patient
KR102419076B1 (ko) * 2022-01-17 2022-07-08 장보경 마취제 조성물 및 이의 제조방법

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Also Published As

Publication number Publication date
MX2012007062A (es) 2012-10-03
EP2512446A1 (en) 2012-10-24
AU2010331761A1 (en) 2012-07-12
DK2512446T3 (en) 2015-06-29
AU2010331761B2 (en) 2015-09-24
CA2784827C (en) 2018-10-23
KR20120092700A (ko) 2012-08-21
US10085939B2 (en) 2018-10-02
BR112012014558A8 (pt) 2018-04-10
JP2013514347A (ja) 2013-04-25
US20120259018A1 (en) 2012-10-11
BR112012014558A2 (pt) 2017-12-19
CN102665681A (zh) 2012-09-12
US20150342879A1 (en) 2015-12-03
KR101884951B1 (ko) 2018-08-02
BR112012014558B1 (pt) 2021-02-02
PE20130245A1 (es) 2013-03-08
CA2784827A1 (en) 2011-06-23
BR112012014558B8 (pt) 2021-05-25
RU2012129527A (ru) 2014-01-27
PL2512446T3 (pl) 2015-08-31
WO2011073998A1 (en) 2011-06-23
ES2541483T3 (es) 2015-07-21
EP2512446B1 (en) 2015-04-08
EP2512446A4 (en) 2012-10-24

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