MX352187B - Composición novedosa de hidrogel transdérmico de dexibuprofeno. - Google Patents
Composición novedosa de hidrogel transdérmico de dexibuprofeno.Info
- Publication number
- MX352187B MX352187B MX2012007062A MX2012007062A MX352187B MX 352187 B MX352187 B MX 352187B MX 2012007062 A MX2012007062 A MX 2012007062A MX 2012007062 A MX2012007062 A MX 2012007062A MX 352187 B MX352187 B MX 352187B
- Authority
- MX
- Mexico
- Prior art keywords
- dexibuprofen
- hydrogel
- prepared
- polymer produced
- stable non
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title abstract 6
- HEFNNWSXXWATRW-JTQLQIEISA-N dexibuprofen Chemical group CC(C)CC1=CC=C([C@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-JTQLQIEISA-N 0.000 title abstract 4
- 229960003428 dexibuprofen Drugs 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title 1
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 239000000499 gel Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Hidrogel transdermico estable no-alcohólico de dexibuprofeno, se preparó mediante un proceso de fabricación simple, y los ensayos experimentales mostraron que el agente modificador de pH, antioxidante y disolvente miscible en agua son los excipientes esenciales para obtener hidrogel transdermico estable no-alcohólico. El hidrogel de dexibuprofeno preparado usando carbopol como un polímero gelificante produjo gel opaco, mientras que el hidrogel preparado utilizando hidroxipropil merlcelulosa (HPMC) como un polímero gelificante produjo un gel transparente. No se observaron cambios significativos con respecto a la descripción física, pH, ensayo y particularmente los valores relacionados con sustancias cuando los hidrogeles fueron sometidos al estudio de estanbilidad en condiciones aceleradas (40°C /75% RH) durante 3 meses en tubos laminados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3121CH2009 | 2009-12-16 | ||
PCT/IN2010/000795 WO2011073998A1 (en) | 2009-12-16 | 2010-12-09 | Composition of dexibuprofen transdermal hydrogel |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012007062A MX2012007062A (es) | 2012-10-03 |
MX352187B true MX352187B (es) | 2017-11-13 |
Family
ID=54200209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012007062A MX352187B (es) | 2009-12-16 | 2010-12-09 | Composición novedosa de hidrogel transdérmico de dexibuprofeno. |
Country Status (15)
Country | Link |
---|---|
US (2) | US20120259018A1 (es) |
EP (1) | EP2512446B1 (es) |
JP (1) | JP2013514347A (es) |
KR (1) | KR101884951B1 (es) |
CN (1) | CN102665681A (es) |
AU (1) | AU2010331761B2 (es) |
BR (1) | BR112012014558B8 (es) |
CA (1) | CA2784827C (es) |
DK (1) | DK2512446T3 (es) |
ES (1) | ES2541483T3 (es) |
MX (1) | MX352187B (es) |
PE (1) | PE20130245A1 (es) |
PL (1) | PL2512446T3 (es) |
RU (1) | RU2012129527A (es) |
WO (1) | WO2011073998A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101894891B1 (ko) * | 2012-11-30 | 2018-09-04 | 동아에스티주식회사 | 흡수가 증가된 덱시부프로펜 에멀젼 함유 겔 제형 |
EP2910244B1 (en) * | 2013-01-17 | 2017-03-01 | Kanae Technos Co., Ltd. | Topical adhesive skin patch |
WO2014124981A1 (en) * | 2013-02-14 | 2014-08-21 | Sanofi | Chewable composition for oral administration and process for preparing thereof |
US9855211B2 (en) | 2013-02-28 | 2018-01-02 | Novan, Inc. | Topical compositions and methods of using the same |
US11813284B2 (en) | 2013-08-08 | 2023-11-14 | Novan, Inc. | Topical compositions and methods of using the same |
WO2016022170A1 (en) | 2014-08-08 | 2016-02-11 | Novan, Inc. | Topical emulsions |
US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
US10322081B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
US10808215B2 (en) * | 2014-08-20 | 2020-10-20 | 3M Innovative Properties Company | Self-contained anaerobic culture device for sulfate-reducing microorganisms |
CN104188899A (zh) * | 2014-09-26 | 2014-12-10 | 天津市聚星康华医药科技有限公司 | 一种洛索洛芬钠凝胶及其制备方法 |
CN105168117B (zh) * | 2015-10-04 | 2018-08-07 | 临沂大学 | 一种右旋布洛芬微乳凝胶及其制备方法 |
EP3423100A4 (en) | 2016-03-02 | 2019-10-16 | Novan, Inc. | COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION AND METHOD FOR THE TREATMENT THEREOF |
CN105935445B (zh) * | 2016-03-28 | 2019-02-01 | 赤峰赛林泰药业有限公司 | 含2-(-4-异丁基苯基)丙酸右旋物的药物组合物及其制备方法 |
EP3442502A4 (en) | 2016-04-13 | 2019-11-06 | Novan, Inc. | COMPOSITIONS, SYSTEMS, KITS AND METHODS FOR TREATING INFECTION |
CN106074459A (zh) * | 2016-07-11 | 2016-11-09 | 雷春生 | 一种持久保水型水凝胶贴支持层材料的制备方法 |
DE102017127433A1 (de) * | 2017-11-21 | 2019-05-23 | Lts Lohmann Therapie-Systeme Ag | TTS auf Basis von klebenden Weichmacher-Polymer-Matrices |
CN109432061B (zh) * | 2018-11-09 | 2020-10-30 | 北京德默高科医药技术有限公司 | 含有布洛芬或其结构类似物的多层经皮给药系统 |
CN111388409B (zh) * | 2020-03-25 | 2023-01-31 | 牡丹江医学院 | 一种皮肤止痒抑菌贴剂用水凝胶材料的制备方法 |
WO2023081539A1 (en) | 2021-11-08 | 2023-05-11 | Weiyong Li | Transdermal drug delivery system for delivering a drug to a patient |
KR102419076B1 (ko) * | 2022-01-17 | 2022-07-08 | 장보경 | 마취제 조성물 및 이의 제조방법 |
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GB8401965D0 (en) * | 1984-01-25 | 1984-02-29 | Beecham Group Plc | Composition |
US4684666A (en) * | 1986-08-19 | 1987-08-04 | Haas Pharmaceuticals, Inc. | Stabilized liquid analgesic compositions |
DE4024801A1 (de) * | 1990-08-04 | 1992-02-06 | Porsche Ag | Abgasanlage einer brennkraftmaschine |
JP3326174B2 (ja) * | 1991-05-13 | 2002-09-17 | ザ ブーツ カンパニー ピーエルシー | 治療薬 |
CZ112496A3 (en) * | 1993-10-20 | 1997-04-16 | Boots Co Plc | Application of ibuprofen and flurbiprofen as agents relieving itching and pharmaceutical preparations for such application |
AT408067B (de) * | 1995-03-17 | 2001-08-27 | Gebro Pharma Gmbh | Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung |
DK0851908T3 (da) * | 1995-06-07 | 2003-08-25 | Lee County Mosquito Control Di | Smøremiddelsammensætning og fremgangsmåde |
US20010023261A1 (en) * | 1997-01-27 | 2001-09-20 | Lg Chemical Limited. | Novel composition for the transdermal administration of drugs |
AU3212199A (en) * | 1998-03-31 | 1999-10-18 | Scimed Life Systems, Inc. | Temperature controlled solute delivery system |
US6399093B1 (en) * | 1999-05-19 | 2002-06-04 | Advanced Medical Instruments | Method and composition to treat musculoskeletal disorders |
AU5409699A (en) * | 1999-07-05 | 2001-01-22 | Idea Ag | A method for the improvement of transport across adaptable semi-permeable barriers |
DE19945522A1 (de) | 1999-09-23 | 2001-04-05 | Hexal Ag | Pharmazeutisches, wirkstoffhaltiges Gel |
US20020102301A1 (en) * | 2000-01-13 | 2002-08-01 | Joseph Schwarz | Pharmaceutical solid self-emulsifying composition for sustained delivery of biologically active compounds and the process for preparation thereof |
KR100452972B1 (ko) * | 2000-05-16 | 2004-10-14 | 주식회사 삼양사 | 경피투여용 하이드로젤 조성물 |
ES2331302T3 (es) * | 2001-05-01 | 2009-12-29 | A.V. Topchiev Institute Of Petrochemical Synthesis | Composiciones de hidrogel. |
US20030082225A1 (en) * | 2001-10-19 | 2003-05-01 | Mason Paul Arthur | Sterile, breathable patch for treating wound pain |
AR041021A1 (es) * | 2002-08-22 | 2005-04-27 | Novartis Consumer Health Sa | Composicion topica |
US7052715B2 (en) * | 2003-04-11 | 2006-05-30 | All Natural Fmg, Inc. | Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof |
EP2279763B1 (en) * | 2003-06-19 | 2017-08-09 | Coloplast A/S | A wound care device |
AU2004253571A1 (en) * | 2003-07-02 | 2005-01-13 | Alza Corporation | Microprojection array immunization patch and method |
CH715855B1 (de) * | 2003-08-28 | 2020-08-14 | Mibelle Ag | Zubereitung bestehend aus mindestens zwei Nanoemulsionen. |
JP4128521B2 (ja) * | 2003-12-19 | 2008-07-30 | 信越化学工業株式会社 | ゲル状シート及びその製造方法 |
WO2006122183A2 (en) * | 2005-05-10 | 2006-11-16 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
JP4969812B2 (ja) * | 2005-07-22 | 2012-07-04 | 久光製薬株式会社 | ハイドロゲル組成物 |
US20070083147A1 (en) * | 2005-09-30 | 2007-04-12 | Transcutaneous Technologies Inc. | Iontophoresis apparatus and method to deliver antibiotics to biological interfaces |
GB0718435D0 (en) * | 2007-09-21 | 2007-10-31 | Northern Health And Social Car | Wpund care formulation |
CN101455654B (zh) * | 2007-12-13 | 2013-03-06 | 天津医科大学 | 精氨酸布洛芬凝胶剂及其制备方法 |
US8383614B2 (en) * | 2008-01-31 | 2013-02-26 | The Trustees Of The University Of Pennsylvania | Hypercholestrolemia and tendinous injuries |
AU2009291755B2 (en) * | 2008-09-10 | 2016-04-21 | Biochemics, Inc. | Ibuprofen for topical administration |
-
2010
- 2010-12-09 JP JP2012543996A patent/JP2013514347A/ja active Pending
- 2010-12-09 WO PCT/IN2010/000795 patent/WO2011073998A1/en active Application Filing
- 2010-12-09 DK DK10837172.5T patent/DK2512446T3/en active
- 2010-12-09 RU RU2012129527/15A patent/RU2012129527A/ru not_active Application Discontinuation
- 2010-12-09 PL PL10837172T patent/PL2512446T3/pl unknown
- 2010-12-09 BR BR112012014558A patent/BR112012014558B8/pt active IP Right Grant
- 2010-12-09 EP EP10837172.5A patent/EP2512446B1/en active Active
- 2010-12-09 CA CA2784827A patent/CA2784827C/en active Active
- 2010-12-09 KR KR1020127017992A patent/KR101884951B1/ko active IP Right Grant
- 2010-12-09 PE PE2012000848A patent/PE20130245A1/es not_active Application Discontinuation
- 2010-12-09 CN CN2010800577381A patent/CN102665681A/zh active Pending
- 2010-12-09 MX MX2012007062A patent/MX352187B/es active IP Right Grant
- 2010-12-09 ES ES10837172.5T patent/ES2541483T3/es active Active
- 2010-12-09 AU AU2010331761A patent/AU2010331761B2/en active Active
-
2012
- 2012-06-18 US US13/525,432 patent/US20120259018A1/en not_active Abandoned
-
2015
- 2015-08-12 US US14/824,787 patent/US10085939B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
MX2012007062A (es) | 2012-10-03 |
EP2512446A1 (en) | 2012-10-24 |
AU2010331761A1 (en) | 2012-07-12 |
DK2512446T3 (en) | 2015-06-29 |
AU2010331761B2 (en) | 2015-09-24 |
CA2784827C (en) | 2018-10-23 |
KR20120092700A (ko) | 2012-08-21 |
US10085939B2 (en) | 2018-10-02 |
BR112012014558A8 (pt) | 2018-04-10 |
JP2013514347A (ja) | 2013-04-25 |
US20120259018A1 (en) | 2012-10-11 |
BR112012014558A2 (pt) | 2017-12-19 |
CN102665681A (zh) | 2012-09-12 |
US20150342879A1 (en) | 2015-12-03 |
KR101884951B1 (ko) | 2018-08-02 |
BR112012014558B1 (pt) | 2021-02-02 |
PE20130245A1 (es) | 2013-03-08 |
CA2784827A1 (en) | 2011-06-23 |
BR112012014558B8 (pt) | 2021-05-25 |
RU2012129527A (ru) | 2014-01-27 |
PL2512446T3 (pl) | 2015-08-31 |
WO2011073998A1 (en) | 2011-06-23 |
ES2541483T3 (es) | 2015-07-21 |
EP2512446B1 (en) | 2015-04-08 |
EP2512446A4 (en) | 2012-10-24 |
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Legal Events
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FG | Grant or registration |