BR112021018159A2 - Método para gerar uma molécula de rna com atividade de silenciamento, célula geneticamente modificada, planta geneticamente modificada, célula vegetal, planta, semente, métodos de produção de uma planta, de tratamento de uma doença e de introdução da atividade de silenciamento - Google Patents

Método para gerar uma molécula de rna com atividade de silenciamento, célula geneticamente modificada, planta geneticamente modificada, célula vegetal, planta, semente, métodos de produção de uma planta, de tratamento de uma doença e de introdução da atividade de silenciamento

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BR112021018159A2
BR112021018159A2 BR112021018159A BR112021018159A BR112021018159A2 BR 112021018159 A2 BR112021018159 A2 BR 112021018159A2 BR 112021018159 A BR112021018159 A BR 112021018159A BR 112021018159 A BR112021018159 A BR 112021018159A BR 112021018159 A2 BR112021018159 A2 BR 112021018159A2
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plant
nucleic acid
acid sequences
genetically modified
silencing activity
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BR112021018159A
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English (en)
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CHAPARRO GARCIA Angela
Cristina Pignocchi
Eyal Maori
Ofir Meir
Yaron Galanty
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Tropic Biosciences Uk Ltd
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Publication of BR112021018159A2 publication Critical patent/BR112021018159A2/pt

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Abstract

método para gerar uma molécula de rna com atividade de silenciamento, célula geneticamente modificada, planta geneticamente modificada, célula vegetal, planta, semente, métodos de produção de uma planta, de tratamento de uma doença e de introdução da atividade de silenciamento. um fornecido um método de gerar uma molécula de rna que possui uma atividade de silenciamento em uma célula, compreendendo: (a) a identificação de sequências de ácidos nucleicos que codificam moléculas de rna que exibem faixa de homologia de sequência predeterminada, não incluindo identidade completa, com relação as sequências de ácidos nucleicos que codificam moléculas de rna envolvidas com risc; (b) a determinação da transcrição de sequências de ácidos nucleicos que codificam moléculas de rna, de modo a selecionar sequências de ácidos nucleicos que codificam moléculas de rna transcritíveis; (c) a determinação da processabilidade em transcritos de rnas pequenos das sequências de ácidos nucleicos transcritíveis que codificam moléculas de rna que exibem uma faixa de homologia de sequência predeterminada de modo a selecionar sequências de ácidos nucleicos transcritíveis que codificam moléculas de rna processadas de forma aberrante, exibindo a faixa de homologia de sequência predeterminada; (d) a modificação de uma sequência de ácido nucleico das sequências de ácidos nucleicos processadas de forma aberrante, transcritíveis, de modo a conferir capacidade de processamento em rnas pequenos que estão envolvidos com risc e são complementares a um primeiro rna alvo ou a um rna alvo de interesse.
BR112021018159A 2019-03-14 2020-03-12 Método para gerar uma molécula de rna com atividade de silenciamento, célula geneticamente modificada, planta geneticamente modificada, célula vegetal, planta, semente, métodos de produção de uma planta, de tratamento de uma doença e de introdução da atividade de silenciamento BR112021018159A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1903519.5A GB201903519D0 (en) 2019-03-14 2019-03-14 Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
PCT/IB2020/052248 WO2020183419A1 (en) 2019-03-14 2020-03-12 Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest

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BR112021018159A2 true BR112021018159A2 (pt) 2022-01-18

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US (1) US20220154187A1 (pt)
EP (1) EP3938512A1 (pt)
JP (1) JP2022524866A (pt)
KR (1) KR20210148187A (pt)
CN (1) CN113906138A (pt)
AU (1) AU2020237667A1 (pt)
BR (1) BR112021018159A2 (pt)
CA (1) CA3133198A1 (pt)
GB (1) GB201903519D0 (pt)
IL (1) IL286380A (pt)
SG (1) SG11202109469VA (pt)
WO (1) WO2020183419A1 (pt)

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CN117377768A (zh) * 2021-04-26 2024-01-09 戈迪安生物技术公司 用于体内筛选治疗剂的组合物和方法
CN113502351B (zh) * 2021-06-29 2023-11-21 中国人民解放军疾病预防控制中心 一种crRNA及用于CRISPR-Cas12a检测人腺病毒核酸的方法
GB202112865D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to black sigatoka disease in banana
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CN115029378B (zh) * 2022-06-23 2023-09-15 河北北方学院 一种利用PtrDJ1C基因创制花斑观赏杨树的方法
CN115250913B (zh) * 2022-07-25 2023-06-20 三峡大学 一种盐肤木体细胞胚胎发生与植株再生方法
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