BR112012010694A2 - métodos para determinar pelo menos uma porção do genoma de um feto não nascido de uma fêmea grávida, para identificar uma mutação de novo no genoma de um feto não nascido de uma fêmea grávida, para determinar uma concentração fracionária de dna fetal em uma amostra biológica tirada de uma fêmea grávida e para determinar uma proporção de um genoma fetal que foi sequenciado a partir de uma amostra biológica tirada de uma fêmea grávida - Google Patents
métodos para determinar pelo menos uma porção do genoma de um feto não nascido de uma fêmea grávida, para identificar uma mutação de novo no genoma de um feto não nascido de uma fêmea grávida, para determinar uma concentração fracionária de dna fetal em uma amostra biológica tirada de uma fêmea grávida e para determinar uma proporção de um genoma fetal que foi sequenciado a partir de uma amostra biológica tirada de uma fêmea grávidaInfo
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- BR112012010694A2 BR112012010694A2 BR112012010694A BR112012010694A BR112012010694A2 BR 112012010694 A2 BR112012010694 A2 BR 112012010694A2 BR 112012010694 A BR112012010694 A BR 112012010694A BR 112012010694 A BR112012010694 A BR 112012010694A BR 112012010694 A2 BR112012010694 A2 BR 112012010694A2
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- pregnant female
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
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Abstract
"métodos para determinar pelo menos uma porção do genoma de um feto não nascido de uma fêmea grávida, para identificar uma mutação de novo genoma de um feto não nascido de uma fêmea grávida, para determinar uma concentração fracionária de dna fetal em uma amostra biológica tirada de uma fêmea grávida e para determinar uma proporção de um genoma fetal que foi sequenciado a partir de uma amostra biológica tirada de uma fêmea grávida" sistemas, métodos, e aparelho para determinar pelo menos uma porção de genoma fetal são fornecidos. os fragmentos de dna de uma amostra materna (dna materno e fetal) podem ser analisados para identificar alelos em certos locais. as quantidades de fragmentos de dna dos respectivos alelos nestes locais podem ser analisados juntas para determinar quantidades relativas dos haplotipos para estes locais e determinar quais haplotipos foram herdados dos genomas dos pais. locais onde os pais são uma combinação específica de homozigoto e heterozigoto podem ser analisados para determinar regiões do genoma fetal. os haplotipos de referência comuns na população podem ser usados juntos como a análise dos fragmentos de dna da amostra materna para determinar os genomas materno e paterno. a determinação de mutações, uma concentração de dna fetal fracionário em uma amostra materna, e uma proporção de cobertura de um sequenciamento da amostra materna também podem ser fornecidos.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25856709P | 2009-11-05 | 2009-11-05 | |
US61/258567 | 2009-11-05 | ||
US25907509P | 2009-11-06 | 2009-11-06 | |
US61/259075 | 2009-11-06 | ||
US38185410P | 2010-09-10 | 2010-09-10 | |
US61/381854 | 2010-09-10 | ||
PCT/US2010/055655 WO2011057094A1 (en) | 2009-11-05 | 2010-11-05 | Fetal genomic analysis from a maternal biological sample |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112012010694A2 true BR112012010694A2 (pt) | 2018-09-11 |
BR112012010694B1 BR112012010694B1 (pt) | 2020-11-17 |
BR112012010694B8 BR112012010694B8 (pt) | 2021-07-27 |
Family
ID=43500337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012010694A BR112012010694B8 (pt) | 2009-11-05 | 2010-11-05 | método para determinar pelo menos uma porção do genoma de um feto não nascido de uma fêmea grávida, e, meio legível por computador não transitório |
Country Status (24)
Country | Link |
---|---|
US (5) | US8467976B2 (pt) |
EP (5) | EP4170043A1 (pt) |
JP (3) | JP5540105B2 (pt) |
CN (2) | CN102770558B (pt) |
AU (1) | AU2010315037B9 (pt) |
BR (1) | BR112012010694B8 (pt) |
CA (1) | CA2779695C (pt) |
CY (1) | CY1122003T1 (pt) |
DK (3) | DK3783110T3 (pt) |
EA (1) | EA033752B1 (pt) |
ES (3) | ES2720282T3 (pt) |
FI (1) | FI3783110T3 (pt) |
HK (1) | HK1222413A1 (pt) |
HR (2) | HRP20230134T1 (pt) |
HU (3) | HUE061110T2 (pt) |
IL (3) | IL219521A (pt) |
LT (2) | LT3783110T (pt) |
MX (3) | MX355132B (pt) |
PL (3) | PL3783110T3 (pt) |
PT (3) | PT3241914T (pt) |
RS (2) | RS58879B1 (pt) |
SI (2) | SI3241914T1 (pt) |
TW (1) | TWI458976B (pt) |
WO (1) | WO2011057094A1 (pt) |
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