BR112012009053A2 - derivado de glicosídeos e usos do mesmo - Google Patents

derivado de glicosídeos e usos do mesmo

Info

Publication number
BR112012009053A2
BR112012009053A2 BR112012009053A BR112012009053A BR112012009053A2 BR 112012009053 A2 BR112012009053 A2 BR 112012009053A2 BR 112012009053 A BR112012009053 A BR 112012009053A BR 112012009053 A BR112012009053 A BR 112012009053A BR 112012009053 A2 BR112012009053 A2 BR 112012009053A2
Authority
BR
Brazil
Prior art keywords
glycosides
derived
diseases
treatment
relates
Prior art date
Application number
BR112012009053A
Other languages
English (en)
Other versions
BR112012009053B1 (pt
Inventor
Atul Kashinath Hajare
Debnath Bhuniya
Dumbala Srinivas Reddy
Gregory Raymond Bebernitz
Jessica Liang
Lili Feng
Mark G Bock
Nadim S Shaikh
P Venkata Palle
Sandeep Bhausaheb Bhosale
Suresh Eknath Kurhade
Videsh Salunkhe
Vinod Vyavahare
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43216622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012009053(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112012009053A2 publication Critical patent/BR112012009053A2/pt
Publication of BR112012009053B1 publication Critical patent/BR112012009053B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

Abstract

derivado de glicosídeos e usos do mesmo. esta invenção refere-se a compostos, representados pela fórmula (i): em que as variáveis são definidas como aqui acima, que são úteis para o tratamento de doenças e condições mediadas pelo cotransportador de d-glicose de sódio (sglt), por exemplo diabetes. a invenção também refere-se a métodos de tratamento de tais doenças e condições, e composições etc. para seu tratamento.
BR112012009053-4A 2009-10-20 2010-10-19 Derivados de glicosídeos, seus usos, e composições farmacêuticas BR112012009053B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN2173DE2009 2009-10-20
IN2173/DEL/2009 2009-10-20
IN2689DE2009 2009-12-23
IN2689/DEL/2009 2009-12-23
PCT/EP2010/065747 WO2011048112A1 (en) 2009-10-20 2010-10-19 Glycoside derivatives and uses thereof

Publications (2)

Publication Number Publication Date
BR112012009053A2 true BR112012009053A2 (pt) 2016-04-19
BR112012009053B1 BR112012009053B1 (pt) 2020-03-03

Family

ID=43216622

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012009053-4A BR112012009053B1 (pt) 2009-10-20 2010-10-19 Derivados de glicosídeos, seus usos, e composições farmacêuticas

Country Status (39)

Country Link
US (7) US8163704B2 (pt)
EP (1) EP2491029B1 (pt)
JP (2) JP5384744B2 (pt)
KR (2) KR20140054415A (pt)
CN (1) CN102656165B (pt)
AR (1) AR078685A1 (pt)
AU (1) AU2010309833B2 (pt)
BR (1) BR112012009053B1 (pt)
CA (1) CA2777812C (pt)
CL (1) CL2012000991A1 (pt)
CO (1) CO6531486A2 (pt)
CR (1) CR20120176A (pt)
CU (1) CU24079B1 (pt)
CY (1) CY1117409T1 (pt)
DK (1) DK2491029T3 (pt)
EA (1) EA023781B1 (pt)
EC (1) ECSP12011909A (pt)
ES (1) ES2564191T3 (pt)
GT (1) GT201200117A (pt)
HK (1) HK1168099A1 (pt)
HN (1) HN2012000798A (pt)
HR (1) HRP20160436T1 (pt)
HU (1) HUE027531T2 (pt)
IL (1) IL219309A (pt)
JO (1) JO3152B1 (pt)
MA (1) MA33737B1 (pt)
MX (1) MX2012004700A (pt)
MY (1) MY158326A (pt)
NZ (1) NZ598717A (pt)
PE (1) PE20121281A1 (pt)
PL (1) PL2491029T3 (pt)
RS (1) RS54563B1 (pt)
SG (1) SG179562A1 (pt)
SI (1) SI2491029T1 (pt)
TN (1) TN2012000109A1 (pt)
TW (2) TWI558723B (pt)
UY (1) UY32958A (pt)
WO (1) WO2011048112A1 (pt)
ZA (1) ZA201201680B (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA108069C2 (uk) 2009-03-23 2015-03-25 Гленмарк Фармасьютікалс, С.А. Злиті піримідиндіонові похідні як модулятори trpa1
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
US8163704B2 (en) * 2009-10-20 2012-04-24 Novartis Ag Glycoside derivatives and uses thereof
CN102134226B (zh) * 2010-01-26 2013-06-12 天津药物研究院 一类苯基c-葡萄糖苷衍生物、其制备方法和用途
US20120115799A1 (en) 2010-05-11 2012-05-10 Wenhua Wang Pharmaceutical formulations
EA028946B1 (ru) 2011-04-13 2018-01-31 Янссен Фармацевтика Нв Способ получения соединений для применения в качестве ингибиторов sglt2
EP2697240B1 (en) 2011-04-14 2015-09-16 Novartis AG Glycoside derivatives and uses thereof
US8614195B2 (en) * 2011-04-14 2013-12-24 Novartis Ag Glycoside derivatives and uses thereof
US9035044B2 (en) * 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
TR201903445T4 (tr) 2011-06-01 2019-03-21 Green Cross Corp Sglt2 i̇nhi̇bi̇törleri̇ olarak yeni̇ di̇feni̇lmetan türevleri̇
CN102827122B (zh) * 2011-06-17 2015-01-14 山东轩竹医药科技有限公司 糖苷衍生物
CN102863417B (zh) * 2011-07-09 2015-01-14 山东轩竹医药科技有限公司 C-糖苷衍生物
JP6263469B2 (ja) 2011-07-15 2018-01-17 ノバルティス アーゲー アザ二環式ジ−アリールエーテルの塩およびその製造方法またはその前駆体の製造方法
AR087701A1 (es) * 2011-08-31 2014-04-09 Japan Tobacco Inc Derivados de pirazol con actividad inhibidora de sglt1
UA113086C2 (xx) 2012-05-10 2016-12-12 Піразольні сполуки як інгібітори sglt1
US9012412B2 (en) * 2013-03-11 2015-04-21 Janssen Pharmaceutica Nv Dual SGLT1/SGLT2 inhibitors
CA2914132A1 (en) 2013-06-21 2014-12-24 Lupin Limited Substituted heterocyclic compounds as crac modulators
EP3013810A1 (en) 2013-06-24 2016-05-04 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
CN104250272B (zh) * 2013-06-27 2018-10-09 上海方楠生物科技有限公司 一种利用微反应器制备列净类药物中间体的方法
CN105518014B (zh) * 2013-09-09 2018-03-23 上海研健新药研发有限公司 C‑芳基葡糖苷衍生物、其制备方法及其在医药上的应用
AR098670A1 (es) 2013-11-08 2016-06-08 Lilly Co Eli Inhibidor de sglt1
CN104031098A (zh) * 2014-06-21 2014-09-10 李友香 降糖药物
CN104017031A (zh) * 2014-06-21 2014-09-03 李友香 降血糖药物和组合物
CN105294624B (zh) * 2015-11-16 2018-01-12 山东罗欣药业集团股份有限公司 一种达格列净的制备方法
EP3473621B1 (en) 2016-06-17 2021-08-04 Daewoong Pharmaceutical Co., Ltd. Method for producing diphenylmethane derivative
US10815210B2 (en) 2016-11-10 2020-10-27 Janssen Pharmaceutica Nv Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators
CN108203432B (zh) * 2016-12-20 2021-03-02 宜昌东阳光长江药业股份有限公司 吡喃葡萄糖基衍生物及其在医药上的应用
US10952989B2 (en) 2017-03-03 2021-03-23 Novartis Ag SGLT1/2 inhibitor LIK066 for treating obesity
JP2019517459A (ja) * 2017-04-12 2019-06-24 ノバルティス アーゲー 心不全患者におけるｌｉｋ０６６の使用
AU2018287810B2 (en) * 2017-06-21 2021-03-25 Novartis Ag Licofligozin for the treatment of non-alcoholic steatohepatitis
US10696662B2 (en) 2017-08-21 2020-06-30 Janssen Pharmaceutica Nv 5-fluoro-C-(aryl or heterocyclyl)-glycoside derivatives useful as dual SGLT1 / SGLT2 modulators
GB201721957D0 (en) * 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
GB201721960D0 (en) 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
GB201721964D0 (en) 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
GB201721967D0 (en) 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
GB201721961D0 (en) 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
US20210308140A1 (en) 2018-07-25 2021-10-07 Novartis Ag Nlrp3 inflammasome inhibitors
CN108863736A (zh) * 2018-07-27 2018-11-23 福州大学 一种羰基功能化的芳香羧酸的制备方法
WO2020039394A1 (en) 2018-08-24 2020-02-27 Novartis Ag New drug combinations
WO2020151620A1 (zh) * 2019-01-24 2020-07-30 北京盈科瑞创新药物研究有限公司 化合物、其制备方法及其作为药物中间体的应用
WO2020151623A1 (zh) * 2019-01-24 2020-07-30 北京盈科瑞创新药物研究有限公司 化合物、其制备方法及其作为药物中间体的应用
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
CN114126657A (zh) 2019-07-23 2022-03-01 诺华股份有限公司 使用fxr激动剂的肝脏疾病的组合治疗
CN111099975A (zh) * 2019-12-23 2020-05-05 河北合佳医药科技集团股份有限公司 一种5-溴-2-氯-4’-乙氧基二苯甲酮的制备方法
EP4249479A1 (en) * 2020-11-19 2023-09-27 Beijing Increase Innovative Drug Co., Ltd. Glucoside derivative, and preparation method therefor and application thereof
TW202406550A (zh) 2022-08-03 2024-02-16 瑞士商諾華公司 Ｎｌｒｐ３炎性小體抑制劑

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1020944C (zh) 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
US5410031A (en) 1992-02-24 1995-04-25 The Regents Of The University Of California Office Of Technology Transfer Nucleoside cotransporter protein cDNA
US5410054A (en) 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
WO1998031697A1 (en) 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
ATE264337T1 (de) 1999-08-31 2004-04-15 Kissei Pharmaceutical Glucopyranosyloxypyrazol-derivate, diese enthaltende arzneimittel und zwischenprodukte zu deren herstellung
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
JP4272319B2 (ja) * 1999-11-30 2009-06-03 アイシン精機株式会社 ヘッドレスト装置
US6627611B2 (en) * 2000-02-02 2003-09-30 Kotobuki Pharmaceutical Co Ltd C-glycosides and preparation of thereof as antidiabetic agents
JP4456768B2 (ja) 2000-02-02 2010-04-28 壽製薬株式会社 Ｃ−配糖体を含有する薬剤
NZ521369A (en) 2000-03-17 2004-07-30 Kissei Pharmaceutical Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives
US6683056B2 (en) * 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
CZ303544B6 (cs) 2000-09-29 2012-11-28 Kissei Pharmaceutical Co., Ltd. Glukopyranosyloxybenzylbenzenový derivát a farmaceutická kompozice s jeho obsahem
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
DE60233655D1 (de) 2001-04-04 2009-10-22 Ortho Mcneil Janssen Pharm R und retinoid x rezeptorenmodulatoren
CA2442917C (en) 2001-04-04 2011-02-01 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and ppar modulators
WO2003020737A1 (en) 2001-09-05 2003-03-13 Bristol-Myers Squibb Company O-pyrazole glucoside sglt2 inhibitors and method of use
DE10231370B4 (de) 2002-07-11 2006-04-06 Sanofi-Aventis Deutschland Gmbh Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
JP2004137245A (ja) 2002-08-23 2004-05-13 Kissei Pharmaceut Co Ltd ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体
US20060035844A1 (en) 2002-12-04 2006-02-16 Fumiaki Ito Preventive or remedy for diseases caused by hyperglycemia
DE10258008B4 (de) 2002-12-12 2006-02-02 Sanofi-Aventis Deutschland Gmbh Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10258007B4 (de) 2002-12-12 2006-02-09 Sanofi-Aventis Deutschland Gmbh Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE60325689D1 (de) 2003-02-05 2009-02-26 Hermann Koepsell RS1 defizientes transgenes Tier und dessen Verwendungen
MXPA05009356A (es) * 2003-03-14 2005-12-05 Astellas Pharma Inc Derivados de c-glicosido y sales de los mismos.
AU2003902263A0 (en) 2003-05-12 2003-05-29 Fujisawa Pharmaceutical Co., Ltd. Monosaccharide compounds
RS20060320A (en) 2003-08-01 2008-08-07 Janssen Pharmaceutica N.V., Substituted indazole-o-glucosides
EA015104B1 (ru) * 2003-08-01 2011-06-30 Мицубиси Танабе Фарма Корпорейшн Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера
CA2539032A1 (en) 2003-08-26 2005-03-10 Boehringer Ingelheim International Gmbh Glucopyranosyloxy-pirazoles, drugs containing said compounds the use and production method thereof
AU2005219779B2 (en) 2004-03-04 2011-04-14 Kissei Pharmaceutical Co., Ltd. Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
WO2005085265A1 (ja) 2004-03-04 2005-09-15 Kissei Pharmaceutical Co., Ltd. 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途
DE102004028241B4 (de) 2004-06-11 2007-09-13 Sanofi-Aventis Deutschland Gmbh Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel
US7393836B2 (en) 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
DE102004034690A1 (de) 2004-07-17 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
WO2006010557A1 (de) 2004-07-27 2006-02-02 Boehringer Ingelheim International Gmbh D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
WO2006018150A1 (de) 2004-08-11 2006-02-23 Boehringer Ingelheim International Gmbh D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
AU2005286494B2 (en) 2004-09-22 2011-06-23 Vib Vzw Intestinal epithelial glucose sensor
DE102004048388A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP5086643B2 (ja) 2004-11-18 2012-11-28 キッセイ薬品工業株式会社 １−置換−３−（β−Ｄ−グリコピラノシル）含窒素ヘテロ環化合物、及びそれを含有する医薬
UA91546C2 (uk) 2005-05-03 2010-08-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ
TWI370818B (en) 2006-04-05 2012-08-21 Astellas Pharma Inc Cocrystal of c-glycoside derivative and l-proline
EP2019679B1 (en) 2006-05-23 2018-06-20 Theracos, Inc. Glucose transport inhibitors and methods of use
US20080027014A1 (en) 2006-07-28 2008-01-31 Tanabe Seiyaku Co., Ltd. Novel SGLT inhibitors
TW200817424A (en) 2006-08-04 2008-04-16 Daiichi Sankyo Co Ltd Benzylphenyl glucopyranoside derivatives
WO2008115574A1 (en) 2007-03-21 2008-09-25 Reliant Pharmaceuticals, Inc. Cb1 antagonist and a dyslipidemic agent and/or metabolic regulator, and methods of making and using same
TW200904454A (en) 2007-03-22 2009-02-01 Bristol Myers Squibb Co Methods for treating obesity employing an SGLT2 inhibitor and compositions thereof
EP2891885A3 (en) 2007-04-18 2015-10-14 Health Diagnostic Laboratory, Inc. Diabetes-related biomarkers and methods of use thereof
EP2197433A4 (en) 2007-08-20 2010-09-08 Sinai School Medicine REGULATION OF GLP-1 AND SGLT-1 IN GASTROINTESTINAL CELLS
LT2187742T (lt) 2007-08-23 2018-01-10 Theracos Sub, Llc (2s,3r,4r,5s,6r)-2-(4-chlor-3-benzilfenil)-6-(hidroksimetil)tetrahidro-2h-piran-3,4,5-triolio dariniai, skirti panaudoti diabeto gydymui
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
WO2009096455A1 (ja) * 2008-01-31 2009-08-06 Astellas Pharma Inc. 脂肪性肝疾患の治療用医薬組成物
US8518895B2 (en) 2008-05-22 2013-08-27 Bristol-Myers Squibb Company Method for treating hyponatremia employing an SGLT2 inhibitor and composition containing same
WO2009143021A1 (en) 2008-05-22 2009-11-26 Bristol-Myers Squibb Company Method for treating and preventing kidney stones employing an sglt2 inhibitor and composition containing same
JP5820269B2 (ja) 2008-05-22 2015-11-24 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Ｓｇｌｔ２阻害剤を使用する高尿酸血症の治療方法およびｓｇｌｔ２阻害剤を含有する組成物
EA201100503A1 (ru) 2008-09-19 2011-10-31 Новартис Аг Глюкозидные производные и их применения
EP2342187A1 (en) 2008-09-19 2011-07-13 Novartis AG Glycoside derivatives and uses thereof
WO2010045656A2 (en) 2008-10-17 2010-04-22 Nectid, Inc. Novel sglt2 inhibitor dosage forms
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20100167988A1 (en) 2008-10-22 2010-07-01 Auspex Pharmaceuticals, Inc. Ethoxyphenylmethyl inhibitors of sglt2
WO2010074219A1 (ja) 2008-12-26 2010-07-01 アステラス製薬株式会社 ベンゾチオフェン化合物
US20120035105A1 (en) 2009-01-09 2012-02-09 Sdg, Inc. Insulin Therapies for the Treatment of Diabetes, Diabetes Related Ailments, and/or Diseases or Conditions Other Than Diabetes or Diabetes Related Ailments
JP5685550B2 (ja) 2009-02-13 2015-03-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｇｌｔ２阻害剤、ｄｐｐ−ｉｖ阻害剤、更に必要により抗糖尿病薬を含む医薬組成物及びその使用
BRPI1013640A2 (pt) 2009-02-13 2019-09-24 Boehringer Ingelheim Int composicao farmaceutica, metodos para o tratamento e usos dos mesmos
WO2010128152A1 (en) * 2009-05-07 2010-11-11 Novartis Ag Fused heterocyclic c-glycosides for the treatment of diabetes
US8163704B2 (en) * 2009-10-20 2012-04-24 Novartis Ag Glycoside derivatives and uses thereof

Also Published As

Publication number Publication date
UY32958A (es) 2011-05-31
KR101465308B1 (ko) 2014-11-28
CO6531486A2 (es) 2012-09-28
IL219309A0 (en) 2012-06-28
AR078685A1 (es) 2011-11-23
US20120178680A1 (en) 2012-07-12
KR20120083484A (ko) 2012-07-25
EA201200600A1 (ru) 2012-12-28
US8163704B2 (en) 2012-04-24
GT201200117A (es) 2013-09-23
CA2777812A1 (en) 2011-04-28
ES2564191T3 (es) 2016-03-18
CN102656165A (zh) 2012-09-05
US8466114B2 (en) 2013-06-18
SI2491029T1 (sl) 2016-05-31
CR20120176A (es) 2012-05-22
HUE027531T2 (en) 2016-10-28
HK1168099A1 (zh) 2012-12-21
TW201118104A (en) 2011-06-01
PE20121281A1 (es) 2012-10-05
JP5384744B2 (ja) 2014-01-08
US8828951B2 (en) 2014-09-09
HRP20160436T1 (hr) 2016-05-20
DK2491029T3 (en) 2016-04-11
CU24079B1 (es) 2015-03-30
JP2014040451A (ja) 2014-03-06
US9895389B2 (en) 2018-02-20
CU20120062A7 (es) 2012-06-29
AU2010309833A1 (en) 2012-03-29
US20110171159A1 (en) 2011-07-14
MA33737B1 (fr) 2012-11-01
ECSP12011909A (es) 2012-07-31
TN2012000109A1 (en) 2013-09-19
US20140274921A1 (en) 2014-09-18
RS54563B1 (en) 2016-06-30
CY1117409T1 (el) 2017-04-26
IL219309A (en) 2015-03-31
PL2491029T3 (pl) 2016-07-29
AU2010309833B2 (en) 2014-06-12
MX2012004700A (es) 2012-05-23
US20170042925A1 (en) 2017-02-16
EP2491029A1 (en) 2012-08-29
US20130017993A1 (en) 2013-01-17
KR20140054415A (ko) 2014-05-08
BR112012009053B1 (pt) 2020-03-03
TWI594756B (zh) 2017-08-11
CA2777812C (en) 2018-07-17
TWI558723B (zh) 2016-11-21
JO3152B1 (ar) 2017-09-20
SG179562A1 (en) 2012-05-30
ZA201201680B (en) 2012-11-28
EP2491029B1 (en) 2016-02-10
HN2012000798A (es) 2015-08-03
TW201632190A (zh) 2016-09-16
MY158326A (en) 2016-09-30
CN102656165B (zh) 2015-02-11
WO2011048112A1 (en) 2011-04-28
CL2012000991A1 (es) 2012-09-07
JP2013508335A (ja) 2013-03-07
US20150141354A1 (en) 2015-05-21
NZ598717A (en) 2014-04-30
EA023781B1 (ru) 2016-07-29
USRE49080E1 (en) 2022-05-24

Similar Documents

Publication Publication Date Title
BR112012009053A2 (pt) derivado de glicosídeos e usos do mesmo
BR112012008924A2 (pt) derivado de glicosídeo e usos do mesmo
BR112014015908A8 (pt) composição
BR112015011298A2 (pt) inibidores de cotransportador 1 de glicose de sódio
BRPI0922220A8 (pt) Uso de compostos antibacterianos, composição farmacêutica e combinação compreendendo os mesmos
BR112014015905A8 (pt) composição
JO2910B1 (en) Organic compounds
BR112016007288A2 (pt) composições fungicidas
MX2011008899A (es) Nuevas orto-aminoamidas para el tratamiento del cancer.
MX336189B (es) Compuesto de dihidroazol antiparasiticos y composiciones qe¡ue comprenden los mismos.
PA8840801A1 (es) Derivaos de dioxa-biciclo[3.2.1]octano-2,3,4-triol
AU2010230585A8 (en) Autotaxin inhibitors
BR112012030923B8 (pt) Composto derivado de piperidinona como inibidor de mdm2 e composição farmacêutica compreendendo o mesmo
GEP20146003B (en) Benzothiazole derivatives as anticancer agents
BR112013012795B8 (pt) processo de tratamento de produtos vegetais e composição
BR112012018343A2 (pt) "composições imunogênicas"
UY32385A (es) Amidas de pirazinona sustituida
BR112015003328A2 (pt) ciclopentilpirazóis como bloqueadores de canal de cálcio de tipo-n
CO2017008721A2 (es) Compuestos derivados de n-[[1,3,4-oxadiazol-2-il]tetrahidropiran-4-il]-n-metilbenzamida o n-[[1,2,4-triazol-3-il]tetrahidro-2h-piran-4-il]-n-metilbenzamida activos como agonistas de gpr142, composiciones que los comprenden y proceso para la producción de los mismos
MA32512B1 (fr) Derive de phenanthrenone, compositions et procedes
UA109415C2 (xx) Глікозидні похідні та їх застосування
TN2011000035A1 (en) Organic compounds
CU20110041A7 (es) Derivados de dioxa-biciclo(3.2.1)octano-2,3,4-triol

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/10/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 13A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2745 DE 15-08-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.