BR0316569A - 9a-n-(n'-carbamoil-gama-aminopropila), 9a-n-(n'-tiocarbamoil-gama-aminopropila), 9a-n-[n'-(beta-cianoetil)-n'-carbamoil-gama-aminoprop ila] e 9a-n-[n'-(beta-cianoetil)-n'-tiocarbamoil-gama-aminop ropila] n"-substituìdas derivadas de 9-desoxo-9-diidro-9a-aza-9a-homoeritromicina a e 5-o-desosaminil-9-desoxo-9-diidro-9a-aza-9a-homoerit ronolida a - Google Patents

9a-n-(n'-carbamoil-gama-aminopropila), 9a-n-(n'-tiocarbamoil-gama-aminopropila), 9a-n-[n'-(beta-cianoetil)-n'-carbamoil-gama-aminoprop ila] e 9a-n-[n'-(beta-cianoetil)-n'-tiocarbamoil-gama-aminop ropila] n"-substituìdas derivadas de 9-desoxo-9-diidro-9a-aza-9a-homoeritromicina a e 5-o-desosaminil-9-desoxo-9-diidro-9a-aza-9a-homoerit ronolida a

Info

Publication number
BR0316569A
BR0316569A BR0316569-8A BR0316569A BR0316569A BR 0316569 A BR0316569 A BR 0316569A BR 0316569 A BR0316569 A BR 0316569A BR 0316569 A BR0316569 A BR 0316569A
Authority
BR
Brazil
Prior art keywords
aminopropyl
gamma
aza
cyanoethyl
dihydro
Prior art date
Application number
BR0316569-8A
Other languages
English (en)
Inventor
Nedjeljko Kijundzic
Krajacic Mirjana Bukvic
Karmen Brajsa
Original Assignee
Pliva Istrazivacki Inst D O O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Inst D O O filed Critical Pliva Istrazivacki Inst D O O
Publication of BR0316569A publication Critical patent/BR0316569A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"9a-N-(N<39>-CARBAMOIL-GAMA-AMINOPROPILA), 9a-N-(N<39>-TIOCARBAMOIL-GAMA-AMINOPROPILA), 9a-N-¢N<39>-(BETA-CIANOETIL)-N<39>-CARBAMOIL-GAMA-AMI NOPROPILA! E 9a-N-¢N<39>-(BETACIANOETIL)-N<39>-TIOCARBAMOIL-GAMA-A MINOPROPILA! N<39><39>-SUBSTITUìDAS DERIVADAS DE 9-DESOXO-9-DIIDRO-9a-AZA-9a-HOMOERITROMICINA A E 5-O-DESOSAMINIL-9-DESOXO-9-DIIDRO-9a-AZA-9a-HOMOERIT RONOLIDA A". A presente invenção refere-se a 9a-N-(N<39>-carbamoil-<sym>-aminopropila), 9a-N-(N<39>-tiocarbamoil-<sym>-aminopropila), 9a-N-¢N<39>-(<225>-cianoetil)-N<39>-carbamoil-<sym>-aminopropil a! e 9a-N-¢N<39>-(<225>-cianoetil)-N<39>-tiocarbamoil-<sym>-aminopro pila! N<39><39>-substituídas derivadas de 9-desoxo-9-diidro-9a-aza-9a-homoeritromicina A e 5-O-desosaminil-9-desoxo-9-diidro-9a-aza-9a-homoeritronolida A, novo antibiótico de macrolida semi-sintético da série azalida, da fórmula geral 1, onde R representa H ou porção cladinosila, R¬ 1¬ representa H ou (porção <225>cianoetila, R¬ 2¬ representa grupo isopropila, 1-naftila, 2-naftila, benzila, 2-(trifluormetil)fenila, 3-fenilpropila, <225>-feniletila, etoxicarbonilmetila, 1-(1-naftil)etila, 3,4,5-trimetoxifenila e 2,4-diclorofenila, e X representa O e S, e seus sais de adição farmaceuticamente aceitáveis com ácidos inorgânicos ou orgânicos, ao processo para preparação das composições farmacêuticas bem como ao uso de suas composições no tratamento de infecções bacterianas.
BR0316569-8A 2002-12-12 2003-12-10 9a-n-(n'-carbamoil-gama-aminopropila), 9a-n-(n'-tiocarbamoil-gama-aminopropila), 9a-n-[n'-(beta-cianoetil)-n'-carbamoil-gama-aminoprop ila] e 9a-n-[n'-(beta-cianoetil)-n'-tiocarbamoil-gama-aminop ropila] n"-substituìdas derivadas de 9-desoxo-9-diidro-9a-aza-9a-homoeritromicina a e 5-o-desosaminil-9-desoxo-9-diidro-9a-aza-9a-homoerit ronolida a BR0316569A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20020991A HRP20020991A2 (en) 2002-12-12 2002-12-12 N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
PCT/HR2003/000062 WO2004052904A2 (en) 2002-12-12 2003-12-10 Novel semisynthetic macrolide antibiotics of the azalide series

Publications (1)

Publication Number Publication Date
BR0316569A true BR0316569A (pt) 2005-10-04

Family

ID=32500425

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316569-8A BR0316569A (pt) 2002-12-12 2003-12-10 9a-n-(n'-carbamoil-gama-aminopropila), 9a-n-(n'-tiocarbamoil-gama-aminopropila), 9a-n-[n'-(beta-cianoetil)-n'-carbamoil-gama-aminoprop ila] e 9a-n-[n'-(beta-cianoetil)-n'-tiocarbamoil-gama-aminop ropila] n"-substituìdas derivadas de 9-desoxo-9-diidro-9a-aza-9a-homoeritromicina a e 5-o-desosaminil-9-desoxo-9-diidro-9a-aza-9a-homoerit ronolida a

Country Status (25)

Country Link
US (1) US7342000B2 (pt)
EP (1) EP1585753B1 (pt)
JP (1) JP2006510660A (pt)
KR (1) KR20050085555A (pt)
CN (1) CN100335489C (pt)
AR (1) AR042351A1 (pt)
AT (1) ATE327999T1 (pt)
AU (1) AU2003285599A1 (pt)
BR (1) BR0316569A (pt)
CA (1) CA2509599A1 (pt)
CL (1) CL2003002585A1 (pt)
CO (1) CO5640139A2 (pt)
CY (1) CY1106321T1 (pt)
DE (1) DE60305741T2 (pt)
DK (1) DK1585753T3 (pt)
ES (1) ES2266883T3 (pt)
HK (1) HK1086273A1 (pt)
HR (1) HRP20020991A2 (pt)
IS (1) IS2309B (pt)
MX (1) MXPA05006220A (pt)
PL (1) PL377322A1 (pt)
PT (1) PT1585753E (pt)
RS (1) RS80204A (pt)
RU (1) RU2328503C2 (pt)
WO (1) WO2004052904A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
US20080200404A1 (en) * 2005-01-14 2008-08-21 Mirjana Bukvic Krajacic Novel Antimalarial 9A-Carbamoyl-Aminoalkyl and 9A-Thiocarbamoyl-Aminoalkyl Azalides
US20080113926A1 (en) * 2005-01-14 2008-05-15 Zrinka Ivezic 9A-Carbamoyl-Y-Aminopropyl- And 9A-Thiocabamoyl-Y-Aminopropyl-Azalides With Antimalarial Activity
JP2009535395A (ja) * 2006-05-03 2009-10-01 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ ９ａ−置換アザリド

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
BE892397A (nl) 1982-03-08 1982-07-01 Marchand Paul Wereldwijde draadloze telefonie voor 10 miljard abonnees
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4492688A (en) 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
MX13723A (es) 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
WO1997035590A1 (en) * 1996-03-25 1997-10-02 Platt Chris E 10-aza-9-deoxo-11-deoxy-erythromycin a and derivatives combined with sulfisoxazole
HRP990130B1 (en) * 1999-05-03 2004-06-30 Pliva D D HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
PL365012A1 (en) * 2000-12-21 2004-12-27 Glaxo Group Limited Macrolide antibiotics
HRP20010146B1 (en) 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
HRP20020886A2 (en) 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A

Also Published As

Publication number Publication date
PL377322A1 (pl) 2006-01-23
HRP20020991A2 (en) 2005-02-28
MXPA05006220A (es) 2005-11-17
EP1585753B1 (en) 2006-05-31
RU2005121892A (ru) 2006-01-20
US20060252709A1 (en) 2006-11-09
IS7875A (is) 2005-05-31
KR20050085555A (ko) 2005-08-29
DE60305741T2 (de) 2007-06-14
AU2003285599A1 (en) 2004-06-30
EP1585753A2 (en) 2005-10-19
WO2004052904A2 (en) 2004-06-24
CL2003002585A1 (es) 2005-01-28
CA2509599A1 (en) 2004-06-24
HK1086273A1 (en) 2006-09-15
CO5640139A2 (es) 2006-05-31
CY1106321T1 (el) 2011-10-12
RU2328503C2 (ru) 2008-07-10
RS80204A (en) 2006-12-15
AU2003285599A8 (en) 2004-06-30
AR042351A1 (es) 2005-06-15
CN100335489C (zh) 2007-09-05
DK1585753T3 (da) 2006-10-02
ES2266883T3 (es) 2007-03-01
IS2309B (is) 2007-10-15
PT1585753E (pt) 2006-08-31
CN1726222A (zh) 2006-01-25
JP2006510660A (ja) 2006-03-30
ATE327999T1 (de) 2006-06-15
US7342000B2 (en) 2008-03-11
WO2004052904A3 (en) 2004-09-02
DE60305741D1 (de) 2006-07-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A., 7A. E 8A. ANUIDADE(S),

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.