ATE327999T1 - Neue halbsynthetische macrolidantibiotika der azalidreihe - Google Patents

Neue halbsynthetische macrolidantibiotika der azalidreihe

Info

Publication number
ATE327999T1
ATE327999T1 AT03778598T AT03778598T ATE327999T1 AT E327999 T1 ATE327999 T1 AT E327999T1 AT 03778598 T AT03778598 T AT 03778598T AT 03778598 T AT03778598 T AT 03778598T AT E327999 T1 ATE327999 T1 AT E327999T1
Authority
AT
Austria
Prior art keywords
synthetic
new semi
macrolid antibiotics
azalide
series
Prior art date
Application number
AT03778598T
Other languages
English (en)
Inventor
Nedjeljko Kujundzic
Krajacic Mirjana Bukvic
Karmen Brajsa
Original Assignee
Pliva Istrazivacki Inst D D O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Inst D D O filed Critical Pliva Istrazivacki Inst D D O
Application granted granted Critical
Publication of ATE327999T1 publication Critical patent/ATE327999T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT03778598T 2002-12-12 2003-12-10 Neue halbsynthetische macrolidantibiotika der azalidreihe ATE327999T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20020991A HRP20020991A2 (en) 2002-12-12 2002-12-12 N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de

Publications (1)

Publication Number Publication Date
ATE327999T1 true ATE327999T1 (de) 2006-06-15

Family

ID=32500425

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03778598T ATE327999T1 (de) 2002-12-12 2003-12-10 Neue halbsynthetische macrolidantibiotika der azalidreihe

Country Status (25)

Country Link
US (1) US7342000B2 (de)
EP (1) EP1585753B1 (de)
JP (1) JP2006510660A (de)
KR (1) KR20050085555A (de)
CN (1) CN100335489C (de)
AR (1) AR042351A1 (de)
AT (1) ATE327999T1 (de)
AU (1) AU2003285599A1 (de)
BR (1) BR0316569A (de)
CA (1) CA2509599A1 (de)
CL (1) CL2003002585A1 (de)
CO (1) CO5640139A2 (de)
CY (1) CY1106321T1 (de)
DE (1) DE60305741T2 (de)
DK (1) DK1585753T3 (de)
ES (1) ES2266883T3 (de)
HK (1) HK1086273A1 (de)
HR (1) HRP20020991A2 (de)
IS (1) IS2309B (de)
MX (1) MXPA05006220A (de)
PL (1) PL377322A1 (de)
PT (1) PT1585753E (de)
RS (1) RS80204A (de)
RU (1) RU2328503C2 (de)
WO (1) WO2004052904A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
WO2006085228A2 (en) * 2005-01-14 2006-08-17 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-carbamoyl-y-aminopropyl and 9a-thiocarbamoyl-y-aminopropyl-azalides with antimalarial activity
EP1835921B1 (de) * 2005-01-14 2010-08-18 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl-y-aminopropyl- und 9a-thiocarbamoyl-y-aminopropyl-azalide mit antimalaria-aktivität
WO2007125414A2 (en) * 2006-05-03 2007-11-08 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-substituted azalides for the tratment of malaria

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
BE892397A (nl) 1982-03-08 1982-07-01 Marchand Paul Wereldwijde draadloze telefonie voor 10 miljard abonnees
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4492688A (en) * 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4464527A (en) 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
MX13723A (es) 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
WO1997035590A1 (en) 1996-03-25 1997-10-02 Platt Chris E 10-aza-9-deoxo-11-deoxy-erythromycin a and derivatives combined with sulfisoxazole
HRP990130B1 (en) * 1999-05-03 2004-06-30 Pliva D D HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
IL156561A0 (en) * 2000-12-21 2004-01-04 Glaxo Group Ltd Macrolide antibiotics
HRP20010146B1 (en) 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020886A2 (en) 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b

Also Published As

Publication number Publication date
WO2004052904A3 (en) 2004-09-02
BR0316569A (pt) 2005-10-04
CA2509599A1 (en) 2004-06-24
WO2004052904A2 (en) 2004-06-24
CL2003002585A1 (es) 2005-01-28
RS80204A (en) 2006-12-15
EP1585753A2 (de) 2005-10-19
ES2266883T3 (es) 2007-03-01
JP2006510660A (ja) 2006-03-30
CY1106321T1 (el) 2011-10-12
CO5640139A2 (es) 2006-05-31
US7342000B2 (en) 2008-03-11
DE60305741T2 (de) 2007-06-14
PT1585753E (pt) 2006-08-31
AU2003285599A1 (en) 2004-06-30
HRP20020991A2 (en) 2005-02-28
IS7875A (is) 2005-05-31
KR20050085555A (ko) 2005-08-29
DK1585753T3 (da) 2006-10-02
MXPA05006220A (es) 2005-11-17
RU2328503C2 (ru) 2008-07-10
PL377322A1 (pl) 2006-01-23
RU2005121892A (ru) 2006-01-20
AU2003285599A8 (en) 2004-06-30
HK1086273A1 (en) 2006-09-15
CN100335489C (zh) 2007-09-05
DE60305741D1 (de) 2006-07-06
IS2309B (is) 2007-10-15
CN1726222A (zh) 2006-01-25
US20060252709A1 (en) 2006-11-09
AR042351A1 (es) 2005-06-15
EP1585753B1 (de) 2006-05-31

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