AR042351A1 - "DERIVADOS N" SUSTITUIDOS 9A-N- (N' CARBAMOIL - GAMMA - AMINOPROPIL) , 9A - N- ( N'- TIOCARBAMOIL- GAMMA- AMINOPROPIL), 9 A - N- [N' - ( a- CIANOETIL) - N' - CARBAMOIL . GAMMA- AMINOPROPIL ] DE 9- DEOXO- 9- DIHIDRO 9A - AZA- 9A- HOMOERITROMICINA A Y 5 - O- DESOMINIL- 9- DEOXO- 9- DIHIDRO-9 A - AZA- - Google Patents

"DERIVADOS N" SUSTITUIDOS 9A-N- (N' CARBAMOIL - GAMMA - AMINOPROPIL) , 9A - N- ( N'- TIOCARBAMOIL- GAMMA- AMINOPROPIL), 9 A - N- [N' - ( a- CIANOETIL) - N' - CARBAMOIL . GAMMA- AMINOPROPIL ] DE 9- DEOXO- 9- DIHIDRO 9A - AZA- 9A- HOMOERITROMICINA A Y 5 - O- DESOMINIL- 9- DEOXO- 9- DIHIDRO-9 A - AZA-

Info

Publication number
AR042351A1
AR042351A1 ARP030104537A ARP030104537A AR042351A1 AR 042351 A1 AR042351 A1 AR 042351A1 AR P030104537 A ARP030104537 A AR P030104537A AR P030104537 A ARP030104537 A AR P030104537A AR 042351 A1 AR042351 A1 AR 042351A1
Authority
AR
Argentina
Prior art keywords
gamma
aminopropil
deoxo
aza
carbamoil
Prior art date
Application number
ARP030104537A
Other languages
English (en)
Inventor
Nedjeljko Kujundzic
Krajacic Mirjana Bukvic
Karmen Brajsa
Original Assignee
Pliva D D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva D D filed Critical Pliva D D
Publication of AR042351A1 publication Critical patent/AR042351A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados N'' sustituidos 9a-N-(N'-carbamoil-gama-aminopropil), 9a-N-(N'-tiocarbamoil-gama-aminopropil), 9a-N-[N'-(beta-cianoetil)-N'-carbamoil-gama-aminopropil] y 9a-N-[N'-(beta-cianoetil)-N'-tiocarbamoil-gama-aminopropil] de 9-deoxo-9-dihidro-9a-aza-9a-homoeritromicina A y 5-O-desosaminil-9-deoxo-9-dihidro-9a-aza-9a-homoeritronolida A, nuevos antibióticos macrólidos semisintéticos de la serie de azalidas de fórmula general (1), donde R representa H o una parte cladinosilo, R1 representa H o una parte beta-cianoetilo, R2 representa un grupo isopropilo, 1-naftilo, 2-naftilo, bencilo, 2-(trilfuorometil)fenilo, 3-fenilpropilo, beta-feniletilo, etoxicarbonil-metilo, 1-(1-naftil)etilo, 3,4,5-trimetoxifenilo y 2,4-diclorofenilo, y X representa O y S, y sus sales de adición aceptables con ácidos inorgánicos u orgánicos, procedimiento para la preparación de sus composiciones farmacéuticas, como así también uso de sus composiciones para el tratamiento de infecciones bacterianas.
ARP030104537A 2002-12-12 2003-12-10 "DERIVADOS N" SUSTITUIDOS 9A-N- (N' CARBAMOIL - GAMMA - AMINOPROPIL) , 9A - N- ( N'- TIOCARBAMOIL- GAMMA- AMINOPROPIL), 9 A - N- [N' - ( a- CIANOETIL) - N' - CARBAMOIL . GAMMA- AMINOPROPIL ] DE 9- DEOXO- 9- DIHIDRO 9A - AZA- 9A- HOMOERITROMICINA A Y 5 - O- DESOMINIL- 9- DEOXO- 9- DIHIDRO-9 A - AZA- AR042351A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20020991A HRP20020991A2 (en) 2002-12-12 2002-12-12 N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de

Publications (1)

Publication Number Publication Date
AR042351A1 true AR042351A1 (es) 2005-06-15

Family

ID=32500425

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104537A AR042351A1 (es) 2002-12-12 2003-12-10 "DERIVADOS N" SUSTITUIDOS 9A-N- (N' CARBAMOIL - GAMMA - AMINOPROPIL) , 9A - N- ( N'- TIOCARBAMOIL- GAMMA- AMINOPROPIL), 9 A - N- [N' - ( a- CIANOETIL) - N' - CARBAMOIL . GAMMA- AMINOPROPIL ] DE 9- DEOXO- 9- DIHIDRO 9A - AZA- 9A- HOMOERITROMICINA A Y 5 - O- DESOMINIL- 9- DEOXO- 9- DIHIDRO-9 A - AZA-

Country Status (25)

Country Link
US (1) US7342000B2 (es)
EP (1) EP1585753B1 (es)
JP (1) JP2006510660A (es)
KR (1) KR20050085555A (es)
CN (1) CN100335489C (es)
AR (1) AR042351A1 (es)
AT (1) ATE327999T1 (es)
AU (1) AU2003285599A1 (es)
BR (1) BR0316569A (es)
CA (1) CA2509599A1 (es)
CL (1) CL2003002585A1 (es)
CO (1) CO5640139A2 (es)
CY (1) CY1106321T1 (es)
DE (1) DE60305741T2 (es)
DK (1) DK1585753T3 (es)
ES (1) ES2266883T3 (es)
HK (1) HK1086273A1 (es)
HR (1) HRP20020991A2 (es)
IS (1) IS2309B (es)
MX (1) MXPA05006220A (es)
PL (1) PL377322A1 (es)
PT (1) PT1585753E (es)
RS (1) RS80204A (es)
RU (1) RU2328503C2 (es)
WO (1) WO2004052904A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
WO2006085228A2 (en) * 2005-01-14 2006-08-17 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-carbamoyl-y-aminopropyl and 9a-thiocarbamoyl-y-aminopropyl-azalides with antimalarial activity
EP1835921B1 (en) * 2005-01-14 2010-08-18 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl-y-aminopropyl- and 9a-thiocarbamoyl-y-aminopropyl-azalides with antimalarial activity
EP2012776A2 (en) * 2006-05-03 2009-01-14 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-substituted azalides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
BE892397A (nl) 1982-03-08 1982-07-01 Marchand Paul Wereldwijde draadloze telefonie voor 10 miljard abonnees
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4492688A (en) * 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4464527A (en) 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
MX13723A (es) 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
WO1997035590A1 (en) 1996-03-25 1997-10-02 Platt Chris E 10-aza-9-deoxo-11-deoxy-erythromycin a and derivatives combined with sulfisoxazole
HRP990130B1 (en) * 1999-05-03 2004-06-30 Pliva D D HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
CN1492874A (zh) * 2000-12-21 2004-04-28 大环内酯
HRP20010146B1 (en) 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
HRP20020886A2 (en) 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A

Also Published As

Publication number Publication date
US20060252709A1 (en) 2006-11-09
CO5640139A2 (es) 2006-05-31
RU2328503C2 (ru) 2008-07-10
IS2309B (is) 2007-10-15
MXPA05006220A (es) 2005-11-17
CL2003002585A1 (es) 2005-01-28
AU2003285599A1 (en) 2004-06-30
WO2004052904A3 (en) 2004-09-02
PL377322A1 (pl) 2006-01-23
DE60305741D1 (de) 2006-07-06
PT1585753E (pt) 2006-08-31
CN100335489C (zh) 2007-09-05
BR0316569A (pt) 2005-10-04
US7342000B2 (en) 2008-03-11
EP1585753B1 (en) 2006-05-31
RU2005121892A (ru) 2006-01-20
DE60305741T2 (de) 2007-06-14
ES2266883T3 (es) 2007-03-01
DK1585753T3 (da) 2006-10-02
HRP20020991A2 (en) 2005-02-28
HK1086273A1 (en) 2006-09-15
KR20050085555A (ko) 2005-08-29
CN1726222A (zh) 2006-01-25
ATE327999T1 (de) 2006-06-15
WO2004052904A2 (en) 2004-06-24
IS7875A (is) 2005-05-31
RS80204A (en) 2006-12-15
JP2006510660A (ja) 2006-03-30
CY1106321T1 (el) 2011-10-12
AU2003285599A8 (en) 2004-06-30
EP1585753A2 (en) 2005-10-19
CA2509599A1 (en) 2004-06-24

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