MXPA05006220A - Nuevos antibioticos macrolidos semisinteticos de la serie de azalidas. - Google Patents

Nuevos antibioticos macrolidos semisinteticos de la serie de azalidas.

Info

Publication number
MXPA05006220A
MXPA05006220A MXPA05006220A MXPA05006220A MXPA05006220A MX PA05006220 A MXPA05006220 A MX PA05006220A MX PA05006220 A MXPA05006220 A MX PA05006220A MX PA05006220 A MXPA05006220 A MX PA05006220A MX PA05006220 A MXPA05006220 A MX PA05006220A
Authority
MX
Mexico
Prior art keywords
aminopropyl
gamma
beta
naphtyl
cyanoethyl
Prior art date
Application number
MXPA05006220A
Other languages
English (en)
Inventor
Brajsa Karmen
Original Assignee
Pliva Istrazivacki Inst D O O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Inst D O O filed Critical Pliva Istrazivacki Inst D O O
Publication of MXPA05006220A publication Critical patent/MXPA05006220A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se relaciona a derivados N" sustituidos 9a-N-(N'-carbamoil-(-aminopropil), 9a-N-(N'-tiocarbamoil-(-aminopropil), 9a-N-[N'((-cianoetil)-N'-carbamoil-(-aminopropil] y 9a-N-[N'-((-cianoetil)-N'-tiocarbamoil-(-aminopropil] de 9-deoxo-9-dihidro-9a-aza-9a-homoeritromicina A y 5-O-desosaminil-9-deoxo-9-dihidro-9a-aza-9a-homoeritronolida A, nuevos antibioticos macrolidos semisinteticos de la serie de azalidas de la formula general 1, en donde R representa H o una parte cladinosilo, R1 representa H o una parte (-cianoetilo, R2 representa un grupo isopropilo, 1-naftilo, 2-naftilo, bencilo, 2-(trifluorometil)fenilo, 3-fenilpropilo, (-feniletilo, etoxicarbonil-metilo, 1-(1-naftil)etilo, 3,4,5-trimetoxifenilo y 2,4-diclorofenilo, y X representa O y S, y sus sales de adicion aceptables con acidos inorganicos u organicos, al procedimiento para la preparacion de sus composiciones farmaceuticas, como asi tambien al uso de sus composiciones para el tratamiento de infecciones bacterianas.
MXPA05006220A 2002-12-12 2003-12-10 Nuevos antibioticos macrolidos semisinteticos de la serie de azalidas. MXPA05006220A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20020991A HRP20020991A2 (en) 2002-12-12 2002-12-12 N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
PCT/HR2003/000062 WO2004052904A2 (en) 2002-12-12 2003-12-10 Novel semisynthetic macrolide antibiotics of the azalide series

Publications (1)

Publication Number Publication Date
MXPA05006220A true MXPA05006220A (es) 2005-11-17

Family

ID=32500425

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05006220A MXPA05006220A (es) 2002-12-12 2003-12-10 Nuevos antibioticos macrolidos semisinteticos de la serie de azalidas.

Country Status (25)

Country Link
US (1) US7342000B2 (es)
EP (1) EP1585753B1 (es)
JP (1) JP2006510660A (es)
KR (1) KR20050085555A (es)
CN (1) CN100335489C (es)
AR (1) AR042351A1 (es)
AT (1) ATE327999T1 (es)
AU (1) AU2003285599A1 (es)
BR (1) BR0316569A (es)
CA (1) CA2509599A1 (es)
CL (1) CL2003002585A1 (es)
CO (1) CO5640139A2 (es)
CY (1) CY1106321T1 (es)
DE (1) DE60305741T2 (es)
DK (1) DK1585753T3 (es)
ES (1) ES2266883T3 (es)
HK (1) HK1086273A1 (es)
HR (1) HRP20020991A2 (es)
IS (1) IS2309B (es)
MX (1) MXPA05006220A (es)
PL (1) PL377322A1 (es)
PT (1) PT1585753E (es)
RS (1) RS80204A (es)
RU (1) RU2328503C2 (es)
WO (1) WO2004052904A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
DE602006016231D1 (de) * 2005-01-14 2010-09-30 Glaxosmithkline Zagreb 9a-carbamoyl-y-aminopropyl- und 9a-thiocarbamoyl-y-aminopropyl-azalide mit antimalaria-aktivität
US20080200404A1 (en) * 2005-01-14 2008-08-21 Mirjana Bukvic Krajacic Novel Antimalarial 9A-Carbamoyl-Aminoalkyl and 9A-Thiocarbamoyl-Aminoalkyl Azalides
JP2009535395A (ja) * 2006-05-03 2009-10-01 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ ９ａ−置換アザリド

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
BE892397A (nl) 1982-03-08 1982-07-01 Marchand Paul Wereldwijde draadloze telefonie voor 10 miljard abonnees
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4492688A (en) 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
MX13723A (es) 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a
HRP931480B1 (en) 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
WO1997035590A1 (en) * 1996-03-25 1997-10-02 Platt Chris E 10-aza-9-deoxo-11-deoxy-erythromycin a and derivatives combined with sulfisoxazole
HRP990130B1 (en) 1999-05-03 2004-06-30 Pliva D D HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
ATE345350T1 (de) * 2000-12-21 2006-12-15 Glaxo Group Ltd Makrolidantibiotika
HRP20010146B1 (en) 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020886A2 (en) 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b

Also Published As

Publication number Publication date
RS80204A (en) 2006-12-15
CY1106321T1 (el) 2011-10-12
CA2509599A1 (en) 2004-06-24
CN1726222A (zh) 2006-01-25
BR0316569A (pt) 2005-10-04
ES2266883T3 (es) 2007-03-01
CN100335489C (zh) 2007-09-05
HRP20020991A2 (en) 2005-02-28
IS7875A (is) 2005-05-31
AU2003285599A1 (en) 2004-06-30
CL2003002585A1 (es) 2005-01-28
DE60305741T2 (de) 2007-06-14
IS2309B (is) 2007-10-15
AU2003285599A8 (en) 2004-06-30
EP1585753B1 (en) 2006-05-31
EP1585753A2 (en) 2005-10-19
US7342000B2 (en) 2008-03-11
AR042351A1 (es) 2005-06-15
RU2328503C2 (ru) 2008-07-10
WO2004052904A3 (en) 2004-09-02
KR20050085555A (ko) 2005-08-29
DK1585753T3 (da) 2006-10-02
WO2004052904A2 (en) 2004-06-24
JP2006510660A (ja) 2006-03-30
DE60305741D1 (de) 2006-07-06
US20060252709A1 (en) 2006-11-09
CO5640139A2 (es) 2006-05-31
HK1086273A1 (en) 2006-09-15
PT1585753E (pt) 2006-08-31
PL377322A1 (pl) 2006-01-23
ATE327999T1 (de) 2006-06-15
RU2005121892A (ru) 2006-01-20

Similar Documents

Publication Publication Date Title
FI954746A0 (fi) Urea- ja amidijohdannaisia ja niiden käyttö solukalvojen kaliumkanavien säätelyyn
NO20061657L (no) Pyrolderivater med antibakteriell aktivitet
AP9801253A0 (en) 9-Oxime erythromycin derivatives.
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
ES2196331T3 (es) Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b.
SE9904108D0 (sv) Nya föreningar
CA2286511A1 (en) Novel macrolide derivatives
SE9803518D0 (sv) Novel compounds
GEP20053626B (en) Substituted 8-Arylquinoline Phosphodiesterase-4 Inhibitors, Pharmaceutical Composition Containing Them and Use Thereof
SE0300908D0 (sv) Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
CA2137395A1 (en) 9a-N-(N'-Carbamoyl) and 9a-N-(N' - Thiocarbamoyl) Derivatives of 9-Deoxo-9a-AZA-9a-Homoerythromycin A
SE9803773D0 (sv) Compounds
MXPA05006220A (es) Nuevos antibioticos macrolidos semisinteticos de la serie de azalidas.
WO2002068438A3 (en) 9a-n-[n'-(phenylsulfonyl)carbamoyl] derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a and of 5-0-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolide a
AP9801235A0 (en) Erythromycin derivatives.
BR0308734A (pt) Composto, composição farmacêutica, uso do composto, e, método para prevenir ou tratar infecção
CA2256017A1 (en) .beta.,.beta.-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a
PT1575969E (pt) Derivados com substituicao 9a-n- (n'-4- ( sulfonil )fenil ) carbamoilo ) de 9-desoxo-9-dihidro-9a-aza-9a-homoeritromicina a e 5-0-desosaminil-9-desoxo-9-di-hidro-9a-aza-9a-homoeritronilida a
SE0301698D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
ECSP982529A (es) Derivados de la 9-oxima eritromicina
TH36959A (th) มาโครไลต์ชนิดใหม่
TH9901004238A (th) อนุพันธ์ไฮโกรโมซิน a
UY25137A1 (es) Procedimiento para preparar derivados de eritromicina

Legal Events

Date Code Title Description
FG Grant or registration