ES2196331T3 - Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b. - Google Patents
Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b.Info
- Publication number
- ES2196331T3 ES2196331T3 ES97922483T ES97922483T ES2196331T3 ES 2196331 T3 ES2196331 T3 ES 2196331T3 ES 97922483 T ES97922483 T ES 97922483T ES 97922483 T ES97922483 T ES 97922483T ES 2196331 T3 ES2196331 T3 ES 2196331T3
- Authority
- ES
- Spain
- Prior art keywords
- erythromycins
- macrociclical
- elements
- chain derivatives
- hypermotilinemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un compuesto que tiene la Fórmula: **(Fórmula)** o una sal farmacéuticamente admisible del mismo, en donde R es H u OH; R1 y R2 son seleccionados, independientemente, del grupo que se compone de H, alquilo C1-C8, fenilalquilo C1-C8, y naftilalquilo C1-C8; R3 se selecciona del grupo que se compone de H, OH, O-alquilo C1-C8, O-CO-alquilo C1-C8, O-COfenilo, O-CO-NR4R5 donde R4 y R5 son, independientemente, H o alquilo C1-C8, NH2, N-CO-alquilo C1-C8, N-CO-fenilo, N-CO-NR4R5 en donde R4 y R5 son, independientemente, H o alquilo C1-C8; y X se selecciona del grupo que se compone de F, Cl, Br, o I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/668,050 US5712253A (en) | 1996-06-18 | 1996-06-18 | Macrocyclic 13-membered ring derivatives of erythromycins A and B |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196331T3 true ES2196331T3 (es) | 2003-12-16 |
Family
ID=24680797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97922483T Expired - Lifetime ES2196331T3 (es) | 1996-06-18 | 1997-04-25 | Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5712253A (es) |
| EP (1) | EP1021456B1 (es) |
| JP (1) | JP2000512653A (es) |
| AT (1) | ATE236185T1 (es) |
| CA (1) | CA2257361A1 (es) |
| DE (1) | DE69720551T2 (es) |
| DK (1) | DK1021456T3 (es) |
| ES (1) | ES2196331T3 (es) |
| PT (1) | PT1021456E (es) |
| WO (1) | WO1997048713A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4968997A (en) * | 1996-11-26 | 1998-06-22 | Chugai Seiyaku Kabushiki Kaisha | 13-membered ring macrolide compounds, medicine containing the same, and process for producing the same |
| TW460478B (en) | 1997-08-15 | 2001-10-21 | Chugai Pharmaceutical Co Ltd | Phenethylamine derivatives |
| US5780605A (en) * | 1997-09-08 | 1998-07-14 | Abbott Laboratories | 6,9-bridged erythromycin derivatives |
| DE19805822B4 (de) * | 1998-02-13 | 2009-02-05 | Solvay Pharmaceuticals Gmbh | 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6165985A (en) * | 1998-02-13 | 2000-12-26 | Solvay Pharmaceuticals Gmbh | 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them |
| JP2002517507A (ja) * | 1998-06-12 | 2002-06-18 | メルク・アンド・カンパニー・インコーポレーテッド | モチリン受容体のクローニングと同定 |
| TW509699B (en) | 1998-09-24 | 2002-11-11 | Chugau Pharmaceutical Co Ltd | Ethylamine derivatives |
| US7553969B1 (en) | 1999-01-28 | 2009-06-30 | Chugai Seiyaku Kabushiki Kaisha | Substituted phenethylamine derivatives |
| US7179886B1 (en) | 1999-06-08 | 2007-02-20 | Merck & Co., Inc. | Cloning and identification of the motilin receptor |
| AU2001238476A1 (en) | 2000-02-18 | 2001-08-27 | Kosan Biosciences, Inc. | Motocide compounds |
| AU2002245051A1 (en) * | 2000-11-29 | 2002-07-30 | Lifespan Biosciences, Inc. | Diagnostic and therapeutic compositions and methods related to grp 38 |
| US20030186336A1 (en) * | 2001-11-29 | 2003-10-02 | Burmer Glenna C. | Diagnostic and therapeutic compositions and methods related to GPCR 38, a G protein-coupled receptor (GPCR) |
| SI1532131T1 (sl) * | 2002-08-29 | 2009-04-30 | Pfizer | Motilidne spojine |
| AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| CA2528375C (en) | 2003-06-18 | 2013-11-19 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor |
| EP1648923B1 (en) * | 2003-07-31 | 2008-12-31 | Tranzyme Pharma Inc. | Spatially-defined macrocycles incorporating peptide bond surrogates |
| DE602004030344D1 (de) | 2003-07-31 | 2011-01-13 | Tranzyme Pharma Inc | Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen |
| US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
| US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
| US7211568B2 (en) * | 2003-12-18 | 2007-05-01 | Kosan Biosciences Incorporated | 9-Desoxoerythromycin compounds as prokinetic agents |
| JP5383037B2 (ja) | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 大環状化合物およびそれらを製造し使用する方法 |
| US20080249034A1 (en) * | 2005-03-21 | 2008-10-09 | Zambon S.P.A. | Use of Macrolides for Treating Intestinal Inflammation |
| EP1861490A4 (en) * | 2005-03-23 | 2010-11-17 | Univ St Louis | USE OF ARRAYS TO MODULATE NUTRIENT CAPTURE FUNCTIONS BY THE GASTROINTESTINAL MICROBIOTE |
| US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
| JP2009518396A (ja) * | 2005-12-08 | 2009-05-07 | ファイザー・インク | エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法 |
| US8088733B2 (en) | 2006-07-06 | 2012-01-03 | Tranzyme Pharma Inc. | Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders |
| JP5684474B2 (ja) | 2006-09-11 | 2015-03-11 | オセラ セラピューティクス， インコーポレイテッド | 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト |
| RU2422453C2 (ru) * | 2006-12-05 | 2011-06-27 | Пфайзер Инк. | Полиморфы мотилида |
| US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878192A (en) * | 1972-06-05 | 1975-04-15 | Blasina Lab Chim Farm | Sweet and palatable water soluble derivatives of erythromycin |
| JPS6187625A (ja) * | 1984-10-05 | 1986-05-06 | Satoshi Omura | 消化管収縮運動促進剤 |
| EP0215355B1 (en) * | 1985-08-31 | 1994-04-06 | Kitasato Kenkyusho | Erythromycin derivative and process for preparing the same |
| US5008249A (en) * | 1985-08-31 | 1991-04-16 | Kitasato Kenkyusho | Therapeutic method of stimulating digestive tract contractile motion in mammals |
| US4640910A (en) * | 1985-11-12 | 1987-02-03 | Abbott Laboratories | Erythromycin A silylated compounds and method of use |
| US4681872A (en) * | 1985-11-12 | 1987-07-21 | Abbott Laboratories | Erythromycin A 11,12-carbonate and method of use |
| JPS63107994A (ja) * | 1986-05-02 | 1988-05-12 | Taisho Pharmaceut Co Ltd | エリスロマイシン誘導体 |
| MY103197A (en) * | 1987-02-20 | 1993-05-29 | Kitasato Inst | A growth promoting composition and production thereof |
| US4920102A (en) * | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
-
1996
- 1996-06-18 US US08/668,050 patent/US5712253A/en not_active Expired - Lifetime
-
1997
- 1997-04-25 CA CA002257361A patent/CA2257361A1/en not_active Abandoned
- 1997-04-25 EP EP97922483A patent/EP1021456B1/en not_active Expired - Lifetime
- 1997-04-25 AT AT97922483T patent/ATE236185T1/de not_active IP Right Cessation
- 1997-04-25 PT PT97922483T patent/PT1021456E/pt unknown
- 1997-04-25 DK DK97922483T patent/DK1021456T3/da active
- 1997-04-25 DE DE69720551T patent/DE69720551T2/de not_active Expired - Fee Related
- 1997-04-25 WO PCT/US1997/007015 patent/WO1997048713A1/en not_active Ceased
- 1997-04-25 JP JP10502937A patent/JP2000512653A/ja not_active Withdrawn
- 1997-04-25 ES ES97922483T patent/ES2196331T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997048713A1 (en) | 1997-12-24 |
| EP1021456A1 (en) | 2000-07-26 |
| DE69720551T2 (de) | 2004-02-26 |
| DK1021456T3 (da) | 2003-08-18 |
| CA2257361A1 (en) | 1997-12-24 |
| EP1021456B1 (en) | 2003-04-02 |
| US5712253A (en) | 1998-01-27 |
| ATE236185T1 (de) | 2003-04-15 |
| JP2000512653A (ja) | 2000-09-26 |
| DE69720551D1 (de) | 2003-05-08 |
| PT1021456E (pt) | 2003-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2196331T3 (es) | Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b. | |
| CA2216796A1 (en) | Quinazoline derivatives | |
| DE69713152D1 (de) | Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen | |
| AP9801378A0 (en) | 9-amino-3- keto erythromycin derivatives. | |
| CA2258548A1 (en) | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases | |
| IL124537A0 (en) | Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same | |
| DE69713148D1 (de) | Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen | |
| NO996108L (no) | 9-oksinerytromycinderivater | |
| AU697679B2 (en) | Treatment of tinnitis using neuroprotective agents | |
| BG103945A (en) | Derivatives of 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a | |
| TR200103395T2 (tr) | 13-metil eritromisin türevleri. | |
| DK0734383T3 (da) | Cykliske amidderivater som neurokinin-A-antagonister | |
| GB9322643D0 (en) | Lactam derivatives | |
| CA2372270A1 (en) | C-2 modified erythromycin derivatives | |
| DK0876388T3 (da) | Tricykliske erythromycinderivater | |
| CA2286511A1 (en) | Novel macrolide derivatives | |
| ATE178332T1 (de) | Benzothiadiazinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zuzammensetzungen | |
| AP9801377A0 (en) | Tricyclic erythromycin derivatives. | |
| DE69330601D1 (de) | Serotoninergische ergolin derivate | |
| WO2001005386A3 (en) | Pharmaceutical composition useful for the treatment of tinnitus and hearing loss | |
| AP9801235A0 (en) | Erythromycin derivatives. | |
| ES2191778T3 (es) | Derivados de 3-desoxi-3-descladinosa de las eritromicinas a y b. |