ES2196331T3 - Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b. - Google Patents

Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b.

Info

Publication number
ES2196331T3
ES2196331T3 ES97922483T ES97922483T ES2196331T3 ES 2196331 T3 ES2196331 T3 ES 2196331T3 ES 97922483 T ES97922483 T ES 97922483T ES 97922483 T ES97922483 T ES 97922483T ES 2196331 T3 ES2196331 T3 ES 2196331T3
Authority
ES
Spain
Prior art keywords
erythromycins
macrociclical
elements
chain derivatives
hypermotilinemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97922483T
Other languages
English (en)
Inventor
Paul A Lartey
Cynthia Brunell Curty
Ramin Faghih
Hugh Nerby Nellans
Albert Christian Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2196331T3 publication Critical patent/ES2196331T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Un compuesto que tiene la Fórmula: **(Fórmula)** o una sal farmacéuticamente admisible del mismo, en donde R es H u OH; R1 y R2 son seleccionados, independientemente, del grupo que se compone de H, alquilo C1-C8, fenilalquilo C1-C8, y naftilalquilo C1-C8; R3 se selecciona del grupo que se compone de H, OH, O-alquilo C1-C8, O-CO-alquilo C1-C8, O-COfenilo, O-CO-NR4R5 donde R4 y R5 son, independientemente, H o alquilo C1-C8, NH2, N-CO-alquilo C1-C8, N-CO-fenilo, N-CO-NR4R5 en donde R4 y R5 son, independientemente, H o alquilo C1-C8; y X se selecciona del grupo que se compone de F, Cl, Br, o I.
ES97922483T 1996-06-18 1997-04-25 Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b. Expired - Lifetime ES2196331T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/668,050 US5712253A (en) 1996-06-18 1996-06-18 Macrocyclic 13-membered ring derivatives of erythromycins A and B

Publications (1)

Publication Number Publication Date
ES2196331T3 true ES2196331T3 (es) 2003-12-16

Family

ID=24680797

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97922483T Expired - Lifetime ES2196331T3 (es) 1996-06-18 1997-04-25 Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b.

Country Status (10)

Country Link
US (1) US5712253A (es)
EP (1) EP1021456B1 (es)
JP (1) JP2000512653A (es)
AT (1) ATE236185T1 (es)
CA (1) CA2257361A1 (es)
DE (1) DE69720551T2 (es)
DK (1) DK1021456T3 (es)
ES (1) ES2196331T3 (es)
PT (1) PT1021456E (es)
WO (1) WO1997048713A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4968997A (en) * 1996-11-26 1998-06-22 Chugai Seiyaku Kabushiki Kaisha 13-membered ring macrolide compounds, medicine containing the same, and process for producing the same
TW460478B (en) 1997-08-15 2001-10-21 Chugai Pharmaceutical Co Ltd Phenethylamine derivatives
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
DE19805822B4 (de) * 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
ATE354582T1 (de) * 1998-06-12 2007-03-15 Merck & Co Inc Klonierung und identifizierung des motilin- rezeptors
TW509699B (en) 1998-09-24 2002-11-11 Chugau Pharmaceutical Co Ltd Ethylamine derivatives
KR100440643B1 (ko) 1999-01-28 2004-07-21 쥬가이 세이야쿠 가부시키가이샤 치환 페네틸아민 유도체
US7179886B1 (en) 1999-06-08 2007-02-20 Merck & Co., Inc. Cloning and identification of the motilin receptor
US6562795B2 (en) 2000-02-18 2003-05-13 Kosan Biosciences, Inc. Motilide compounds
AU2002245051A1 (en) * 2000-11-29 2002-07-30 Lifespan Biosciences, Inc. Diagnostic and therapeutic compositions and methods related to grp 38
US20030186336A1 (en) * 2001-11-29 2003-10-02 Burmer Glenna C. Diagnostic and therapeutic compositions and methods related to GPCR 38, a G protein-coupled receptor (GPCR)
JP4796300B2 (ja) * 2002-08-29 2011-10-19 ファイザー インコーポレイテッド モチライド化合物
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
US7521420B2 (en) 2003-06-18 2009-04-21 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
PT1648922E (pt) 2003-07-31 2011-01-04 Tranzyme Pharma Inc Compostos macrocíclicos espacialmente definidos úteis para descoberta de fármacos
WO2005012332A1 (en) * 2003-07-31 2005-02-10 Tranzyme Pharma Spatially-defined macrocycles incorporating peptide bond surrogates
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
US20080249034A1 (en) * 2005-03-21 2008-10-09 Zambon S.P.A. Use of Macrolides for Treating Intestinal Inflammation
US20100048595A1 (en) * 2005-03-23 2010-02-25 Washington University In St. Louis Use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota
US7582611B2 (en) 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
EP1960414A4 (en) * 2005-12-08 2008-12-17 Pfizer METHOD FOR DEMETHYLATING THE 3-DIMETHYLAMINOGRUPPE OF ERYTHROMYCIN COMPOUNDS
US8088733B2 (en) 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
US9133235B2 (en) 2006-09-11 2015-09-15 Ocera Therapeutics, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
CN101547931B (zh) * 2006-12-05 2012-11-14 辉瑞有限公司 促动内酯多晶型
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878192A (en) * 1972-06-05 1975-04-15 Blasina Lab Chim Farm Sweet and palatable water soluble derivatives of erythromycin
JPS6187625A (ja) * 1984-10-05 1986-05-06 Satoshi Omura 消化管収縮運動促進剤
EP0215355B1 (en) * 1985-08-31 1994-04-06 Kitasato Kenkyusho Erythromycin derivative and process for preparing the same
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
US4640910A (en) * 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use
US4681872A (en) * 1985-11-12 1987-07-21 Abbott Laboratories Erythromycin A 11,12-carbonate and method of use
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
MY103197A (en) * 1987-02-20 1993-05-29 Kitasato Inst A growth promoting composition and production thereof
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders

Also Published As

Publication number Publication date
DE69720551T2 (de) 2004-02-26
ATE236185T1 (de) 2003-04-15
CA2257361A1 (en) 1997-12-24
JP2000512653A (ja) 2000-09-26
US5712253A (en) 1998-01-27
WO1997048713A1 (en) 1997-12-24
EP1021456B1 (en) 2003-04-02
PT1021456E (pt) 2003-08-29
DE69720551D1 (de) 2003-05-08
DK1021456T3 (da) 2003-08-18
EP1021456A1 (en) 2000-07-26

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