BR0315113A - Processo enantioseletivo para a preparação de ambos enantiÈmeros de 10,11-diidro-10-hidróxi-5h-dibenz[b,f]azepina-5-carbox amida e suas formas de cristal - Google Patents
Processo enantioseletivo para a preparação de ambos enantiÈmeros de 10,11-diidro-10-hidróxi-5h-dibenz[b,f]azepina-5-carbox amida e suas formas de cristalInfo
- Publication number
- BR0315113A BR0315113A BR0315113-1A BR0315113A BR0315113A BR 0315113 A BR0315113 A BR 0315113A BR 0315113 A BR0315113 A BR 0315113A BR 0315113 A BR0315113 A BR 0315113A
- Authority
- BR
- Brazil
- Prior art keywords
- dibenz
- crystal forms
- azepine
- hydroxy
- dihydro
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- BMPDWHIDQYTSHX-UHFFFAOYSA-N licarbazepine Chemical class C1C(O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 BMPDWHIDQYTSHX-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- JRKDKWDSUYBIQB-UHFFFAOYSA-N 7,8-dihydrobenzo[b][1]benzazepin-5-one Chemical compound O=C1C=C2CCC=CC2=NC2=CC=CC=C12 JRKDKWDSUYBIQB-UHFFFAOYSA-N 0.000 abstract 1
- 241001139947 Mida Species 0.000 abstract 1
- UVGSRARLWOYTNE-UHFFFAOYSA-N OC1=C2C=CC=CC2=NC2=CCCCC2=C1 Chemical class OC1=C2C=CC=CC2=NC2=CCCCC2=C1 UVGSRARLWOYTNE-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0223224.7A GB0223224D0 (en) | 2002-10-07 | 2002-10-07 | Organic compounds |
| PCT/EP2003/011034 WO2004031155A1 (en) | 2002-10-07 | 2003-10-06 | ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0315113A true BR0315113A (pt) | 2005-08-23 |
Family
ID=9945425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0315113-1A BR0315113A (pt) | 2002-10-07 | 2003-10-06 | Processo enantioseletivo para a preparação de ambos enantiÈmeros de 10,11-diidro-10-hidróxi-5h-dibenz[b,f]azepina-5-carbox amida e suas formas de cristal |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20060142566A1 (enExample) |
| EP (1) | EP1551808A1 (enExample) |
| JP (1) | JP2006504710A (enExample) |
| KR (1) | KR20050071549A (enExample) |
| CN (2) | CN101062932A (enExample) |
| AR (1) | AR041544A1 (enExample) |
| AU (1) | AU2003276055B2 (enExample) |
| BR (1) | BR0315113A (enExample) |
| CA (1) | CA2501237A1 (enExample) |
| EC (1) | ECSP055738A (enExample) |
| GB (1) | GB0223224D0 (enExample) |
| HK (1) | HK1079790A1 (enExample) |
| MX (1) | MXPA05003737A (enExample) |
| NO (1) | NO20052244L (enExample) |
| PE (1) | PE20040686A1 (enExample) |
| PL (1) | PL376379A1 (enExample) |
| RU (1) | RU2005114350A (enExample) |
| TW (1) | TW200413324A (enExample) |
| WO (1) | WO2004031155A1 (enExample) |
| ZA (1) | ZA200502561B (enExample) |
Families Citing this family (65)
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|---|---|---|---|---|
| GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
| GB0425320D0 (en) | 2004-11-17 | 2004-12-22 | Johnson Matthey Plc | Diamines |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
| GB2437078A (en) * | 2006-04-11 | 2007-10-17 | Portela & Ca Sa | 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives |
| JP5172124B2 (ja) * | 2006-09-29 | 2013-03-27 | 関東化学株式会社 | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| WO2011045648A2 (en) * | 2009-10-12 | 2011-04-21 | Matrix Laboratories Limited | Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof |
| EP2383261B1 (en) | 2010-04-23 | 2013-09-04 | Euticals GmbH | Process for the asymmetric hydrogenation of ketones |
| CN102250005B (zh) * | 2010-05-19 | 2015-04-08 | 浙江九洲药物科技有限公司 | 艾利西平的制备方法 |
| WO2012120356A2 (en) | 2011-03-08 | 2012-09-13 | Jubilant Life Sciences Limited | Process for the preparation of (s)-(+)-or (r)-(-)-10 hydroxy dihydrodibenz[b,f]azepines by enantioselective reduction of 10, 11-dihydro-10-oxo-5h-dibenz[b,f]azepines and polymorphs thereof |
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| EP3064490A1 (en) | 2015-03-06 | 2016-09-07 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate |
| CN107033079B (zh) * | 2016-10-17 | 2020-07-28 | 扬子江药业集团北京海燕药业有限公司 | 醋酸艾司利卡西平的制备方法 |
| CN112679433B (zh) * | 2019-10-18 | 2024-05-24 | 浙江九洲药业股份有限公司 | 一种艾利西平的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| JP2003502296A (ja) * | 1999-06-15 | 2003-01-21 | ロディア・シミ | スルホニルアミド及びカルボキサミド並びに不斉触媒作用におけるそれらの使用 |
| ES2211373T1 (es) * | 2001-02-12 | 2004-07-16 | Teva Pharmaceutical Industries Ltd. | Nuevas formas cristalinas de oxcarbazepina y procedimientos para su preparacion. |
-
2002
- 2002-10-07 GB GBGB0223224.7A patent/GB0223224D0/en not_active Ceased
-
2003
- 2003-10-06 CA CA002501237A patent/CA2501237A1/en not_active Abandoned
- 2003-10-06 KR KR1020057005920A patent/KR20050071549A/ko not_active Withdrawn
- 2003-10-06 AU AU2003276055A patent/AU2003276055B2/en not_active Expired - Fee Related
- 2003-10-06 BR BR0315113-1A patent/BR0315113A/pt not_active IP Right Cessation
- 2003-10-06 EP EP03798930A patent/EP1551808A1/en not_active Withdrawn
- 2003-10-06 HK HK05112208.8A patent/HK1079790A1/zh unknown
- 2003-10-06 US US10/530,617 patent/US20060142566A1/en not_active Abandoned
- 2003-10-06 CN CNA2007101126346A patent/CN101062932A/zh active Pending
- 2003-10-06 PL PL03376379A patent/PL376379A1/xx unknown
- 2003-10-06 RU RU2005114350/04A patent/RU2005114350A/ru not_active Application Discontinuation
- 2003-10-06 MX MXPA05003737A patent/MXPA05003737A/es not_active Application Discontinuation
- 2003-10-06 JP JP2004540788A patent/JP2006504710A/ja active Pending
- 2003-10-06 WO PCT/EP2003/011034 patent/WO2004031155A1/en not_active Ceased
- 2003-10-06 CN CNA2003801013117A patent/CN1703404A/zh active Pending
- 2003-10-07 PE PE2003001022A patent/PE20040686A1/es not_active Application Discontinuation
- 2003-10-07 AR ARP030103648A patent/AR041544A1/es not_active Application Discontinuation
- 2003-10-07 TW TW092127799A patent/TW200413324A/zh unknown
-
2005
- 2005-03-30 ZA ZA200502561A patent/ZA200502561B/en unknown
- 2005-04-06 EC EC2005005738A patent/ECSP055738A/es unknown
- 2005-05-06 NO NO20052244A patent/NO20052244L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL376379A1 (en) | 2005-12-27 |
| AU2003276055A1 (en) | 2004-04-23 |
| RU2005114350A (ru) | 2006-01-20 |
| ECSP055738A (es) | 2005-07-06 |
| KR20050071549A (ko) | 2005-07-07 |
| CN101062932A (zh) | 2007-10-31 |
| AU2003276055B2 (en) | 2008-01-03 |
| NO20052244L (no) | 2005-07-07 |
| AR041544A1 (es) | 2005-05-18 |
| WO2004031155A1 (en) | 2004-04-15 |
| TW200413324A (en) | 2004-08-01 |
| GB0223224D0 (en) | 2002-11-13 |
| ZA200502561B (en) | 2006-02-22 |
| EP1551808A1 (en) | 2005-07-13 |
| NO20052244D0 (no) | 2005-05-06 |
| PE20040686A1 (es) | 2004-10-29 |
| CN1703404A (zh) | 2005-11-30 |
| MXPA05003737A (es) | 2005-06-17 |
| JP2006504710A (ja) | 2006-02-09 |
| CA2501237A1 (en) | 2004-04-15 |
| HK1079790A1 (zh) | 2006-04-13 |
| US20060142566A1 (en) | 2006-06-29 |
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