HUP0302616A2 - Triptaminszármazékok és analóg vegyületek, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Triptaminszármazékok és analóg vegyületek, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0302616A2 HUP0302616A2 HU0302616A HUP0302616A HUP0302616A2 HU P0302616 A2 HUP0302616 A2 HU P0302616A2 HU 0302616 A HU0302616 A HU 0302616A HU P0302616 A HUP0302616 A HU P0302616A HU P0302616 A2 HUP0302616 A2 HU P0302616A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- aryl
- compounds
- diseases
- nervous system
- Prior art date
Links
- APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 abstract 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 abstract 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000002920 convulsive effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 abstract 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003987 melatonin Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000001932 seasonal effect Effects 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
A találmány tárgya új (I) általános képletű szubsztituált triptaminokés származékaik, valamint ezeknek gyógyszerészeti készítmény formái.Ezek a vegyületek, összetételek és sóik alkalmazhatók olyangyógyszerek előállítására, melyek kölcsönhatásba lépnek a melatoninrendszerrel. Ezek a vegyületek és formák felhasználhatóak többféleorvosi kezelésre szoruló állapot kezelésére, úgymint a központiidegrendszer és elmegyógyászati betegségek esetén (alvászavarok,epilepszia és további görcsös betegségek, szorongás, idegrendszeribetegségek), a biológiai órával összefüggő betegségek esetén (jet-lag,késő alvásfázis szindróma, több műszakban dolgozók problémái ésévszak-függő betegség), daganatos megbetegedések és az idős korraljáró állapotok esetén. Az (I) képlet szerinti vegyületek: éssavaddíciós sóik, ha a vegyületek bázisosak, ahol: minden R1, ésminden R2 és R3 jelentése egymástól függetlenül hidrogén, halogén, C1-4 alkil-csoport, C1-4 alkoxi-csoport, NR'R<, N(R')C(:O)Ro, nitro,aril, aril-C1-4 alkil, vagy aril-C1-4 alkoxi, Ro jelentése C1-4 alkil-vagy aril-csoport, és minden egyes R' és R< jelentése függetlenül Hvagy C1-4 alkil-csoport, vagy R' = R< = CICH2CH2, vagy NR'R< jelentésetelített 3-8 tagú heterociklusos gyűrű, m lehet 0-4; t lehet 0-3; és Xjelentése NH, N-C1-4 alkil-csoport, O vagy S; oly módon, hogy X nemlehet NH, ha ugyanakkor (R1)m jelentése 5-metoxi-csoport, R2 jelentéseH vagy I és t = 0. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL138825A IL138825A (en) | 2000-10-03 | 2000-10-03 | Pharmaceutical preparations containing tryptamine derivatives and similar compounds, and such new compounds |
| PCT/IL2001/000898 WO2002028347A2 (en) | 2000-10-03 | 2001-09-25 | Derivatives of tryptamine and analogous compounds, and pharmaceutical formulations containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0302616A2 true HUP0302616A2 (hu) | 2003-11-28 |
| HU227163B1 HU227163B1 (en) | 2010-09-28 |
Family
ID=11074694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302616A HU227163B1 (en) | 2000-10-03 | 2001-09-25 | Dervatives of tryptamine and analogous compounds and pharmaceutical compositions containing them |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US6780884B2 (hu) |
| EP (1) | EP1331935B1 (hu) |
| JP (1) | JP2004533986A (hu) |
| KR (1) | KR100855385B1 (hu) |
| CN (1) | CN100518735C (hu) |
| AR (1) | AR035587A1 (hu) |
| AT (1) | ATE409474T1 (hu) |
| AU (1) | AU9416201A (hu) |
| BG (1) | BG107759A (hu) |
| BR (1) | BR0114464A (hu) |
| CA (1) | CA2423628C (hu) |
| CL (1) | CL2001002303A1 (hu) |
| CR (1) | CR6968A (hu) |
| CY (1) | CY1110417T1 (hu) |
| CZ (1) | CZ301098B6 (hu) |
| DE (1) | DE60136003D1 (hu) |
| DK (1) | DK1331935T3 (hu) |
| EA (1) | EA005918B1 (hu) |
| EE (1) | EE05192B1 (hu) |
| ES (1) | ES2315307T3 (hu) |
| GT (1) | GT200100197A (hu) |
| HK (1) | HK1074163A1 (hu) |
| HN (1) | HN2001000218A (hu) |
| HU (1) | HU227163B1 (hu) |
| IL (1) | IL138825A (hu) |
| IS (1) | IS2607B (hu) |
| MX (1) | MXPA03002612A (hu) |
| NO (1) | NO20031396L (hu) |
| NZ (1) | NZ525587A (hu) |
| PA (1) | PA8529801A1 (hu) |
| PE (1) | PE20020411A1 (hu) |
| PL (1) | PL365679A1 (hu) |
| PT (1) | PT1331935E (hu) |
| SI (1) | SI1331935T1 (hu) |
| SK (1) | SK4042003A3 (hu) |
| TW (1) | TWI270544B (hu) |
| UA (1) | UA75091C2 (hu) |
| UY (1) | UY26946A1 (hu) |
| WO (1) | WO2002028347A2 (hu) |
| ZA (1) | ZA200303113B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2550091A1 (en) * | 2003-12-19 | 2005-07-07 | Elixir Pharmaceuticals, Inc. | Methods of treating a disorder |
| WO2005082143A1 (en) * | 2004-02-20 | 2005-09-09 | Lifescape Biosciences Incorporated | Compositions and methods for sleep regulation |
| KR20080031266A (ko) * | 2005-06-10 | 2008-04-08 | 바이파 사이언스 인코포레이티드 | Ｐａｒｐ 조절제 및 암의 치료 |
| US7622495B2 (en) | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
| KR101760139B1 (ko) | 2007-06-29 | 2017-07-31 | 클라렌슈 피티와이 리미티드 | 안투여를 통한 신경 또는 신경정신 장애의 치료 또는 예방용 약학 조성물 |
| ES2556629T3 (es) * | 2008-05-13 | 2016-01-19 | Yale University | Moléculas pequeñas quiméricas para el reclutamiento de anticuerpos contra células cancerosas |
| US8852630B2 (en) | 2008-05-13 | 2014-10-07 | Yale University | Chimeric small molecules for the recruitment of antibodies to cancer cells |
| KR102407182B1 (ko) | 2011-05-31 | 2022-06-10 | 클라렌슈 피티와이 리미티드 | 광선 요법 장치 |
| EP2771341A4 (en) * | 2011-10-28 | 2015-09-23 | Univ Texas | NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER |
| CN102816103B (zh) * | 2012-08-20 | 2014-05-07 | 冉瑞琼 | 硫化天冬氨酸修饰的退黑素衍生物及其应用 |
| DK3430022T3 (da) * | 2016-03-14 | 2020-05-18 | Somalogic Inc | Forbindelser og fremgangsmåder til syntese af 5-(N-beskyttet-tryptaminocarboxyamid)-2'-deoxyuridin-phosphoramidit til inkorporering i en nukleinsyresekvens |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79264A0 (en) * | 1986-06-27 | 1986-09-30 | Univ Ramot | Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors |
| AUPO274596A0 (en) * | 1996-10-04 | 1996-10-31 | Armstrong, Stuart Maxwell | Method for the treatment of neurological or neuropsychiatric disorders |
| US6310085B1 (en) * | 1997-10-03 | 2001-10-30 | Clarencew Pty Ltd. | Method for the treatment of neurological or neuropsychiatric disorders |
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2000
- 2000-10-03 IL IL138825A patent/IL138825A/en not_active IP Right Cessation
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2001
- 2001-09-14 TW TW090122940A patent/TWI270544B/zh not_active IP Right Cessation
- 2001-09-25 AR ARP010104520A patent/AR035587A1/es unknown
- 2001-09-25 CL CL2001002303A patent/CL2001002303A1/es unknown
- 2001-09-25 AT AT01974651T patent/ATE409474T1/de active
- 2001-09-25 HU HU0302616A patent/HU227163B1/hu not_active IP Right Cessation
- 2001-09-25 WO PCT/IL2001/000898 patent/WO2002028347A2/en active IP Right Grant
- 2001-09-25 SK SK404-2003A patent/SK4042003A3/sk unknown
- 2001-09-25 DE DE60136003T patent/DE60136003D1/de not_active Expired - Lifetime
- 2001-09-25 PT PT01974651T patent/PT1331935E/pt unknown
- 2001-09-25 DK DK01974651T patent/DK1331935T3/da active
- 2001-09-25 KR KR1020037004661A patent/KR100855385B1/ko not_active IP Right Cessation
- 2001-09-25 UA UA2003043421A patent/UA75091C2/uk unknown
- 2001-09-25 CZ CZ20030940A patent/CZ301098B6/cs not_active IP Right Cessation
- 2001-09-25 UY UY26946A patent/UY26946A1/es not_active Application Discontinuation
- 2001-09-25 EA EA200300436A patent/EA005918B1/ru not_active IP Right Cessation
- 2001-09-25 AU AU9416201A patent/AU9416201A/xx not_active Withdrawn
- 2001-09-25 SI SI200130889T patent/SI1331935T1/sl unknown
- 2001-09-25 BR BR0114464-2A patent/BR0114464A/pt not_active Application Discontinuation
- 2001-09-25 MX MXPA03002612A patent/MXPA03002612A/es active IP Right Grant
- 2001-09-25 EE EEP200300135A patent/EE05192B1/xx not_active IP Right Cessation
- 2001-09-25 CA CA2423628A patent/CA2423628C/en not_active Expired - Fee Related
- 2001-09-25 PL PL01365679A patent/PL365679A1/xx not_active Application Discontinuation
- 2001-09-25 US US10/381,976 patent/US6780884B2/en not_active Expired - Fee Related
- 2001-09-25 NZ NZ525587A patent/NZ525587A/en unknown
- 2001-09-25 EP EP01974651A patent/EP1331935B1/en not_active Expired - Lifetime
- 2001-09-25 CN CNB018168043A patent/CN100518735C/zh not_active Expired - Fee Related
- 2001-09-25 ES ES01974651T patent/ES2315307T3/es not_active Expired - Lifetime
- 2001-09-25 JP JP2002531973A patent/JP2004533986A/ja active Pending
- 2001-09-26 PE PE2001000960A patent/PE20020411A1/es not_active Application Discontinuation
- 2001-09-27 GT GT200100197A patent/GT200100197A/es unknown
- 2001-10-01 PA PA20018529801A patent/PA8529801A1/es unknown
- 2001-10-02 HN HN2001000218A patent/HN2001000218A/es unknown
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2003
- 2003-03-21 IS IS6752A patent/IS2607B/is unknown
- 2003-03-27 NO NO20031396A patent/NO20031396L/no not_active Application Discontinuation
- 2003-04-23 ZA ZA200303113A patent/ZA200303113B/xx unknown
- 2003-04-24 BG BG107759A patent/BG107759A/bg unknown
- 2003-05-02 CR CR6968A patent/CR6968A/es unknown
-
2004
- 2004-08-20 US US10/921,823 patent/US20050020664A1/en not_active Abandoned
-
2005
- 2005-06-24 HK HK05105286.7A patent/HK1074163A1/xx not_active IP Right Cessation
-
2008
- 2008-12-22 CY CY20081101480T patent/CY1110417T1/el unknown
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