BR0314185A - Derivados da quinolil propil piperidina e sua utilização como agentes antimicrobianos. - Google Patents
Derivados da quinolil propil piperidina e sua utilização como agentes antimicrobianos.Info
- Publication number
- BR0314185A BR0314185A BR0314185-3A BR0314185A BR0314185A BR 0314185 A BR0314185 A BR 0314185A BR 0314185 A BR0314185 A BR 0314185A BR 0314185 A BR0314185 A BR 0314185A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- cooh
- alkoxy
- substituted
- cyc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"DERIVADOS DA QUINOLIL PROPIL PIPERIDINA E SUA UTILIZAçãO COMO AGENTES ANTIMICROBIANOS". A presente invenção refere-se a um derivado de quinolil piperidina, de fórmula geral (I) na qual: R~ 1a~ é hidrogênio, halogênio, hidróxi, amino, alcoilamino, dialcoilamino, hidroxiamino, alcoiloxiamino ou alcoil alcoilóxi amino e R~ 1b~ é hidrogênio, ou R~ 1a~ e R~ 1b~ formam um grupo oxo; R~ 2~ é carbóxi, carboximetila ou hidroximetila; R~ 3~ é alcoíla substituída por um feniltio, eventualmente substituído por halogênio, hidróxi, alcoíla, alcoilóxi, trífluorometila, trifluorometóxi, carbóxi, alcoiloxicarbonila, ciano ou amino, por um cicloalcoiltio (3 a 7 cadeias) eventualmente substituído por halogênio ou trifluorometila, ou por heteroariltio de (5 a 6 cadeias e 1 a 4 heteroátomos selecionados dentre N, O e S), eventualmente substituído por halogênio, hidróxi, alcoíla, alcoilóxi, trifluorometila, trifluorometóxi, carbóxi, alcoiloxicarbonila, ciano ou amino ou R~ 3~ representa um radical propargila substituído por fenila ou heteroarila, tais como definidos acima, R~ 4~ é alcoíla, alcenil-CH~ 2~- ou alcinil-CH~ 2~-, cicloalquila ou cicloalcoil alcoíla, sob suas diferentes formas isómeras separadas ou em misturas, assim como seus sais, seu processo e intermediárias de preparo e as composições que os contêm. Esses novos derivados são potentes agentes antibacterianos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211213A FR2844268B1 (fr) | 2002-09-11 | 2002-09-11 | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| PCT/FR2003/002687 WO2004024713A1 (fr) | 2002-09-11 | 2003-09-10 | Derives de la quinolyl propyl piperidine et leur utilisation en tant qu'agents antimicrobiens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0314185A true BR0314185A (pt) | 2005-08-09 |
Family
ID=31725984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0314185-3A BR0314185A (pt) | 2002-09-11 | 2003-09-10 | Derivados da quinolil propil piperidina e sua utilização como agentes antimicrobianos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6841562B2 (pt) |
| EP (1) | EP1539734B1 (pt) |
| JP (1) | JP2006500403A (pt) |
| KR (1) | KR20050042196A (pt) |
| CN (1) | CN100415736C (pt) |
| AT (1) | ATE319705T1 (pt) |
| AU (1) | AU2003278297A1 (pt) |
| BR (1) | BR0314185A (pt) |
| CA (1) | CA2498628A1 (pt) |
| DE (1) | DE60303954T2 (pt) |
| DK (1) | DK1539734T3 (pt) |
| EA (1) | EA009769B1 (pt) |
| ES (1) | ES2256783T3 (pt) |
| FR (1) | FR2844268B1 (pt) |
| MA (1) | MA27433A1 (pt) |
| MX (1) | MXPA05002655A (pt) |
| NO (1) | NO20051754L (pt) |
| OA (1) | OA12922A (pt) |
| PT (1) | PT1539734E (pt) |
| RS (1) | RS20050212A (pt) |
| TN (1) | TNSN05069A1 (pt) |
| WO (1) | WO2004024713A1 (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| EP2181996A1 (en) * | 2002-01-29 | 2010-05-05 | Glaxo Group Limited | Aminopiperidine derivatives |
| EP1470131A2 (en) | 2002-01-29 | 2004-10-27 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| AR040335A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
| TW200409637A (en) * | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| AU2003291227A1 (en) | 2002-11-05 | 2004-06-07 | Smithkline Beecham Corporation | Antibacterial agents |
| EP1560821B8 (en) | 2002-11-05 | 2010-05-19 | Glaxo Group Limited | Antibacterial agents |
| TW200427688A (en) * | 2002-12-18 | 2004-12-16 | Glaxo Group Ltd | Antibacterial agents |
| GB2413863A (en) * | 2004-05-08 | 2005-11-09 | Ibm | Method and system for distribution of information |
| US20070254872A1 (en) * | 2004-07-08 | 2007-11-01 | Glaxo Group Limited | Antibacterial Agents |
| DE602005021133D1 (de) * | 2004-10-05 | 2010-06-17 | Actelion Pharmaceuticals Ltd | Neue piperidin-antibiotika |
| JP2008528598A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| WO2006081178A2 (en) * | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| WO2006081182A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| US7709472B2 (en) | 2005-01-25 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
| WO2006081289A2 (en) * | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| JP2009532423A (ja) | 2006-04-06 | 2009-09-10 | グラクソ グループ リミテッド | 抗菌剤としてのピロロ−キノキサリノン誘導体 |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| US20100144717A1 (en) * | 2006-12-15 | 2010-06-10 | Janelle Comita-Prevoir | 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents |
| US8389524B2 (en) * | 2007-04-20 | 2013-03-05 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| FR2936798B1 (fr) * | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| FR2936951B1 (fr) * | 2008-10-10 | 2010-12-03 | Novexel | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
| FR2937034B1 (fr) * | 2008-10-10 | 2012-11-23 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens |
| US20110275661A1 (en) | 2008-10-17 | 2011-11-10 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
| US8318940B2 (en) | 2009-01-15 | 2012-11-27 | Glaxo Group Limited | Naphthyridin-2 (1 H)-one compounds useful as antibacterials |
| PE20170501A1 (es) | 2014-08-22 | 2017-04-27 | Glaxosmithkline Ip Dev Ltd | Un procedimiento que comprende compuestos que administran a un sujeto infectado con neisseria gonorrhoeae |
| UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| KR102231872B1 (ko) * | 2019-10-04 | 2021-03-26 | 성균관대학교산학협력단 | 포스포늄일리드를 이용한 디아진-n-옥사이드의 위치선택적 알킬화 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT198900008A (es) * | 1988-01-29 | 1990-07-17 | Derivados de quinolina, quinazolina y cinolina. | |
| US6117884A (en) * | 1997-07-31 | 2000-09-12 | Daeuble; John | 4-substituted quinoline derivatives having fungicidal activity |
| AU2437900A (en) * | 1999-01-20 | 2000-08-07 | Smithkline Beecham Plc | Piperidinylquinolines as protein tyrosine kinase inhibitors |
| FR2798656B1 (fr) * | 1999-09-17 | 2004-12-17 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
| US6603005B2 (en) * | 2000-11-15 | 2003-08-05 | Aventis Pharma S.A. | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them |
| FR2816618B1 (fr) * | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
| FR2822154B1 (fr) * | 2001-03-13 | 2005-10-21 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
-
2002
- 2002-09-11 FR FR0211213A patent/FR2844268B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-10 PT PT03769606T patent/PT1539734E/pt unknown
- 2003-09-10 RS YUP-2005/0212A patent/RS20050212A/sr unknown
- 2003-09-10 CN CNB038214911A patent/CN100415736C/zh not_active Expired - Fee Related
- 2003-09-10 DK DK03769606T patent/DK1539734T3/da active
- 2003-09-10 BR BR0314185-3A patent/BR0314185A/pt not_active Application Discontinuation
- 2003-09-10 MX MXPA05002655A patent/MXPA05002655A/es unknown
- 2003-09-10 OA OA1200500070A patent/OA12922A/fr unknown
- 2003-09-10 US US10/659,095 patent/US6841562B2/en not_active Expired - Fee Related
- 2003-09-10 CA CA002498628A patent/CA2498628A1/fr not_active Abandoned
- 2003-09-10 EA EA200500474A patent/EA009769B1/ru not_active IP Right Cessation
- 2003-09-10 DE DE60303954T patent/DE60303954T2/de not_active Expired - Lifetime
- 2003-09-10 EP EP03769606A patent/EP1539734B1/fr not_active Expired - Lifetime
- 2003-09-10 JP JP2004535595A patent/JP2006500403A/ja active Pending
- 2003-09-10 ES ES03769606T patent/ES2256783T3/es not_active Expired - Lifetime
- 2003-09-10 AT AT03769606T patent/ATE319705T1/de not_active IP Right Cessation
- 2003-09-10 AU AU2003278297A patent/AU2003278297A1/en not_active Abandoned
- 2003-09-10 KR KR1020057004150A patent/KR20050042196A/ko not_active Application Discontinuation
- 2003-09-10 WO PCT/FR2003/002687 patent/WO2004024713A1/fr active IP Right Grant
-
2005
- 2005-03-10 TN TNP2005000069A patent/TNSN05069A1/fr unknown
- 2005-03-11 MA MA28142A patent/MA27433A1/fr unknown
- 2005-04-08 NO NO20051754A patent/NO20051754L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6841562B2 (en) | 2005-01-11 |
| MA27433A1 (fr) | 2005-07-01 |
| EA009769B1 (ru) | 2008-04-28 |
| NO20051754D0 (no) | 2005-04-08 |
| EP1539734B1 (fr) | 2006-03-08 |
| DK1539734T3 (da) | 2006-06-06 |
| RS20050212A (en) | 2007-09-21 |
| CN100415736C (zh) | 2008-09-03 |
| US20040082610A1 (en) | 2004-04-29 |
| OA12922A (fr) | 2006-10-13 |
| CN1681801A (zh) | 2005-10-12 |
| ATE319705T1 (de) | 2006-03-15 |
| ES2256783T3 (es) | 2006-07-16 |
| AU2003278297A1 (en) | 2004-04-30 |
| EA200500474A1 (ru) | 2005-08-25 |
| FR2844268A1 (fr) | 2004-03-12 |
| CA2498628A1 (fr) | 2004-03-25 |
| EP1539734A1 (fr) | 2005-06-15 |
| PT1539734E (pt) | 2006-05-31 |
| WO2004024713A1 (fr) | 2004-03-25 |
| NO20051754L (no) | 2005-04-08 |
| FR2844268B1 (fr) | 2004-10-22 |
| KR20050042196A (ko) | 2005-05-04 |
| MXPA05002655A (es) | 2005-09-08 |
| DE60303954T2 (de) | 2006-12-07 |
| JP2006500403A (ja) | 2006-01-05 |
| DE60303954D1 (de) | 2006-05-04 |
| TNSN05069A1 (fr) | 2007-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TNSN05069A1 (fr) | Derives de la quinolyl propyl piperidine et leur utilisation en tant qu'agents antimicrobiens | |
| ECSP055644A (es) | Derivados de la quinolil-propil-piperidina y su utilización | |
| RU2404982C2 (ru) | Применение соединений пирролохинолина для уничтожения клинически латентных микроорганизмов | |
| AR049739A1 (es) | Derivados de aril-piridina | |
| EA200400305A1 (ru) | 2,4,5-тризамещенные производные тиазолила и их противовоспалительная активность | |
| NO20070555L (no) | Kinazolinonderivater som parp-inhibitorer | |
| ME01089B (me) | Derivat benzimidazola i njegova upotreba kao antagonista receptora aii | |
| DE60124761D1 (de) | Chinoline und deren in der 4-stellung durch eine piperazinhaltige gruppe substituierte nitrogenierte derivate und deren verwendung als antibakterielle mittel | |
| ATE450532T1 (de) | Pyridinyl- oder pyrimidinylthiazole mit proteinkinasehemmender wirkung | |
| PE20061124A1 (es) | Compuestos y derivados de dibencil amina | |
| PE20060243A1 (es) | Derivados de 4-amino insustituido-5-(4-urea-fenil)-pirrolotriazina | |
| AR049699A1 (es) | Derivados de pirimidina | |
| DE602006004865D1 (de) | Antimykotische mittel | |
| NO20065902L (no) | 3-{4-(pyridin-3-yl)fenyl}-5-(1H-,1,2,3-triazol-1-ylmetyl)-1,3-oksazolidin-2-oner som antibakterielle midler | |
| TR200201205T2 (tr) | N-ikame edilmiş karbamoiloksialkil-azolyum türevleri. | |
| MXPA05010816A (es) | Derivados de 4-(4- (heterociclilalcox}fenil)- 1-(heterociclil- carbonil) piperidina y compuestos relacionados como antagonistas de h3 de la histamina para el tratamiento de enfermedades neurologicas tales como alzheimer. | |
| NO20063330L (no) | Amidderivater med en syklopropylaminokarbonylsubstituent som er nyttige som cytokininhibitorer | |
| NO20061832L (no) | Karboksamidderivat av amidtype | |
| ATE277042T1 (de) | Antimikrobielle 4-oxochinolizine mit 2- pyridongerüsten als teilstruktur | |
| MX2009003051A (es) | Derivados de quinolinona. | |
| MXPA05010986A (es) | Compuestos de n-[(piperazinil)hetaril]arilsulfonamida con afinidad para el receptor d3 de la dopamina. | |
| ATE282037T1 (de) | Benzoxazolderivate als tnf und pde iv inhibitoren | |
| TW200504059A (en) | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | |
| NO20076037L (no) | Nye tiazolidinoner uten basisk nitrogen, deres fremstilling og anvendelse som farmasoytiske midler | |
| MEP17408A (en) | N-(heterocyclyl)benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |