NO20051754L - Quinolylpropylpiperidinderivater, fremgangsmate for fremstilling derav og mellomprodukter og preparater inneholdende slike derivater - Google Patents
Quinolylpropylpiperidinderivater, fremgangsmate for fremstilling derav og mellomprodukter og preparater inneholdende slike derivaterInfo
- Publication number
- NO20051754L NO20051754L NO20051754A NO20051754A NO20051754L NO 20051754 L NO20051754 L NO 20051754L NO 20051754 A NO20051754 A NO 20051754A NO 20051754 A NO20051754 A NO 20051754A NO 20051754 L NO20051754 L NO 20051754L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- cooh
- derivatives
- alkoxy
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Quinolylpropylpiperidinderivater med den generelle formel (I) hvori R1a er hydrogen, halogen, hydroksyl, amin, alkylamin, dialkylamin, hydroksyamin, alkyloksyamin eller alkylalkyloksyamin og R1b er hydrogen, eller R1a og R1b danner en okso, R2 er karboksyl, karboksymetyl eller hydroksymetyl, R3 er alkyl enten substituert med fenyltio eventuelt substituert med halogen, hydroksyl, alkyl, alkyloksy, trifluormetyl, trifluormetoksy, karboksyl, alkyloksykarbonyl, cyano eller amin, eller med sykloalkyltio (3 til 7 ledd) eventuelt substituert med halogen eller trifluormetyl, eller med heteroaryltio (5 til 6 ledd og 1 til 4 heteroatomer valgt fra N, O og S), eventuelt substituert med halogen, hydroksyl, alkyl, alkyloksy, trifluormetyl, trifluormetoksy, karboksyl, alkoksykarbonyl, cyano eller amin eller R3 er propargyl substituert med fenyl eller heteroaryl som definert over, R4 er alkyl, alkenyl-CH2- eller alkynyl-CH2-, sykloalkyl eller sykloalkylalkyl, i deres ulike isomere former, separate eller som blandinger, og salter derav, fremgangsmåte for fremstilling derav og mellomprodukter og preparater inneholdende disse. De nye derivatene er kraftige antibakterielle midler.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0211213A FR2844268B1 (fr) | 2002-09-11 | 2002-09-11 | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
PCT/FR2003/002687 WO2004024713A1 (fr) | 2002-09-11 | 2003-09-10 | Derives de la quinolyl propyl piperidine et leur utilisation en tant qu'agents antimicrobiens |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20051754L true NO20051754L (no) | 2005-04-08 |
NO20051754D0 NO20051754D0 (no) | 2005-04-08 |
Family
ID=31725984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20051754A NO20051754D0 (no) | 2002-09-11 | 2005-04-08 | Quinolylpropylpiperidinderivater, fremgangsmate for fremstilling derav og mellomprodukter og preparater inneholdende slike derivater |
Country Status (22)
Country | Link |
---|---|
US (1) | US6841562B2 (no) |
EP (1) | EP1539734B1 (no) |
JP (1) | JP2006500403A (no) |
KR (1) | KR20050042196A (no) |
CN (1) | CN100415736C (no) |
AT (1) | ATE319705T1 (no) |
AU (1) | AU2003278297A1 (no) |
BR (1) | BR0314185A (no) |
CA (1) | CA2498628A1 (no) |
DE (1) | DE60303954T2 (no) |
DK (1) | DK1539734T3 (no) |
EA (1) | EA009769B1 (no) |
ES (1) | ES2256783T3 (no) |
FR (1) | FR2844268B1 (no) |
MA (1) | MA27433A1 (no) |
MX (1) | MXPA05002655A (no) |
NO (1) | NO20051754D0 (no) |
OA (1) | OA12922A (no) |
PT (1) | PT1539734E (no) |
RS (1) | RS20050212A (no) |
TN (1) | TNSN05069A1 (no) |
WO (1) | WO2004024713A1 (no) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
US7312212B2 (en) * | 2002-01-29 | 2007-12-25 | Glaxo Group Limited | Aminopiperidine derivatives |
EP1470131A2 (en) | 2002-01-29 | 2004-10-27 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
AR040335A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
TW200409637A (en) * | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
AU2003291227A1 (en) | 2002-11-05 | 2004-06-07 | Smithkline Beecham Corporation | Antibacterial agents |
WO2004096982A2 (en) | 2002-11-05 | 2004-11-11 | Smithkline Beecham Corporation | Antibacterial agents |
AR042486A1 (es) * | 2002-12-18 | 2005-06-22 | Glaxo Group Ltd | Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . |
GB2413863A (en) * | 2004-05-08 | 2005-11-09 | Ibm | Method and system for distribution of information |
EP1773831A1 (en) * | 2004-07-08 | 2007-04-18 | Glaxo Group Limited | Antibacterial agents |
ES2343127T3 (es) * | 2004-10-05 | 2010-07-23 | Actelion Pharmaceuticals Ltd. | Nuevos antibioticos de piperidina. |
US7592334B2 (en) * | 2005-01-25 | 2009-09-22 | Glaxo Group Limited | Antibacterial agents |
WO2006081289A2 (en) * | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
US7709472B2 (en) * | 2005-01-25 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
US7605169B2 (en) * | 2005-01-25 | 2009-10-20 | Glaxo Group Limited | Antibacterial agents |
EP1846416A4 (en) | 2005-01-25 | 2009-07-01 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
EP2001887B1 (en) | 2006-04-06 | 2010-09-15 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
US20100144717A1 (en) * | 2006-12-15 | 2010-06-10 | Janelle Comita-Prevoir | 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents |
MY149347A (en) * | 2007-04-20 | 2013-08-30 | Glaxo Group Ltd | Tricyclic nitrogen containing compounds as antibacterial agents |
EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
FR2936798B1 (fr) * | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
FR2936951B1 (fr) * | 2008-10-10 | 2010-12-03 | Novexel | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
FR2937034B1 (fr) * | 2008-10-10 | 2012-11-23 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens |
WO2010043714A1 (en) | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
US8318940B2 (en) | 2009-01-15 | 2012-11-27 | Glaxo Group Limited | Naphthyridin-2 (1 H)-one compounds useful as antibacterials |
AU2015304847B2 (en) | 2014-08-22 | 2018-10-25 | Glaxosmithkline Intellectual Property Development Limited | Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection |
TW201722965A (zh) | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
KR102231872B1 (ko) * | 2019-10-04 | 2021-03-26 | 성균관대학교산학협력단 | 포스포늄일리드를 이용한 디아진-n-옥사이드의 위치선택적 알킬화 방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89028A0 (en) * | 1988-01-29 | 1989-08-15 | Lilly Co Eli | Quinoline,quinazoline and cinnoline derivatives |
US6117884A (en) * | 1997-07-31 | 2000-09-12 | Daeuble; John | 4-substituted quinoline derivatives having fungicidal activity |
WO2000043383A1 (en) * | 1999-01-20 | 2000-07-27 | Smithkline Beecham P.L.C. | Piperidinylquinolines as protein tyrosine kinase inhibitors |
FR2798656B1 (fr) * | 1999-09-17 | 2004-12-17 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
US6603005B2 (en) * | 2000-11-15 | 2003-08-05 | Aventis Pharma S.A. | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them |
FR2816618B1 (fr) * | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
FR2822154B1 (fr) * | 2001-03-13 | 2005-10-21 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
-
2002
- 2002-09-11 FR FR0211213A patent/FR2844268B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-10 BR BR0314185-3A patent/BR0314185A/pt not_active Application Discontinuation
- 2003-09-10 AT AT03769606T patent/ATE319705T1/de not_active IP Right Cessation
- 2003-09-10 ES ES03769606T patent/ES2256783T3/es not_active Expired - Lifetime
- 2003-09-10 CA CA002498628A patent/CA2498628A1/fr not_active Abandoned
- 2003-09-10 US US10/659,095 patent/US6841562B2/en not_active Expired - Fee Related
- 2003-09-10 CN CNB038214911A patent/CN100415736C/zh not_active Expired - Fee Related
- 2003-09-10 KR KR1020057004150A patent/KR20050042196A/ko not_active Application Discontinuation
- 2003-09-10 JP JP2004535595A patent/JP2006500403A/ja active Pending
- 2003-09-10 EA EA200500474A patent/EA009769B1/ru not_active IP Right Cessation
- 2003-09-10 DK DK03769606T patent/DK1539734T3/da active
- 2003-09-10 DE DE60303954T patent/DE60303954T2/de not_active Expired - Lifetime
- 2003-09-10 MX MXPA05002655A patent/MXPA05002655A/es unknown
- 2003-09-10 OA OA1200500070A patent/OA12922A/fr unknown
- 2003-09-10 RS YUP-2005/0212A patent/RS20050212A/sr unknown
- 2003-09-10 AU AU2003278297A patent/AU2003278297A1/en not_active Abandoned
- 2003-09-10 WO PCT/FR2003/002687 patent/WO2004024713A1/fr active IP Right Grant
- 2003-09-10 PT PT03769606T patent/PT1539734E/pt unknown
- 2003-09-10 EP EP03769606A patent/EP1539734B1/fr not_active Expired - Lifetime
-
2005
- 2005-03-10 TN TNP2005000069A patent/TNSN05069A1/fr unknown
- 2005-03-11 MA MA28142A patent/MA27433A1/fr unknown
- 2005-04-08 NO NO20051754A patent/NO20051754D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
US6841562B2 (en) | 2005-01-11 |
EA200500474A1 (ru) | 2005-08-25 |
RS20050212A (en) | 2007-09-21 |
MXPA05002655A (es) | 2005-09-08 |
ATE319705T1 (de) | 2006-03-15 |
TNSN05069A1 (fr) | 2007-05-14 |
MA27433A1 (fr) | 2005-07-01 |
NO20051754D0 (no) | 2005-04-08 |
CN100415736C (zh) | 2008-09-03 |
US20040082610A1 (en) | 2004-04-29 |
DK1539734T3 (da) | 2006-06-06 |
EA009769B1 (ru) | 2008-04-28 |
AU2003278297A1 (en) | 2004-04-30 |
DE60303954D1 (de) | 2006-05-04 |
BR0314185A (pt) | 2005-08-09 |
FR2844268A1 (fr) | 2004-03-12 |
CA2498628A1 (fr) | 2004-03-25 |
JP2006500403A (ja) | 2006-01-05 |
KR20050042196A (ko) | 2005-05-04 |
EP1539734A1 (fr) | 2005-06-15 |
WO2004024713A1 (fr) | 2004-03-25 |
EP1539734B1 (fr) | 2006-03-08 |
DE60303954T2 (de) | 2006-12-07 |
PT1539734E (pt) | 2006-05-31 |
ES2256783T3 (es) | 2006-07-16 |
OA12922A (fr) | 2006-10-13 |
FR2844268B1 (fr) | 2004-10-22 |
CN1681801A (zh) | 2005-10-12 |
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