NO20051754L - Quinolylpropylpiperidinderivater, fremgangsmate for fremstilling derav og mellomprodukter og preparater inneholdende slike derivater - Google Patents

Quinolylpropylpiperidinderivater, fremgangsmate for fremstilling derav og mellomprodukter og preparater inneholdende slike derivater

Info

Publication number
NO20051754L
NO20051754L NO20051754A NO20051754A NO20051754L NO 20051754 L NO20051754 L NO 20051754L NO 20051754 A NO20051754 A NO 20051754A NO 20051754 A NO20051754 A NO 20051754A NO 20051754 L NO20051754 L NO 20051754L
Authority
NO
Norway
Prior art keywords
alkyl
cooh
derivatives
alkoxy
substituted
Prior art date
Application number
NO20051754A
Other languages
English (en)
Other versions
NO20051754D0 (no
Inventor
Jean-Luc Malleron
Serge Mignani
Baptiste Ronan
Michel Tabart
Youssef El Ahmad
Fabrice Viviani
Antony Bigot
Eric Bacque
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO20051754D0 publication Critical patent/NO20051754D0/no
Publication of NO20051754L publication Critical patent/NO20051754L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Quinolylpropylpiperidinderivater med den generelle formel (I) hvori R1a er hydrogen, halogen, hydroksyl, amin, alkylamin, dialkylamin, hydroksyamin, alkyloksyamin eller alkylalkyloksyamin og R1b er hydrogen, eller R1a og R1b danner en okso, R2 er karboksyl, karboksymetyl eller hydroksymetyl, R3 er alkyl enten substituert med fenyltio eventuelt substituert med halogen, hydroksyl, alkyl, alkyloksy, trifluormetyl, trifluormetoksy, karboksyl, alkyloksykarbonyl, cyano eller amin, eller med sykloalkyltio (3 til 7 ledd) eventuelt substituert med halogen eller trifluormetyl, eller med heteroaryltio (5 til 6 ledd og 1 til 4 heteroatomer valgt fra N, O og S), eventuelt substituert med halogen, hydroksyl, alkyl, alkyloksy, trifluormetyl, trifluormetoksy, karboksyl, alkoksykarbonyl, cyano eller amin eller R3 er propargyl substituert med fenyl eller heteroaryl som definert over, R4 er alkyl, alkenyl-CH2- eller alkynyl-CH2-, sykloalkyl eller sykloalkylalkyl, i deres ulike isomere former, separate eller som blandinger, og salter derav, fremgangsmåte for fremstilling derav og mellomprodukter og preparater inneholdende disse. De nye derivatene er kraftige antibakterielle midler.
NO20051754A 2002-09-11 2005-04-08 Quinolylpropylpiperidinderivater, fremgangsmate for fremstilling derav og mellomprodukter og preparater inneholdende slike derivater NO20051754L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0211213A FR2844268B1 (fr) 2002-09-11 2002-09-11 Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
PCT/FR2003/002687 WO2004024713A1 (fr) 2002-09-11 2003-09-10 Derives de la quinolyl propyl piperidine et leur utilisation en tant qu'agents antimicrobiens

Publications (2)

Publication Number Publication Date
NO20051754D0 NO20051754D0 (no) 2005-04-08
NO20051754L true NO20051754L (no) 2005-04-08

Family

ID=31725984

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051754A NO20051754L (no) 2002-09-11 2005-04-08 Quinolylpropylpiperidinderivater, fremgangsmate for fremstilling derav og mellomprodukter og preparater inneholdende slike derivater

Country Status (22)

Country Link
US (1) US6841562B2 (no)
EP (1) EP1539734B1 (no)
JP (1) JP2006500403A (no)
KR (1) KR20050042196A (no)
CN (1) CN100415736C (no)
AT (1) ATE319705T1 (no)
AU (1) AU2003278297A1 (no)
BR (1) BR0314185A (no)
CA (1) CA2498628A1 (no)
DE (1) DE60303954T2 (no)
DK (1) DK1539734T3 (no)
EA (1) EA009769B1 (no)
ES (1) ES2256783T3 (no)
FR (1) FR2844268B1 (no)
MA (1) MA27433A1 (no)
MX (1) MXPA05002655A (no)
NO (1) NO20051754L (no)
OA (1) OA12922A (no)
PT (1) PT1539734E (no)
RS (1) RS20050212A (no)
TN (1) TNSN05069A1 (no)
WO (1) WO2004024713A1 (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
TW200406410A (en) * 2002-01-29 2004-05-01 Glaxo Group Ltd Compounds
AU2003239302A1 (en) * 2002-01-29 2003-09-02 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
WO2004041210A2 (en) 2002-11-05 2004-05-21 Smithkline Beecham Corporation Antibacterial agents
DE60331849D1 (de) 2002-11-05 2010-05-06 Glaxosmithkline Llc Antibakterielle wirkstoffe
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
GB2413863A (en) * 2004-05-08 2005-11-09 Ibm Method and system for distribution of information
US20070254872A1 (en) * 2004-07-08 2007-11-01 Glaxo Group Limited Antibacterial Agents
ATE466857T1 (de) * 2004-10-05 2010-05-15 Actelion Pharmaceuticals Ltd Neue piperidin-antibiotika
US7592334B2 (en) 2005-01-25 2009-09-22 Glaxo Group Limited Antibacterial agents
EP1846411A4 (en) * 2005-01-25 2010-08-04 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
US7605169B2 (en) 2005-01-25 2009-10-20 Glaxo Group Limited Antibacterial agents
JP2008528586A (ja) * 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
EP1845995A4 (en) 2005-01-25 2010-03-03 Glaxo Group Ltd ANTIBACTERIAL AGENTS
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
JP2009532423A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌剤としてのピロロ−キノキサリノン誘導体
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
US20100144717A1 (en) * 2006-12-15 2010-06-10 Janelle Comita-Prevoir 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents
BRPI0810064B8 (pt) * 2007-04-20 2021-05-25 Glaxo Group Ltd compostos contendo nitrogênio tricíclico como agentes antibacterianos, composições farmacêuticas que compreendem os ditos compostos e uso dos mesmos para o tratamento de infecções bacterianas em mamíferos
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
ES2561631T3 (es) 2009-01-15 2016-02-29 Glaxo Group Limited Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos
EP3182973B1 (en) 2014-08-22 2019-09-18 GlaxoSmithKline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
KR102231872B1 (ko) * 2019-10-04 2021-03-26 성균관대학교산학협력단 포스포늄일리드를 이용한 디아진-n-옥사이드의 위치선택적 알킬화 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT198900008A (es) * 1988-01-29 1990-07-17 Derivados de quinolina, quinazolina y cinolina.
US6117884A (en) * 1997-07-31 2000-09-12 Daeuble; John 4-substituted quinoline derivatives having fungicidal activity
WO2000043383A1 (en) * 1999-01-20 2000-07-27 Smithkline Beecham P.L.C. Piperidinylquinolines as protein tyrosine kinase inhibitors
FR2798656B1 (fr) * 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
US6603005B2 (en) * 2000-11-15 2003-08-05 Aventis Pharma S.A. Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
FR2822154B1 (fr) * 2001-03-13 2005-10-21 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
KR20050042196A (ko) 2005-05-04
DE60303954T2 (de) 2006-12-07
FR2844268A1 (fr) 2004-03-12
US6841562B2 (en) 2005-01-11
NO20051754D0 (no) 2005-04-08
EA200500474A1 (ru) 2005-08-25
FR2844268B1 (fr) 2004-10-22
TNSN05069A1 (fr) 2007-05-14
DE60303954D1 (de) 2006-05-04
US20040082610A1 (en) 2004-04-29
MA27433A1 (fr) 2005-07-01
CN100415736C (zh) 2008-09-03
ES2256783T3 (es) 2006-07-16
BR0314185A (pt) 2005-08-09
EA009769B1 (ru) 2008-04-28
CA2498628A1 (fr) 2004-03-25
JP2006500403A (ja) 2006-01-05
CN1681801A (zh) 2005-10-12
PT1539734E (pt) 2006-05-31
AU2003278297A1 (en) 2004-04-30
DK1539734T3 (da) 2006-06-06
MXPA05002655A (es) 2005-09-08
OA12922A (fr) 2006-10-13
RS20050212A (en) 2007-09-21
EP1539734B1 (fr) 2006-03-08
ATE319705T1 (de) 2006-03-15
EP1539734A1 (fr) 2005-06-15
WO2004024713A1 (fr) 2004-03-25

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