BR0313674A - Composto, composição farmacêutica, uso de um composto, e, método para o tratamento ou a profilaxia de um distúrbio afetivo relacionado com a tensão - Google Patents
Composto, composição farmacêutica, uso de um composto, e, método para o tratamento ou a profilaxia de um distúrbio afetivo relacionado com a tensãoInfo
- Publication number
- BR0313674A BR0313674A BR0313674-4A BR0313674A BR0313674A BR 0313674 A BR0313674 A BR 0313674A BR 0313674 A BR0313674 A BR 0313674A BR 0313674 A BR0313674 A BR 0313674A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- prophylaxis
- treatment
- affective
- pamoate
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000011321 prophylaxis Methods 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- YOGIZNRHMDDKAA-UHFFFAOYSA-N 3-(3,5-dimethoxyphenyl)-3-[3-(dimethylamino)propyl]-4,4-dimethylpiperidine-2,6-dione Chemical compound COC1=CC(OC)=CC(C2(CCCN(C)C)C(CC(=O)NC2=O)(C)C)=C1 YOGIZNRHMDDKAA-UHFFFAOYSA-N 0.000 abstract 1
- -1 3-dimethylaminopropyl Chemical group 0.000 abstract 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000003841 chloride salts Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, MéTODO PARA O TRATAMENTO OU A PROFILAXIA DE UM DISTúRBIO AFETIVO RELACIONADO COM A TENSãO". Os novos sais de pamoato de certas 3-fenil-3-dimetilaminoalquil-4,4-dimetilpiperidin-2,6-dionas (I) e solvatos farmacologicamente aceitáveis destes são destituídos da perda de peso e das mudanças de hepatócitos no rato que limitou-se a níveis marginalmente efetivos das doses clínicas permitidas dos cloridretos correspondentes no tratamento ou profilaxia de distúrbios afetivos relacionados com a tensão tais como ansiedade, depressão, enxaqueca e apnéia do sono. Os sais de pamoato preferidos são o pamoato de 3-(3,5-dimetoxifenil)-3-(3-dimetilaminopropil)-4,4-dimetilpiperidina-2,6- diona e, especialmente o pamoato de 3-(3-metoxifenil)-3-(3-dimetilaminopropil)-4,4-dimetilpiperidina-2,6-dio na.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0219639.2A GB0219639D0 (en) | 2002-08-22 | 2002-08-22 | Novel piperidin-2,6-dione salts and their use for the treatment of stress-related affective disorders |
PCT/IB2003/003698 WO2004017970A1 (en) | 2002-08-22 | 2003-08-18 | Piperidin-2,6-dione pamoate salts and their use for the treatment of stress-related affective disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313674A true BR0313674A (pt) | 2005-06-21 |
Family
ID=9942831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313674-4A BR0313674A (pt) | 2002-08-22 | 2003-08-18 | Composto, composição farmacêutica, uso de um composto, e, método para o tratamento ou a profilaxia de um distúrbio afetivo relacionado com a tensão |
Country Status (23)
Country | Link |
---|---|
US (2) | US7514454B2 (pt) |
EP (1) | EP1539160B1 (pt) |
JP (1) | JP2005538146A (pt) |
KR (1) | KR20050038014A (pt) |
CN (1) | CN1678316A (pt) |
AT (1) | ATE330605T1 (pt) |
BR (1) | BR0313674A (pt) |
CA (1) | CA2495377A1 (pt) |
CY (1) | CY1105541T1 (pt) |
DE (1) | DE60306396T2 (pt) |
DK (1) | DK1539160T3 (pt) |
EA (1) | EA007900B1 (pt) |
ES (1) | ES2268474T3 (pt) |
GB (1) | GB0219639D0 (pt) |
GE (1) | GEP20074051B (pt) |
IL (1) | IL166941A (pt) |
MX (1) | MXPA05001919A (pt) |
NO (1) | NO20051471L (pt) |
NZ (1) | NZ538341A (pt) |
PL (1) | PL373416A1 (pt) |
PT (1) | PT1539160E (pt) |
UA (1) | UA80144C2 (pt) |
WO (1) | WO2004017970A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6987111B2 (en) * | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
GB0518763D0 (en) * | 2005-09-14 | 2005-10-19 | Prestwick Pharmaceuticals Inc | Treatment of hypertension |
BRPI0702900A2 (pt) * | 2006-06-28 | 2011-03-15 | Teva Pharma | formas cristalinas da atorvastatina |
WO2013150052A1 (en) | 2012-04-04 | 2013-10-10 | Intervet International B.V. | Soft chewable pharmaceutical products |
CN105727117A (zh) * | 2016-02-03 | 2016-07-06 | 瓮杰林 | 一种治疗前列腺增生的药物及其制备方法 |
CN106831594B (zh) * | 2017-01-18 | 2018-02-02 | 力赛生物医药科技(厦门)有限公司 | 可乐定双羟萘酸盐及其制备方法 |
CN115702894A (zh) * | 2021-08-11 | 2023-02-17 | 朱信红 | 一种用于止吐的缓释组合物及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1455687A (en) * | 1972-12-28 | 1976-11-17 | Aspro Nicholas Ltd | Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines |
US4461771A (en) * | 1983-03-01 | 1984-07-24 | Gittos Maurice W | Treatment of migraine with dioxopiperidine derivatives |
DE3686622T2 (de) * | 1985-09-11 | 1993-04-01 | British Tech Group | Verwendung von dioxopiperidin-derivaten zur behandlung von anxietas, zur herabsetzung von chronischen abnormal hohen gehirn-spiegeln serotonins oder 5-hydroxy-indolessigsaeure und zur behandlung von bakteriellen oder viralen infektionen. |
GB2196251B (en) | 1986-09-08 | 1990-07-04 | Nat Res Dev | Anxiolytic compositions containing dioxopiperidine derivatives |
GB8716338D0 (en) | 1987-07-10 | 1987-08-19 | Nat Res Dev | Anti-anxiogenic compositions |
GB2379216A (en) * | 2001-08-28 | 2003-03-05 | Maurice Ward Gittos | Piperidin-2,6-dione salts useful for the treatment of stress-related affective disorders |
-
2002
- 2002-08-22 GB GBGB0219639.2A patent/GB0219639D0/en not_active Ceased
-
2003
- 2003-08-18 AT AT03792588T patent/ATE330605T1/de active
- 2003-08-18 UA UAA200501443A patent/UA80144C2/uk unknown
- 2003-08-18 NZ NZ538341A patent/NZ538341A/en not_active IP Right Cessation
- 2003-08-18 DE DE60306396T patent/DE60306396T2/de not_active Expired - Lifetime
- 2003-08-18 WO PCT/IB2003/003698 patent/WO2004017970A1/en active IP Right Grant
- 2003-08-18 PL PL03373416A patent/PL373416A1/xx not_active Application Discontinuation
- 2003-08-18 KR KR1020057002687A patent/KR20050038014A/ko not_active Application Discontinuation
- 2003-08-18 EA EA200500242A patent/EA007900B1/ru not_active IP Right Cessation
- 2003-08-18 CN CNA038199149A patent/CN1678316A/zh active Pending
- 2003-08-18 EP EP03792588A patent/EP1539160B1/en not_active Expired - Lifetime
- 2003-08-18 CA CA002495377A patent/CA2495377A1/en not_active Abandoned
- 2003-08-18 JP JP2004530467A patent/JP2005538146A/ja active Pending
- 2003-08-18 US US10/524,693 patent/US7514454B2/en not_active Expired - Fee Related
- 2003-08-18 ES ES03792588T patent/ES2268474T3/es not_active Expired - Lifetime
- 2003-08-18 MX MXPA05001919A patent/MXPA05001919A/es active IP Right Grant
- 2003-08-18 BR BR0313674-4A patent/BR0313674A/pt not_active Application Discontinuation
- 2003-08-18 DK DK03792588T patent/DK1539160T3/da active
- 2003-08-18 GE GEAP8650A patent/GEP20074051B/en unknown
- 2003-08-18 PT PT03792588T patent/PT1539160E/pt unknown
-
2005
- 2005-02-16 IL IL166941A patent/IL166941A/en not_active IP Right Cessation
- 2005-03-21 NO NO20051471A patent/NO20051471L/no not_active Application Discontinuation
-
2006
- 2006-09-15 CY CY20061101323T patent/CY1105541T1/el unknown
-
2009
- 2009-03-18 US US12/382,511 patent/US20090182012A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL166941A (en) | 2010-04-15 |
MXPA05001919A (es) | 2005-06-03 |
JP2005538146A (ja) | 2005-12-15 |
EP1539160B1 (en) | 2006-06-21 |
DE60306396T2 (de) | 2007-05-03 |
NZ538341A (en) | 2006-09-29 |
PL373416A1 (en) | 2005-08-22 |
PT1539160E (pt) | 2006-10-31 |
EA007900B1 (ru) | 2007-02-27 |
EP1539160A1 (en) | 2005-06-15 |
GEP20074051B (en) | 2007-02-26 |
DK1539160T3 (da) | 2006-10-09 |
US7514454B2 (en) | 2009-04-07 |
US20090182012A1 (en) | 2009-07-16 |
NO20051471L (no) | 2005-05-23 |
WO2004017970A1 (en) | 2004-03-04 |
ATE330605T1 (de) | 2006-07-15 |
US20060025443A1 (en) | 2006-02-02 |
CN1678316A (zh) | 2005-10-05 |
KR20050038014A (ko) | 2005-04-25 |
ES2268474T3 (es) | 2007-03-16 |
UA80144C2 (uk) | 2007-08-27 |
DE60306396D1 (de) | 2006-08-03 |
EA200500242A1 (ru) | 2005-08-25 |
AU2003255947A1 (en) | 2004-03-11 |
GB0219639D0 (en) | 2002-10-02 |
CY1105541T1 (el) | 2010-07-28 |
CA2495377A1 (en) | 2004-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |