BR9814280A - Arilpiperazinas que apresentam atividade noreceptor 1a de serotonina - Google Patents

Arilpiperazinas que apresentam atividade noreceptor 1a de serotonina

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Publication number
BR9814280A
BR9814280A BR9814280-1A BR9814280A BR9814280A BR 9814280 A BR9814280 A BR 9814280A BR 9814280 A BR9814280 A BR 9814280A BR 9814280 A BR9814280 A BR 9814280A
Authority
BR
Brazil
Prior art keywords
serotonin
activity
receptor
noreceptor
arylpiperazines
Prior art date
Application number
BR9814280-1A
Other languages
English (en)
Inventor
Tony Yantao Zhang
Yao-Chang Xu
Alexander Glenn Godfrey
John Cunningham O'toole
Daniel Timothy Kohlman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9814280A publication Critical patent/BR9814280A/pt

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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Abstract

Patente de Invenção: "ARILPIPERAZINAS QUE APRESENTAMATIVIDADE NO RECEPTOR 1~ A~ DE SEROTONINA". Estainvenção apresenta uma série de compostos de arilpiperazina quesão produtos farmacêuticos eficazes para o tratamento decondições relacionadas com ou afetadas pelo receptor 1~ A~ deserotonina; os compostos são particularmente antagonistaseficazes nesse receptor e são particularmente úteis para aliviar ossintomas de retirada de nicotina e tabaco.
BR9814280-1A 1997-12-16 1998-12-08 Arilpiperazinas que apresentam atividade noreceptor 1a de serotonina BR9814280A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6979197P 1997-12-16 1997-12-16
US6972297P 1997-12-16 1997-12-16
US8958998P 1998-06-17 1998-06-17
PCT/US1998/026008 WO1999031077A1 (en) 1997-12-16 1998-12-08 Arylpiperazines having activity at the serotonin 1a receptor

Publications (1)

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BR9814280A true BR9814280A (pt) 2001-10-30

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BR9814280-1A BR9814280A (pt) 1997-12-16 1998-12-08 Arilpiperazinas que apresentam atividade noreceptor 1a de serotonina

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US (9) US6239135B1 (pt)
EP (2) EP0924205B1 (pt)
JP (2) JP2002508364A (pt)
KR (1) KR100539651B1 (pt)
CN (2) CN1227241C (pt)
AR (1) AR017864A1 (pt)
AT (1) ATE296296T1 (pt)
AU (1) AU747040B2 (pt)
BR (1) BR9814280A (pt)
CA (2) CA2506802A1 (pt)
CO (1) CO4980859A1 (pt)
DE (1) DE69830297T2 (pt)
DK (1) DK0924205T3 (pt)
EA (1) EA003703B1 (pt)
EG (1) EG23983A (pt)
ES (1) ES2244036T3 (pt)
HK (2) HK1020732A1 (pt)
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IL (3) IL136723A0 (pt)
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NO (1) NO317098B1 (pt)
NZ (1) NZ505220A (pt)
PE (1) PE20000134A1 (pt)
PL (1) PL193428B1 (pt)
PT (1) PT924205E (pt)
SV (1) SV1998000148A (pt)
TR (1) TR200001727T2 (pt)
TW (1) TW520366B (pt)
UA (1) UA66370C2 (pt)
WO (1) WO1999031077A1 (pt)
ZA (1) ZA9811473B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA66370C2 (en) * 1997-12-16 2004-05-17 Lilly Co Eli Arylpiperazines having activity to setotonin 1 receptors
ATE318135T1 (de) 1999-09-03 2006-03-15 Apbi Holdings Llc Verwendung von dapoxetin, a selektiver serotonin- aufnahme inhibitor mit schnellem wirkungseintritt,zur behandlung von sexueller dysfunction
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