EA200500242A1 - Пиперидин-2,5-дионовые памоатные соли и их использование для лечения связанных со стрессом аффективных расстройств - Google Patents

Пиперидин-2,5-дионовые памоатные соли и их использование для лечения связанных со стрессом аффективных расстройств

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Publication number
EA200500242A1
EA200500242A1 EA200500242A EA200500242A EA200500242A1 EA 200500242 A1 EA200500242 A1 EA 200500242A1 EA 200500242 A EA200500242 A EA 200500242A EA 200500242 A EA200500242 A EA 200500242A EA 200500242 A1 EA200500242 A1 EA 200500242A1
Authority
EA
Eurasian Patent Office
Prior art keywords
salts
treatment
dimethylpiperidine
dione
affective disorders
Prior art date
Application number
EA200500242A
Other languages
English (en)
Other versions
EA007900B1 (ru
Inventor
Камилл Жорж Вермут
Original Assignee
Прествик Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Прествик Фармасьютикалз, Инк. filed Critical Прествик Фармасьютикалз, Инк.
Publication of EA200500242A1 publication Critical patent/EA200500242A1/ru
Publication of EA007900B1 publication Critical patent/EA007900B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Новые памоатные соли некоторых 3-фенил-3-диметиламиноалкил-4,4-диметилпиперидин-2,6-дионов (1) и их фармакологически приемлемые сольваты не вызывают потери в массе и изменений в гепатоцитах у крыс, которые были характерны для минимально эффективных уровней разрешенных клинических доз соответствующих гидрохлоридов при лечении или профилактике связанных со стрессом аффективных расстройств, таких как тревога, депрессия, мигрень или апноэ во сне. Предпочтительными памоатными солями являются 3-(3,5-диметоксифенил)-3-(3-диметиламинопропил)-4,4-диметилпиперидин-2,6-диона памоат и, в особенности, 3-(3-метоксифенил)-3-(3-диметиламинопропил)-4,4-диметилпиперидин-2,6-диона памоат.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500242A 2002-08-22 2003-08-18 Пиперидин-2,6-дионовые памоатные соли и их использование для лечения связанных со стрессом аффективных расстройств EA007900B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0219639.2A GB0219639D0 (en) 2002-08-22 2002-08-22 Novel piperidin-2,6-dione salts and their use for the treatment of stress-related affective disorders
PCT/IB2003/003698 WO2004017970A1 (en) 2002-08-22 2003-08-18 Piperidin-2,6-dione pamoate salts and their use for the treatment of stress-related affective disorders

Publications (2)

Publication Number Publication Date
EA200500242A1 true EA200500242A1 (ru) 2005-08-25
EA007900B1 EA007900B1 (ru) 2007-02-27

Family

ID=9942831

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500242A EA007900B1 (ru) 2002-08-22 2003-08-18 Пиперидин-2,6-дионовые памоатные соли и их использование для лечения связанных со стрессом аффективных расстройств

Country Status (23)

Country Link
US (2) US7514454B2 (ru)
EP (1) EP1539160B1 (ru)
JP (1) JP2005538146A (ru)
KR (1) KR20050038014A (ru)
CN (1) CN1678316A (ru)
AT (1) ATE330605T1 (ru)
BR (1) BR0313674A (ru)
CA (1) CA2495377A1 (ru)
CY (1) CY1105541T1 (ru)
DE (1) DE60306396T2 (ru)
DK (1) DK1539160T3 (ru)
EA (1) EA007900B1 (ru)
ES (1) ES2268474T3 (ru)
GB (1) GB0219639D0 (ru)
GE (1) GEP20074051B (ru)
IL (1) IL166941A (ru)
MX (1) MXPA05001919A (ru)
NO (1) NO20051471L (ru)
NZ (1) NZ538341A (ru)
PL (1) PL373416A1 (ru)
PT (1) PT1539160E (ru)
UA (1) UA80144C2 (ru)
WO (1) WO2004017970A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
GB0518763D0 (en) * 2005-09-14 2005-10-19 Prestwick Pharmaceuticals Inc Treatment of hypertension
BRPI0702900A2 (pt) * 2006-06-28 2011-03-15 Teva Pharma formas cristalinas da atorvastatina
WO2013150052A1 (en) 2012-04-04 2013-10-10 Intervet International B.V. Soft chewable pharmaceutical products
CN105727117A (zh) * 2016-02-03 2016-07-06 瓮杰林 一种治疗前列腺增生的药物及其制备方法
CN106831594B (zh) * 2017-01-18 2018-02-02 力赛生物医药科技（厦门）有限公司 可乐定双羟萘酸盐及其制备方法
CN115702894A (zh) * 2021-08-11 2023-02-17 朱信红 一种用于止吐的缓释组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1455687A (en) * 1972-12-28 1976-11-17 Aspro Nicholas Ltd Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
US4461771A (en) * 1983-03-01 1984-07-24 Gittos Maurice W Treatment of migraine with dioxopiperidine derivatives
DE3686622T2 (de) * 1985-09-11 1993-04-01 British Tech Group Verwendung von dioxopiperidin-derivaten zur behandlung von anxietas, zur herabsetzung von chronischen abnormal hohen gehirn-spiegeln serotonins oder 5-hydroxy-indolessigsaeure und zur behandlung von bakteriellen oder viralen infektionen.
GB2196251B (en) 1986-09-08 1990-07-04 Nat Res Dev Anxiolytic compositions containing dioxopiperidine derivatives
GB8716338D0 (en) 1987-07-10 1987-08-19 Nat Res Dev Anti-anxiogenic compositions
GB2379216A (en) * 2001-08-28 2003-03-05 Maurice Ward Gittos Piperidin-2,6-dione salts useful for the treatment of stress-related affective disorders

Also Published As

Publication number Publication date
IL166941A (en) 2010-04-15
MXPA05001919A (es) 2005-06-03
JP2005538146A (ja) 2005-12-15
EP1539160B1 (en) 2006-06-21
DE60306396T2 (de) 2007-05-03
NZ538341A (en) 2006-09-29
PL373416A1 (en) 2005-08-22
PT1539160E (pt) 2006-10-31
EA007900B1 (ru) 2007-02-27
EP1539160A1 (en) 2005-06-15
GEP20074051B (en) 2007-02-26
DK1539160T3 (da) 2006-10-09
US7514454B2 (en) 2009-04-07
US20090182012A1 (en) 2009-07-16
NO20051471L (no) 2005-05-23
WO2004017970A1 (en) 2004-03-04
ATE330605T1 (de) 2006-07-15
US20060025443A1 (en) 2006-02-02
CN1678316A (zh) 2005-10-05
KR20050038014A (ko) 2005-04-25
ES2268474T3 (es) 2007-03-16
UA80144C2 (ru) 2007-08-27
DE60306396D1 (de) 2006-08-03
AU2003255947A1 (en) 2004-03-11
GB0219639D0 (en) 2002-10-02
CY1105541T1 (el) 2010-07-28
CA2495377A1 (en) 2004-03-04
BR0313674A (pt) 2005-06-21

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU