BR0307759A - Gene de protease desubiquitinante humano no cromossoma 7 e ortólogo de camundongo do mesmo - Google Patents

Gene de protease desubiquitinante humano no cromossoma 7 e ortólogo de camundongo do mesmo

Info

Publication number
BR0307759A
BR0307759A BR0307759-4A BR0307759A BR0307759A BR 0307759 A BR0307759 A BR 0307759A BR 0307759 A BR0307759 A BR 0307759A BR 0307759 A BR0307759 A BR 0307759A
Authority
BR
Brazil
Prior art keywords
desubiquitinating
chromosome
human
protease gene
transduction
Prior art date
Application number
BR0307759-4A
Other languages
English (en)
Inventor
Chang Hahn
Hong Liu
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0218518.9A external-priority patent/GB0218518D0/en
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BR0307759A publication Critical patent/BR0307759A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"GENE DE PROTEASE DESUBIQUITINANTE HUMANO NO CROMOSSOMA 7 E ORTóLOGO DE CAMUNDONGO DO MESMO". Análogos de ser humano e de camundogo de DUBs, proteases desubiquitinantes induzíveis por citocina, específicas hematopoiéticas, aglomerados no cromossoma 7 e suas regiões reguladoras respectivas são identificadas. O nucleotídeo ou as proteínas codificadas desse modo podem ser usados em ensaios para identificar inibidores de hDUB7 ou de mDUB7. A invenção também inclui peptídeos de transdução compreendendo uma NLS ou seq³ência de transdução de hDUB7 ou de mDUB7 ligada a uma molécula de carregamento, e métodos de fornecimento de uma proteína biologicamente ativa, um composto terapeuticamente eficaz, um nucleotídeo de anti-sentido, ou um composto de teste a uma célula em que um peptídeo de transdução é adicionado exogenamente a uma célula.
BR0307759-4A 2002-03-22 2003-03-21 Gene de protease desubiquitinante humano no cromossoma 7 e ortólogo de camundongo do mesmo BR0307759A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36660102P 2002-03-22 2002-03-22
GBGB0218518.9A GB0218518D0 (en) 2002-03-22 2002-08-09 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
PCT/US2003/008590 WO2003083050A2 (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog

Publications (1)

Publication Number Publication Date
BR0307759A true BR0307759A (pt) 2004-12-21

Family

ID=28676509

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307759-4A BR0307759A (pt) 2002-03-22 2003-03-21 Gene de protease desubiquitinante humano no cromossoma 7 e ortólogo de camundongo do mesmo

Country Status (8)

Country Link
EP (1) EP1495117A4 (pt)
JP (1) JP2005520567A (pt)
AU (1) AU2003230701C1 (pt)
BR (1) BR0307759A (pt)
CA (1) CA2479647A1 (pt)
IL (1) IL164088A0 (pt)
MX (1) MXPA04006975A (pt)
WO (1) WO2003083050A2 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006247A2 (en) * 1995-08-09 1997-02-20 Dana Farber Cancer Institute Deubiquitinating enzymes that regulate cell growth
JP2003510024A (ja) * 1999-08-09 2003-03-18 インサイト・ゲノミックス・インコーポレイテッド プロテアーゼ及びプロテアーゼインヒビター
AU1071901A (en) * 1999-09-29 2001-04-30 Millennium Pharmaceuticals, Inc. 23431, a novel human ubiquitin protease

Also Published As

Publication number Publication date
JP2005520567A (ja) 2005-07-14
WO2003083050A2 (en) 2003-10-09
AU2003230701B2 (en) 2008-06-05
AU2003230701A1 (en) 2003-10-13
CA2479647A1 (en) 2003-10-09
WO2003083050A3 (en) 2004-02-26
MXPA04006975A (es) 2004-11-10
EP1495117A4 (en) 2005-06-08
IL164088A0 (en) 2005-12-18
EP1495117A2 (en) 2005-01-12
AU2003230701C1 (en) 2009-08-27

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Legal Events

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B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]