WO2003083050A3 - Human deubiquitinating protease gene on chromosome 7 and its murine ortholog - Google Patents

Human deubiquitinating protease gene on chromosome 7 and its murine ortholog Download PDF

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Publication number
WO2003083050A3
WO2003083050A3 PCT/US2003/008590 US0308590W WO03083050A3 WO 2003083050 A3 WO2003083050 A3 WO 2003083050A3 US 0308590 W US0308590 W US 0308590W WO 03083050 A3 WO03083050 A3 WO 03083050A3
Authority
WO
WIPO (PCT)
Prior art keywords
chromosome
transducing
protease gene
human
mdub7
Prior art date
Application number
PCT/US2003/008590
Other languages
French (fr)
Other versions
WO2003083050A2 (en
Inventor
Chang Hahn
Hong Liu
Original Assignee
Aventis Pharma Inc
Chang Hahn
Hong Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0218518.9A external-priority patent/GB0218518D0/en
Application filed by Aventis Pharma Inc, Chang Hahn, Hong Liu filed Critical Aventis Pharma Inc
Priority to JP2003580486A priority Critical patent/JP2005520567A/en
Priority to IL16408803A priority patent/IL164088A0/en
Priority to EP03723791A priority patent/EP1495117A4/en
Priority to AU2003230701A priority patent/AU2003230701C1/en
Priority to BR0307759-4A priority patent/BR0307759A/en
Priority to CA002479647A priority patent/CA2479647A1/en
Priority to MXPA04006975A priority patent/MXPA04006975A/en
Publication of WO2003083050A2 publication Critical patent/WO2003083050A2/en
Publication of WO2003083050A3 publication Critical patent/WO2003083050A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Human and murine analogs of DUBs, hematopoietic-specific, cytokine-inducible deubiquitinating proteases, clustered on chromosome 7 and their respective regulatory regions are identified. The nucleotide or proteins encoded thereby may be used in assays to identify inhibitors of hDUB7 or mDUB7. The invention also includes transducing peptides comprising an NLS or transducing sequence of hDUB7 or mDUB7 linked to a cargo molecule, and methods of delivering a biologically active protein, therapeutically effective compound, antisense nucleotide, or test compound to a cell wherein a transducing peptide is added exogenously to a cell.
PCT/US2003/008590 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog WO2003083050A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2003580486A JP2005520567A (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its mouse ortholog
IL16408803A IL164088A0 (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome7 and its murineortholog
EP03723791A EP1495117A4 (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
AU2003230701A AU2003230701C1 (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
BR0307759-4A BR0307759A (en) 2002-03-22 2003-03-21 Human desubiquitinating protease gene on chromosome 7 and mouse ortholog
CA002479647A CA2479647A1 (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
MXPA04006975A MXPA04006975A (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36660102P 2002-03-22 2002-03-22
US60/366,601 2002-03-22
GB0218518.9 2002-08-09
GBGB0218518.9A GB0218518D0 (en) 2002-03-22 2002-08-09 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog

Publications (2)

Publication Number Publication Date
WO2003083050A2 WO2003083050A2 (en) 2003-10-09
WO2003083050A3 true WO2003083050A3 (en) 2004-02-26

Family

ID=28676509

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008590 WO2003083050A2 (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog

Country Status (8)

Country Link
EP (1) EP1495117A4 (en)
JP (1) JP2005520567A (en)
AU (1) AU2003230701C1 (en)
BR (1) BR0307759A (en)
CA (1) CA2479647A1 (en)
IL (1) IL164088A0 (en)
MX (1) MXPA04006975A (en)
WO (1) WO2003083050A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006247A2 (en) * 1995-08-09 1997-02-20 Dana Farber Cancer Institute Deubiquitinating enzymes that regulate cell growth
JP2003510024A (en) * 1999-08-09 2003-03-18 インサイト・ゲノミックス・インコーポレイテッド Proteases and protease inhibitors
AU1071901A (en) * 1999-09-29 2001-04-30 Millennium Pharmaceuticals, Inc. 23431, a novel human ubiquitin protease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WILKINSON K.D.: "Regulation uf ubiquitin-dependent processes by deubiquitinating enzymes", FASEB JOURNAL, vol. 11, December 1997 (1997-12-01), pages 1245 - 1256, XP002969147 *

Also Published As

Publication number Publication date
JP2005520567A (en) 2005-07-14
WO2003083050A2 (en) 2003-10-09
AU2003230701B2 (en) 2008-06-05
AU2003230701A1 (en) 2003-10-13
CA2479647A1 (en) 2003-10-09
MXPA04006975A (en) 2004-11-10
EP1495117A4 (en) 2005-06-08
BR0307759A (en) 2004-12-21
IL164088A0 (en) 2005-12-18
EP1495117A2 (en) 2005-01-12
AU2003230701C1 (en) 2009-08-27

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