BR0210225A - Holotoxina do cólera imunogênica mutante, composição imunogênica, método para realçar a resposta imune de um hospedeiro vertebrado a um antìgeno, sequência de dna isolada e purificada, molécula de ácido nucleico, célula hospedeira, método para produzir uma holotoxina do cólera imunogênica mutante, e, uso de uma holotoxina do cólera mutante - Google Patents
Holotoxina do cólera imunogênica mutante, composição imunogênica, método para realçar a resposta imune de um hospedeiro vertebrado a um antìgeno, sequência de dna isolada e purificada, molécula de ácido nucleico, célula hospedeira, método para produzir uma holotoxina do cólera imunogênica mutante, e, uso de uma holotoxina do cólera mutanteInfo
- Publication number
- BR0210225A BR0210225A BR0210225-0A BR0210225A BR0210225A BR 0210225 A BR0210225 A BR 0210225A BR 0210225 A BR0210225 A BR 0210225A BR 0210225 A BR0210225 A BR 0210225A
- Authority
- BR
- Brazil
- Prior art keywords
- mutant
- immunogenic
- cholera
- cholera holotoxin
- holotoxin
- Prior art date
Links
- 206010008631 Cholera Diseases 0.000 title abstract 9
- 229930186900 holotoxin Natural products 0.000 title abstract 9
- 230000002163 immunogen Effects 0.000 title abstract 7
- 241000251539 Vertebrata <Metazoa> Species 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 230000028993 immune response Effects 0.000 title abstract 2
- 230000002708 enhancing effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 102000009016 Cholera Toxin Human genes 0.000 abstract 1
- 108010049048 Cholera Toxin Proteins 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/106—Vibrio; Campylobacter; Not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
"HOLOTOXINA DO CóLERA IMUNOGêNICA MUTANTE, COMPOSIçãO IMUNOGêNICA, MéTODO PARA REALçAR A RESPOSTA IMUNE DE UM HOSPEDEIRO VERTEBRADO A UM ANTìGENO, SEQuêNCIA DE DNA ISOLADA E PURIFICADA, MOLéCULA DE áCIDO DO NUCLéICO, CéLULA HOSPEDEIRA, MéTODO PARA PRODUZIR UMA HOLOTOXINA DO CóLERA IMUNOGêNICA MUTANTE, E, USO DE UMA HOLOTOXINA DO CóLERA MUTANTE". Holotoxinas do cólera mutante compreendendo uma subunidade da toxina do cólera (A) tendo substituições de aminoácido únicas nas posições de aminoácido (16 ou 72) ou uma substituição dupla nas posições de aminoácido (16 e 68) ou (68 e 72) têm toxicidade reduzida comparada com a holotoxina do cólera do tipo selvagem. As holotoxinas do cólera mutantes são úteis como adjuvantes em composições imunogênicas para realçar a resposta imune em um hospedeiro vertebrado a um antígeno selecionado a partir de uma bactéria, vírus, fungo ou parasita patogênicos, uma célula cancerosa, uma célula de tumor, um alergeno ou uma auto-molécula.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29653701P | 2001-06-07 | 2001-06-07 | |
PCT/US2002/020978 WO2002098368A2 (en) | 2001-06-07 | 2002-06-05 | Mutant forms of cholera holotoxin as an adjuvant |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0210225A true BR0210225A (pt) | 2004-09-08 |
Family
ID=23142433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0210225-0A BR0210225A (pt) | 2001-06-07 | 2002-06-05 | Holotoxina do cólera imunogênica mutante, composição imunogênica, método para realçar a resposta imune de um hospedeiro vertebrado a um antìgeno, sequência de dna isolada e purificada, molécula de ácido nucleico, célula hospedeira, método para produzir uma holotoxina do cólera imunogênica mutante, e, uso de uma holotoxina do cólera mutante |
Country Status (13)
Country | Link |
---|---|
US (3) | US7285281B2 (pt) |
EP (1) | EP1404368B1 (pt) |
JP (2) | JP2004535187A (pt) |
KR (1) | KR100898648B1 (pt) |
CN (2) | CN1977971A (pt) |
AT (1) | ATE451386T1 (pt) |
AU (1) | AU2002346249B2 (pt) |
BR (1) | BR0210225A (pt) |
CA (1) | CA2449663A1 (pt) |
DE (1) | DE60234695D1 (pt) |
IL (2) | IL159210A0 (pt) |
MX (1) | MXPA03011133A (pt) |
WO (1) | WO2002098368A2 (pt) |
Families Citing this family (72)
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DE60234695D1 (de) * | 2001-06-07 | 2010-01-21 | Univ Colorado | Mutantenformen von cholera holotoxin als adjuvans |
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-
2002
- 2002-06-05 DE DE60234695T patent/DE60234695D1/de not_active Expired - Fee Related
- 2002-06-05 CN CNA2006101684314A patent/CN1977971A/zh active Pending
- 2002-06-05 IL IL15921002A patent/IL159210A0/xx unknown
- 2002-06-05 MX MXPA03011133A patent/MXPA03011133A/es not_active Application Discontinuation
- 2002-06-05 EP EP02752145A patent/EP1404368B1/en not_active Expired - Lifetime
- 2002-06-05 US US10/478,307 patent/US7285281B2/en not_active Expired - Fee Related
- 2002-06-05 JP JP2003501410A patent/JP2004535187A/ja not_active Withdrawn
- 2002-06-05 CA CA002449663A patent/CA2449663A1/en not_active Abandoned
- 2002-06-05 AU AU2002346249A patent/AU2002346249B2/en not_active Ceased
- 2002-06-05 BR BR0210225-0A patent/BR0210225A/pt not_active IP Right Cessation
- 2002-06-05 KR KR1020037015999A patent/KR100898648B1/ko not_active IP Right Cessation
- 2002-06-05 AT AT02752145T patent/ATE451386T1/de not_active IP Right Cessation
- 2002-06-05 WO PCT/US2002/020978 patent/WO2002098368A2/en active Application Filing
- 2002-06-05 CN CNB028154126A patent/CN1297316C/zh not_active Expired - Fee Related
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2003
- 2003-12-04 IL IL159210A patent/IL159210A/en not_active IP Right Cessation
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- 2006-12-15 US US11/639,810 patent/US7361355B2/en not_active Expired - Fee Related
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2007
- 2007-10-22 US US11/876,418 patent/US20080213303A1/en not_active Abandoned
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- 2009-09-18 JP JP2009217704A patent/JP2010017190A/ja active Pending
Also Published As
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US20040181036A1 (en) | 2004-09-16 |
IL159210A (en) | 2010-04-29 |
US7285281B2 (en) | 2007-10-23 |
CN1977971A (zh) | 2007-06-13 |
EP1404368A4 (en) | 2006-05-17 |
WO2002098368A3 (en) | 2003-05-08 |
EP1404368A2 (en) | 2004-04-07 |
DE60234695D1 (de) | 2010-01-21 |
JP2010017190A (ja) | 2010-01-28 |
ATE451386T1 (de) | 2009-12-15 |
KR20040073965A (ko) | 2004-08-21 |
AU2002346249B2 (en) | 2007-03-15 |
CN1297316C (zh) | 2007-01-31 |
WO2002098368A2 (en) | 2002-12-12 |
CN1538854A (zh) | 2004-10-20 |
KR100898648B1 (ko) | 2009-05-22 |
MXPA03011133A (es) | 2004-12-06 |
EP1404368B1 (en) | 2009-12-09 |
CA2449663A1 (en) | 2002-12-12 |
JP2004535187A (ja) | 2004-11-25 |
US20080213303A1 (en) | 2008-09-04 |
US7361355B2 (en) | 2008-04-22 |
US20070116715A1 (en) | 2007-05-24 |
IL159210A0 (en) | 2004-06-01 |
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