BR0209193A - Ligandos de receptor de melanocortina, seus usos na preparação de uma composição farmacêutica e composição farmacêutica compreendendo os mesmos - Google Patents

Ligandos de receptor de melanocortina, seus usos na preparação de uma composição farmacêutica e composição farmacêutica compreendendo os mesmos

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Publication number
BR0209193A
BR0209193A BR0209193-3A BR0209193A BR0209193A BR 0209193 A BR0209193 A BR 0209193A BR 0209193 A BR0209193 A BR 0209193A BR 0209193 A BR0209193 A BR 0209193A
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Brazil
Prior art keywords
pharmaceutical composition
preparation
rings
aromatic
same
Prior art date
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BR0209193-3A
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English (en)
Inventor
Adam Wieslaw Mazur
Xinrong Tian
Xiufeng Eric Hu
Frank Hallock Ebetino
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Procter & Gamble
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Publication of BR0209193A publication Critical patent/BR0209193A/pt

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    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
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    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Abstract

"LIGANDOS DE RECEPTOR DE MELANOCORTINA, SEUS USOS NA PREPARAçãO DE UMA COMPOSIçãO FARMACêUTICA E COMPOSIçãO FARMACêUTICA COMPREENDENDO OS MESMOS". A presente invenção refere-se aos ligantes de receptor de MC-3/MC-4 que são aprentados, os quais têm a fórmula: onde A é um sistema de anel conformacionalmente restrito selecionado do grupo que consiste em: a) anéis carbocíclicos não-aromáticos; b) anéis carbocíclicos aromáticos; C) anéis heterocíclicos não-aromáticos; d) anéis heterocíclicos aromáticos; sendo que os ditos anéis compreendem de 5 a 8 átomos e W é uma unidade que compreende de preferência D-1-fluorofenialanina, Y compreende um heteroátomo e Z compreende um anel carbocíclico aromático. Também são apresentadas composições farmacêuticas que incluem os ligantes da invenção, assim como os métodos de tratamento de doenças mediadas por receptores de MC-3/MC-4,
BR0209193-3A 2001-04-25 2002-04-24 Ligandos de receptor de melanocortina, seus usos na preparação de uma composição farmacêutica e composição farmacêutica compreendendo os mesmos BR0209193A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28661001P 2001-04-25 2001-04-25
PCT/US2002/013340 WO2002085925A2 (en) 2001-04-25 2002-04-24 Melanocortin receptor ligands

Publications (1)

Publication Number Publication Date
BR0209193A true BR0209193A (pt) 2005-10-25

Family

ID=23099366

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BR0209193-3A BR0209193A (pt) 2001-04-25 2002-04-24 Ligandos de receptor de melanocortina, seus usos na preparação de uma composição farmacêutica e composição farmacêutica compreendendo os mesmos

Country Status (22)

Country Link
US (3) US6911447B2 (pt)
EP (1) EP1390361A4 (pt)
JP (1) JP2005503342A (pt)
KR (2) KR100662309B1 (pt)
CN (1) CN1543461A (pt)
AR (1) AR035863A1 (pt)
AU (1) AU2002254744B2 (pt)
BR (1) BR0209193A (pt)
CA (1) CA2444599A1 (pt)
CZ (1) CZ20032806A3 (pt)
HU (1) HUP0500870A3 (pt)
IL (1) IL157969A0 (pt)
MA (1) MA27016A1 (pt)
MX (1) MXPA03009791A (pt)
NO (1) NO20034774L (pt)
NZ (1) NZ528262A (pt)
PE (1) PE20021087A1 (pt)
PL (1) PL373503A1 (pt)
RU (1) RU2277535C2 (pt)
SK (1) SK13222003A3 (pt)
WO (1) WO2002085925A2 (pt)
ZA (1) ZA200307439B (pt)

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