BR0112166A - Derivados heterocìclico de piperidino ou de tetraidropiridino ou um sal farmaceuticamente aceitável do mesmo ou o seu hidrato, antagonista contra receptores de crf, e, uso de um derivado heterocìclico de tetraidropiridino ou um sal farmaceuticamente aceitável do mesmo ou o seu hidrato - Google Patents
Derivados heterocìclico de piperidino ou de tetraidropiridino ou um sal farmaceuticamente aceitável do mesmo ou o seu hidrato, antagonista contra receptores de crf, e, uso de um derivado heterocìclico de tetraidropiridino ou um sal farmaceuticamente aceitável do mesmo ou o seu hidratoInfo
- Publication number
- BR0112166A BR0112166A BR0112166-9A BR0112166A BR0112166A BR 0112166 A BR0112166 A BR 0112166A BR 0112166 A BR0112166 A BR 0112166A BR 0112166 A BR0112166 A BR 0112166A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrate
- pharmaceutically acceptable
- acceptable salt
- heterocyclic
- tetrahydropyridine
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 3
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical class C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 title abstract 2
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- -1 heterocyclic tetrahydropyridine derivative Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"DERIVADOS HETEROCìCLICO DE PIPERIDINO OU DE TETRAIDROPIRIDINO OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO OU O SEU HIDRATO, ANTAGONISTA CONTRA RECEPTORES DE CRF, E, USO DE UM DERIVADO HETEROCìCLICO DE TETRAIDROPIRIDINO OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO OU O SEU HIDRATO". Um derivado de piperidino ou de tetraidropiridino representado pela fórmula (I): A-Het [1] possui uma alta afinidade para receptores de CRF e é efetivo contra doenças, nas quais é considerado que o CRF esteja envolvido.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000204021 | 2000-07-05 | ||
JP2000270535 | 2000-09-06 | ||
PCT/JP2001/005806 WO2002002549A1 (en) | 2000-07-05 | 2001-07-04 | Tetrahydropyridino or piperidino heterocyclic derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0112166A true BR0112166A (pt) | 2003-09-02 |
Family
ID=26595443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0112166-9A BR0112166A (pt) | 2000-07-05 | 2001-07-04 | Derivados heterocìclico de piperidino ou de tetraidropiridino ou um sal farmaceuticamente aceitável do mesmo ou o seu hidrato, antagonista contra receptores de crf, e, uso de um derivado heterocìclico de tetraidropiridino ou um sal farmaceuticamente aceitável do mesmo ou o seu hidrato |
Country Status (25)
Country | Link |
---|---|
US (2) | US6852732B2 (pt) |
EP (1) | EP1299378B1 (pt) |
JP (1) | JP2004502685A (pt) |
KR (1) | KR20030015368A (pt) |
CN (2) | CN1260225C (pt) |
AR (1) | AR028782A1 (pt) |
AT (1) | ATE353885T1 (pt) |
AU (2) | AU6943701A (pt) |
BG (1) | BG107374A (pt) |
BR (1) | BR0112166A (pt) |
CA (1) | CA2412287A1 (pt) |
CZ (1) | CZ20024229A3 (pt) |
DE (1) | DE60126616T2 (pt) |
EA (1) | EA005289B1 (pt) |
EE (1) | EE200300007A (pt) |
HK (1) | HK1057042A1 (pt) |
HR (1) | HRP20030074A2 (pt) |
HU (1) | HUP0301165A2 (pt) |
IL (1) | IL153718A0 (pt) |
MX (1) | MXPA02012820A (pt) |
NO (1) | NO20026125L (pt) |
PL (1) | PL358411A1 (pt) |
SK (1) | SK132003A3 (pt) |
TW (1) | TW591022B (pt) |
WO (1) | WO2002002549A1 (pt) |
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JPH11335376A (ja) * | 1998-05-25 | 1999-12-07 | Taisho Pharmaceut Co Ltd | アリールテトラヒドロピリジン誘導体 |
JPH11335373A (ja) * | 1998-05-25 | 1999-12-07 | Taisho Pharmaceut Co Ltd | アリールメチレンピペリジノピリミジン誘導体 |
JP2000086663A (ja) * | 1998-09-09 | 2000-03-28 | Taisho Pharmaceut Co Ltd | アリールテトラヒドロピリジン誘導体 |
AU756702B2 (en) * | 1999-03-11 | 2003-01-23 | Taisho Pharmaceutical Co., Ltd. | Carbamoyl tetrahydropyridine derivatives |
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2001
- 2001-07-03 AR ARP010103171A patent/AR028782A1/es unknown
- 2001-07-04 CN CNB018120016A patent/CN1260225C/zh not_active Expired - Fee Related
- 2001-07-04 EA EA200300118A patent/EA005289B1/ru not_active IP Right Cessation
- 2001-07-04 KR KR10-2003-7000112A patent/KR20030015368A/ko not_active Application Discontinuation
- 2001-07-04 AU AU6943701A patent/AU6943701A/xx active Pending
- 2001-07-04 AU AU2001269437A patent/AU2001269437B2/en not_active Ceased
- 2001-07-04 WO PCT/JP2001/005806 patent/WO2002002549A1/en active IP Right Grant
- 2001-07-04 CZ CZ20024229A patent/CZ20024229A3/cs unknown
- 2001-07-04 DE DE60126616T patent/DE60126616T2/de not_active Expired - Fee Related
- 2001-07-04 EP EP01947819A patent/EP1299378B1/en not_active Expired - Lifetime
- 2001-07-04 HU HU0301165A patent/HUP0301165A2/hu unknown
- 2001-07-04 BR BR0112166-9A patent/BR0112166A/pt not_active IP Right Cessation
- 2001-07-04 CA CA002412287A patent/CA2412287A1/en not_active Abandoned
- 2001-07-04 JP JP2002507801A patent/JP2004502685A/ja active Pending
- 2001-07-04 TW TW090116391A patent/TW591022B/zh not_active IP Right Cessation
- 2001-07-04 MX MXPA02012820A patent/MXPA02012820A/es unknown
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- 2001-07-04 PL PL01358411A patent/PL358411A1/xx not_active Application Discontinuation
- 2001-07-04 US US10/311,277 patent/US6852732B2/en not_active Expired - Fee Related
- 2001-07-04 AT AT01947819T patent/ATE353885T1/de not_active IP Right Cessation
- 2001-07-04 EE EEP200300007A patent/EE200300007A/xx unknown
- 2001-07-04 CN CNA2004100338762A patent/CN1535968A/zh active Pending
- 2001-07-04 SK SK13-2003A patent/SK132003A3/sk unknown
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2002
- 2002-12-11 BG BG107374A patent/BG107374A/bg unknown
- 2002-12-19 NO NO20026125A patent/NO20026125L/no not_active Application Discontinuation
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2003
- 2003-02-05 HR HR20030074A patent/HRP20030074A2/hr not_active Application Discontinuation
- 2003-12-23 HK HK03109322A patent/HK1057042A1/xx not_active IP Right Cessation
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2004
- 2004-08-06 US US10/912,185 patent/US7160900B2/en not_active Expired - Fee Related
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