BR0109936A - Compostos contendo piperidina benzoamida e compostos relacionados - Google Patents

Compostos contendo piperidina benzoamida e compostos relacionados

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Publication number
BR0109936A
BR0109936A BR0109936-1A BR0109936A BR0109936A BR 0109936 A BR0109936 A BR 0109936A BR 0109936 A BR0109936 A BR 0109936A BR 0109936 A BR0109936 A BR 0109936A
Authority
BR
Brazil
Prior art keywords
disorders
compounds
benzoamide
piperidine
related compounds
Prior art date
Application number
BR0109936-1A
Other languages
English (en)
Inventor
Eric Platt Arnold
Thomas Allen Chappie
Jianhua Huang
John Michael Humphrey
Arthur Adam Nagel
Brian Thomas O'neill
Susan Beth Sobolov-Jaynes
Lawrence Albert Vincent
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0109936A publication Critical patent/BR0109936A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
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Abstract

"COMPOSTOS CONTENDO PIPERIDINA BENZOAMIDA E COMPOSTOS RELACIONADOS". A presente invenção refere-se a compostos contendo uma determinada piperidina benzoamida e compostos relacionados que exibem atividade como antagonistas do receptor NK-1, (por exemplo antagonistas do receptor da substância P), a composições farmacêuticas que os contém, e a sua utilização no tratamento e prevenção de distúrbios do sistema nervoso central, distúrbios inflamatórios, distúrbios cardiovasculares, distúrbios oftálmicos, distúrbios gastrintestinais, distúrbios causados por helicobacter pylori, distúrbios do sistema imunitário, incontinência urinária, dores, enxaqueca, vómito, angiogênese e outros distúrbios.
BR0109936-1A 2000-04-10 2001-04-06 Compostos contendo piperidina benzoamida e compostos relacionados BR0109936A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19592200P 2000-04-10 2000-04-10
US21292200P 2000-06-20 2000-06-20
PCT/IB2001/000629 WO2001077100A2 (en) 2000-04-10 2001-04-06 Benzoamide piperidine compounds as substance p antagonists

Publications (1)

Publication Number Publication Date
BR0109936A true BR0109936A (pt) 2003-05-06

Family

ID=26891472

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109936-1A BR0109936A (pt) 2000-04-10 2001-04-06 Compostos contendo piperidina benzoamida e compostos relacionados

Country Status (32)

Country Link
EP (1) EP1272484B1 (pt)
JP (1) JP4001486B2 (pt)
KR (1) KR20020087134A (pt)
CN (1) CN1432011A (pt)
AP (1) AP2002002647A0 (pt)
AR (2) AR033976A1 (pt)
AT (1) ATE299875T1 (pt)
AU (1) AU2001246761A1 (pt)
BG (1) BG107135A (pt)
BR (1) BR0109936A (pt)
CA (1) CA2405089A1 (pt)
CZ (1) CZ20023213A3 (pt)
DE (1) DE60112064T2 (pt)
EA (1) EA005409B1 (pt)
EE (1) EE200200588A (pt)
ES (1) ES2244599T3 (pt)
HR (1) HRP20020808A2 (pt)
HU (1) HUP0300413A2 (pt)
IL (1) IL152209A0 (pt)
IS (1) IS6561A (pt)
MA (1) MA26891A1 (pt)
MX (1) MXPA02010029A (pt)
NO (1) NO20024874L (pt)
NZ (1) NZ521346A (pt)
OA (1) OA12245A (pt)
PA (1) PA8515101A1 (pt)
PE (1) PE20011311A1 (pt)
PL (1) PL358623A1 (pt)
SK (1) SK13942002A3 (pt)
UY (1) UY26662A1 (pt)
WO (1) WO2001077100A2 (pt)
YU (1) YU73902A (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0109871D0 (en) * 2001-04-20 2001-06-13 Glaxo Group Ltd Metering method for particulate material
WO2003053929A1 (fr) * 2001-12-21 2003-07-03 Toray Fine Chemicals Co., Ltd. Procede de production de derives de cis-piperidine optiquement actifs
US20040006135A1 (en) * 2002-06-19 2004-01-08 Pfizer Inc. Combination treatment for depression and anxiety
CA2489810A1 (en) 2002-06-25 2003-12-31 Wyeth Use of thio-oxindole derivatives in treatment of skin disorders
KR20050013627A (ko) 2002-06-25 2005-02-04 와이어쓰 Ｐｒ 조절제로서의 사이클로티오카바메이트 유도체 및피부 질환을 치료하기 위한 이의 용도
JP2006503858A (ja) * 2002-10-04 2006-02-02 メルク シャープ エンド ドーム リミテッド Ｎｋ−１受容体拮抗薬としてのアザ二環式アミン誘導体
WO2004037247A1 (en) * 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
EP1585720A1 (en) * 2002-11-12 2005-10-19 Pfizer Products Inc. Process for converting a cis-trans mixture of substituted benzylidene amines into the pure cis isomer
US7022605B2 (en) * 2002-11-12 2006-04-04 Micron Technology, Inc. Atomic layer deposition methods
AU2003902882A0 (en) * 2003-06-10 2003-06-26 Fujisawa Pharmaceutical Co., Ltd. Piperidyl derivatives
ES2246687B2 (es) 2004-02-11 2006-11-16 Miguel Muñoz Saez Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales.
UA92327C2 (ru) * 2004-08-20 2010-10-25 Таргасепт, Инк. Применение n-арилдиазаспироциклических соединений для лечения зависимостей
US20060281670A1 (en) * 2005-06-10 2006-12-14 Wisconsin Alumni Research Foundation (Warf) Compositions and methods for modulating angiogenesis
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
US7507842B2 (en) 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
US20070135380A1 (en) 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
DE102006033114A1 (de) * 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
WO2008090114A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
US8471041B2 (en) 2010-02-09 2013-06-25 Alliant Techsystems Inc. Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
SG186989A1 (en) 2010-07-14 2013-02-28 Novartis Ag Ip receptor agonist heterocyclic compounds
ES2376564B1 (es) 2010-08-12 2013-01-24 Manuel Vicente Salinas Martín Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer.
US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
AU2012319071B2 (en) 2011-10-07 2017-08-03 Epicentrx, Inc. Organonitro thioether compounds and medical uses thereof
WO2013052803A2 (en) 2011-10-07 2013-04-11 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
EP2837381A4 (en) 2011-12-13 2015-12-09 Servicio Andaluz De Salud USE OF AGENTS MODIFYING THE PERITUMORAL ENVIRONMENT FOR THE TREATMENT OF CANCER
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
RU2506077C1 (ru) * 2013-01-25 2014-02-10 Общество С Ограниченной Ответственностью "Валента-Интеллект" Комбинация для профилактики, коррекции и терапии боли, связанной с нейродегенерацией или ассоциированной с соматоформными расстройствами
ES2493693B1 (es) 2013-02-11 2015-07-07 Servicio Andaluz De Salud Método para predecir o pronosticar la respuesta de un sujeto humano que padece un cáncer al tratamiento con un antagonista del receptor NK1
JP2016507582A (ja) 2013-02-13 2016-03-10 ノバルティス アーゲー Ｉｐ受容体アゴニスト複素環式化合物
ES2541870B1 (es) 2013-12-27 2016-05-12 Servicio Andaluz De Salud Uso de antagonistas no peptídicos de NK1 en una determinada dosis para el tratamiento del cáncer
WO2016105448A1 (en) * 2014-12-22 2016-06-30 Darryl Rideout Imidazoline receptor type 1 ligands for use as therapeutics
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
ES2880482T3 (es) 2016-01-11 2021-11-24 Epicentrx Inc Composiciones y métodos para la administración intravenosa de 2-bromo-1-(3,3-dinitroazetidin-1-il)etanona
RU2643091C2 (ru) * 2016-04-08 2018-01-31 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Производные оксимов 4-бензоилпиридина, обладающие противосудорожной активностью, как средства лечения эпилепсии и пароксизмальных состояний
US11008287B2 (en) 2016-10-14 2021-05-18 Epicentrx, Inc. Sulfoxyalkyl organonitro and related compounds and pharmaceutical compounds for use in medicine
US11744859B2 (en) 2017-07-07 2023-09-05 Epicentrx, Inc. Compositions and methods for parenteral administration of therapeutic agents
US11510901B2 (en) 2018-01-08 2022-11-29 Epicentrx, Inc. Methods and compositions utilizing RRx-001 combination therapy for radioprotection
US20230257348A1 (en) * 2020-08-18 2023-08-17 Merck Sharp & Dohme Llc Cyclopentapyrrole orexin receptor agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539584A (en) * 1967-11-14 1970-11-10 Colgate Palmolive Co 5-substituted-2,1-benzisothiazolines
US4581356A (en) * 1983-03-22 1986-04-08 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same
DK0550635T3 (da) * 1990-09-28 1995-09-04 Pfizer Cykliske forbindelser med kondeserede ringe, som er analoger til nitrogenholdige ikke-aromatiske het erocykliske forbindelser
TW202432B (pt) * 1991-06-21 1993-03-21 Pfizer
WO1997003066A1 (en) * 1995-07-07 1997-01-30 Pfizer Pharmaceuticals Inc. Substituted benzolactam compounds as substance p antagonists
TWI220143B (en) * 1998-05-13 2004-08-11 Solvay Pharm Gmbh Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds and novel cyclic compounds, and intermediate products
WO2000073312A1 (en) * 1999-05-26 2000-12-07 Astrazeneca Ab Compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds

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