BR0016111A - Derivados de triazaespiro[5,5]undecano e medicamentos contendo os mesmos como ingrediente ativo - Google Patents
Derivados de triazaespiro[5,5]undecano e medicamentos contendo os mesmos como ingrediente ativoInfo
- Publication number
- BR0016111A BR0016111A BR0016111-0A BR0016111A BR0016111A BR 0016111 A BR0016111 A BR 0016111A BR 0016111 A BR0016111 A BR 0016111A BR 0016111 A BR0016111 A BR 0016111A
- Authority
- BR
- Brazil
- Prior art keywords
- triazaspiro
- derivatives
- active ingredient
- medicines containing
- undecane derivatives
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 2
- RSJKGSCJYJTIGS-BJUDXGSMSA-N undecane Chemical class CCCCCCCCCC[11CH3] RSJKGSCJYJTIGS-BJUDXGSMSA-N 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 102000019034 Chemokines Human genes 0.000 abstract 2
- 108010012236 Chemokines Proteins 0.000 abstract 2
- RSJKGSCJYJTIGS-UHFFFAOYSA-N undecane Chemical compound CCCCCCCCCCC RSJKGSCJYJTIGS-UHFFFAOYSA-N 0.000 abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 201000008383 nephritis Diseases 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"DERIVADOS DE TRIAZAESPIRO[5,5] UNDECANO E MEDICAMENTOS CONTENDO OS MESMOS COMO INGREDIENTE ATIVO". Derivados de triazaespiro[5,5] undecano representados pela fórmula geral (I), sais de amónio quaternário, Nóxidos e sais não tóxicos dos mesmos, onde cada símbolo possui o significado definido na descrição. Em razão do controle do efeito das quimocinas/reguladores de quimocinas, os compostos representados pela fórmula (I) são úteis na prevenção e/ou tratamento de várias doenças inflamatórias, asma, dermatite atópica, urticária, doenças alérgicas, nefrite, nefropatia, hepatite, artrite, artrite reumatóide, etc.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34496799 | 1999-12-03 | ||
JP2000018673 | 2000-01-27 | ||
JP2000027968 | 2000-02-04 | ||
JP2000147882 | 2000-05-19 | ||
PCT/JP2000/008517 WO2001040227A1 (fr) | 1999-12-03 | 2000-12-01 | Derives triazaspiro[5.5]undecane et medicaments contenant ces derives en tant que principe actif |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0016111A true BR0016111A (pt) | 2003-03-25 |
Family
ID=27480653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0016111-0A BR0016111A (pt) | 1999-12-03 | 2000-12-01 | Derivados de triazaespiro[5,5]undecano e medicamentos contendo os mesmos como ingrediente ativo |
Country Status (18)
Country | Link |
---|---|
US (1) | US7119091B2 (pt) |
EP (1) | EP1236726B1 (pt) |
JP (1) | JP4721087B2 (pt) |
KR (1) | KR100613176B1 (pt) |
CN (1) | CN1246321C (pt) |
AT (1) | ATE283854T1 (pt) |
AU (1) | AU780419C (pt) |
BR (1) | BR0016111A (pt) |
CA (1) | CA2394679A1 (pt) |
DE (1) | DE60016454T2 (pt) |
ES (1) | ES2233479T3 (pt) |
HU (1) | HUP0300641A2 (pt) |
MX (1) | MXPA02005465A (pt) |
NO (1) | NO323631B1 (pt) |
NZ (1) | NZ519183A (pt) |
PT (1) | PT1236726E (pt) |
TW (1) | TWI224597B (pt) |
WO (1) | WO2001040227A1 (pt) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2266452T3 (es) | 2001-03-19 | 2007-03-01 | Ono Pharmaceutical Co., Ltd. | Derivados de triazaespiro (5.5) undecano y composiciones farmaceuticas que los contienen como ingrediente activo. |
WO2002074769A1 (fr) * | 2001-03-19 | 2002-09-26 | Ono Pharmaceutical Co., Ltd. | Medicaments contenant comme principe actif des derives du triazaspiro [5.5] undecane |
CN1571671A (zh) * | 2001-10-23 | 2005-01-26 | 小野药品工业株式会社 | 含三氮杂螺[5.5]十一烷衍生物与细胞色素p450同工酶3a4抑制剂和/或p-糖蛋白抑制剂组合的药剂 |
AU2003211427A1 (en) * | 2002-02-18 | 2003-09-04 | Ishihara Sangyo Kaisha, Ltd. | Pyridine derivatives or salts thereof and cytokine production inhibitors containing the same |
US7064211B2 (en) * | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
CN1688577A (zh) * | 2002-09-18 | 2005-10-26 | 小野药品工业株式会社 | 三氮杂螺[5.5]十一烷衍生物及以它为活性成分的药物 |
EP1541573A4 (en) | 2002-09-18 | 2007-05-02 | Ono Pharmaceutical Co | NEW CRYSTALS OF DERIVATIVE TRIAZASPIRO 5.5 | UNDECANES |
EP1571146A4 (en) | 2002-12-10 | 2010-09-01 | Ono Pharmaceutical Co | NITROGENIC HETEROCYCLIC COMPOUNDS AND THEIR MEDICAL USE |
AU2003289329A1 (en) * | 2002-12-13 | 2004-07-09 | Ono Pharmaceutical Co., Ltd. | Antagonist and agonist binding to strong binding site of chemokine receptor |
EP1569647B1 (en) | 2002-12-13 | 2008-08-20 | Smithkline Beecham Corporation | Cyclohexyl compounds as ccr5 antagonists |
WO2004080966A1 (ja) | 2003-03-14 | 2004-09-23 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
US7498323B2 (en) | 2003-04-18 | 2009-03-03 | Ono Pharmaceuticals Co., Ltd. | Spiro-piperidine compounds and medicinal use thereof |
EP1621540A4 (en) * | 2003-04-21 | 2008-07-23 | Ono Pharmaceutical Co | HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN AND USE THEREOF |
WO2005075484A2 (en) | 2004-02-10 | 2005-08-18 | F. Hoffmann-La Roche Ag | Chemokine ccr5 receptor modulators |
AU2005251891A1 (en) * | 2004-06-09 | 2005-12-22 | F. Hoffmann-La Roche Ag | Octahydro-pyrrolo[3,4-C] derivatives and their use as antiviral compounds |
NZ551603A (en) * | 2004-06-24 | 2010-11-26 | Incyte Corp | N-substituted piperidines and their use as pharmaceuticals |
JP2008504280A (ja) * | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | 2−メチルプロパンアミドおよびその医薬としての使用 |
US20060009491A1 (en) * | 2004-06-24 | 2006-01-12 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
KR20070024639A (ko) * | 2004-06-24 | 2007-03-02 | 인사이트 산 디에고 인코포레이티드 | 아미도 화합물 및 약제로서의 이의 용도 |
MX2007001540A (es) * | 2004-08-10 | 2007-04-23 | Incyte Corp | Compuestos amido y sus usos como farmaceuticos. |
KR101231466B1 (ko) | 2004-09-13 | 2013-02-07 | 오노 야꾸힝 고교 가부시키가이샤 | 질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는약제 |
US8110581B2 (en) | 2004-11-10 | 2012-02-07 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
US20060160859A1 (en) * | 2004-12-01 | 2006-07-20 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and GW873140 |
EP2527337A1 (en) * | 2005-04-14 | 2012-11-28 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type I |
JPWO2006129679A1 (ja) | 2005-05-31 | 2009-01-08 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
CA2644368A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
EP2051977A2 (en) * | 2006-07-20 | 2009-04-29 | Amgen Inc. | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1 |
JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
GB0625523D0 (en) * | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
CN101646679A (zh) | 2007-03-29 | 2010-02-10 | 弗·哈夫曼-拉罗切有限公司 | 杂环抗病毒化合物 |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
US7977358B2 (en) * | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
TW201000107A (en) | 2008-04-09 | 2010-01-01 | Infinity Pharmaceuticals Inc | Inhibitors of fatty acid amide hydrolase |
WO2010118159A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
ES2493916T3 (es) | 2009-04-07 | 2014-09-12 | Infinity Pharmaceuticals, Inc. | Inhibidores de hidrolasa de amida de ácidos grasos |
IN2012DN00352A (pt) * | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
RU2569061C2 (ru) | 2010-02-03 | 2015-11-20 | Инфинити Фармасьютикалз, Инк. | Ингибиторы амид-гидролазы жирных кислот |
US10383894B2 (en) * | 2010-03-17 | 2019-08-20 | Lutran Industries, Inc. | Human medicinal treatment using salt of peroxymonosulfuric acid |
US20130196990A1 (en) | 2010-10-06 | 2013-08-01 | Junya Qu | Benzimidazole Derivatives As PI3 Kinase Inhibitors |
US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
EP2932533A4 (en) | 2012-12-13 | 2016-08-10 | Daniel S Marshall | MAGNETICALLY POLARIZED PHOTONIC DEVICE |
CA3034211A1 (en) | 2016-08-18 | 2018-02-22 | Vidac Pharma Ltd. | Piperazine derivatives, pharmaceutical compositions and methods of use thereof |
CN108727400B (zh) * | 2017-05-24 | 2021-07-09 | 四川晶华生物科技有限公司 | 一种治疗肿瘤的化合物 |
CN107216335B (zh) * | 2017-06-29 | 2019-04-30 | 上海药明康德新药开发有限公司 | 一种叔丁基1-(羟甲基)-3-氧杂-9-氮杂螺[5.5]十一烷-9-甲酸基酯制法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS231227B1 (en) * | 1982-10-01 | 1984-10-15 | Evzen Kasafirek | 2,5-pierazindion derivatives |
CS260899B1 (en) * | 1986-11-07 | 1989-01-12 | Evzen Kasafirek | Remedy for gastrointestinal diseases |
WO1993013101A1 (en) * | 1991-12-27 | 1993-07-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridonecarboxylate compound, pharmaceutical use thereof, and spiro compound |
DE69633245T2 (de) * | 1995-09-29 | 2005-09-08 | Eli Lilly And Co., Indianapolis | Spiroverbindungen als Inhibitoren der Fibrinogen-abhängigen Blutplättchenaggregation |
WO1998025605A1 (en) | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
US6288083B1 (en) * | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
-
2000
- 2000-12-01 JP JP2001540982A patent/JP4721087B2/ja not_active Expired - Fee Related
- 2000-12-01 CN CNB008187703A patent/CN1246321C/zh not_active Expired - Fee Related
- 2000-12-01 BR BR0016111-0A patent/BR0016111A/pt not_active Application Discontinuation
- 2000-12-01 AT AT00979050T patent/ATE283854T1/de not_active IP Right Cessation
- 2000-12-01 CA CA002394679A patent/CA2394679A1/en not_active Abandoned
- 2000-12-01 PT PT00979050T patent/PT1236726E/pt unknown
- 2000-12-01 AU AU16506/01A patent/AU780419C/en not_active Ceased
- 2000-12-01 ES ES00979050T patent/ES2233479T3/es not_active Expired - Lifetime
- 2000-12-01 NZ NZ519183A patent/NZ519183A/xx unknown
- 2000-12-01 MX MXPA02005465A patent/MXPA02005465A/es active IP Right Grant
- 2000-12-01 KR KR1020027007117A patent/KR100613176B1/ko not_active IP Right Cessation
- 2000-12-01 DE DE60016454T patent/DE60016454T2/de not_active Expired - Lifetime
- 2000-12-01 EP EP00979050A patent/EP1236726B1/en not_active Expired - Lifetime
- 2000-12-01 US US10/148,382 patent/US7119091B2/en not_active Expired - Fee Related
- 2000-12-01 TW TW089125555A patent/TWI224597B/zh not_active IP Right Cessation
- 2000-12-01 HU HU0300641A patent/HUP0300641A2/hu unknown
- 2000-12-01 WO PCT/JP2000/008517 patent/WO2001040227A1/ja active IP Right Grant
-
2002
- 2002-05-31 NO NO20022609A patent/NO323631B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO20022609L (no) | 2002-07-26 |
JP4721087B2 (ja) | 2011-07-13 |
CN1433419A (zh) | 2003-07-30 |
NO323631B1 (no) | 2007-06-18 |
AU780419C (en) | 2005-09-29 |
ATE283854T1 (de) | 2004-12-15 |
US7119091B2 (en) | 2006-10-10 |
EP1236726B1 (en) | 2004-12-01 |
CA2394679A1 (en) | 2001-06-07 |
KR20030003218A (ko) | 2003-01-09 |
US20040097511A1 (en) | 2004-05-20 |
MXPA02005465A (es) | 2003-10-15 |
PT1236726E (pt) | 2005-04-29 |
HUP0300641A2 (hu) | 2003-06-28 |
AU1650601A (en) | 2001-06-12 |
EP1236726A4 (en) | 2003-01-15 |
KR100613176B1 (ko) | 2006-08-17 |
NO20022609D0 (no) | 2002-05-31 |
NZ519183A (en) | 2005-02-25 |
AU780419B2 (en) | 2005-03-17 |
CN1246321C (zh) | 2006-03-22 |
DE60016454D1 (de) | 2005-01-05 |
ES2233479T3 (es) | 2005-06-16 |
EP1236726A1 (en) | 2002-09-04 |
WO2001040227A1 (fr) | 2001-06-07 |
DE60016454T2 (de) | 2005-08-04 |
TWI224597B (en) | 2004-12-01 |
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