BR0015031A - Planta, método para prover uma planta transgênica capaz de expressar uma proteìna recombinante com a capacidade de estender um glicano n-ligado com galactose, uso de uma planta, método para obter uma glicoproteìna desejada ou seu fragmento funcional, glicoproteìna derivada de uma planta ou seu fragmento funcional, uso de uma glicoproteìna ou seu fragmento funcional, e, composição farmacêutica - Google Patents

Planta, método para prover uma planta transgênica capaz de expressar uma proteìna recombinante com a capacidade de estender um glicano n-ligado com galactose, uso de uma planta, método para obter uma glicoproteìna desejada ou seu fragmento funcional, glicoproteìna derivada de uma planta ou seu fragmento funcional, uso de uma glicoproteìna ou seu fragmento funcional, e, composição farmacêutica

Info

Publication number
BR0015031A
BR0015031A BR0015031-2A BR0015031A BR0015031A BR 0015031 A BR0015031 A BR 0015031A BR 0015031 A BR0015031 A BR 0015031A BR 0015031 A BR0015031 A BR 0015031A
Authority
BR
Brazil
Prior art keywords
plant
functional fragment
glycoprotein
glycan
unbound
Prior art date
Application number
BR0015031-2A
Other languages
English (en)
Other versions
BRPI0015031B1 (pt
Inventor
Hendrikus Antonius Corn Bakker
Hendrik Jan Bosch
Original Assignee
Plant Res Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plant Res Int Bv filed Critical Plant Res Int Bv
Publication of BR0015031A publication Critical patent/BR0015031A/pt
Publication of BRPI0015031B1 publication Critical patent/BRPI0015031B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

Abstract

"PLANTA, MéTODO PARA PROVER UMA PLANTA TRANSGêNICA CAPAZ DE EXPRESSAR UMA PROTEìNA RECOMBINANTE COM A CAPACIDADE DE ESTENDER UM GLICANO N-LIGADO COM GALACTOSE, USO DE UMA PLANTA, MéTODO PARA OBTER UMA GLICOPROTEìNA DESEJADA OU SEU FRAGMENTO FUNCIONAL, GLICOPROTEìNA DERIVADA DE UMA PLANTA OU SEU FRAGMENTO FUNCIONAL, USO DE UMA GLICOPROTEìNA OU SEU FRAGMENTO FUNCIONAL, E, COMPOSIçãO FARMACêUTICA". A invenção diz respeito ao campo de processamento de glicoproteína em plantas transgênicas usado como fatores de baixo custo e em fábricas livres de contaminação para a produção de proteínas biofarmacêuticas recombinantes ou composições farmacêuticas que incluam estas proteínas. A invenção proporciona uma planta que compreenda uma enzima funcional de mamíferos que fornece a biossíntese de N-glicano que normalmente não se faz presente nas plantas, dita planta adicionalmente compreendendo pelo menos uma segunda proteína de mamíferos ou seu fragmento funcional que normalmente não está presente nas plantas.
BRPI0015031A 1999-10-26 2000-10-26 método para prover uma planta transgênica capaz de expressar um anticorpo com galactosilação terminal e método para obtenção de uma glicoproteína desejada ou fragmento funcional da mesma BRPI0015031B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99203523 1999-10-26
EP99203524 1999-10-26
PCT/NL2000/000775 WO2001031045A1 (en) 1999-10-26 2000-10-26 Mammalian-type glycosylation in plants

Publications (2)

Publication Number Publication Date
BR0015031A true BR0015031A (pt) 2002-06-18
BRPI0015031B1 BRPI0015031B1 (pt) 2017-05-30

Family

ID=26153384

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0015031A BRPI0015031B1 (pt) 1999-10-26 2000-10-26 método para prover uma planta transgênica capaz de expressar um anticorpo com galactosilação terminal e método para obtenção de uma glicoproteína desejada ou fragmento funcional da mesma

Country Status (17)

Country Link
US (3) US7781647B2 (pt)
EP (3) EP1228231B1 (pt)
JP (1) JP4890712B2 (pt)
AT (2) ATE365219T1 (pt)
AU (1) AU1738401A (pt)
BR (1) BRPI0015031B1 (pt)
CA (2) CA2925231A1 (pt)
DE (2) DE60035285T2 (pt)
DK (2) DK1228231T3 (pt)
ES (1) ES2288882T3 (pt)
HK (1) HK1105785A1 (pt)
IL (6) IL149271A0 (pt)
MX (1) MXPA02004142A (pt)
NZ (1) NZ518532A (pt)
PT (2) PT1772518E (pt)
TR (1) TR200201121T2 (pt)
WO (1) WO2001031045A1 (pt)

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US20120237972A1 (en) 2012-09-20
IL212888A (en) 2017-12-31
AU1738401A (en) 2001-05-08
US20080003680A1 (en) 2008-01-03
EP1228231A1 (en) 2002-08-07
DK1228231T3 (da) 2007-10-29
DE60035285T2 (de) 2008-02-21
IL149271A (en) 2010-11-30
ATE478150T1 (de) 2010-09-15
CA2389217C (en) 2016-12-06
DK1772518T3 (da) 2010-11-22
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IL204883A (en) 2012-05-31
IL149271A0 (en) 2002-11-10
PT1228231E (pt) 2007-09-25
DE60044858D1 (de) 2010-09-30
NZ518532A (en) 2004-02-27
ATE365219T1 (de) 2007-07-15
US7781647B2 (en) 2010-08-24
EP1228231B1 (en) 2007-06-20
PT1772518E (pt) 2010-10-28
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EP1772518B1 (en) 2010-08-18
CA2389217A1 (en) 2001-05-03
US20110030108A1 (en) 2011-02-03
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