IL149271A0 - Mammalian-type glycosylation in plants - Google Patents
Mammalian-type glycosylation in plantsInfo
- Publication number
- IL149271A0 IL149271A0 IL14927100A IL14927100A IL149271A0 IL 149271 A0 IL149271 A0 IL 149271A0 IL 14927100 A IL14927100 A IL 14927100A IL 14927100 A IL14927100 A IL 14927100A IL 149271 A0 IL149271 A0 IL 149271A0
- Authority
- IL
- Israel
- Prior art keywords
- plants
- mammalian
- normally
- present
- plant
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99203523 | 1999-10-26 | ||
EP99203524 | 1999-10-26 | ||
PCT/NL2000/000775 WO2001031045A1 (en) | 1999-10-26 | 2000-10-26 | Mammalian-type glycosylation in plants |
Publications (1)
Publication Number | Publication Date |
---|---|
IL149271A0 true IL149271A0 (en) | 2002-11-10 |
Family
ID=26153384
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14927100A IL149271A0 (en) | 1999-10-26 | 2000-10-26 | Mammalian-type glycosylation in plants |
IL149271A IL149271A (en) | 1999-10-26 | 2002-04-22 | Transgenic plants comprising mammalian ??-1, 4-galactosyltransferase, methods of producing such plants and obtaining an antibody comprising galactosylated n-linked glycan |
IL204883A IL204883A (en) | 1999-10-26 | 2010-04-06 | Transgenic plant comprising mammalian beta-1, 4-galactosyltransferase and beta1,3 glucuronyltransferage |
IL212887A IL212887A0 (en) | 1999-10-26 | 2011-05-15 | A transgenic plant comprising mammalian ??-1, 4-galactosyltransferase and ??-1, 3-glucuronyltransferase |
IL212889A IL212889A0 (en) | 1999-10-26 | 2011-05-15 | A transgenic plant comprising mammalian ??-1, 4-galactosyltransferase and ??-1, 3-glucuronyltransferase |
IL212888A IL212888A (en) | 1999-10-26 | 2011-05-15 | Transgenic plant containing 4, 1 - β galactosyltransferase and 3, 1β - mammalian glucuronyltransferase |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL149271A IL149271A (en) | 1999-10-26 | 2002-04-22 | Transgenic plants comprising mammalian ??-1, 4-galactosyltransferase, methods of producing such plants and obtaining an antibody comprising galactosylated n-linked glycan |
IL204883A IL204883A (en) | 1999-10-26 | 2010-04-06 | Transgenic plant comprising mammalian beta-1, 4-galactosyltransferase and beta1,3 glucuronyltransferage |
IL212887A IL212887A0 (en) | 1999-10-26 | 2011-05-15 | A transgenic plant comprising mammalian ??-1, 4-galactosyltransferase and ??-1, 3-glucuronyltransferase |
IL212889A IL212889A0 (en) | 1999-10-26 | 2011-05-15 | A transgenic plant comprising mammalian ??-1, 4-galactosyltransferase and ??-1, 3-glucuronyltransferase |
IL212888A IL212888A (en) | 1999-10-26 | 2011-05-15 | Transgenic plant containing 4, 1 - β galactosyltransferase and 3, 1β - mammalian glucuronyltransferase |
Country Status (17)
Country | Link |
---|---|
US (3) | US7781647B2 (pt) |
EP (3) | EP1772518B1 (pt) |
JP (1) | JP4890712B2 (pt) |
AT (2) | ATE478150T1 (pt) |
AU (1) | AU1738401A (pt) |
BR (1) | BRPI0015031B1 (pt) |
CA (2) | CA2389217C (pt) |
DE (2) | DE60044858D1 (pt) |
DK (2) | DK1228231T3 (pt) |
ES (1) | ES2288882T3 (pt) |
HK (1) | HK1105785A1 (pt) |
IL (6) | IL149271A0 (pt) |
MX (1) | MXPA02004142A (pt) |
NZ (1) | NZ518532A (pt) |
PT (2) | PT1228231E (pt) |
TR (1) | TR200201121T2 (pt) |
WO (1) | WO2001031045A1 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ512185A (en) | 1998-12-09 | 2004-02-27 | Dow Chemical Co | A method for manufacturing glycoproteins having human- type glycosylation in plant cells |
AU1573601A (en) * | 1999-10-21 | 2001-04-30 | Monsanto Company | Post-translational modification of recombinant proteins produced in plants |
BRPI0015031B1 (pt) | 1999-10-26 | 2017-05-30 | Plant Res Int B V | método para prover uma planta transgênica capaz de expressar um anticorpo com galactosilação terminal e método para obtenção de uma glicoproteína desejada ou fragmento funcional da mesma |
JP5623683B2 (ja) * | 2000-03-22 | 2014-11-12 | フィトン ホールディングス,リミティド ライアビリティ カンパニー | 動物型糖鎖付加機能をもつ植物細胞 |
FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
US8022270B2 (en) | 2000-07-31 | 2011-09-20 | Biolex Therapeutics, Inc. | Expression of biologically active polypeptides in duckweed |
IL156879A0 (en) * | 2001-01-19 | 2004-02-08 | Dow Chemical Co | Method for secretory production of glycoprotein having human-type sugar chain using plant cell |
EP1367881A2 (en) * | 2001-03-06 | 2003-12-10 | The Dow Chemical Company | Plant cell having animal-type sugar chain adding function |
GB2377446B (en) * | 2001-07-13 | 2005-06-29 | Lars Erik Berglund | Expression of cobalamin binding proteins in transgenic plants |
EP1485492B1 (en) * | 2002-03-19 | 2011-12-21 | Stichting Dienst Landbouwkundig Onderzoek | Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta(1,4)-n-acetylglucosaminyltransferase iii) expression in plants |
AU2013205260B2 (en) * | 2002-03-19 | 2016-02-18 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
EP2339004B1 (en) * | 2002-03-19 | 2015-02-25 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
AU2008202355B2 (en) * | 2002-03-19 | 2011-04-07 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
CL2003002461A1 (es) * | 2002-11-27 | 2005-01-07 | Dow Chemical Company Agroscien | Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. |
NZ541503A (en) * | 2003-01-22 | 2008-09-26 | Glycart Biotechnology Ag | Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function |
EP1536229A1 (en) * | 2003-11-26 | 2005-06-01 | Plant Research International B.V. | Method to identify a biomolecular profile |
CA2562772A1 (en) * | 2004-04-15 | 2005-10-27 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
ATE547526T1 (de) * | 2004-05-31 | 2012-03-15 | Kitasato Inst Formerly Known As School Juridical Person Kitasato Gakuen | Orale anti-leucocytozoonosis-impfstoffe basierend auf transgenen pflanzen |
WO2006004675A2 (en) * | 2004-06-25 | 2006-01-12 | Altor Bioscience Corporation | Production of tissue factor in plants |
JP2006288210A (ja) | 2005-04-05 | 2006-10-26 | National Institute Of Advanced Industrial & Technology | 糖転移酵素遺伝子の導入による生体内糖鎖伸長の技術 |
JP2009501011A (ja) * | 2005-07-12 | 2009-01-15 | グリーンオーベーション ビオテッヒ ゲーエムベーハー | タンパク質生成におけるまたはそれに関する改善 |
AU2007205939B2 (en) | 2006-01-17 | 2012-12-13 | Synthon Biopharmaceuticals B.V. | Compositions and methods for humanization and optimization of N-glycans in plants |
KR101385051B1 (ko) | 2006-02-09 | 2014-04-24 | 메디카고 인코포레이티드 | 식물에서 시알산의 합성 |
EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
CA2684370C (en) | 2007-04-17 | 2017-10-17 | Plant Research International B.V. | Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases |
AU2013203379B2 (en) * | 2007-04-17 | 2016-01-21 | Stichting Dienst Landbouwkundig Onderzoek | Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases |
US20100154081A1 (en) * | 2007-05-21 | 2010-06-17 | Bayer Bioscience N.V. | Methods and means for producing glycoproteins with altered glycosylation pattern in higher plants |
HUE031698T2 (en) * | 2007-06-15 | 2017-07-28 | Medicago Inc | Modification of glycoprotein production in plants |
WO2010006452A1 (en) | 2008-07-18 | 2010-01-21 | Medicago Inc. | New influenza virus immunizing epitope |
US8809009B2 (en) | 2009-01-02 | 2014-08-19 | Biomarin Pharmaceutical Inc. | Methods of diagnosing a disease and methods of monitoring treatment of a disease by quantifying a non-reducing end glycan residual compound and comparing to a second biomarker |
US8232073B2 (en) | 2009-01-02 | 2012-07-31 | Zacharon Pharmaceuticals, Inc. | Quantification of non-reducing end glycan residual compounds |
US9029530B2 (en) | 2009-01-02 | 2015-05-12 | Biomarin Pharmaceutical Inc. | Detection of oligosaccharides |
EP2411529A4 (en) * | 2009-03-27 | 2012-09-19 | Zacharon Pharmaceuticals Inc | MODULATORS OF BIOSYNTHESIS OF N-BOUND GLYCANS |
US8846373B2 (en) | 2011-07-29 | 2014-09-30 | The University Of Wyoming | Methods of using a bacterial GlcNAc-6-P 2′- epimerase to promote sialylation of glycoconjugates |
US9816107B2 (en) | 2011-07-29 | 2017-11-14 | The University Of Wyoming | Transgenic insect cells comprising a bacterial GlcNAc-6-P 2′-epimerase |
WO2013119419A1 (en) | 2012-02-08 | 2013-08-15 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
JP7127859B2 (ja) | 2016-11-09 | 2022-08-30 | ノース カロライナ ステート ユニバーシティ | キメラタンパク質を用いたアレルギー疾患の治療 |
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JP6934666B2 (ja) * | 2018-01-18 | 2021-09-15 | 国立研究開発法人産業技術総合研究所 | 植物細胞においてキシロース修飾タンパク質を製造する方法、コアオリゴ糖修飾タンパク質を製造する方法、及びプロテオグリカンを製造する方法 |
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EP2339004B1 (en) | 2002-03-19 | 2015-02-25 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
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