BR0014633A - Processo para isolamento e/ou identificação de pelo menos uma substância quìmica ativa a partir de uma mistura de substâncias quìmicas e dispositivo para a realização do processo - Google Patents
Processo para isolamento e/ou identificação de pelo menos uma substância quìmica ativa a partir de uma mistura de substâncias quìmicas e dispositivo para a realização do processoInfo
- Publication number
- BR0014633A BR0014633A BR0014633-1A BR0014633A BR0014633A BR 0014633 A BR0014633 A BR 0014633A BR 0014633 A BR0014633 A BR 0014633A BR 0014633 A BR0014633 A BR 0014633A
- Authority
- BR
- Brazil
- Prior art keywords
- mixture
- active
- isolation
- identification
- chemicals
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/466—Flow patterns using more than one column with separation columns in parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
- G01N2030/067—Preparation by reaction, e.g. derivatising the sample
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
- G01N2030/625—Detectors specially adapted therefor signal-to-noise ratio by measuring reference material, e.g. carrier without sample
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Electrostatic Separation (AREA)
- Centrifugal Separators (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Hydrogenated Pyridines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
"PROCESSO PARA ISOLAMENTO E/OU IDENTIFICAçãO DE PELO MENOS UMA SUBSTANCIA QUìMICA ATIVA A PARTIR DE UMA MISTURA DE SUBSTâNCIAS QUìMICAS E DISPOSITIVO PARA A REALIZAçãO DO PROCESSO". A presente invenção refere-se a um processo para o isolamento e/ou a identificação de pelo menos uma substancia química ativa a partir da mistura de substâncias químicas ativas e inativas, o processo é caracterizado pelas seguintes etapas: a) adicionar o alvo à referida mistura e formar um complexo de alvo e pelo menos uma substância química ativa da mistura, b) separar o complexo das substâncias químicas inativas da mistura, e, ou c) liberar e isolar e/ou identificar pelo menos uma substância química ativa a partir do complexo separado ou d) identificar pelo menos uma substância química ativa da mistura ao subtrair do cromatograma da mistura de substâncias químicas ativas e inativas o cromatograma de substâncias químicas inativas que é obtido após a separação do complexo, e possivelmente liberar e isolar a pelo menos uma substância química ativa a partir do complexo separado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19945351A DE19945351C2 (de) | 1999-09-22 | 1999-09-22 | Verfahren zum Auffinden und zur Isolierung pharmakologisch wirksamer Verbindungen aus Substanzgemischen |
PCT/EP2000/008919 WO2001022078A1 (de) | 1999-09-22 | 2000-09-13 | Verfahren und vorrichtung zum auffinden und zur isolierung pharmakologisher verbindungen aus substanzgemischen |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0014633A true BR0014633A (pt) | 2002-08-20 |
Family
ID=7922864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0014633-1A BR0014633A (pt) | 1999-09-22 | 2000-09-13 | Processo para isolamento e/ou identificação de pelo menos uma substância quìmica ativa a partir de uma mistura de substâncias quìmicas e dispositivo para a realização do processo |
Country Status (23)
Country | Link |
---|---|
US (1) | US7232690B1 (pt) |
EP (1) | EP1214589B1 (pt) |
JP (1) | JP4842477B2 (pt) |
KR (1) | KR100676154B1 (pt) |
CN (1) | CN100420945C (pt) |
AR (1) | AR025740A1 (pt) |
AT (1) | ATE268474T1 (pt) |
AU (1) | AU777927B2 (pt) |
BR (1) | BR0014633A (pt) |
CA (1) | CA2387999C (pt) |
CZ (1) | CZ2002990A3 (pt) |
DE (2) | DE19945351C2 (pt) |
DK (1) | DK1214589T3 (pt) |
ES (1) | ES2222230T3 (pt) |
HU (1) | HU227662B1 (pt) |
IL (1) | IL148823A0 (pt) |
MX (1) | MXPA02002992A (pt) |
PL (1) | PL202679B1 (pt) |
PT (1) | PT1214589E (pt) |
TR (1) | TR200200779T2 (pt) |
TW (1) | TWI245121B (pt) |
WO (1) | WO2001022078A1 (pt) |
ZA (1) | ZA200202396B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10125258A1 (de) * | 2001-05-23 | 2003-01-09 | November Ag Molekulare Medizin | Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden |
WO2006015797A2 (en) * | 2004-08-09 | 2006-02-16 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for high-throughput screening of test molecules binding to target molecules |
WO2008079407A1 (en) * | 2006-12-26 | 2008-07-03 | Brigham Young University | Serum proteomics system and associated methods |
KR102589887B1 (ko) | 2022-08-11 | 2023-10-17 | 인포보스 주식회사 | 미지 물질 내 함유물질의 예측방법, 장치 및 프로그램 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4948726A (en) * | 1986-06-02 | 1990-08-14 | Longoria Claude C | Enzyme immunoassay based on membrane separation of antigen-antibody complexes |
US5202421A (en) * | 1988-12-27 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant substance obtained from urine and process for the preparation thereof |
JPH05506774A (ja) * | 1990-02-14 | 1993-10-07 | リセプター ラボラトリーズ インコーポレーテッド | 有益ペプチドの産生法およびスクリーニング法 |
WO1992002815A2 (en) * | 1990-08-10 | 1992-02-20 | Perseptive Biosystems, Inc. | Quantitative analysis and monitoring of protein structure by subtractive chromatography |
WO1992002818A1 (en) | 1990-08-10 | 1992-02-20 | Purdue Research Foundation | Matrix sequential addition immunoassay |
JP3175941B2 (ja) * | 1991-03-28 | 2001-06-11 | パーセプティブ バイオシステムズ インコーポレイテッド | クロマトグラフ溶出液の減法に依るオンライン生成物確認方法及び装置 |
EP0632895B1 (en) | 1992-03-27 | 1998-07-08 | Perseptive Biosystems, Inc. | Rapid hypersensitive flowthrough immunodetection system |
JPH08510325A (ja) * | 1993-05-28 | 1996-10-29 | カイロン コーポレイション | 生物学的に活性なペプチド配列の選択方法 |
US5491096A (en) * | 1993-12-27 | 1996-02-13 | Eli Lilly And Company | Antigen detection with affinity chromatography and parallel processing a control |
US6030804A (en) * | 1995-06-06 | 2000-02-29 | Human Genome Sciences, Inc. | Polynucleotides encoding G-protein parathyroid hormone receptor HLTDG74 polypeptides |
JP3737516B2 (ja) * | 1995-06-26 | 2006-01-18 | パーセプティブ バイオシステムズ,インコーポレーテッド | 高速自動化連続流、多次元分子選別および分析 |
EP0759470B1 (en) * | 1995-06-29 | 2006-10-25 | Takara Bio Inc. | Gene encoding endoglycoceramidase activator |
HUP9900459A3 (en) * | 1996-01-23 | 1999-11-29 | Rapigene Inc Bothell | Methods and compositions for detecting binding of ligand pair using non-fluorescent label |
DE19629141A1 (de) * | 1996-07-19 | 1998-04-16 | Bayer Ag | Verfahren und Vorrichtung zum Screening von Molekülen bezüglich ihres individuellen Bindungsverhaltens zu mindestens einem vorgegebenen Ligand |
JPH1150724A (ja) * | 1997-08-05 | 1999-02-23 | Shinkansai Bearing Co Ltd | 窓用ヒンジ |
DE19757574A1 (de) * | 1997-12-23 | 1999-06-24 | Bayer Ag | Verbesserte Doppelmetallcyanid-Katalysatoren für die Herstellung von Polyetherpolyolen |
AUPP103497A0 (en) * | 1997-12-19 | 1998-01-15 | Panbio Pty Ltd | Assay apparatus |
US6077940A (en) | 1997-12-24 | 2000-06-20 | Genentech, Inc. | Free solution ligand interaction molecular separation method |
-
1999
- 1999-09-22 DE DE19945351A patent/DE19945351C2/de not_active Expired - Fee Related
-
2000
- 2000-09-13 MX MXPA02002992A patent/MXPA02002992A/es active IP Right Grant
- 2000-09-13 TR TR2002/00779T patent/TR200200779T2/xx unknown
- 2000-09-13 DE DE50006696T patent/DE50006696D1/de not_active Expired - Lifetime
- 2000-09-13 WO PCT/EP2000/008919 patent/WO2001022078A1/de active IP Right Grant
- 2000-09-13 CA CA002387999A patent/CA2387999C/en not_active Expired - Fee Related
- 2000-09-13 PT PT00960653T patent/PT1214589E/pt unknown
- 2000-09-13 ES ES00960653T patent/ES2222230T3/es not_active Expired - Lifetime
- 2000-09-13 IL IL14882300A patent/IL148823A0/xx not_active IP Right Cessation
- 2000-09-13 AT AT00960653T patent/ATE268474T1/de active
- 2000-09-13 US US10/088,868 patent/US7232690B1/en not_active Expired - Fee Related
- 2000-09-13 AU AU72867/00A patent/AU777927B2/en not_active Ceased
- 2000-09-13 CZ CZ2002990A patent/CZ2002990A3/cs unknown
- 2000-09-13 DK DK00960653T patent/DK1214589T3/da active
- 2000-09-13 EP EP00960653A patent/EP1214589B1/de not_active Expired - Lifetime
- 2000-09-13 PL PL357350A patent/PL202679B1/pl not_active IP Right Cessation
- 2000-09-13 HU HU0203686A patent/HU227662B1/hu not_active IP Right Cessation
- 2000-09-13 KR KR1020027003696A patent/KR100676154B1/ko not_active IP Right Cessation
- 2000-09-13 JP JP2001525199A patent/JP4842477B2/ja not_active Expired - Fee Related
- 2000-09-13 CN CNB008131104A patent/CN100420945C/zh not_active Expired - Fee Related
- 2000-09-13 BR BR0014633-1A patent/BR0014633A/pt not_active Application Discontinuation
- 2000-09-20 TW TW089119307A patent/TWI245121B/zh not_active IP Right Cessation
- 2000-09-22 AR ARP000104964A patent/AR025740A1/es active IP Right Grant
-
2002
- 2002-03-26 ZA ZA200202396A patent/ZA200202396B/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU227662B1 (en) | 2011-10-28 |
WO2001022078A1 (de) | 2001-03-29 |
ES2222230T3 (es) | 2005-02-01 |
KR20020048413A (ko) | 2002-06-22 |
HUP0203686A2 (hu) | 2003-03-28 |
DE19945351C2 (de) | 2002-04-18 |
DK1214589T3 (da) | 2004-10-11 |
JP4842477B2 (ja) | 2011-12-21 |
TR200200779T2 (tr) | 2002-09-23 |
DE19945351A1 (de) | 2001-07-12 |
CA2387999C (en) | 2008-09-02 |
CZ2002990A3 (cs) | 2002-07-17 |
ATE268474T1 (de) | 2004-06-15 |
CA2387999A1 (en) | 2001-03-29 |
MXPA02002992A (es) | 2002-09-30 |
TWI245121B (en) | 2005-12-11 |
AR025740A1 (es) | 2002-12-11 |
DE50006696D1 (de) | 2004-07-08 |
CN100420945C (zh) | 2008-09-24 |
ZA200202396B (en) | 2003-03-28 |
KR100676154B1 (ko) | 2007-01-31 |
EP1214589A1 (de) | 2002-06-19 |
PL202679B1 (pl) | 2009-07-31 |
IL148823A0 (en) | 2002-09-12 |
PT1214589E (pt) | 2004-09-30 |
US7232690B1 (en) | 2007-06-19 |
CN1375058A (zh) | 2002-10-16 |
HUP0203686A3 (en) | 2010-01-28 |
JP2003510569A (ja) | 2003-03-18 |
EP1214589B1 (de) | 2004-06-02 |
PL357350A1 (en) | 2004-07-26 |
AU777927B2 (en) | 2004-11-04 |
AU7286700A (en) | 2001-04-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Sajiki et al. | Sensitive method for the determination of bisphenol-A in serum using two systems of high-performance liquid chromatography | |
Gulaya et al. | Phospholipid composition of human sperm and seminal plasma in relation to sperm fertility | |
Walter et al. | Endothelin‐1 increases 2‐arachidonoyl glycerol (2‐AG) production in astrocytes | |
BR9811450A (pt) | Processos para a condensação fracionada de uma mistura gasosa e para a preparação de ácido acrìlico ou ácido metacrìlico | |
ES2173469T3 (es) | Composicion de eliminacion de oxigeno de varios componentes. | |
Yasui et al. | Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice | |
AR003415A1 (es) | Compuestos analogos de lactacistina, metodo para inhibir la proteolisis dependiente de proteasoma, metodo para identificar un proceso biologico mediado por proteolisis dependiente de proteasoma, uso de dichos compuestos para preparar un medicamento para tratar una condicion mediada por proteolisis dependiente de proteasoma. | |
BRPI0511977A (pt) | dispositivos e métodos para remover agentes alvo de uma amostra | |
DE69433136D1 (de) | Nukleinsäure-isolierung | |
BR9900844A (pt) | Método para microencapsulação de uma substância sólida | |
BR9912702A (pt) | Composto e método para a prevenção e/ou para o tratamento de alergias | |
BR9509938A (pt) | Processo para aumentar a biodisponibilidade de um agente farmacéutico formulação farmacéutica para tratar um mamifero sofrendo de hipoesteroidismo osteoporose asma composição de substáncia | |
GB2330655A (en) | Method and system for performing a binding assay | |
BR9909312B1 (pt) | processos para separar ácido acrìlico, e para preparar um acrilato, ou uma mistura de dois ou mais do mesmo. | |
Orhan et al. | UPLC–TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities | |
BR9004790A (pt) | Dispersoes aquosas de organopolissiloxanos e processo para sua preparacao | |
PT820303E (pt) | Analogos do peptido p277 e composicoes farmaceuticas que os compreendem, para tratamento ou diagnostico de diabetes | |
BR0014633A (pt) | Processo para isolamento e/ou identificação de pelo menos uma substância quìmica ativa a partir de uma mistura de substâncias quìmicas e dispositivo para a realização do processo | |
BR9908730A (pt) | Processos para o isolamento retificativo e para a preparação de ácido (met) acrìlico | |
BR0211922A (pt) | Método para secagem de artigos de tecido contendo fluido lipofìlico, sistema de secagem dos referidos artigos, bem como artigo de tecido assim obtido | |
WO2002008751A3 (de) | Schonende hochanreicherung von fetalen zellen aus peripherem blut und verwendung derselben | |
BR0212260A (pt) | Agente antimicrobiano | |
IT1284571B1 (it) | Composizione antitumorale contenente come sostanza attiva un estratto embrionale o di utero gravido e relativo procedimento di preparazione | |
BR9808011A (pt) | Processo para a purificação de caprolactama | |
BR9816009A (pt) | Método para a rápida filtragem de analitos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] |
Free format text: E EM CONSONANCIA COM A RESOLUCAO NO 34 DO CGEN. |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |