AR025740A1 - Procedimiento para la identificacion de al menos una sustancia quimica activa en una mezcla de substancias activas e inactivas con masas molares relativas de 150 a 30.000 - Google Patents

Procedimiento para la identificacion de al menos una sustancia quimica activa en una mezcla de substancias activas e inactivas con masas molares relativas de 150 a 30.000

Info

Publication number
AR025740A1
AR025740A1 ARP000104964A ARP000104964A AR025740A1 AR 025740 A1 AR025740 A1 AR 025740A1 AR P000104964 A ARP000104964 A AR P000104964A AR P000104964 A ARP000104964 A AR P000104964A AR 025740 A1 AR025740 A1 AR 025740A1
Authority
AR
Argentina
Prior art keywords
active
mixture
identification
chemical substance
procedure
Prior art date
Application number
ARP000104964A
Other languages
English (en)
Inventor
Rudolf Matusch
Hans Hoffmann
Jana Lenz
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of AR025740A1 publication Critical patent/AR025740A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N2030/067—Preparation by reaction, e.g. derivatising the sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
    • G01N2030/625—Detectors specially adapted therefor signal-to-noise ratio by measuring reference material, e.g. carrier without sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Abstract

Un procedimiento para el aislamiento y/o identificacion de al menos una sustancia química activa a partir de una mezcla de sustancias activas e inactivas,caracterizado por los pasos siguientes: a) Adicion de una diana a dicha mezcla y formacion deun complejo de la diana y al menos una sustancia química activade la mezcla. b) Separacion del complejo de las sustancias químicas inactivas de la mezcla y, o bien c) Liberacion y aislamiento y/o identificacion de al menosuna sustancia químicaactiva d el complejo separado, o d) Identificacion de al menos una sustancia química activa de la mezcla por comparacion de uncromatograma de la mezcla de sustancias químicas activas e inactivas y un cromatograma de la mezcla de sustancias químicasinactivas obtenida después de laseparacion del complejo y, en su caso, liberacion y aislamiento de al menos una sustancia activa del complejo separado.
ARP000104964A 1999-09-22 2000-09-22 Procedimiento para la identificacion de al menos una sustancia quimica activa en una mezcla de substancias activas e inactivas con masas molares relativas de 150 a 30.000 AR025740A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19945351A DE19945351C2 (de) 1999-09-22 1999-09-22 Verfahren zum Auffinden und zur Isolierung pharmakologisch wirksamer Verbindungen aus Substanzgemischen

Publications (1)

Publication Number Publication Date
AR025740A1 true AR025740A1 (es) 2002-12-11

Family

ID=7922864

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000104964A AR025740A1 (es) 1999-09-22 2000-09-22 Procedimiento para la identificacion de al menos una sustancia quimica activa en una mezcla de substancias activas e inactivas con masas molares relativas de 150 a 30.000

Country Status (23)

Country Link
US (1) US7232690B1 (es)
EP (1) EP1214589B1 (es)
JP (1) JP4842477B2 (es)
KR (1) KR100676154B1 (es)
CN (1) CN100420945C (es)
AR (1) AR025740A1 (es)
AT (1) ATE268474T1 (es)
AU (1) AU777927B2 (es)
BR (1) BR0014633A (es)
CA (1) CA2387999C (es)
CZ (1) CZ2002990A3 (es)
DE (2) DE19945351C2 (es)
DK (1) DK1214589T3 (es)
ES (1) ES2222230T3 (es)
HU (1) HU227662B1 (es)
IL (1) IL148823A0 (es)
MX (1) MXPA02002992A (es)
PL (1) PL202679B1 (es)
PT (1) PT1214589E (es)
TR (1) TR200200779T2 (es)
TW (1) TWI245121B (es)
WO (1) WO2001022078A1 (es)
ZA (1) ZA200202396B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125258A1 (de) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
WO2006015797A2 (en) * 2004-08-09 2006-02-16 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for high-throughput screening of test molecules binding to target molecules
WO2008079407A1 (en) * 2006-12-26 2008-07-03 Brigham Young University Serum proteomics system and associated methods
KR102589887B1 (ko) 2022-08-11 2023-10-17 인포보스 주식회사 미지 물질 내 함유물질의 예측방법, 장치 및 프로그램

Family Cites Families (18)

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US4948726A (en) * 1986-06-02 1990-08-14 Longoria Claude C Enzyme immunoassay based on membrane separation of antigen-antibody complexes
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
ATE152771T1 (de) * 1990-02-14 1997-05-15 Receptor Lab Inc Methode zur herstellung und prüfung von verwendbaren peptiden
WO1992002818A1 (en) * 1990-08-10 1992-02-20 Purdue Research Foundation Matrix sequential addition immunoassay
WO1992002815A2 (en) 1990-08-10 1992-02-20 Perseptive Biosystems, Inc. Quantitative analysis and monitoring of protein structure by subtractive chromatography
EP0533909B1 (en) * 1991-03-28 1997-01-08 Perseptive Biosystems, Inc. On-line product identification in a chromatography effluent by subtraction
JPH07505477A (ja) * 1992-03-27 1995-06-15 パーセプティブ　バイオシステムズ　インコーポレイテッド 高感度フロースルー迅速免疫検出系
JPH08510325A (ja) * 1993-05-28 1996-10-29 カイロン コーポレイション 生物学的に活性なペプチド配列の選択方法
US5491096A (en) 1993-12-27 1996-02-13 Eli Lilly And Company Antigen detection with affinity chromatography and parallel processing a control
US6030804A (en) * 1995-06-06 2000-02-29 Human Genome Sciences, Inc. Polynucleotides encoding G-protein parathyroid hormone receptor HLTDG74 polypeptides
DE69627333T2 (de) 1995-06-26 2004-02-12 PerSeptive Biosystems, Inc., Framingham Automatisierte, kontinuierliche mehrdimensionale hochgeschwindigkeitsmolekularselektion und -analyse
DE69636649T2 (de) * 1995-06-29 2007-10-04 Takara Bio Inc., Otsu Für einen Endoglycoceramidase-Aktivator kodierendes Gen
KR100473903B1 (ko) * 1996-01-23 2005-09-30 퀴아진 지노믹스, 인코포레이티드 리간드쌍의결합을검출하는방법
DE19629141A1 (de) * 1996-07-19 1998-04-16 Bayer Ag Verfahren und Vorrichtung zum Screening von Molekülen bezüglich ihres individuellen Bindungsverhaltens zu mindestens einem vorgegebenen Ligand
JPH1150724A (ja) * 1997-08-05 1999-02-23 Shinkansai Bearing Co Ltd 窓用ヒンジ
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Also Published As

Publication number Publication date
PT1214589E (pt) 2004-09-30
ES2222230T3 (es) 2005-02-01
HUP0203686A3 (en) 2010-01-28
ATE268474T1 (de) 2004-06-15
DE19945351A1 (de) 2001-07-12
CA2387999C (en) 2008-09-02
EP1214589A1 (de) 2002-06-19
JP2003510569A (ja) 2003-03-18
AU7286700A (en) 2001-04-24
KR100676154B1 (ko) 2007-01-31
TR200200779T2 (tr) 2002-09-23
ZA200202396B (en) 2003-03-28
AU777927B2 (en) 2004-11-04
PL357350A1 (en) 2004-07-26
DE19945351C2 (de) 2002-04-18
WO2001022078A1 (de) 2001-03-29
JP4842477B2 (ja) 2011-12-21
IL148823A0 (en) 2002-09-12
MXPA02002992A (es) 2002-09-30
KR20020048413A (ko) 2002-06-22
BR0014633A (pt) 2002-08-20
US7232690B1 (en) 2007-06-19
CZ2002990A3 (cs) 2002-07-17
HUP0203686A2 (hu) 2003-03-28
TWI245121B (en) 2005-12-11
CA2387999A1 (en) 2001-03-29
CN1375058A (zh) 2002-10-16
DE50006696D1 (de) 2004-07-08
EP1214589B1 (de) 2004-06-02
PL202679B1 (pl) 2009-07-31
HU227662B1 (en) 2011-10-28
DK1214589T3 (da) 2004-10-11
CN100420945C (zh) 2008-09-24

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