DE69216520T2 - Produktinformation in chromatographischem effluenten durch differenzbildung - Google Patents

Produktinformation in chromatographischem effluenten durch differenzbildung

Info

Publication number
DE69216520T2
DE69216520T2 DE69216520T DE69216520T DE69216520T2 DE 69216520 T2 DE69216520 T2 DE 69216520T2 DE 69216520 T DE69216520 T DE 69216520T DE 69216520 T DE69216520 T DE 69216520T DE 69216520 T2 DE69216520 T2 DE 69216520T2
Authority
DE
Germany
Prior art keywords
differentiation
product information
chromatographic effluent
effluent
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69216520T
Other languages
English (en)
Other versions
DE69216520D1 (de
Inventor
Noubar Afeyan
Fred Regnier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
PerSeptive Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PerSeptive Biosystems Inc filed Critical PerSeptive Biosystems Inc
Publication of DE69216520D1 publication Critical patent/DE69216520D1/de
Application granted granted Critical
Publication of DE69216520T2 publication Critical patent/DE69216520T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/14—Preparation by elimination of some components
    • G01N2030/143—Preparation by elimination of some components selective absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N2030/524—Physical parameters structural properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
    • G01N2030/625—Detectors specially adapted therefor signal-to-noise ratio by measuring reference material, e.g. carrier without sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G01N30/82—Automatic means therefor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • External Artificial Organs (AREA)
  • Fats And Perfumes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Detergent Compositions (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Processing Of Solid Wastes (AREA)
DE69216520T 1991-03-28 1992-03-20 Produktinformation in chromatographischem effluenten durch differenzbildung Expired - Fee Related DE69216520T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67687291A 1991-03-28 1991-03-28
PCT/US1992/002263 WO1992017259A1 (en) 1991-03-28 1992-03-20 On-line product identification in a chromatography effluent by subtraction

Publications (2)

Publication Number Publication Date
DE69216520D1 DE69216520D1 (de) 1997-02-20
DE69216520T2 true DE69216520T2 (de) 1997-04-24

Family

ID=24716390

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69216520T Expired - Fee Related DE69216520T2 (de) 1991-03-28 1992-03-20 Produktinformation in chromatographischem effluenten durch differenzbildung

Country Status (8)

Country Link
US (1) US5234586A (de)
EP (1) EP0533909B1 (de)
JP (1) JP3175941B2 (de)
AT (1) ATE147281T1 (de)
AU (1) AU647929B2 (de)
CA (1) CA2083820A1 (de)
DE (1) DE69216520T2 (de)
WO (1) WO1992017259A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US5228960A (en) * 1992-07-17 1993-07-20 Beckman Instruments, Inc. Analysis of samples by capillary electrophoretic immunosubtraction
US5316630A (en) * 1993-03-30 1994-05-31 Dionex Corporation Methods for chromatography analysis
US5491096A (en) * 1993-12-27 1996-02-13 Eli Lilly And Company Antigen detection with affinity chromatography and parallel processing a control
JPH08511874A (ja) * 1994-04-13 1996-12-10 ベックマン インスツルメンツ インコーポレーテッド 生物学的流体中の検体の分析
WO1996040398A1 (en) * 1995-06-07 1996-12-19 Biosepra Inc. On line detection of a desired solute in an effluent stream using fluorescence spectroscopy
US5783397A (en) * 1995-12-11 1998-07-21 Northeastern University Screening natural samples for new therapeutic compounds using capillary electrophoresis
US6174670B1 (en) 1996-06-04 2001-01-16 University Of Utah Research Foundation Monitoring amplification of DNA during PCR
US5837135A (en) * 1996-07-09 1998-11-17 Agency Of Industrial Science And Technology Chromatography and related apparatus system
US5938932A (en) * 1997-11-14 1999-08-17 Pharmacopeia, Inc. High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
US6299747B1 (en) 1997-12-17 2001-10-09 Cetek Corporation Capillary electrophoretic methods to detect new biologically active compounds in complex biological material
WO1999034220A2 (en) * 1997-12-31 1999-07-08 Genentech, Inc. Real-time monitoring of an analyte by chromatography using an on-line assay
US6136197A (en) * 1998-05-27 2000-10-24 Battelle Memorial Institute Systems for column-based separations, methods of forming packed columns, and methods of purifying sample components
US6077438A (en) 1998-12-22 2000-06-20 Combichem, Inc. Automated on-line evaporation light scattering detection to quantify isolated fluid sample compounds in microtiter plate format
DE19914358C2 (de) * 1999-03-30 2001-05-17 Agilent Technologies Inc Vorrichtung und Verfahren zur Bereitstellung von Volumenströmen von Flüssigkeiten in Kapillaren
WO2000064557A1 (en) 1999-04-23 2000-11-02 Advanced Bioanalytical Services, Inc. High-throughput parallel liquid chromatography system
AU6350300A (en) * 1999-07-13 2001-01-30 Dow Chemical Company, The Method for chemical analysis of biological material
US6106710A (en) * 1999-09-10 2000-08-22 Agilent Technologies, Inc. Fraction collection delay calibration for liquid chromatography
DE19945351C2 (de) * 1999-09-22 2002-04-18 Lohmann Therapie Syst Lts Verfahren zum Auffinden und zur Isolierung pharmakologisch wirksamer Verbindungen aus Substanzgemischen
US6767467B2 (en) * 2000-07-06 2004-07-27 Agilent Technologies, Inc. Fraction collection delay calibration for liquid chromatography
US6402946B1 (en) * 2000-10-26 2002-06-11 Bruker Analytik Gmbh Device for feeding a chromatography flow
CA2427022A1 (en) * 2000-11-02 2002-05-10 Gene Bio-Application Ltd. Gel trap for electrophoresis
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US6813929B2 (en) * 2002-08-01 2004-11-09 Dionex Corporation Method and apparatus for monitoring fluid flow
US7332087B2 (en) * 2003-11-26 2008-02-19 Waters Investments Limited Flow sensing apparatus used to monitor/provide feedback to a split flow pumping system
US7186336B2 (en) * 2003-11-26 2007-03-06 Waters Investments Limited Flow sensing apparatus
US7204264B2 (en) * 2004-04-21 2007-04-17 Waters Investments Ltd. High pressure capillary micro-fluidic valve device and a method of fabricating same
US8877051B2 (en) * 2006-07-21 2014-11-04 Waters Technologies Corporation Time delay for sample collection in chromatography systems
CN103630639A (zh) 2007-12-05 2014-03-12 全技术联合公司 用于分析样本和收集样本流份的方法和装置
US20090308811A1 (en) * 2008-06-11 2009-12-17 Argonide Corporation Chromatography device
SG171929A1 (en) 2008-12-04 2011-07-28 Alltech Associates Inc Methods and apparatus for moving aliquot samples of fluid
JP2012511725A (ja) 2008-12-10 2012-05-24 オールテック・アソシエイツ・インコーポレーテッド クロマトグラフィーシステムおよびシステム部品
US8305582B2 (en) 2009-09-01 2012-11-06 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
US9527010B2 (en) * 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
WO2015011522A1 (en) 2013-07-23 2015-01-29 Tubitak Ume Multi-task sample preparation system with reconfigurable modules for on-line dilution, enzymatic digestion and fractionation
US11287403B2 (en) * 2016-01-07 2022-03-29 Board Of Regents, The University Of Texas System Ion chromatography system and methods utilizing a weak acid or weak base extraction device
US11478524B1 (en) * 2017-07-31 2022-10-25 University Of South Florida Methods and compositions for modulating complex mixtures by selective deletion chromatography

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3676649A (en) * 1970-05-08 1972-07-11 Phillips Petroleum Co Signal analysis and recording
DE2036525B2 (de) * 1970-07-23 1974-06-20 Boehringer Mannheim Gmbh Verfahren und Vorrichtung zur chromatographischen Auftrennung von Mehrstoffgemischen
US3847550A (en) * 1973-03-27 1974-11-12 Atomic Energy Commission Differential chromatographic method
US3981179A (en) * 1975-10-15 1976-09-21 Phillips Petroleum Company Fluid detecting system
US4243753A (en) * 1978-02-27 1981-01-06 Purdue Research Foundation Apparatus for enzyme detection
US4274967A (en) * 1978-07-07 1981-06-23 Technicon Instruments Corporation Chromatographic apparatus and method
US4364263A (en) * 1980-09-15 1982-12-21 Burroughs Wellcome Co. High pressure liquid chromatographic system
US4403503A (en) * 1981-11-09 1983-09-13 Sujit Banerjee Apparatus and method for the reduction of interferences in chromatography
US4577492A (en) * 1983-05-12 1986-03-25 Phillips Petroleum Company Analytical method and apparatus
US4478713A (en) * 1983-09-23 1984-10-23 Pharmuka Laboratoires Automatic installation for liquid chromatography
US4592842A (en) * 1984-03-08 1986-06-03 Spectra-Physics, Inc. Method and apparatus for optimizing peak detection in a chromatogram
JPS60219554A (ja) * 1984-04-16 1985-11-02 Yokogawa Hokushin Electric Corp 多量成分中の微量成分を測定する方法およびその装置
US4544485A (en) * 1984-08-31 1985-10-01 Purdue Research Foundation Chromatographic method and means
US4579663A (en) * 1984-09-24 1986-04-01 The Perkin-Elmer Corporation Apparatus and method for optimizing separation of an unknown sample by liquid chromatography
US4935145A (en) * 1985-01-25 1990-06-19 The Dow Chemical Company On-line coupled liquid and gas chromatography system
JPS61212759A (ja) * 1985-03-18 1986-09-20 Shimadzu Corp 液体クロマトグラフ
US4724081A (en) * 1986-04-28 1988-02-09 Soken Kagaku Kabushiki Kaisha Process and apparatus for separation by liquid chromatography
DE3619301A1 (de) * 1986-06-07 1987-12-10 Ruhrgas Ag Verfahren und einrichtung zur messung der aldehydkonzentration in abgasen
US4762617A (en) * 1987-01-15 1988-08-09 The United States Of America As Represented By The United States Department Of Energy Size-exclusion chromatography system for macromolecular interaction analysis
JPS6415652A (en) * 1987-07-09 1989-01-19 Hitachi Ltd Data processing apparatus for chromatograph
JPH01191055A (ja) * 1988-01-26 1989-08-01 Shimadzu Corp クロマトグラフ用データ処理装置
IL87004A (en) * 1988-07-06 1992-08-18 Technion Res & Dev Foundation Method and apparatus for bioaffinity separation
EP0446285A4 (en) * 1988-12-05 1993-03-10 Primus Corporation Method for determination of glycated proteinaceous species
US5071547A (en) * 1990-03-23 1991-12-10 Separations Technology, Inc. Column chromatographic column apparatus with switching capability
CA2088360A1 (en) * 1990-08-10 1992-02-11 Noubar B. Afeyan Quantitative analysis and monitoring of protein structure by substractive chromatography

Also Published As

Publication number Publication date
WO1992017259A1 (en) 1992-10-15
JPH06500402A (ja) 1994-01-13
AU647929B2 (en) 1994-03-31
DE69216520D1 (de) 1997-02-20
CA2083820A1 (en) 1992-09-29
AU1768292A (en) 1992-11-02
ATE147281T1 (de) 1997-01-15
US5234586A (en) 1993-08-10
EP0533909A1 (de) 1993-03-31
JP3175941B2 (ja) 2001-06-11
EP0533909A4 (en) 1993-06-30
EP0533909B1 (de) 1997-01-08

Similar Documents

Publication Publication Date Title
DE69216520T2 (de) Produktinformation in chromatographischem effluenten durch differenzbildung
DK0781985T3 (da) Fremgangsmåde og indretning til overvågning af en separeret væskestråle
IL63662A (en) Chromatography column and method for effecting molecular separation
FR2520913B1 (fr) Procede et appareil de reconnaissance de mots-cles dans des paroles
DK0676070T3 (da) Fremgangsmåde og indretning til signalanalyse, procesidentifikation og overvågning af en teknisk proces.
DE69206136T2 (de) Vorrichtung und Verfahren zur Trennung von Flüssigkeitsproben.
DK0656874T3 (da) Apparat og fremgangsmåde til adskillelse af ikke blandbare væsker
FR2657443B1 (fr) Procede et appareil de traitement de signal electro-encephalographique.
DE69124285D1 (de) Datenverarbeitungssystem mit einem Eingangs-/Ausgangswegetrennmechanismus und Verfahren zur Steuerung des Datenverarbeitungssystems
DE69233207D1 (de) Verfahren und gerät zur bildverarbeitung.
EP0540762A4 (en) Method for detecting moving vector and apparatus therefor, and system for processing image signal using the apparatus
FI935393A (fi) Menetelmä metallien uuttamiseksi suurista liuosvirtauksista ja laitteisto tämän toteuttamiseksi
DE69429847T2 (de) Bildverarbeitungsgerät und Verfahren zur Erkennung eines eingegebenen Bildes und Fotokopierer, der dasselbe einschliesst
DE68917413T2 (de) Verfahren und Vorrichtung zur Bildsignalverarbeitung.
FR2715753B1 (fr) Appareil et procédé de traitement et de sortie d'informations d'images.
KR960701570A (ko) 광학적으로 부호화된 신호를 처리하는 방법 및 장치(optically encoded signals)
FR2482814B1 (fr) Procede et dispositif pour coder et decoder des signaux video par inversion repetitive de la polarite de ces signaux
FR2493075B1 (fr) Procede et appareil de traitement de signaux numeriques, notamment de signaux numeriques d'image
DE69612304T2 (de) Verfahren zur Trennung der Metalle der Platingruppe
DE69305799D1 (de) Methode und Apparat für die Trennung durch Agglomeration
DE69325099D1 (de) Verfahren und vorrichtung zur diebstahldetektion durch digitalsignalverarbeitung.
KR960702767A (ko) 액체에서 고체를 분리시키는 방법 및 장치(method and apparatus for separating solids from a aiquid)
FR2653557B1 (fr) Appareil et procede pour le traitement de la parole.
ATE200303T1 (de) Verfahren und vorrichtung zur schnellen trennung und/oder umwandlung von substraten
DE59101698D1 (de) Verfahren und Vorrichtung zur gaschromatographischen Trennung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee