BR0012801A - Agonistas orl-1 receptores de nociceptina para uso no tratamento da tosse - Google Patents
Agonistas orl-1 receptores de nociceptina para uso no tratamento da tosseInfo
- Publication number
- BR0012801A BR0012801A BR0012801-5A BR0012801A BR0012801A BR 0012801 A BR0012801 A BR 0012801A BR 0012801 A BR0012801 A BR 0012801A BR 0012801 A BR0012801 A BR 0012801A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- orl
- cough
- treatment
- aryl
- Prior art date
Links
- 206010011224 Cough Diseases 0.000 title abstract 4
- 239000002762 nociceptin receptor agonist Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 239000000556 agonist Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 108010020615 nociceptin receptor Proteins 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- -1 substituted Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/359,771 US6262066B1 (en) | 1998-07-27 | 1999-07-26 | High affinity ligands for nociceptin receptor ORL-1 |
PCT/US2000/001853 WO2001007050A1 (en) | 1999-07-26 | 2000-01-26 | Nociceptin receptor orl-1 agonists for use in treating cough |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0012801A true BR0012801A (pt) | 2002-05-07 |
Family
ID=23415204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0012801-5A BR0012801A (pt) | 1999-07-26 | 2000-01-26 | Agonistas orl-1 receptores de nociceptina para uso no tratamento da tosse |
Country Status (13)
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040067950A1 (en) * | 1998-07-27 | 2004-04-08 | Schering-Plough Corporation | High affinity ligands for nociceptin receptor ORL-1 |
US7485650B2 (en) * | 1998-07-27 | 2009-02-03 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
DE60033071T2 (de) * | 1999-12-06 | 2007-08-23 | Euro-Celtique S.A. | Triazospiroverbindungen mit nociceptin-rezeptoraffinität |
JP2003524634A (ja) * | 1999-12-06 | 2003-08-19 | ユーロ−セルティーク,エス.エイ. | ノシセプチン受容体親和性を有するベンズイミダゾール化合物 |
DE20005049U1 (de) * | 2000-03-20 | 2000-05-18 | Dewert Antriebs Systemtech | Elektromotorische Antriebseinheit |
EP1392687B1 (en) * | 2001-04-10 | 2017-02-01 | Janssen Pharmaceuticals, Inc. | 1,3,8-triazaspiro[4,5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders |
PE20021081A1 (es) * | 2001-04-12 | 2002-12-18 | Pharmacopeia Drug Discovery | Aril y biaril piperidinas con actividad moduladora mch |
EP1385514B9 (en) | 2001-04-18 | 2009-08-12 | Euro-Celtique S.A. | Spiroindene and spiroindane compounds |
CA2444634C (en) | 2001-04-18 | 2011-06-07 | R. Richard Goehring | Spiropyrazole compounds |
MXPA03009600A (es) | 2001-04-18 | 2004-04-02 | Euro Celtique Sa | Analogos de nociceptina. |
CN100441182C (zh) | 2001-04-18 | 2008-12-10 | 欧罗赛铁克股份有限公司 | 伤害感受肽化合物 |
EP1385518B1 (en) | 2001-04-18 | 2008-08-06 | Euro-Celtique S.A. | Benzimidazolone compounds |
WO2002088089A1 (fr) * | 2001-04-19 | 2002-11-07 | Banyu Pharmaceutical Co., Ltd. | Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales |
WO2002100861A1 (en) * | 2001-06-13 | 2002-12-19 | Akzo Nobel N.V. | 1-(3-phenyloxypropyl)piperidine derivatives |
US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
EP1406629A1 (en) * | 2001-07-02 | 2004-04-14 | Omeros Corporation | Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump |
FR2827281B1 (fr) * | 2001-07-16 | 2003-12-19 | Sanofi Synthelabo | Procede pour la preparation de la 4-methylamino-4-phenylpiperidine |
FR2827282B1 (fr) * | 2001-07-16 | 2004-08-13 | Sanofi Synthelabo | Procede pour la preparation de 4-amino-4-phenylpiperidines |
US7049287B2 (en) * | 2001-10-09 | 2006-05-23 | Synvax, Inc. | Nociceptin-based analgesics |
TWI317360B (en) * | 2001-11-07 | 2009-11-21 | Schering Corp | Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1 |
AR037364A1 (es) | 2001-11-16 | 2004-11-03 | Schering Corp | Azetidinil diaminas utiles como ligandos del receptor de nociceptina orl-1 |
US7652039B2 (en) | 2002-05-17 | 2010-01-26 | Sequella, Inc. | Methods of use and compositions for the diagnosis and treatment of infectious disease |
US20040033986A1 (en) | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
US6995168B2 (en) | 2002-05-31 | 2006-02-07 | Euro-Celtique S.A. | Triazaspiro compounds useful for treating or preventing pain |
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UY28417A1 (es) * | 2003-07-17 | 2005-02-28 | Glaxo Group Ltd | Antagonistas de los receptores muscarinicos de la acetilcolina |
TW200519101A (en) * | 2003-09-25 | 2005-06-16 | Solvay Pharm Bv | Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors |
EA013435B1 (ru) * | 2003-10-14 | 2010-04-30 | Глэксо Груп Лимитед | Антагонисты мускариновых ацетилхолиновых рецепторов |
CN1897947A (zh) * | 2003-10-17 | 2007-01-17 | 葛兰素集团有限公司 | 蕈毒碱乙酰胆碱受体拮抗剂 |
JPWO2005037269A1 (ja) * | 2003-10-21 | 2006-12-28 | 住友製薬株式会社 | 新規ピペリジン誘導体 |
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AR046756A1 (es) | 2003-12-12 | 2005-12-21 | Solvay Pharm Gmbh | Derivados de hidronopol como agonistas de receptores orl-1 humanos. |
US20050228023A1 (en) * | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
US20090253908A1 (en) * | 2004-03-11 | 2009-10-08 | Glaxo Group Limited | Novel m3 muscarinic acetylchoine receptor antagonists |
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US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
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WO2006130416A2 (en) * | 2005-06-02 | 2006-12-07 | Janssen Pharmaceutica, N.V. | Novel 3-spirocyclic indolyl derivatives useful as orl-1 receptor modulators |
AU2006270084B2 (en) | 2005-07-18 | 2011-08-25 | Merck Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
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WO2007085357A1 (en) * | 2006-01-30 | 2007-08-02 | Euro-Celtique S.A. | Cyclourea compounds as calcium channel blockers |
EP1847542A1 (en) * | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor |
JP5606734B2 (ja) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
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AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
JPWO2013164954A1 (ja) * | 2012-05-01 | 2015-12-24 | 住友化学株式会社 | ピペリジン化合物及びその有害生物防除用途 |
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WO2014102592A2 (en) * | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof |
JP6359560B2 (ja) * | 2012-12-31 | 2018-07-18 | サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. | 複素環式化合物及びその使用方法 |
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BE633914A (US06262066-20010717-C00662.png) * | 1962-06-22 | |||
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-
1999
- 1999-07-26 US US09/359,771 patent/US6262066B1/en not_active Expired - Lifetime
-
2000
- 2000-01-26 JP JP2001511934A patent/JP2003505420A/ja active Pending
- 2000-01-26 WO PCT/US2000/001853 patent/WO2001007050A1/en not_active Application Discontinuation
- 2000-01-26 EP EP00904560A patent/EP1200087A1/en not_active Withdrawn
- 2000-01-26 CA CA002379398A patent/CA2379398A1/en not_active Abandoned
- 2000-01-26 BR BR0012801-5A patent/BR0012801A/pt not_active IP Right Cessation
- 2000-01-26 CN CN00813077A patent/CN1374865A/zh active Pending
- 2000-01-26 MX MXPA02001033A patent/MXPA02001033A/es unknown
- 2000-01-26 AU AU26298/00A patent/AU2629800A/en not_active Abandoned
- 2000-01-26 HU HU0203458A patent/HUP0203458A3/hu unknown
-
2001
- 2001-01-25 US US09/769,824 patent/US6455527B2/en not_active Expired - Lifetime
-
2002
- 2002-01-11 ZA ZA200200275A patent/ZA200200275B/xx unknown
- 2002-01-25 NO NO20020392A patent/NO20020392L/no not_active Application Discontinuation
- 2002-05-08 HK HK02103499.8A patent/HK1042236A1/zh unknown
- 2002-05-23 US US10/155,277 patent/US6716846B2/en not_active Expired - Fee Related
-
2004
- 2004-01-21 US US10/761,977 patent/US7094784B2/en not_active Expired - Fee Related
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ZA200200275B (en) | 2003-06-25 |
AU2629800A (en) | 2001-02-13 |
HK1042236A1 (zh) | 2002-08-09 |
EP1200087A1 (en) | 2002-05-02 |
US6716846B2 (en) | 2004-04-06 |
US20030073690A1 (en) | 2003-04-17 |
US6262066B1 (en) | 2001-07-17 |
NO20020392L (no) | 2002-03-25 |
CN1374865A (zh) | 2002-10-16 |
HUP0203458A3 (en) | 2004-01-28 |
CA2379398A1 (en) | 2001-02-01 |
US20010011092A1 (en) | 2001-08-02 |
JP2003505420A (ja) | 2003-02-12 |
US6455527B2 (en) | 2002-09-24 |
NO20020392D0 (no) | 2002-01-25 |
HUP0203458A2 (hu) | 2003-02-28 |
WO2001007050A1 (en) | 2001-02-01 |
MXPA02001033A (es) | 2002-08-20 |
US7094784B2 (en) | 2006-08-22 |
US20040152707A1 (en) | 2004-08-05 |
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