BR0012575A - Derivados de indol - Google Patents

Derivados de indol

Info

Publication number
BR0012575A
BR0012575A BR0012575-0A BR0012575A BR0012575A BR 0012575 A BR0012575 A BR 0012575A BR 0012575 A BR0012575 A BR 0012575A BR 0012575 A BR0012575 A BR 0012575A
Authority
BR
Brazil
Prior art keywords
disorders
disease
compounds
indole derivatives
compulsive
Prior art date
Application number
BR0012575-0A
Other languages
English (en)
Inventor
Henning Boettcher
Joachim Maerz
Hartmut Greiner
Juergen Harting
Gerd Bartoszyk
Christoph Seyfried
Christoph Van Amsterdam
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0012575A publication Critical patent/BR0012575A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"DERIVADOS DE INDOL". A invenção refere-se a compostos de fórmula (I), onde R^ 1^ e R^ 3^ têm o significado dado em reivindicação 1. Ditos compostos são antagonistas a 5-HT~ 2A~ potentes e são adequados para o tratamento de psicoses, esquizofrenia, depressão, distúrbios neurológicos, distúrbios de memória, mal de Parkinson, esclerose lateral amiotrófica, mal de Alzheimer, mal de Huntington, distúrbios de alimentação tais como bulimia e anorexia nervosa, síndrome pré-menstrual e/ou para positivamente influenciar comportamentos compulsivos (distúrbio obsessivo-compulsivo, OCD).
BR0012575-0A 1999-07-22 2000-07-07 Derivados de indol BR0012575A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19934432A DE19934432A1 (de) 1999-07-22 1999-07-22 Indolderivate
PCT/EP2000/006463 WO2001007434A2 (de) 1999-07-22 2000-07-07 Indolderivate und deren verwendung als 5ht2a liganden

Publications (1)

Publication Number Publication Date
BR0012575A true BR0012575A (pt) 2002-04-16

Family

ID=7915701

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012575-0A BR0012575A (pt) 1999-07-22 2000-07-07 Derivados de indol

Country Status (26)

Country Link
US (1) US6723725B1 (pt)
EP (1) EP1228041B1 (pt)
JP (1) JP2003505457A (pt)
KR (1) KR100756506B1 (pt)
CN (1) CN1198801C (pt)
AR (1) AR024818A1 (pt)
AT (1) ATE252079T1 (pt)
AU (1) AU761166B2 (pt)
BR (1) BR0012575A (pt)
CA (1) CA2383769C (pt)
CZ (1) CZ200220A3 (pt)
DE (2) DE19934432A1 (pt)
DK (1) DK1228041T3 (pt)
ES (1) ES2204673T3 (pt)
HK (1) HK1049161B (pt)
HU (1) HUP0202479A3 (pt)
MX (1) MXPA02000731A (pt)
MY (1) MY123686A (pt)
NO (1) NO322152B1 (pt)
PL (1) PL197847B1 (pt)
PT (1) PT1228041E (pt)
RU (1) RU2256659C2 (pt)
SK (1) SK285893B6 (pt)
UA (1) UA73312C2 (pt)
WO (1) WO2001007434A2 (pt)
ZA (1) ZA200201483B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
DE10157673A1 (de) * 2001-11-24 2003-06-05 Merck Patent Gmbh Verwendung von N-(Indolcarbonyl-)piperazinderivaten
GB0203811D0 (en) * 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
WO2003099265A2 (de) * 2002-05-24 2003-12-04 Coester Carl-Fr Pharmazeutische wirkstoffkombination sowie deren verwendung
EP1613972A1 (en) * 2003-04-17 2006-01-11 Hydrogenics Corporation Alarm recovery system and method for fuel cell testing systems
ATE455755T1 (de) * 2004-12-21 2010-02-15 Hoffmann La Roche Tetralin- und indanderivate und deren anwendungen
US7994331B2 (en) * 2005-07-13 2011-08-09 Msd K.K. Heterocycle-substituted benzimidazole derivative
FR2941947B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique
EP3091984B1 (en) * 2014-01-09 2020-04-22 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Substituted benzoxazine and related compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1280421C (en) 1985-07-02 1991-02-19 Albert A. Carr 1,4-disubstituted piperidinyl derivatives
US5032598A (en) 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US6004980A (en) 1990-06-01 1999-12-21 Merrell Pharmaceuticals, Inc. (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
US5330986A (en) * 1992-11-24 1994-07-19 Hoechst-Roussel Pharmaceuticals Inc. Indole-7-carboxamide derivatives
RU2124511C1 (ru) 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
US5618824A (en) 1994-03-09 1997-04-08 Merrell Pharmaceuticals Inc. Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
GB9718712D0 (en) * 1997-09-03 1997-11-12 Merck Sharp & Dohme Theraputic Agents
TWI249526B (en) 1998-03-13 2006-02-21 Aventis Pharma Inc Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate

Also Published As

Publication number Publication date
CZ200220A3 (cs) 2002-04-17
ES2204673T3 (es) 2004-05-01
KR100756506B1 (ko) 2007-09-10
NO20020306L (no) 2002-03-21
SK202002A3 (en) 2002-04-04
PL197847B1 (pl) 2008-05-30
ZA200201483B (en) 2003-07-30
HK1049161A1 (en) 2003-05-02
UA73312C2 (en) 2005-07-15
MY123686A (en) 2006-05-31
DK1228041T3 (da) 2004-01-19
DE50004104D1 (de) 2003-11-20
HK1049161B (zh) 2005-10-14
DE19934432A1 (de) 2001-02-01
JP2003505457A (ja) 2003-02-12
KR20020025179A (ko) 2002-04-03
US6723725B1 (en) 2004-04-20
RU2256659C2 (ru) 2005-07-20
CA2383769A1 (en) 2001-02-01
AR024818A1 (es) 2002-10-23
CN1198801C (zh) 2005-04-27
NO20020306D0 (no) 2002-01-21
HUP0202479A3 (en) 2003-12-29
NO322152B1 (no) 2006-08-21
CN1372545A (zh) 2002-10-02
EP1228041B1 (de) 2003-10-15
PT1228041E (pt) 2004-02-27
AU6690100A (en) 2001-02-13
EP1228041A2 (de) 2002-08-07
WO2001007434A3 (de) 2002-05-16
ATE252079T1 (de) 2003-11-15
AU761166B2 (en) 2003-05-29
WO2001007434A2 (de) 2001-02-01
PL354971A1 (en) 2004-03-22
CA2383769C (en) 2010-01-05
HUP0202479A2 (hu) 2002-11-28
SK285893B6 (sk) 2007-10-04
MXPA02000731A (es) 2002-08-12

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07D 403/00

Ipc: C07D 403/00 (2010.01), A61K 31/404 (2010.01), A61K

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13 E 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.