BR0003105A - Compostos de beta-carbolina, processo para sua preparação e composições farmacêuticas contendo os mesmos - Google Patents

Compostos de beta-carbolina, processo para sua preparação e composições farmacêuticas contendo os mesmos

Info

Publication number
BR0003105A
BR0003105A BR0003105-4A BR0003105A BR0003105A BR 0003105 A BR0003105 A BR 0003105A BR 0003105 A BR0003105 A BR 0003105A BR 0003105 A BR0003105 A BR 0003105A
Authority
BR
Brazil
Prior art keywords
group
same
beta
preparation
pharmaceutical compositions
Prior art date
Application number
BR0003105-4A
Other languages
English (en)
Inventor
Solo Goldstein
Jean Boutin
Guillaume Poissonnet
Jean-Gilles Parmentier
Jean-Daniel Brion
Mark Millan
Anne Dekeyne
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of BR0003105A publication Critical patent/BR0003105A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS DE BETA-CARBOLINA, PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS"<D>. Compostos de fórmula (I): onde: <sym>representa uma ligação simples ou dupla, R~ 1~ representa um átomo de hidrogênio, um grupo alquila, um grupo -R~ 6~-arila, um grupo -R~ 6~-cicloalquila, um -R~ 6~-heterociclo, -CO~ 2~R~ 7~-, -COR~ 8~ ou -CONHR~ 8~ onde R~ 6~, R~ 7~ e R~ 8~ são como definidos no relatório descritivo, R~ 2~ representa um grupo ciano, um grupo mono ou dialquilaminoalquilaminocarbonila, ou -CO~ 2~R~ 8~, -CONHR~ 8~, -NR~ 8~R~ 9~, -NHCO~ 2~R~ 7~ ou -COR~ 8~ onde R~ 7~, R~ 8~ e R~ 9~ são como definidos no relatório descritivo, R~ 3~ e R~ 4~ juntos formam um grupo (C~ 3~-C~ 10~) cicloalquila, R~ 5~ representa um átomo de hidrogênio ou um grupo alquila ou arilalquila, Ra, Rb, Rc, Rd, que podem ser iguais ou diferentes, representam um grupo como definido no relatório descritivo, seus isómeros, e sais de adição dos mesmos com um ácido ou base farmaceuticamente aceitável. Medicamentos.
BR0003105-4A 1999-07-23 2000-07-24 Compostos de beta-carbolina, processo para sua preparação e composições farmacêuticas contendo os mesmos BR0003105A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9909576A FR2796644B1 (fr) 1999-07-23 1999-07-23 Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR0003105A true BR0003105A (pt) 2001-03-13

Family

ID=9548447

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0003105-4A BR0003105A (pt) 1999-07-23 2000-07-24 Compostos de beta-carbolina, processo para sua preparação e composições farmacêuticas contendo os mesmos

Country Status (16)

Country Link
US (1) US6350757B1 (pt)
EP (1) EP1070716A1 (pt)
JP (1) JP2001072679A (pt)
KR (1) KR20010049859A (pt)
CN (1) CN1282743A (pt)
AU (1) AU762958B2 (pt)
BR (1) BR0003105A (pt)
CA (1) CA2314473A1 (pt)
EA (1) EA004140B1 (pt)
FR (1) FR2796644B1 (pt)
HU (1) HUP0002843A3 (pt)
MX (1) MXPA00007058A (pt)
NO (1) NO20003764L (pt)
NZ (1) NZ505903A (pt)
PL (1) PL341549A1 (pt)
ZA (1) ZA200003702B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74826C2 (en) * 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US20040253891A1 (en) * 2000-09-12 2004-12-16 Schierenbeck Alan W. Composite structure for protective garment
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
CA2524125A1 (en) * 2003-04-29 2004-11-11 Oscient Pharmaceuticals Antibiotic tetrahydro-.beta.-carboline derivatives
WO2004113300A1 (ja) * 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. 新規三環性複素環化合物
US20050143371A1 (en) * 2003-07-23 2005-06-30 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
CA2554150A1 (en) 2004-01-23 2005-08-04 Chiron Corporation Tetrahydrocarboline compounds as anticancer agents
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
PL1737461T3 (pl) 2004-03-15 2013-05-31 Ptc Therapeutics Inc Pochodne karbolinowe użyteczne w hamowaniu angiogenezy
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
WO2006068164A1 (ja) 2004-12-22 2006-06-29 Ono Pharmaceutical Co., Ltd. 三環式化合物およびその用途
FR2901795A1 (fr) * 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
FR2908768A1 (fr) * 2006-06-19 2008-05-23 Fourtillan Snc DERIVES DE 3H,11H-OXAZOLO (3',4':1,2)PYRIDO(3,4-b)INDOLE ET LEUR UTILISATION EN THERAPEUTIQUE
FR2912405A1 (fr) * 2007-02-08 2008-08-15 Fourtillan Snc Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique
JP2010540439A (ja) * 2007-09-20 2010-12-24 ディー２イー，エルエルシー 神経保護性の及び認知を向上させる性質を備えた水素化されたピリド［４，３−ｂ］インドール類のフッ素を含有する誘導体、調製するための工程、並びに使用
JP2011505373A (ja) * 2007-11-30 2011-02-24 ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド 抗菌剤としての２環式ｐｐａｔ阻害剤
PL2262505T3 (pl) * 2008-03-12 2015-04-30 Intra Cellular Therapies Inc Podstawione heterocykliczne skondensowane gamma-karboliny w postaci stałej
PE20091717A1 (es) 2008-03-24 2009-11-25 Medivation Technologies Inc Pirido[3,4-b] indoles como moduladores de receptores de histamina
DE102008025893B4 (de) * 2008-05-26 2014-09-18 Technische Universität Dresden Verfahren zur Herstellung von Fettsäureamiden mit gesättigten, ungesättigten oder Hydroxy-Fettsäuren
BR112012006646A2 (pt) * 2009-09-23 2019-09-24 Medivation Technologies Inc composto, composição farmacêutica, método de tratamento de um distùrbio cognitivo, distúrbio psicótico, distúrbio mediado por neurotransmissor ou um distúrbio neuronal e kit
CN102711467A (zh) * 2009-09-23 2012-10-03 梅迪维新技术公司 吡啶并[3,4-b]吲哚类及使用方法
BR112013021126A2 (pt) 2011-02-18 2019-09-24 Medivation Technologies Inc método para reduzir a pressão sanguínea, método para aumentar o fluxo sanguíneo renal ou diminuir a reabsorção de sódio, método para tratar uma doença, kit, composto e composição farmacêutica
ES2587856T3 (es) 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina
KR101534523B1 (ko) * 2013-04-30 2015-07-09 경희대학교 산학협력단 1,2,3,4-테트라히드로-6-메톡시-1-옥소-베타-카르볼린을 포함하는 피부 미백용 화장료 조성물
EP3004090B1 (en) * 2013-05-28 2017-10-25 Astrazeneca AB Chemical compounds
WO2020072675A1 (en) * 2018-10-02 2020-04-09 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c)
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
FR2455044A1 (fr) * 1979-04-26 1980-11-21 Synthelabo Pyrido-indoles et leur application en therapeutique
JP2527319B2 (ja) * 1986-12-25 1996-08-21 川研ファインケミカル株式会社 ７―ブロモ―β―カルボリン誘導体の製造方法
US5300645A (en) * 1993-04-14 1994-04-05 Eli Lilly And Company Tetrahydro-pyrido-indole
EP0620222A3 (en) * 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
US5663178A (en) * 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines
US5688807A (en) * 1994-03-11 1997-11-18 Eli Lilly And Company Method for treating 5HT2B receptor related conditions

Also Published As

Publication number Publication date
MXPA00007058A (es) 2002-04-24
EA004140B1 (ru) 2004-02-26
CA2314473A1 (fr) 2001-01-23
NO20003764L (no) 2001-01-24
FR2796644A1 (fr) 2001-01-26
NZ505903A (en) 2001-08-31
PL341549A1 (en) 2001-01-29
FR2796644B1 (fr) 2001-09-07
US6350757B1 (en) 2002-02-26
JP2001072679A (ja) 2001-03-21
KR20010049859A (ko) 2001-06-15
HUP0002843A3 (en) 2001-07-30
EP1070716A1 (fr) 2001-01-24
CN1282743A (zh) 2001-02-07
AU4876900A (en) 2001-01-25
HUP0002843A2 (hu) 2001-04-28
ZA200003702B (en) 2001-05-21
EA200000700A3 (ru) 2001-04-23
HU0002843D0 (en) 2000-09-28
NO20003764D0 (no) 2000-07-21
EA200000700A2 (ru) 2001-02-26
AU762958B2 (en) 2003-07-10

Similar Documents

Publication Publication Date Title
BR0003105A (pt) Compostos de beta-carbolina, processo para sua preparação e composições farmacêuticas contendo os mesmos
ATE469136T1 (de) Inhibitoren von 11-beta- hydroxysteroiddehydrogenase typ 1
BR0214344A (pt) Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1
ES2185307T3 (es) Inhibidores de la farnesil transferasa que tienen una estructura piperidinica y procedimiento para su preparacion.
BRPI0507830A (pt) derivados azabicìclicos, o respectivo processo de preparo e as composições farmacêuticas que os contêm
HN2003000184A (es) Preparaciones acidas de insulina con estabilidad mejorada
BRPI0408240A (pt) composto, utilização de um composto e composição farmacêutica
AR027360A1 (es) Composicion farmaceutica
SE9904421D0 (sv) New compounds
NO20055601L (no) Farmasoytisk preparat i form av en hydrogel for transdermal administrasjon av aktive virkestoffer
BR0308765A (pt) Compostos (4,2-dissubstituìdo-tiazol-5-il)amina como inibidores de pde7
BR0100234A (pt) Compostos de piperidina-4-sulfonamida, processo para a sua preparação e composições farmacêuticas contendo os mesmos
BR9916669A (pt) Uso de derivados de ácidos 4-biarilbutìricos e 5-biarilpentanóicos substituìdos como inibidores de metaloproteases de matriz para o tratamento de doenças respiratórias
AR037521A1 (es) Derivados de piperazina que tienen actividad antagonista del sst1, un proceso para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento para el tratamiento de la depresion, ansiedad y padecimientos bipolares y una combinacion
BRPI0411308A8 (pt) Composto, composição farmacêutica, processo para a preparação de um composto, e, uso de um composto
BR0013582A (pt) Agonistas retinóides seletivos para rar
BR0308807A (pt) Compostos tiazol-2-il-imina como inibidores de pde-7
BR0106248A (pt) Inibidores de metaloprotease, processo para a sua preparação e composições farmacêuticas contendo os mesmos
BR0005557A (pt) Compostos diidrofuro[3,4-b] quinolin-1-ona, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos
BR0300698A (pt) Compostos derivados de quinazolina, um processo para sua preparação e composições farmacêuticas contendo-os
BR0202681A (pt) Compostos de octaidro-2h-pirido[1,2a]pirazina, um processo para sua preparação e composições farmacêuticas contendo-as
BR9804485A (pt) Compostos de indanol, processo para sua preparação e composições farmacêuticas contendo os mesmos.
ATE214051T1 (de) Substituierte tetrahydropyridinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
BR9800763A (pt) Novos compostos 2-amino indano, um processo para sua preparação e composições farmacêuticas contendo os mesmos.
SE0101978D0 (sv) New compounds

Legal Events

Date Code Title Description
PC Transfer

Free format text: LES LABORATOIRES SERVIER (FR)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.