EA200000700A2 - НОВЫЕ β- КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИХ - Google Patents

НОВЫЕ β- КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИХ

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Publication number
EA200000700A2
EA200000700A2 EA200000700A EA200000700A EA200000700A2 EA 200000700 A2 EA200000700 A2 EA 200000700A2 EA 200000700 A EA200000700 A EA 200000700A EA 200000700 A EA200000700 A EA 200000700A EA 200000700 A2 EA200000700 A2 EA 200000700A2
Authority
EA
Eurasian Patent Office
Prior art keywords
group
cor
beta
preparation
pharmaceutical compositions
Prior art date
Application number
EA200000700A
Other languages
English (en)
Other versions
EA200000700A3 (ru
EA004140B1 (ru
Inventor
Соло Гольдстейн
Гийом Пуассонне
Жан-Жилль Парментье
Жан-Даниель Брион
Марк Миллан
Анн Декейн
Жан Бутэн
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200000700A2 publication Critical patent/EA200000700A2/ru
Publication of EA200000700A3 publication Critical patent/EA200000700A3/ru
Publication of EA004140B1 publication Critical patent/EA004140B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Соединения формулы (I)в которойпредставляет простую или двойную связь,Rпредставляет атом водорода, алкильную группу, -R-арильную группу, -R-циклоалкильную группу, -R-гетероцикл, -COR, -CORили -CONHR, где R, Rи Rопределены в описании изобретения;Rпредставляет цианогруппу, моно- или диалкиламино-алкиламинокарбонильную группу, или -COR, -CONHR, -NRR, -NHCORили -COR, где R, Rи Rопределены в описании изобретения,Rи R, взятые вместе, образуют (C-C)циклоалкильную группу,Rпредставляет атом водорода, или алкильную группу, или арилалкильную группу,каждый из Ra, Rb, Rc и Rd, которые могут быть одинаковыми или различными, независимо представляет группу, определенную в описании изобретения,их изомеры, а также их аддитивные соли с фармацевтически приемлемой кислотой или фармацевтически приемлемым основанием. Лекарственные препараты.
EA200000700A 1999-07-23 2000-07-21 β-КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ИХ СОДЕРЖАЩАЯ EA004140B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9909576A FR2796644B1 (fr) 1999-07-23 1999-07-23 Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200000700A2 true EA200000700A2 (ru) 2001-02-26
EA200000700A3 EA200000700A3 (ru) 2001-04-23
EA004140B1 EA004140B1 (ru) 2004-02-26

Family

ID=9548447

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000700A EA004140B1 (ru) 1999-07-23 2000-07-21 β-КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ИХ СОДЕРЖАЩАЯ

Country Status (16)

Country Link
US (1) US6350757B1 (ru)
EP (1) EP1070716A1 (ru)
JP (1) JP2001072679A (ru)
KR (1) KR20010049859A (ru)
CN (1) CN1282743A (ru)
AU (1) AU762958B2 (ru)
BR (1) BR0003105A (ru)
CA (1) CA2314473A1 (ru)
EA (1) EA004140B1 (ru)
FR (1) FR2796644B1 (ru)
HU (1) HUP0002843A3 (ru)
MX (1) MXPA00007058A (ru)
NO (1) NO20003764L (ru)
NZ (1) NZ505903A (ru)
PL (1) PL341549A1 (ru)
ZA (1) ZA200003702B (ru)

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UA74826C2 (en) * 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US20040253891A1 (en) * 2000-09-12 2004-12-16 Schierenbeck Alan W. Composite structure for protective garment
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
WO2004096802A2 (en) * 2003-04-29 2004-11-11 Oscient Pharmaceuticals ANTIBIOTIC TETRAHYDRO-β-CARBOLINE DERIVATIVES
EP1637521B1 (en) * 2003-06-23 2013-06-19 Ono Pharmaceutical Co., Ltd. Novel tricyclic heterocycle compound
US20050137220A1 (en) * 2003-07-23 2005-06-23 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
CA2554150A1 (en) 2004-01-23 2005-08-04 Chiron Corporation Tetrahydrocarboline compounds as anticancer agents
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
DK1737461T3 (da) 2004-03-15 2013-03-18 Ptc Therapeutics Inc Carbolin-derivater til inhibering af angiogenese
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
DK1829874T3 (da) 2004-12-22 2014-05-12 Ono Pharmaceutical Co Tricyklisk forbindelse og anvendelse deraf
FR2901795A1 (fr) * 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
FR2908768A1 (fr) * 2006-06-19 2008-05-23 Fourtillan Snc DERIVES DE 3H,11H-OXAZOLO (3',4':1,2)PYRIDO(3,4-b)INDOLE ET LEUR UTILISATION EN THERAPEUTIQUE
FR2912405A1 (fr) * 2007-02-08 2008-08-15 Fourtillan Snc Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique
JP2010540439A (ja) * 2007-09-20 2010-12-24 ディー２イー，エルエルシー 神経保護性の及び認知を向上させる性質を備えた水素化されたピリド［４，３−ｂ］インドール類のフッ素を含有する誘導体、調製するための工程、並びに使用
EP2225250A2 (en) * 2007-11-30 2010-09-08 Biota Scientific Management Pty Ltd Bicyclic ppat inhibitors as antibacterial agents
MX347257B (es) * 2008-03-12 2017-04-20 Intra-Cellular Therapies Inc Solido de gamma-carbolinas fusionadas con heterociclos substituidos.
CA2719412A1 (en) 2008-03-24 2009-10-01 Medivation Technologies, Inc. Pyrido[3,4-b]indoles and methods of use
DE102008025893B4 (de) * 2008-05-26 2014-09-18 Technische Universität Dresden Verfahren zur Herstellung von Fettsäureamiden mit gesättigten, ungesättigten oder Hydroxy-Fettsäuren
EP2480080A4 (en) * 2009-09-23 2014-01-08 Medivation Technologies Inc PYRIDO [3,4-B] INDOLES AND METHODS OF USE
CN102711467A (zh) * 2009-09-23 2012-10-03 梅迪维新技术公司 吡啶并[3,4-b]吲哚类及使用方法
WO2012112966A1 (en) 2011-02-18 2012-08-23 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
KR101534523B1 (ko) * 2013-04-30 2015-07-09 경희대학교 산학협력단 1,2,3,4-테트라히드로-6-메톡시-1-옥소-베타-카르볼린을 포함하는 피부 미백용 화장료 조성물
PL3004090T3 (pl) * 2013-05-28 2018-02-28 Astrazeneca Ab Związki chemiczne
EP3860996A4 (en) 2018-10-02 2022-08-31 Northwestern University BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers

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AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
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US5663178A (en) * 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines

Also Published As

Publication number Publication date
US6350757B1 (en) 2002-02-26
AU762958B2 (en) 2003-07-10
HUP0002843A2 (hu) 2001-04-28
NO20003764D0 (no) 2000-07-21
KR20010049859A (ko) 2001-06-15
NZ505903A (en) 2001-08-31
ZA200003702B (en) 2001-05-21
JP2001072679A (ja) 2001-03-21
BR0003105A (pt) 2001-03-13
AU4876900A (en) 2001-01-25
FR2796644B1 (fr) 2001-09-07
EP1070716A1 (fr) 2001-01-24
PL341549A1 (en) 2001-01-29
EA200000700A3 (ru) 2001-04-23
EA004140B1 (ru) 2004-02-26
FR2796644A1 (fr) 2001-01-26
CN1282743A (zh) 2001-02-07
HU0002843D0 (en) 2000-09-28
MXPA00007058A (es) 2002-04-24
NO20003764L (no) 2001-01-24
HUP0002843A3 (en) 2001-07-30
CA2314473A1 (fr) 2001-01-23

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