BR0300698A - Compostos derivados de quinazolina, um processo para sua preparação e composições farmacêuticas contendo-os - Google Patents

Compostos derivados de quinazolina, um processo para sua preparação e composições farmacêuticas contendo-os

Info

Publication number
BR0300698A
BR0300698A BR0300698-0A BR0300698A BR0300698A BR 0300698 A BR0300698 A BR 0300698A BR 0300698 A BR0300698 A BR 0300698A BR 0300698 A BR0300698 A BR 0300698A
Authority
BR
Brazil
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
quinazoline derivatives
quinazoline
Prior art date
Application number
BR0300698-0A
Other languages
English (en)
Inventor
Solo Goldstein
Alain Dhainaut
Andre Tizot
Jean-Luc Fauchere
Nathalie Kucharczyk
John Hickman
Alain Pierre
Gordon Tucker
Laurence Kraus-Berthier
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0300698A publication Critical patent/BR0300698A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS DERIVADOS DE QUINAZOLINA, UM PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO-OS". Compostos de fórmula (I): na qual: A, B, D, X, R^ 1^, R^ 2^, m e n são como definidos na descrição, seus diastereoisómeros e sais de adição destes com um ácido ou base farmaceuticamente aceitável. Medicamentos.
BR0300698-0A 2002-03-18 2003-03-18 Compostos derivados de quinazolina, um processo para sua preparação e composições farmacêuticas contendo-os BR0300698A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0203299A FR2837201A1 (fr) 2002-03-18 2002-03-18 Nouveaux composes derives de la quinazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR0300698A true BR0300698A (pt) 2004-09-08

Family

ID=8871501

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0300698-0A BR0300698A (pt) 2002-03-18 2003-03-18 Compostos derivados de quinazolina, um processo para sua preparação e composições farmacêuticas contendo-os

Country Status (16)

Country Link
US (1) US20030199530A1 (pt)
EP (1) EP1346992A1 (pt)
JP (1) JP2003292491A (pt)
KR (1) KR20030076350A (pt)
CN (1) CN1445226A (pt)
AR (1) AR038988A1 (pt)
AU (1) AU2003201326A1 (pt)
BR (1) BR0300698A (pt)
CA (1) CA2423259A1 (pt)
EA (1) EA200300272A1 (pt)
FR (1) FR2837201A1 (pt)
MX (1) MXPA03002088A (pt)
NO (1) NO20031219L (pt)
NZ (1) NZ524771A (pt)
PL (1) PL359208A1 (pt)
ZA (1) ZA200302159B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1741709A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
US7834023B2 (en) * 2006-09-20 2010-11-16 Portola Pharmaceuticals, Inc. Substituted dihydroquinazolines as platelet ADP receptor inhibitors
ME02829B (me) * 2006-09-26 2018-01-20 Celgene Corp 5-supstituirani derivati kinazolinona kao sredstva protiv raka
JP5634263B2 (ja) * 2007-08-16 2014-12-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング キナゾリンジオンキマーゼ阻害剤
CN103288761B (zh) * 2012-02-25 2017-08-11 浙江华海药业股份有限公司 一种合成1，2，3，4‑喹唑啉‑2，4‑二酮衍生物的新方法
CN102993105B (zh) * 2012-12-19 2014-06-11 西南大学 1-甲基-2,4-喹唑啉二酮衍生物及其制备方法和应用
TW201623257A (zh) * 2014-05-09 2016-07-01 奧利安公司 藥理活性之喹唑啉二酮衍生物
JP6625541B2 (ja) * 2014-08-29 2019-12-25 東京応化工業株式会社 イミダゾール化合物、金属表面処理液、金属の表面処理方法、及び積層体の製造方法
WO2023158845A1 (en) * 2022-02-18 2023-08-24 Musc Foundation For Researchdevelopment Small molecules targeting the vdac nadh-binding pocket to modulate cancer metabolism
WO2024091450A1 (en) * 2022-10-24 2024-05-02 The Regents Of The University Of California Compounds and methods for treating cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293500A1 (en) * 1987-06-01 1988-12-07 American Cyanamid Company 3-heteroalkyl-2,4.quinzaoline-diones
DE69838025T2 (de) * 1997-04-25 2008-05-08 Janssen Pharmaceutica N.V. Chinazolinone die farnesyltransferase hemmen

Also Published As

Publication number Publication date
CN1445226A (zh) 2003-10-01
CA2423259A1 (fr) 2003-09-18
AU2003201326A1 (en) 2003-10-02
AR038988A1 (es) 2005-02-02
FR2837201A1 (fr) 2003-09-19
NZ524771A (en) 2003-08-29
MXPA03002088A (es) 2004-12-07
US20030199530A1 (en) 2003-10-23
ZA200302159B (en) 2003-09-23
JP2003292491A (ja) 2003-10-15
KR20030076350A (ko) 2003-09-26
PL359208A1 (en) 2003-09-22
NO20031219D0 (no) 2003-03-17
EP1346992A1 (fr) 2003-09-24
NO20031219L (no) 2003-09-19
EA200300272A1 (ru) 2003-10-30

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Legal Events

Date Code Title Description
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]