BR0005557A - Compostos diidrofuro[3,4-b] quinolin-1-ona, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos - Google Patents
Compostos diidrofuro[3,4-b] quinolin-1-ona, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmosInfo
- Publication number
- BR0005557A BR0005557A BR0005557-3A BR0005557A BR0005557A BR 0005557 A BR0005557 A BR 0005557A BR 0005557 A BR0005557 A BR 0005557A BR 0005557 A BR0005557 A BR 0005557A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- optionally substituted
- aryl
- same
- alkyl group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção: <B>"COMPOSTOS DIIDROFURO[3,4-B] QUINOLIN-1-ONA, PROCESSO PARA A PREPARAçãO DOS MESMOS E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS"<D>. Composto de fórmula (I): onde: <sym> representa uma ligação simples ou dupla, - R~ 0~ representa um átomo de hidrogênio, um grupo hidróxi ou um grupo (C~ 1-6~) alcóxi linear ou ramificado, - R~ 1~ e R~ 2~, que são idênticos ou diferentes, cada um representa um átomo de hidrogênio, ou um átomo de halogênio ou um grupo alquila, alcóxi, hidróxi, polihaloalquila, nitro ou amino opcionalmente substituído ou um grupo onde m representa um número inteiro de modo que 1 <243> m <243> 4, ou formam junto com os átomos de carbono carreando-os um grupo aromático ou não-aromático, mono- ou bicíclico tendo de 5 a 12 membros de anel e opcionalmente contendo 1 ou 2 heteroátomos selecionados de O, S e N, - R~ 3~ representa um átomo de hidrogênio, ou um grupo arila, heteroarila, cicloalquila, alquila opcionalmente substituído ou um grupo de fórmula COR~ 7~ onde R~ 7~ representa um grupo arila, um grupo alquila opcionalmente substituído, um grupo amino opcionalmente substituído ou OR~ 10~ onde R~ 10~ representa um grupo arila ou alquila opcionalmente substituído, - X representa um átomo de oxigênio ou enxofre ou um grupo -CH~ 2~ ou -CH~ 2~-CH~ 2~, - Ar representa um grupo arila, heteroarila ou aril alquila, seus isómeros óticos, seus hidratos, solvatos, e também seus sais de adição com um ácido farmaceuticamente aceitável. Medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9914771A FR2801310B1 (fr) | 1999-11-24 | 1999-11-24 | NOUVEAUX DERIVES DE DIHYDROFURO-[3,4-b]QUINOLEIN-1-ONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0005557A true BR0005557A (pt) | 2001-07-17 |
Family
ID=9552476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0005557-3A BR0005557A (pt) | 1999-11-24 | 2000-11-24 | Compostos diidrofuro[3,4-b] quinolin-1-ona, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6548515B1 (pt) |
| EP (1) | EP1103554B9 (pt) |
| JP (1) | JP3566649B2 (pt) |
| KR (1) | KR100433705B1 (pt) |
| CN (1) | CN1157394C (pt) |
| AT (1) | ATE234305T1 (pt) |
| AU (1) | AU781300B2 (pt) |
| BR (1) | BR0005557A (pt) |
| CA (1) | CA2326710C (pt) |
| DE (1) | DE60001622T2 (pt) |
| DK (1) | DK1103554T5 (pt) |
| EA (1) | EA003996B1 (pt) |
| ES (1) | ES2194692T3 (pt) |
| FR (1) | FR2801310B1 (pt) |
| HK (1) | HK1036983A1 (pt) |
| HU (1) | HUP0004704A3 (pt) |
| MX (1) | MXPA00011240A (pt) |
| NO (1) | NO20005922L (pt) |
| NZ (1) | NZ508390A (pt) |
| PL (1) | PL344100A1 (pt) |
| SI (1) | SI1103554T1 (pt) |
| ZA (1) | ZA200006912B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2825091B1 (fr) * | 2001-05-23 | 2003-07-04 | Servier Lab | Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2825092B1 (fr) * | 2001-05-23 | 2005-01-14 | Servier Lab | Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN100376582C (zh) * | 2006-04-26 | 2008-03-26 | 浙江大学 | 一种六氢呋喃[3,2-c]喹啉衍生物的制备方法 |
| CN101092420B (zh) * | 2006-06-23 | 2010-08-25 | 北京师范大学 | (1z,4e,5z)-6-n-异丙基-6-氮杂-2-氧代-3-氧杂-4-甲氧基-双环[3.1.0]己烷及其制备方法和用途 |
| CN101092419B (zh) * | 2006-06-23 | 2010-05-12 | 北京师范大学 | (1z,4z,5z)-6-n-烷基-6-氮杂-2-氧代-3-氧杂-4-甲氧基-双环[3.1.0]己烷及其制备方法和用途 |
| WO2012076942A1 (en) * | 2010-12-06 | 2012-06-14 | Council Of Scientific & Industrial Research | 4-aza-2, 3-didehydropodophyllotoxin compounds and process for the preparation thereof |
| AU2015205995A1 (en) | 2014-01-15 | 2016-07-28 | Centre National De La Recherche Scientifique (Cnrs) | Water soluble 4-azapodophyllotoxin analogs |
| WO2017151947A1 (en) * | 2016-03-02 | 2017-09-08 | George Robert Pettit | 4-azapodophylotoxins compounds |
| CN110256457A (zh) * | 2019-06-21 | 2019-09-20 | 江苏师范大学 | 一种4,7-二氢噻吩并[3,4-b]吡啶-5(1H)-酮化合物的合成方法 |
| CN110684033B (zh) * | 2019-09-06 | 2021-05-11 | 广西师范大学 | 四氢呋喃二喹啉化合物及其合成方法和应用 |
| CN114989180B (zh) * | 2022-05-26 | 2024-06-04 | 广东海洋大学 | 杨叶肖槿内生真菌来源的化合物及其制备方法与应用 |
| US11731980B1 (en) | 2023-03-22 | 2023-08-22 | King Faisal University | Furo[3,4-b]quinolone compounds as antibacterial agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2310746A1 (de) * | 1973-03-03 | 1974-09-12 | Bayer Ag | Verfahren zur herstellung von neuen 1,4-dihydrochinolinen sowie ihre verwendung als arzneimittel |
| IT1228293B (it) * | 1989-02-06 | 1991-06-07 | Angeli Inst Spa | Benzoderivati di composti eterociclici contenenti azoto. |
| ATE161530T1 (de) * | 1992-09-04 | 1998-01-15 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische verbindungen, deren herstellung und verwendung |
| DE69422450T2 (de) * | 1993-06-29 | 2000-06-08 | Takeda Chemical Industries Ltd | Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose |
| AU8414098A (en) * | 1997-08-19 | 1999-03-08 | Emory University | Noscapine derivatives, useful as anticancer agents |
-
1999
- 1999-11-24 FR FR9914771A patent/FR2801310B1/fr not_active Expired - Fee Related
-
2000
- 2000-11-15 MX MXPA00011240A patent/MXPA00011240A/es active IP Right Grant
- 2000-11-22 AT AT00403255T patent/ATE234305T1/de not_active IP Right Cessation
- 2000-11-22 SI SI200030061T patent/SI1103554T1/xx unknown
- 2000-11-22 JP JP2000355438A patent/JP3566649B2/ja not_active Expired - Fee Related
- 2000-11-22 ES ES00403255T patent/ES2194692T3/es not_active Expired - Lifetime
- 2000-11-22 DE DE60001622T patent/DE60001622T2/de not_active Expired - Fee Related
- 2000-11-22 EP EP00403255A patent/EP1103554B9/fr not_active Expired - Lifetime
- 2000-11-22 DK DK00403255T patent/DK1103554T5/da active
- 2000-11-22 US US09/718,917 patent/US6548515B1/en not_active Expired - Fee Related
- 2000-11-23 NZ NZ508390A patent/NZ508390A/xx unknown
- 2000-11-23 EA EA200001101A patent/EA003996B1/ru not_active IP Right Cessation
- 2000-11-23 HU HU0004704A patent/HUP0004704A3/hu unknown
- 2000-11-23 NO NO20005922A patent/NO20005922L/no not_active Application Discontinuation
- 2000-11-24 CN CNB001283189A patent/CN1157394C/zh not_active Expired - Fee Related
- 2000-11-24 ZA ZA200006912A patent/ZA200006912B/xx unknown
- 2000-11-24 PL PL00344100A patent/PL344100A1/xx not_active Application Discontinuation
- 2000-11-24 AU AU71825/00A patent/AU781300B2/en not_active Ceased
- 2000-11-24 KR KR10-2000-0070290A patent/KR100433705B1/ko not_active IP Right Cessation
- 2000-11-24 CA CA002326710A patent/CA2326710C/fr not_active Expired - Fee Related
- 2000-11-24 BR BR0005557-3A patent/BR0005557A/pt not_active IP Right Cessation
-
2001
- 2001-11-08 HK HK01107838A patent/HK1036983A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer |
Free format text: LES LABORATOIRES SERVIER (FR) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009. |