BG93508A - Производни на пиримидина - Google Patents
Производни на пиримидинаInfo
- Publication number
- BG93508A BG93508A BG093508A BG9350890A BG93508A BG 93508 A BG93508 A BG 93508A BG 093508 A BG093508 A BG 093508A BG 9350890 A BG9350890 A BG 9350890A BG 93508 A BG93508 A BG 93508A
- Authority
- BG
- Bulgaria
- Prior art keywords
- pyrimidine derivatives
- pyrimidine
- derivatives
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898909054A GB8909054D0 (en) | 1989-04-21 | 1989-04-21 | Amino heterocycles |
| GB898910548A GB8910548D0 (en) | 1989-05-08 | 1989-05-08 | Heterocyclic compounds |
| PCT/GB1990/000595 WO1990012790A1 (en) | 1989-04-21 | 1990-04-19 | Pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG93508A true BG93508A (bg) | 1993-12-24 |
Family
ID=26295250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG093508A BG93508A (bg) | 1989-04-21 | 1990-12-21 | Производни на пиримидина |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5223505A (bg) |
| EP (1) | EP0422178B1 (bg) |
| JP (1) | JP2528218B2 (bg) |
| KR (1) | KR920700203A (bg) |
| CN (1) | CN1024793C (bg) |
| AT (1) | ATE112561T1 (bg) |
| AU (1) | AU635260B2 (bg) |
| BG (1) | BG93508A (bg) |
| CA (1) | CA2014457C (bg) |
| DE (1) | DE69013112T2 (bg) |
| DK (1) | DK0422178T3 (bg) |
| ES (1) | ES2064727T3 (bg) |
| FI (1) | FI95377C (bg) |
| GB (1) | GB2230527B (bg) |
| GR (1) | GR1000371B (bg) |
| HR (1) | HRP930793A2 (bg) |
| HU (1) | HU209586B (bg) |
| IE (1) | IE63502B1 (bg) |
| IL (1) | IL94062A (bg) |
| MW (1) | MW9090A1 (bg) |
| MY (1) | MY105637A (bg) |
| NO (1) | NO177054C (bg) |
| NZ (1) | NZ233292A (bg) |
| PL (2) | PL165502B1 (bg) |
| PT (1) | PT93823B (bg) |
| RU (1) | RU2108329C1 (bg) |
| SI (1) | SI9010799A (bg) |
| WO (1) | WO1990012790A1 (bg) |
| YU (1) | YU79990A (bg) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| GB9022644D0 (en) * | 1990-10-18 | 1990-11-28 | Ici Plc | Heterocyclic compounds |
| TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| US5952331A (en) * | 1996-05-23 | 1999-09-14 | Syntex (Usa) Inc. | Aryl pyrimidine derivatives |
| US5958934A (en) * | 1996-05-23 | 1999-09-28 | Syntex (U.S.A.) Inc. | Aryl pyrimidine derivatives and uses thereof |
| EA200000840A1 (ru) | 1998-02-17 | 2001-02-26 | Туларик, Инк. | Антивирусные производные пиримидина |
| DE69943247D1 (de) | 1998-03-27 | 2011-04-14 | Janssen Pharmaceutica Nv | HIV hemmende Pyrimidin Derivate |
| DE19851421A1 (de) * | 1998-11-07 | 2000-05-11 | Boehringer Ingelheim Pharma | Neue Pyrimidine, deren Herstellung und Verwendung |
| JP4919566B2 (ja) | 1999-09-24 | 2012-04-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗ウイルス組成物 |
| US6410726B1 (en) | 2000-01-12 | 2002-06-25 | Tularik Inc. | Arylsulfonic acid salts of pyrimidine-based antiviral |
| SK13752003A3 (en) * | 2001-05-14 | 2004-11-03 | Bristol Myers Squibb Pharma Co | Substituted pyrazinones, pyridines and pyrimidines as ligands of factor releasing corticotropine |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| ATE451104T1 (de) | 2002-07-29 | 2009-12-15 | Rigel Pharmaceuticals Inc | Verfahren zur behandlung oder pruvention von autoimmunkrankheiten mit 2,4-pyrimidindiamin- verbindungen |
| US7550590B2 (en) | 2003-03-25 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| CN1984660B (zh) * | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| PL1656372T3 (pl) | 2003-07-30 | 2013-08-30 | Rigel Pharmaceuticals Inc | Związki 2,4-pirymidynodiaminy do stosowania w leczeniu lub zapobieganiu chorobom autoimmunologicznym |
| ZA200602051B (en) | 2003-08-13 | 2007-10-31 | Takeda Pharmaceutical | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
| WO2005026148A1 (en) | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| CN102127053A (zh) | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| US7557207B2 (en) | 2004-11-24 | 2009-07-07 | Rigel Pharmaceuticals, Inc. | Spiro 2,4-pyrimidinediamine compounds and their uses |
| US7872124B2 (en) | 2004-12-21 | 2011-01-18 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| BRPI0606318B8 (pt) | 2005-01-19 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, composição, e, uso de um composto |
| JP2008540436A (ja) * | 2005-05-03 | 2008-11-20 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋキナーゼインヒビターおよびそれらの使用 |
| PL1888537T3 (pl) * | 2005-05-26 | 2014-02-28 | Janssen Sciences Ireland Uc | Sposób otrzymywania 4-[(1,6-dihydro-6-okso-2-pirymidynylo)amino benzonitrylu |
| DK1942898T4 (da) | 2005-09-14 | 2014-06-02 | Takeda Pharmaceutical | Dipeptidylpeptidase-inhibitorer til behandling af diabetes |
| KR101368988B1 (ko) | 2005-09-16 | 2014-02-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 디펩티딜 펩티다제 억제제 |
| WO2007089774A2 (en) * | 2006-01-31 | 2007-08-09 | Yale University | Compositions and methods for treating cognitive disorders |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US20080217501A1 (en) * | 2007-02-14 | 2008-09-11 | Chad Jensen | Power a-frame |
| CL2008000467A1 (es) * | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| TWI401023B (zh) * | 2008-02-06 | 2013-07-11 | Du Pont | 中離子農藥 |
| WO2012135697A2 (en) * | 2011-03-30 | 2012-10-04 | H. Lee Moffitt Cancer Center & Research Institute Inc. | Novel rho kinase inhibitors and methods of use |
| US10172856B2 (en) | 2017-04-06 | 2019-01-08 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives as histamine H4 modulators |
| US10793551B2 (en) | 2017-10-19 | 2020-10-06 | Effector Therapeutics Inc. | Benzimidazole-indole inhibitors of Mnk1 and Mnk2 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB815833A (en) * | 1956-09-26 | 1959-07-01 | Boots Pure Drug Co Ltd | Phenanthridine compounds |
| BE492034A (bg) * | 1948-11-05 | |||
| US2784124A (en) * | 1953-07-01 | 1957-03-05 | Howard R Moore | Method of coating ferrous metal surface and composition therefor |
| US2748124A (en) * | 1954-05-06 | 1956-05-29 | Searle & Co | 1-(4-anilino-2-pyrimidino)-3-alkylureas |
| US2845425A (en) * | 1956-10-04 | 1958-07-29 | Lilly Co Eli | Substituted aminopyrimidines |
| DE1241832B (de) * | 1963-02-23 | 1967-06-08 | Hoechst Ag | Verfahren zur Herstellung von Pyrimidiniumverbindungen |
| DE1445740A1 (de) * | 1963-09-04 | 1968-11-28 | Bayer Ag | Verfahren zur Herstellung von Bispyrimidinium-Verbindungen |
| GB1229413A (bg) * | 1967-06-14 | 1971-04-21 | ||
| IN142539B (bg) * | 1974-05-10 | 1977-07-23 | Ciba Geigy India Ltd | |
| US4339453A (en) * | 1979-07-23 | 1982-07-13 | Merck & Co., Inc. | Antimicrobial aminopyrimidinium salts |
| GR80171B (en) * | 1983-08-29 | 1985-01-02 | Ciba Geigy Ag | N-(2-nitrophenyl)-4-aminopyrimidine derivatives process for the preparation thereof and use |
| US4725600A (en) * | 1984-07-13 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent |
| DE3717480A1 (de) * | 1987-05-23 | 1988-12-01 | Shell Agrar Gmbh & Co Kg | Neue herbizid und mikrobizid wirksame 2,6-diaminopyrimidine |
| IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
-
1990
- 1990-04-06 IE IE125890A patent/IE63502B1/en not_active IP Right Cessation
- 1990-04-09 GB GB9007964A patent/GB2230527B/en not_active Expired - Fee Related
- 1990-04-11 NZ NZ233292A patent/NZ233292A/en unknown
- 1990-04-11 IL IL9406290A patent/IL94062A/en not_active IP Right Cessation
- 1990-04-12 CA CA002014457A patent/CA2014457C/en not_active Expired - Fee Related
- 1990-04-19 RU SU4894489A patent/RU2108329C1/ru active
- 1990-04-19 AT AT90906289T patent/ATE112561T1/de not_active IP Right Cessation
- 1990-04-19 DE DE69013112T patent/DE69013112T2/de not_active Expired - Fee Related
- 1990-04-19 HU HU903555A patent/HU209586B/hu not_active IP Right Cessation
- 1990-04-19 EP EP90906289A patent/EP0422178B1/en not_active Expired - Lifetime
- 1990-04-19 JP JP2506034A patent/JP2528218B2/ja not_active Expired - Lifetime
- 1990-04-19 AU AU54354/90A patent/AU635260B2/en not_active Ceased
- 1990-04-19 DK DK90906289.5T patent/DK0422178T3/da active
- 1990-04-19 ES ES90906289T patent/ES2064727T3/es not_active Expired - Lifetime
- 1990-04-19 YU YU00799/90A patent/YU79990A/xx unknown
- 1990-04-19 WO PCT/GB1990/000595 patent/WO1990012790A1/en active IP Right Grant
- 1990-04-19 KR KR1019900702652A patent/KR920700203A/ko not_active Application Discontinuation
- 1990-04-20 SI SI9010799A patent/SI9010799A/sl unknown
- 1990-04-20 US US07/513,304 patent/US5223505A/en not_active Expired - Fee Related
- 1990-04-20 PL PL90284871A patent/PL165502B1/pl unknown
- 1990-04-20 PL PL90301231A patent/PL165917B1/pl unknown
- 1990-04-20 PT PT93823A patent/PT93823B/pt not_active IP Right Cessation
- 1990-04-21 MY MYPI90000670A patent/MY105637A/en unknown
- 1990-04-21 CN CN90103931A patent/CN1024793C/zh not_active Expired - Fee Related
- 1990-04-23 GR GR900100304A patent/GR1000371B/el not_active IP Right Cessation
- 1990-12-06 MW MW90/90A patent/MW9090A1/xx unknown
- 1990-12-20 NO NO905519A patent/NO177054C/no not_active IP Right Cessation
- 1990-12-20 FI FI906307A patent/FI95377C/fi not_active IP Right Cessation
- 1990-12-21 BG BG093508A patent/BG93508A/bg unknown
-
1993
- 1993-04-06 HR HRP-799/90A patent/HRP930793A2/hr not_active Application Discontinuation
Also Published As
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