BG64940B1 - Метод за подобряване на ефикасността на антитуморни средства - Google Patents
Метод за подобряване на ефикасността на антитуморни средства Download PDFInfo
- Publication number
- BG64940B1 BG64940B1 BG106057A BG10605701A BG64940B1 BG 64940 B1 BG64940 B1 BG 64940B1 BG 106057 A BG106057 A BG 106057A BG 10605701 A BG10605701 A BG 10605701A BG 64940 B1 BG64940 B1 BG 64940B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- erythropoietin
- cisplatin
- hematocrit
- group
- tumor
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 35
- 230000000259 anti-tumor effect Effects 0.000 title claims abstract description 15
- 230000002708 enhancing effect Effects 0.000 title abstract description 4
- 238000005534 hematocrit Methods 0.000 claims abstract description 42
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical group [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 76
- 102000003951 Erythropoietin Human genes 0.000 claims description 75
- 108090000394 Erythropoietin Proteins 0.000 claims description 75
- 229940105423 erythropoietin Drugs 0.000 claims description 74
- 229960004316 cisplatin Drugs 0.000 claims description 58
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 57
- 239000002246 antineoplastic agent Substances 0.000 claims description 35
- 239000003623 enhancer Substances 0.000 claims description 15
- 150000003058 platinum compounds Chemical class 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 230000001965 increasing effect Effects 0.000 claims description 7
- 229960004562 carboplatin Drugs 0.000 claims description 6
- YAYRGNWWLMLWJE-UHFFFAOYSA-L carboplatin Chemical compound O=C1O[Pt](N)(N)OC(=O)C11CCC1 YAYRGNWWLMLWJE-UHFFFAOYSA-L 0.000 claims 2
- GZXVJRNJTCNEIL-UHFFFAOYSA-L platinum(2+);propanedioate Chemical compound [Pt+2].[O-]C(=O)CC([O-])=O GZXVJRNJTCNEIL-UHFFFAOYSA-L 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 63
- 230000000694 effects Effects 0.000 abstract description 10
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 34
- 241000699670 Mus sp. Species 0.000 description 33
- 150000001875 compounds Chemical class 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 16
- 229910052697 platinum Inorganic materials 0.000 description 16
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 14
- 239000002953 phosphate buffered saline Substances 0.000 description 14
- 201000011510 cancer Diseases 0.000 description 10
- 108010075944 Erythropoietin Receptors Proteins 0.000 description 7
- 102100036509 Erythropoietin receptor Human genes 0.000 description 7
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- 229940045985 antineoplastic platinum compound Drugs 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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- 238000011579 SCID mouse model Methods 0.000 description 4
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- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 4
- 230000008859 change Effects 0.000 description 4
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- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
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- YCAGGFXSFQFVQL-UHFFFAOYSA-N Endothion Chemical compound COC1=COC(CSP(=O)(OC)OC)=CC1=O YCAGGFXSFQFVQL-UHFFFAOYSA-N 0.000 description 2
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 description 2
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
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- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
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- 238000001356 surgical procedure Methods 0.000 description 2
- -1 transition metal salts Chemical class 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 244000189799 Asimina triloba Species 0.000 description 1
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- 235000009467 Carica papaya Nutrition 0.000 description 1
- 241001456553 Chanodichthys dabryi Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
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- 108091058545 Secretory proteins Proteins 0.000 description 1
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- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
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- 125000003636 chemical group Chemical group 0.000 description 1
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- CLSUSRZJUQMOHH-UHFFFAOYSA-L platinum dichloride Chemical compound Cl[Pt]Cl CLSUSRZJUQMOHH-UHFFFAOYSA-L 0.000 description 1
- 238000011518 platinum-based chemotherapy Methods 0.000 description 1
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- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/300,124 US6171620B1 (en) | 1999-04-27 | 1999-04-27 | Method of enhancing the efficacy of anti-tumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG106057A BG106057A (en) | 2002-04-30 |
| BG64940B1 true BG64940B1 (bg) | 2006-10-31 |
Family
ID=23157813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG106057A BG64940B1 (bg) | 1999-04-27 | 2001-10-26 | Метод за подобряване на ефикасността на антитуморни средства |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6171620B1 (https=) |
| EP (1) | EP1212068A4 (https=) |
| JP (1) | JP2002542296A (https=) |
| KR (1) | KR100693796B1 (https=) |
| CN (1) | CN1188137C (https=) |
| AU (1) | AU781301B2 (https=) |
| BG (1) | BG64940B1 (https=) |
| BR (1) | BR0010082A (https=) |
| CA (1) | CA2368618C (https=) |
| HU (1) | HUP0200840A3 (https=) |
| IL (1) | IL146012A0 (https=) |
| MX (1) | MXPA01010899A (https=) |
| NO (1) | NO20015227L (https=) |
| NZ (1) | NZ514521A (https=) |
| PL (1) | PL350918A1 (https=) |
| RU (1) | RU2271829C2 (https=) |
| WO (1) | WO2000064455A1 (https=) |
| ZA (1) | ZA200108012B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2232613T3 (es) | 2000-04-26 | 2005-06-01 | Cellegy Pharmaceuticals, Inc | Formulaciones y metodos de utilizacion de agentes mimeticos del oxido nitrico contra un fenotipo celular maligno. |
| US7678391B2 (en) * | 2000-04-26 | 2010-03-16 | Queen's University At Kingston | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
| US20050142217A1 (en) * | 2000-04-26 | 2005-06-30 | Adams Michael A. | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
| DE60332358D1 (de) * | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| CA2811272C (en) | 2003-04-08 | 2016-12-20 | Progenics Pharmaceuticals, Inc. | Pharmaceutical formulations containing methylnaltrexone |
| DE10361813A1 (de) * | 2003-12-30 | 2005-09-08 | Bionethos Holding Gmbh | Verfahren zur Regeneration von Gewebe |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| ES2714198T3 (es) * | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| WO2008065372A2 (en) | 2006-11-28 | 2008-06-05 | Nautilus Biotech, S.A. | Modified erythropoietin polypeptides and uses thereof for treatment |
| EP2565195B1 (en) | 2007-03-29 | 2015-05-06 | Wyeth LLC | Peripheral opioid receptor and antagonists and uses thereof |
| JP2010522756A (ja) | 2007-03-29 | 2010-07-08 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 結晶形およびその使用 |
| PL2137191T3 (pl) | 2007-03-29 | 2016-12-30 | Antagoniści obwodowego receptora opioidowego i ich zastosowania | |
| AU2008349873B2 (en) | 2008-02-06 | 2014-02-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone |
| CA2719134C (en) | 2008-03-21 | 2015-06-30 | The University Of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| US20110142834A1 (en) * | 2008-05-15 | 2011-06-16 | Edison Pharmaceuticals, Inc. | Treatment of hearing and balance impairments using compounds having erythropoietin activity |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| PL230756B1 (pl) * | 2015-09-11 | 2018-12-31 | Univ Medyczny W Bialymstoku | Erytropoetyna oraz inhibitor kinazy Brutona w postaci 2- cyjan o-N-( 2,5-dibromofenylo)- 3-hydroksy-2- butenamidu do zastosowania jako lek oraz ich zastosowanie do wytwarzania leku do terapii nowotworu |
| JPWO2019083023A1 (ja) * | 2017-10-26 | 2020-11-12 | 国立大学法人 筑波大学 | 癌の治療に使用するための組成物 |
Family Cites Families (5)
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|---|---|---|---|---|
| US4745099A (en) * | 1985-02-06 | 1988-05-17 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for the treatment of the anemia of malignant tumors |
| JP2632014B2 (ja) * | 1988-03-03 | 1997-07-16 | 中外製薬株式会社 | 骨髄機能障害性貧血治療剤 |
| RU2111750C1 (ru) * | 1995-02-23 | 1998-05-27 | Институт элементоорганических соединений РАН | Модификатор для противоопухолевой терапии |
| JPH1067678A (ja) * | 1996-06-20 | 1998-03-10 | Chugai Pharmaceut Co Ltd | 肝疾患治療用医薬組成物 |
| US20020052309A1 (en) * | 1996-09-11 | 2002-05-02 | Athanasius A. Anagnostou | Method of treating endothelial injury |
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- 2000-04-24 NZ NZ514521A patent/NZ514521A/en not_active IP Right Cessation
- 2000-04-24 JP JP2000613446A patent/JP2002542296A/ja active Pending
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- 2000-04-24 BR BR0010082-0A patent/BR0010082A/pt not_active Application Discontinuation
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| KR100693796B1 (ko) | 2007-03-12 |
| HUP0200840A3 (en) | 2003-04-28 |
| US6620779B2 (en) | 2003-09-16 |
| BG106057A (en) | 2002-04-30 |
| IL146012A0 (en) | 2002-07-25 |
| AU781301B2 (en) | 2005-05-12 |
| CA2368618A1 (en) | 2000-11-02 |
| EP1212068A1 (en) | 2002-06-12 |
| ZA200108012B (en) | 2003-03-26 |
| JP2002542296A (ja) | 2002-12-10 |
| AU4486300A (en) | 2000-11-10 |
| PL350918A1 (en) | 2003-02-10 |
| CN1188137C (zh) | 2005-02-09 |
| US6171620B1 (en) | 2001-01-09 |
| MXPA01010899A (es) | 2003-06-24 |
| CN1352561A (zh) | 2002-06-05 |
| HUP0200840A2 (hu) | 2002-07-29 |
| NO20015227L (no) | 2001-12-27 |
| US20020198153A1 (en) | 2002-12-26 |
| NZ514521A (en) | 2003-07-25 |
| BR0010082A (pt) | 2002-01-15 |
| WO2000064455A1 (en) | 2000-11-02 |
| RU2271829C2 (ru) | 2006-03-20 |
| NO20015227D0 (no) | 2001-10-25 |
| US20010000730A1 (en) | 2001-05-03 |
| EP1212068A4 (en) | 2007-03-14 |
| US6426094B2 (en) | 2002-07-30 |
| KR20020000557A (ko) | 2002-01-05 |
| CA2368618C (en) | 2011-03-01 |
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