MXPA01010899A - Metodo para mejorar la eficacia de agentes anti-tumor. - Google Patents
Metodo para mejorar la eficacia de agentes anti-tumor.Info
- Publication number
- MXPA01010899A MXPA01010899A MXPA01010899A MXPA01010899A MXPA01010899A MX PA01010899 A MXPA01010899 A MX PA01010899A MX PA01010899 A MXPA01010899 A MX PA01010899A MX PA01010899 A MXPA01010899 A MX PA01010899A MX PA01010899 A MXPA01010899 A MX PA01010899A
- Authority
- MX
- Mexico
- Prior art keywords
- tumor
- epo
- cisplatin
- hematocrit
- erythropoietin
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 34
- 230000002708 enhancing effect Effects 0.000 title abstract 2
- 238000005534 hematocrit Methods 0.000 claims abstract description 42
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical group [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 82
- 102000003951 Erythropoietin Human genes 0.000 claims description 81
- 108090000394 Erythropoietin Proteins 0.000 claims description 81
- 229940105423 erythropoietin Drugs 0.000 claims description 80
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 59
- 229960004316 cisplatin Drugs 0.000 claims description 54
- 238000011282 treatment Methods 0.000 claims description 24
- 230000000259 anti-tumor effect Effects 0.000 claims description 11
- 150000003058 platinum compounds Chemical class 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- 229960004562 carboplatin Drugs 0.000 claims description 6
- YAYRGNWWLMLWJE-UHFFFAOYSA-L carboplatin Chemical compound O=C1O[Pt](N)(N)OC(=O)C11CCC1 YAYRGNWWLMLWJE-UHFFFAOYSA-L 0.000 claims 2
- GZXVJRNJTCNEIL-UHFFFAOYSA-L platinum(2+);propanedioate Chemical group [Pt+2].[O-]C(=O)CC([O-])=O GZXVJRNJTCNEIL-UHFFFAOYSA-L 0.000 claims 2
- 230000002195 synergetic effect Effects 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 64
- 230000000694 effects Effects 0.000 abstract description 11
- 241000699670 Mus sp. Species 0.000 description 36
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 31
- 210000004027 cell Anatomy 0.000 description 19
- 150000001875 compounds Chemical class 0.000 description 16
- 229910052697 platinum Inorganic materials 0.000 description 15
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 14
- 239000002953 phosphate buffered saline Substances 0.000 description 14
- 201000011510 cancer Diseases 0.000 description 11
- 238000007920 subcutaneous administration Methods 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 231100000433 cytotoxic Toxicity 0.000 description 7
- 230000001472 cytotoxic effect Effects 0.000 description 7
- 230000010437 erythropoiesis Effects 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 206010061535 Ovarian neoplasm Diseases 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 5
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- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 4
- 230000008859 change Effects 0.000 description 4
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- 102100036509 Erythropoietin receptor Human genes 0.000 description 3
- 206010024264 Lethargy Diseases 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 108010029485 Protein Isoforms Proteins 0.000 description 3
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- 102000004169 proteins and genes Human genes 0.000 description 3
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- 230000004614 tumor growth Effects 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 238000011887 Necropsy Methods 0.000 description 2
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- 210000003734 kidney Anatomy 0.000 description 2
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- 229920001542 oligosaccharide Polymers 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 description 2
- NDBYXKQCPYUOMI-UHFFFAOYSA-N platinum(4+) Chemical class [Pt+4] NDBYXKQCPYUOMI-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
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- 230000004580 weight loss Effects 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101100333654 Homo sapiens EPO gene Proteins 0.000 description 1
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 description 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010029155 Nephropathy toxic Diseases 0.000 description 1
- 206010033109 Ototoxicity Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 102000040739 Secretory proteins Human genes 0.000 description 1
- 108091058545 Secretory proteins Proteins 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 206010057644 Testis cancer Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 208000037844 advanced solid tumor Diseases 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000006023 anti-tumor response Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- BUZRUIZTMOKRPB-UHFFFAOYSA-N carboxycarbamic acid Chemical class OC(=O)NC(O)=O BUZRUIZTMOKRPB-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical compound NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
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- 210000003128 head Anatomy 0.000 description 1
- 102000044890 human EPO Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
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- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
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- 230000006654 negative regulation of apoptotic process Effects 0.000 description 1
- 230000007694 nephrotoxicity Effects 0.000 description 1
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- 210000003101 oviduct Anatomy 0.000 description 1
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- 230000036961 partial effect Effects 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- CLSUSRZJUQMOHH-UHFFFAOYSA-L platinum dichloride Chemical compound Cl[Pt]Cl CLSUSRZJUQMOHH-UHFFFAOYSA-L 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
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- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/300,124 US6171620B1 (en) | 1999-04-27 | 1999-04-27 | Method of enhancing the efficacy of anti-tumor agents |
| PCT/US2000/011000 WO2000064455A1 (en) | 1999-04-27 | 2000-04-24 | Method of enhancing the efficacy of anti-tumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01010899A true MXPA01010899A (es) | 2003-06-24 |
Family
ID=23157813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01010899A MXPA01010899A (es) | 1999-04-27 | 2000-04-24 | Metodo para mejorar la eficacia de agentes anti-tumor. |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6171620B1 (https=) |
| EP (1) | EP1212068A4 (https=) |
| JP (1) | JP2002542296A (https=) |
| KR (1) | KR100693796B1 (https=) |
| CN (1) | CN1188137C (https=) |
| AU (1) | AU781301B2 (https=) |
| BG (1) | BG64940B1 (https=) |
| BR (1) | BR0010082A (https=) |
| CA (1) | CA2368618C (https=) |
| HU (1) | HUP0200840A3 (https=) |
| IL (1) | IL146012A0 (https=) |
| MX (1) | MXPA01010899A (https=) |
| NO (1) | NO20015227L (https=) |
| NZ (1) | NZ514521A (https=) |
| PL (1) | PL350918A1 (https=) |
| RU (1) | RU2271829C2 (https=) |
| WO (1) | WO2000064455A1 (https=) |
| ZA (1) | ZA200108012B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003531179A (ja) | 2000-04-26 | 2003-10-21 | クイーンズ ユニバーシティ アット キングストン | 悪性細胞表現型に対し一酸化窒素模倣体を使用する処方および方法 |
| US20050142217A1 (en) * | 2000-04-26 | 2005-06-30 | Adams Michael A. | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
| US7678391B2 (en) * | 2000-04-26 | 2010-03-16 | Queen's University At Kingston | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
| DE60332358D1 (de) * | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| HRP20150037T4 (hr) | 2003-04-08 | 2022-09-02 | Progenics Pharmaceuticals, Inc. | Farmaceutske formulacije koje sadrže metilnaltrekson |
| DE10361813A1 (de) * | 2003-12-30 | 2005-09-08 | Bionethos Holding Gmbh | Verfahren zur Regeneration von Gewebe |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| ES2714198T3 (es) * | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| CN101678079B (zh) | 2006-11-28 | 2013-12-25 | 韩诺生物制约株式会社 | 修饰的促红细胞生成素多肽及其治疗用途 |
| MX2009010550A (es) | 2007-03-29 | 2009-12-14 | Progenics Pharm Inc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
| SI2565195T1 (sl) | 2007-03-29 | 2015-09-30 | Wyeth Llc | Periferalni opioidni receptorji in antagonisti in njih uporaba |
| CL2008000905A1 (es) | 2007-03-29 | 2008-08-22 | Progenics Pharm Inc | Compuestos derivados de morfina, antagonistas del receptor opioide periferico; metodo de preparacion; composicion farmaceutica; y uso para reducir los efectos de la actividad opioide endogena. |
| EP2240489A1 (en) | 2008-02-06 | 2010-10-20 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
| EP2278966B1 (en) | 2008-03-21 | 2019-10-09 | The University of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| CA2723621A1 (en) * | 2008-05-15 | 2009-11-19 | Edison Pharmaceuticals, Inc | Treatment of hearing and balance impairments using compounds having erythropoietin activity |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| PL230756B1 (pl) * | 2015-09-11 | 2018-12-31 | Univ Medyczny W Bialymstoku | Erytropoetyna oraz inhibitor kinazy Brutona w postaci 2- cyjan o-N-( 2,5-dibromofenylo)- 3-hydroksy-2- butenamidu do zastosowania jako lek oraz ich zastosowanie do wytwarzania leku do terapii nowotworu |
| WO2019083023A1 (ja) * | 2017-10-26 | 2019-05-02 | 国立大学法人筑波大学 | 癌の治療に使用するための組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745099A (en) * | 1985-02-06 | 1988-05-17 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for the treatment of the anemia of malignant tumors |
| JP2632014B2 (ja) * | 1988-03-03 | 1997-07-16 | 中外製薬株式会社 | 骨髄機能障害性貧血治療剤 |
| RU2111750C1 (ru) * | 1995-02-23 | 1998-05-27 | Институт элементоорганических соединений РАН | Модификатор для противоопухолевой терапии |
| JPH1067678A (ja) * | 1996-06-20 | 1998-03-10 | Chugai Pharmaceut Co Ltd | 肝疾患治療用医薬組成物 |
| US20020052309A1 (en) * | 1996-09-11 | 2002-05-02 | Athanasius A. Anagnostou | Method of treating endothelial injury |
-
1999
- 1999-04-27 US US09/300,124 patent/US6171620B1/en not_active Expired - Fee Related
-
2000
- 2000-04-24 JP JP2000613446A patent/JP2002542296A/ja active Pending
- 2000-04-24 MX MXPA01010899A patent/MXPA01010899A/es active IP Right Grant
- 2000-04-24 IL IL14601200A patent/IL146012A0/xx unknown
- 2000-04-24 PL PL00350918A patent/PL350918A1/xx not_active Application Discontinuation
- 2000-04-24 WO PCT/US2000/011000 patent/WO2000064455A1/en not_active Ceased
- 2000-04-24 EP EP00926315A patent/EP1212068A4/en not_active Withdrawn
- 2000-04-24 HU HU0200840A patent/HUP0200840A3/hu unknown
- 2000-04-24 BR BR0010082-0A patent/BR0010082A/pt not_active Application Discontinuation
- 2000-04-24 CA CA2368618A patent/CA2368618C/en not_active Expired - Fee Related
- 2000-04-24 CN CNB008065659A patent/CN1188137C/zh not_active Expired - Fee Related
- 2000-04-24 KR KR1020017012929A patent/KR100693796B1/ko not_active Expired - Fee Related
- 2000-04-24 RU RU2001131894/14A patent/RU2271829C2/ru not_active IP Right Cessation
- 2000-04-24 NZ NZ514521A patent/NZ514521A/en not_active IP Right Cessation
- 2000-04-24 AU AU44863/00A patent/AU781301B2/en not_active Ceased
- 2000-12-19 US US09/740,501 patent/US6426094B2/en not_active Expired - Fee Related
-
2001
- 2001-09-28 ZA ZA200108012A patent/ZA200108012B/xx unknown
- 2001-10-25 NO NO20015227A patent/NO20015227L/no not_active Application Discontinuation
- 2001-10-26 BG BG106057A patent/BG64940B1/bg unknown
-
2002
- 2002-07-26 US US10/206,533 patent/US6620779B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BG64940B1 (bg) | 2006-10-31 |
| US6426094B2 (en) | 2002-07-30 |
| BR0010082A (pt) | 2002-01-15 |
| HUP0200840A2 (hu) | 2002-07-29 |
| WO2000064455A1 (en) | 2000-11-02 |
| PL350918A1 (en) | 2003-02-10 |
| JP2002542296A (ja) | 2002-12-10 |
| EP1212068A4 (en) | 2007-03-14 |
| US6620779B2 (en) | 2003-09-16 |
| NO20015227D0 (no) | 2001-10-25 |
| ZA200108012B (en) | 2003-03-26 |
| CA2368618A1 (en) | 2000-11-02 |
| CA2368618C (en) | 2011-03-01 |
| KR20020000557A (ko) | 2002-01-05 |
| CN1352561A (zh) | 2002-06-05 |
| NZ514521A (en) | 2003-07-25 |
| BG106057A (en) | 2002-04-30 |
| HUP0200840A3 (en) | 2003-04-28 |
| US20010000730A1 (en) | 2001-05-03 |
| AU781301B2 (en) | 2005-05-12 |
| RU2271829C2 (ru) | 2006-03-20 |
| NO20015227L (no) | 2001-12-27 |
| KR100693796B1 (ko) | 2007-03-12 |
| EP1212068A1 (en) | 2002-06-12 |
| AU4486300A (en) | 2000-11-10 |
| US6171620B1 (en) | 2001-01-09 |
| US20020198153A1 (en) | 2002-12-26 |
| IL146012A0 (en) | 2002-07-25 |
| CN1188137C (zh) | 2005-02-09 |
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