BG64473B1 - Използване на сибутраминови аналози за предотвратяване развитието на диабет - Google Patents

Използване на сибутраминови аналози за предотвратяване развитието на диабет Download PDF

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Publication number
BG64473B1
BG64473B1 BG103277A BG10327799A BG64473B1 BG 64473 B1 BG64473 B1 BG 64473B1 BG 103277 A BG103277 A BG 103277A BG 10327799 A BG10327799 A BG 10327799A BG 64473 B1 BG64473 B1 BG 64473B1
Authority
BG
Bulgaria
Prior art keywords
insulin
formula
compound
dependent diabetes
diabetes mellitus
Prior art date
Application number
BG103277A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103277A (en
Inventor
Clifford Bailey
Robert Jones
Helen Jackson
Original Assignee
Knoll Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Aktiengesellschaft filed Critical Knoll Aktiengesellschaft
Publication of BG103277A publication Critical patent/BG103277A/xx
Publication of BG64473B1 publication Critical patent/BG64473B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrotherapy Devices (AREA)
BG103277A 1996-09-21 1999-03-24 Използване на сибутраминови аналози за предотвратяване развитието на диабет BG64473B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9619757.9A GB9619757D0 (en) 1996-09-21 1996-09-21 Chemical process

Publications (2)

Publication Number Publication Date
BG103277A BG103277A (en) 2000-01-31
BG64473B1 true BG64473B1 (bg) 2005-04-30

Family

ID=10800326

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103277A BG64473B1 (bg) 1996-09-21 1999-03-24 Използване на сибутраминови аналози за предотвратяване развитието на диабет

Country Status (26)

Country Link
US (3) US6174925B1 (uk)
EP (1) EP0927028A1 (uk)
JP (1) JP2001503737A (uk)
KR (1) KR20000048501A (uk)
CN (1) CN1237905A (uk)
AU (1) AU724488B2 (uk)
BG (1) BG64473B1 (uk)
BR (1) BR9711517A (uk)
CA (1) CA2266401C (uk)
CZ (1) CZ93699A3 (uk)
GB (1) GB9619757D0 (uk)
HR (1) HRP970505A2 (uk)
HU (1) HUP9904026A3 (uk)
ID (1) ID18320A (uk)
IL (1) IL128850A (uk)
MY (1) MY116150A (uk)
NO (1) NO991358D0 (uk)
NZ (1) NZ334580A (uk)
PL (1) PL332305A1 (uk)
RU (1) RU2245709C2 (uk)
SK (1) SK31999A3 (uk)
TR (1) TR199900618T2 (uk)
TW (1) TW580385B (uk)
UA (1) UA64726C2 (uk)
WO (1) WO1998011884A1 (uk)
ZA (1) ZA978450B (uk)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process
JP2000080047A (ja) * 1998-06-30 2000-03-21 Takeda Chem Ind Ltd 医 薬
KR20010043455A (ko) * 1998-06-30 2001-05-25 다케다 야쿠힌 고교 가부시키가이샤 당뇨병 치료용 약학적 조성물
US6476078B2 (en) * 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6331571B1 (en) 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
AR023699A1 (es) * 1998-11-12 2002-09-04 Smithkline Beecham Corp Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
US20040102486A1 (en) * 1998-11-12 2004-05-27 Smithkline Beecham Corporation Novel method of treatment
CZ20011629A3 (cs) * 1998-11-12 2001-12-12 Smithkline Beecham Plc Farmaceutický prostředek pro upravené uvolňování senzitizéru inzulínu a jiných antidiabetických přípravků
US6323242B1 (en) 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
US6696495B2 (en) 1998-12-02 2004-02-24 Snowden Pharmaceuticals, Llc Treatment of disorders secondary to organic impairments
US6552087B1 (en) 1999-03-19 2003-04-22 Abbott Gmbh & Co. Kg Therapeutic agent comprising (+)-sibutramine
US6723717B1 (en) 1999-06-01 2004-04-20 The University Of Texas Southwestern Medical Center Sulfur-containing thyroxane derivatives and their use as hair growth promotors
EP1185232A1 (en) 1999-06-01 2002-03-13 University Of Texas Southwestern Medical Center Method of treating hair loss using sulfonyl thyromimetic compounds
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
WO2002083631A1 (en) 2001-04-13 2002-10-24 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
EP1515701B1 (en) 2002-06-17 2014-09-17 Inventia Healthcare Private Limited Process for the manufacture of multilayer tablet compositions comprising thiazolidinedione and biguanide
WO2004030663A1 (en) * 2002-10-05 2004-04-15 Hanmi Pharm. Co., Ltd. Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate
US20050131074A1 (en) * 2003-08-04 2005-06-16 Beckman Kristen M. Methods for treating metabolic syndrome
TW200517127A (en) * 2003-08-07 2005-06-01 Sb Pharmco Inc Novel composition
GB0318824D0 (en) * 2003-08-11 2003-09-10 Glaxo Group Ltd Novel composition
GEP20084570B (en) * 2003-10-31 2008-12-25 Takeda Pharmaceutical Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester
KR100627687B1 (ko) * 2005-04-20 2006-09-25 주식회사 씨티씨바이오 시부트라민 유리염기 함유 조성물 및 이의 제조방법
CN101394847B (zh) 2006-01-06 2017-05-24 塞普拉柯公司 作为单胺重摄取抑制剂的环烷基胺类
AU2007296074B2 (en) 2006-09-15 2012-07-12 Reviva Pharmaceuticals, Inc. Synthesis, methods of using, and compositions of cycloalkylmethylamines
KR100812538B1 (ko) * 2006-10-23 2008-03-11 한올제약주식회사 약물 제어방출형 메트포르민-글리메피리드 복합제제
EP2083867A1 (en) * 2006-11-22 2009-08-05 SK Chemicals, Co., Ltd. Inclusion complex of sibutramine and beta-cyclodextrin
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
WO2008121767A2 (en) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Stitched polypeptides
WO2012003501A2 (en) 2010-07-02 2012-01-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
EP2603600B1 (en) 2010-08-13 2018-11-21 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
MX358886B (es) 2011-10-18 2018-08-31 Aileron Therapeutics Inc Macrociclos peptidomimeticos.
CA2858837C (en) 2011-12-30 2022-08-30 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
AU2013221432B2 (en) 2012-02-15 2018-01-18 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CN112245565A (zh) 2014-09-24 2021-01-22 艾瑞朗医疗公司 拟肽大环化合物及其用途
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098602A (en) * 1981-04-06 1982-11-24 Boots Co Plc Therapeutic agents
EP0230742A1 (en) * 1985-12-17 1987-08-05 The Boots Company PLC N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate and pharmaceutical compositions containing it
EP0282206A1 (en) * 1987-02-28 1988-09-14 The Boots Company PLC Arylcyclobutylalkylamine-derivative for the treatment of Parkinson's disease
US4939175A (en) * 1988-03-31 1990-07-03 The Boots Co. Plc Use of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine
EP0397831A1 (en) * 1988-11-29 1990-11-22 Boots Co Plc TREATMENT OF OBESITAS.
WO1995020949A1 (en) * 1994-02-03 1995-08-10 Boots Pharmaceuticals, Inc. Improving glucose tolerance

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010292A1 (en) 1993-10-14 1995-04-20 Biomedica California, Inc. Diabetes treatment and prophylaxis
GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098602A (en) * 1981-04-06 1982-11-24 Boots Co Plc Therapeutic agents
EP0230742A1 (en) * 1985-12-17 1987-08-05 The Boots Company PLC N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate and pharmaceutical compositions containing it
EP0282206A1 (en) * 1987-02-28 1988-09-14 The Boots Company PLC Arylcyclobutylalkylamine-derivative for the treatment of Parkinson's disease
US4939175A (en) * 1988-03-31 1990-07-03 The Boots Co. Plc Use of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine
EP0397831A1 (en) * 1988-11-29 1990-11-22 Boots Co Plc TREATMENT OF OBESITAS.
WO1995020949A1 (en) * 1994-02-03 1995-08-10 Boots Pharmaceuticals, Inc. Improving glucose tolerance

Also Published As

Publication number Publication date
US6174925B1 (en) 2001-01-16
RU2245709C2 (ru) 2005-02-10
MY116150A (en) 2003-11-28
IL128850A0 (en) 2000-01-31
TR199900618T2 (xx) 1999-06-21
UA64726C2 (uk) 2004-03-15
HUP9904026A2 (hu) 2000-05-28
US6617360B1 (en) 2003-09-09
NO991358L (no) 1999-03-19
ZA978450B (en) 1999-03-19
US20040077730A1 (en) 2004-04-22
GB9619757D0 (en) 1996-11-06
TW580385B (en) 2004-03-21
CZ93699A3 (cs) 1999-08-11
ID18320A (id) 1998-03-26
BG103277A (en) 2000-01-31
BR9711517A (pt) 1999-08-24
NZ334580A (en) 2000-09-29
AU724488B2 (en) 2000-09-21
CA2266401A1 (en) 1998-03-26
HUP9904026A3 (en) 2000-07-28
CA2266401C (en) 2007-01-30
HRP970505A2 (en) 1998-08-31
WO1998011884A1 (en) 1998-03-26
EP0927028A1 (en) 1999-07-07
NO991358D0 (no) 1999-03-19
AU4774097A (en) 1998-04-14
CN1237905A (zh) 1999-12-08
KR20000048501A (ko) 2000-07-25
PL332305A1 (en) 1999-08-30
SK31999A3 (en) 1999-12-10
IL128850A (en) 2003-07-31
JP2001503737A (ja) 2001-03-21

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