BG64300B1 - Използване на фанхинон за лечение на болестта на алцхаймер - Google Patents
Използване на фанхинон за лечение на болестта на алцхаймер Download PDFInfo
- Publication number
- BG64300B1 BG64300B1 BG104179A BG10417900A BG64300B1 BG 64300 B1 BG64300 B1 BG 64300B1 BG 104179 A BG104179 A BG 104179A BG 10417900 A BG10417900 A BG 10417900A BG 64300 B1 BG64300 B1 BG 64300B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- pharmaceutical composition
- phanquinone
- vitamin
- clioquinol
- disease
- Prior art date
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- VLPADTBFADIFKG-UHFFFAOYSA-N phanquone Chemical compound C1=CN=C2C(=O)C(=O)C3=NC=CC=C3C2=C1 VLPADTBFADIFKG-UHFFFAOYSA-N 0.000 title claims abstract description 84
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- QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 claims description 61
- 229960005228 clioquinol Drugs 0.000 claims description 59
- 239000000203 mixture Substances 0.000 claims description 39
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical group [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims description 33
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| GR97100330 | 1997-08-21 | ||
| GR97100507 | 1997-12-31 | ||
| PCT/IB1998/001095 WO1999009981A1 (en) | 1997-08-21 | 1998-07-17 | Use of phanquinone for the treatment of alzheimer's disease |
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|---|---|
| BG104179A BG104179A (en) | 2000-10-31 |
| BG64300B1 true BG64300B1 (bg) | 2004-09-30 |
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| BG104179A BG64300B1 (bg) | 1997-08-21 | 2000-02-22 | Използване на фанхинон за лечение на болестта на алцхаймер |
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| JP (1) | JP2001513558A (cs) |
| CN (1) | CN1145482C (cs) |
| AT (1) | ATE217191T1 (cs) |
| AU (1) | AU741782B2 (cs) |
| BG (1) | BG64300B1 (cs) |
| BR (1) | BR9814945A (cs) |
| CA (1) | CA2301706C (cs) |
| CZ (1) | CZ299739B6 (cs) |
| DE (1) | DE69805305T2 (cs) |
| DK (1) | DK1007040T3 (cs) |
| EA (1) | EA002526B1 (cs) |
| ES (1) | ES2177024T3 (cs) |
| HU (1) | HUP0004331A3 (cs) |
| IL (1) | IL134263A (cs) |
| IS (1) | IS1910B (cs) |
| NO (1) | NO317770B1 (cs) |
| NZ (1) | NZ502565A (cs) |
| PL (1) | PL191208B1 (cs) |
| PT (1) | PT1007040E (cs) |
| SK (1) | SK284708B6 (cs) |
| TR (1) | TR200000455T2 (cs) |
| WO (1) | WO1999009981A1 (cs) |
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| US7045531B1 (en) | 1997-03-11 | 2006-05-16 | The General Hospital Corporation | Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator |
| US5994323A (en) * | 1997-12-31 | 1999-11-30 | P.N. Gerolymatos S.A. | Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof |
| US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US6638711B1 (en) | 1999-04-29 | 2003-10-28 | The General Hospital Corporation | Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation |
| EP1140090B1 (en) * | 1999-01-07 | 2004-12-22 | P.N. Gerolymatos S.A. | Use of phanquinone for the treatment or prevention of memory impairment |
| AU2001250571A1 (en) * | 2000-04-28 | 2001-11-12 | P.N. Gerolymatos S.A. | Treatment of pathological conditions influenced by the action of matrix metalloproteinases (mmps) using clioquinol |
| WO2001082912A2 (en) * | 2000-04-28 | 2001-11-08 | Gerolymatos P N Sa | TREATMENT OF PATHOLOGICAL CONDITIONS INFLUENCED BY THE ACTION OF MATRIX METALLOPROTEINASES (MMPs) USING PHANQUINONE |
| WO2002015942A1 (en) | 2000-08-18 | 2002-02-28 | The General Hospital Corporation | Method for the identification of agents that inhibit or promote cataracts and uses thereof |
| FR2818551B1 (fr) * | 2000-12-22 | 2007-06-01 | Claude Marc Pierre Hannoun | Utilisation de chelateurs pour le traitement des maladies a prions |
| AU2002950217A0 (en) | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
| DE602004023823D1 (de) * | 2003-03-11 | 2009-12-10 | Kaneka Corp | Öl-in-wasser-emulsion, die coenzym q10 enthält, und verfahren zu ihrer herstellung |
| WO2006117660A2 (en) * | 2005-05-04 | 2006-11-09 | Clio Pharmaceutical Corporation | Method for treating cancer, coronary, inflammatory and macular disease, combining the modulation of zinc- and/or copper dependent proteins |
| ES2651537T3 (es) * | 2014-04-29 | 2018-01-29 | Affiris Ag | Tratamiento y prevención de la enfermedad de Alzheimer (AD) |
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| DE1617417A1 (de) * | 1966-12-08 | 1971-03-25 | Ciba Geigy | Pharmazeutisches Praeparat |
| DE1804736A1 (de) | 1967-11-02 | 1969-06-26 | Ciba Geigy | Pharmazeutisches Praeparat |
| IL40311A (en) | 1972-09-06 | 1973-04-30 | Pharmaplantex Ltd | Pharmaceutical preparation for the treatment of gastro-intestinal troubles containing phanquone and furazolidone |
| GB1472257A (en) | 1973-09-10 | 1977-05-04 | Christiaens Sa A | Derivative of 4-hydroxy-5-azacoumarin |
| US5719197A (en) | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US4981844A (en) * | 1988-10-04 | 1991-01-01 | University Of Cincinnati | Method to improve immune response and resistance to infection following surgery by diet composition |
| US5091391A (en) * | 1990-08-16 | 1992-02-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of resisting neurodegenerative disorders |
| US6165500A (en) | 1990-08-24 | 2000-12-26 | Idea Ag | Preparation for the application of agents in mini-droplets |
| CA2078019C (en) * | 1991-09-13 | 2002-08-27 | Siegbert Heinrich Bissbort | Substance or composition and uses thereof |
| EP0613560B2 (en) | 1991-11-12 | 2006-06-21 | Prana Biotechnology Ltd | A method for assaying and treating alzheimer's disease |
| GB9126874D0 (en) * | 1991-12-18 | 1992-02-19 | Wellcome Found | Medicaments |
| WO1995031199A1 (en) * | 1994-05-11 | 1995-11-23 | P.N. Gerolymatos S.A. | Use of clioquinol for treating helicobacter, including h. pylori, infections and related diseases |
| WO1997046526A1 (en) * | 1996-06-07 | 1997-12-11 | Eisai Co., Ltd. | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| CZ292411B6 (cs) * | 1996-08-13 | 2003-09-17 | P. N. Gerolymatos S. A. | Farmaceutický prostředek |
| WO1998040071A1 (en) | 1997-03-11 | 1998-09-17 | The General Hospital Corporation | Identification of agents for use in the treatment of alzheimer's disease |
| US5980882A (en) | 1997-04-16 | 1999-11-09 | Medeva Pharmaceuticals Manufacturing | Drug-resin complexes stabilized by chelating agents |
| US5980914A (en) | 1997-08-22 | 1999-11-09 | P.N. Gerolymatos S.A. | Clioquinol for the treatment of Parkinson's disease |
| US5994323A (en) | 1997-12-31 | 1999-11-30 | P.N. Gerolymatos S.A. | Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof |
| EP1140090B1 (en) | 1999-01-07 | 2004-12-22 | P.N. Gerolymatos S.A. | Use of phanquinone for the treatment or prevention of memory impairment |
| AU2001250571A1 (en) | 2000-04-28 | 2001-11-12 | P.N. Gerolymatos S.A. | Treatment of pathological conditions influenced by the action of matrix metalloproteinases (mmps) using clioquinol |
| WO2001082912A2 (en) | 2000-04-28 | 2001-11-08 | Gerolymatos P N Sa | TREATMENT OF PATHOLOGICAL CONDITIONS INFLUENCED BY THE ACTION OF MATRIX METALLOPROTEINASES (MMPs) USING PHANQUINONE |
-
1998
- 1998-07-17 CN CNB988082926A patent/CN1145482C/zh not_active Expired - Fee Related
- 1998-07-17 WO PCT/IB1998/001095 patent/WO1999009981A1/en active IP Right Grant
- 1998-07-17 NZ NZ502565A patent/NZ502565A/en unknown
- 1998-07-17 AU AU81241/98A patent/AU741782B2/en not_active Ceased
- 1998-07-17 US US09/485,909 patent/US6670369B1/en not_active Expired - Fee Related
- 1998-07-17 EP EP98930970A patent/EP1007040B1/en not_active Expired - Lifetime
- 1998-07-17 BR BR9814945-8A patent/BR9814945A/pt not_active Application Discontinuation
- 1998-07-17 SK SK206-2000A patent/SK284708B6/sk not_active IP Right Cessation
- 1998-07-17 TR TR2000/00455T patent/TR200000455T2/xx unknown
- 1998-07-17 IL IL134263A patent/IL134263A/en not_active IP Right Cessation
- 1998-07-17 AT AT98930970T patent/ATE217191T1/de not_active IP Right Cessation
- 1998-07-17 JP JP2000507371A patent/JP2001513558A/ja active Pending
- 1998-07-17 CA CA002301706A patent/CA2301706C/en not_active Expired - Fee Related
- 1998-07-17 PL PL338673A patent/PL191208B1/pl not_active IP Right Cessation
- 1998-07-17 HU HU0004331A patent/HUP0004331A3/hu unknown
- 1998-07-17 CZ CZ20000611A patent/CZ299739B6/cs not_active IP Right Cessation
- 1998-07-17 DK DK98930970T patent/DK1007040T3/da active
- 1998-07-17 PT PT98930970T patent/PT1007040E/pt unknown
- 1998-07-17 ES ES98930970T patent/ES2177024T3/es not_active Expired - Lifetime
- 1998-07-17 DE DE69805305T patent/DE69805305T2/de not_active Expired - Fee Related
- 1998-07-17 EA EA200000242A patent/EA002526B1/ru not_active IP Right Cessation
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2000
- 2000-01-28 IS IS5366A patent/IS1910B/is unknown
- 2000-02-16 NO NO20000771A patent/NO317770B1/no not_active IP Right Cessation
- 2000-02-22 BG BG104179A patent/BG64300B1/bg unknown
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2003
- 2003-11-18 US US10/717,182 patent/US7629354B2/en not_active Expired - Fee Related
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