BG62999B1 - Анти туморна ваксина и метод за нейното получаване - Google Patents

Анти туморна ваксина и метод за нейното получаване Download PDF

Info

Publication number
BG62999B1
BG62999B1 BG102439A BG10243998A BG62999B1 BG 62999 B1 BG62999 B1 BG 62999B1 BG 102439 A BG102439 A BG 102439A BG 10243998 A BG10243998 A BG 10243998A BG 62999 B1 BG62999 B1 BG 62999B1
Authority
BG
Bulgaria
Prior art keywords
cells
tumor
patient
peptide
peptides
Prior art date
Application number
BG102439A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG102439A (en
Inventor
Walter Schmidt
Max Birnstiel
Tamas Schweighoffer
Peter Steinlein
Michael Buschle
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19543649A external-priority patent/DE19543649C2/de
Priority claimed from DE19607044A external-priority patent/DE19607044A1/de
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of BG102439A publication Critical patent/BG102439A/xx
Publication of BG62999B1 publication Critical patent/BG62999B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0693Tumour cells; Cancer cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG102439A 1995-11-23 1998-05-08 Анти туморна ваксина и метод за нейното получаване BG62999B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19543649A DE19543649C2 (de) 1995-11-23 1995-11-23 Tumorvakzine und Verfahren zu ihrer Herstellung
DE19607044A DE19607044A1 (de) 1996-02-24 1996-02-24 Tumorvakzine und Verfahren zu ihrer Herstellung
PCT/EP1996/005126 WO1997019169A1 (fr) 1995-11-23 1996-11-21 Vaccin tumoral et son procede de fabrication

Publications (2)

Publication Number Publication Date
BG102439A BG102439A (en) 1999-01-29
BG62999B1 true BG62999B1 (bg) 2001-01-31

Family

ID=26020603

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102439A BG62999B1 (bg) 1995-11-23 1998-05-08 Анти туморна ваксина и метод за нейното получаване

Country Status (24)

Country Link
US (1) US20020085997A1 (fr)
EP (1) EP0866851A1 (fr)
JP (1) JP2000502052A (fr)
KR (1) KR19990067653A (fr)
CN (1) CN1202931A (fr)
AR (1) AR004341A1 (fr)
AU (1) AU720131B2 (fr)
BG (1) BG62999B1 (fr)
BR (1) BR9611466A (fr)
CA (1) CA2238176A1 (fr)
CO (1) CO4520254A1 (fr)
CZ (1) CZ158998A3 (fr)
EE (1) EE03778B1 (fr)
HU (1) HUP0000318A3 (fr)
NO (1) NO982329D0 (fr)
NZ (1) NZ322910A (fr)
PL (1) PL188537B1 (fr)
RO (1) RO115275B1 (fr)
RU (1) RU2206329C2 (fr)
SK (1) SK66998A3 (fr)
TR (1) TR199800912T2 (fr)
TW (1) TW514530B (fr)
UY (2) UY24367A1 (fr)
WO (1) WO1997019169A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS50101B (sr) 1996-02-24 2009-01-22 Boehringer Ingelheim International Gmbh., Farmaceutski preparati za imunomodulaciju
US6187307B1 (en) 1997-01-31 2001-02-13 Research Corporation Technologies, Inc. Cancer immunotherapy with semi-allogeneic cells
ES2232845T3 (es) * 1997-08-22 2005-06-01 Science Park Raf S.P.A. Vacunacion tumoral mediante la utilizacion de celulas autologas o celulas presentadoras de antigeno (apc) relacionadas con hla transducidas con un antigeno tumoral y un antigeno ajeno capaz de producir una reaccion inmune.
AU3102799A (en) * 1998-03-20 1999-10-11 Genzyme Corporation Enhanced anti-tumor immunity
US7014848B1 (en) 1998-03-20 2006-03-21 Genzyme Corporation Enhanced anti-tumor immunity
FR2807661A1 (fr) * 2000-04-14 2001-10-19 Univ Nantes Agent et procede pour la simulation de lymphocytes t specifiques et lymphocytes t obtenus
CA2476995A1 (fr) * 2001-09-18 2003-03-27 Kyogo Itoh Procede de detection de l'immunite cellulaire et son application sur des medicaments
GB0209896D0 (en) 2002-04-30 2002-06-05 Molmed Spa Conjugate
CN1315536C (zh) * 2002-09-13 2007-05-16 李进 肿瘤抗原疫苗及其制备方法和疫苗组合物
GB0224442D0 (en) 2002-10-21 2002-11-27 Molmed Spa A delivery system
ATE475430T1 (de) * 2003-08-25 2010-08-15 Univax Llc Präventive krebsvakzine auf basis des boris (brother of regulator of imprinted sites) moleküls
US7674456B2 (en) * 2004-06-14 2010-03-09 Charles Wiseman Breast cancer cell lines and uses thereof
WO2006105255A2 (fr) * 2005-03-29 2006-10-05 The Board Of Trustees Of The University Of Illinois Vaccins contre le cancer et methodes therapeutiques
ATE461214T1 (de) * 2005-09-05 2010-04-15 Immatics Biotechnologies Gmbh Tumor-assoziierte peptide, welche an unterschiedliche menschliche leukozytenantigene der klasse ii binden
US20090004213A1 (en) * 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
US8765148B2 (en) 2010-02-19 2014-07-01 Valneva Austria Gmbh 1C31 nanoparticles
CN104662171B (zh) * 2012-07-12 2018-07-13 普瑟姆尼股份有限公司 个性化癌症疫苗和过继免疫细胞治疗
JP2020518648A (ja) 2017-05-08 2020-06-25 グリットストーン オンコロジー インコーポレイテッド アルファウイルス新生抗原ベクター
CA3140019A1 (fr) 2019-05-30 2020-12-03 Gritstone Bio, Inc. Adenovirus modifies
WO2022032196A2 (fr) 2020-08-06 2022-02-10 Gritstone Bio, Inc. Cassettes de vaccin à plusieurs épitopes
US20240156869A1 (en) * 2021-03-12 2024-05-16 T-Cure Bioscience, Inc. Methods of enhancing diversity of hla haplotype expression in tumors to broaden tumor cell susceptibility to tcr-t therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235525B1 (en) * 1991-05-23 2001-05-22 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof
EP0569678A3 (fr) * 1992-03-13 1994-10-26 Yeda Res & Dev Cellules transfectées avec deux gènes codant pour le CMH, utilisées comme vaccins cellulaires pour la prévention immunitaire de métastases.

Also Published As

Publication number Publication date
SK66998A3 (en) 1998-12-02
EP0866851A1 (fr) 1998-09-30
EE9800161A (et) 1998-12-15
RU2206329C2 (ru) 2003-06-20
HUP0000318A2 (hu) 2000-06-28
CN1202931A (zh) 1998-12-23
CO4520254A1 (es) 1997-10-15
PL326756A1 (en) 1998-10-26
BG102439A (en) 1999-01-29
NO982329D0 (no) 1998-05-22
HUP0000318A3 (en) 2002-02-28
UY24367A1 (es) 2000-10-31
WO1997019169A1 (fr) 1997-05-29
AR004341A1 (es) 1998-11-04
AU7694796A (en) 1997-06-11
JP2000502052A (ja) 2000-02-22
BR9611466A (pt) 1999-05-18
UY24430A1 (es) 1997-07-01
US20020085997A1 (en) 2002-07-04
AU720131B2 (en) 2000-05-25
TR199800912T2 (xx) 1998-08-21
CZ158998A3 (cs) 1999-06-16
KR19990067653A (ko) 1999-08-25
NZ322910A (en) 2000-05-26
EE03778B1 (et) 2002-06-17
RO115275B1 (ro) 1999-12-30
PL188537B1 (pl) 2005-02-28
TW514530B (en) 2002-12-21
CA2238176A1 (fr) 1997-05-29

Similar Documents

Publication Publication Date Title
BG62999B1 (bg) Анти туморна ваксина и метод за нейното получаване
Bocchia et al. Antitumor vaccination: where we stand
Gu et al. A novel hydrophobized polysaccharide/oncoprotein complex vaccine induces in vitro and in vivo cellular and humoral immune responses against HER2-expressing murine sarcomas
AU2005321904B2 (en) Methods to elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic or therapeutic purposes
HRP970100A2 (en) Pharmaceutical composition for immunomodulation
US8895017B2 (en) HER-2 peptides and vaccines
AU2004253479A1 (en) Methods to elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic or therapeutic purposes
KR100850473B1 (ko) 면역원성이 불량한 항원의 면역원성을 향상시키는 약제조성물
US10688165B2 (en) Medicament for use in a method of inducing or extending a cellular cytotoxic immune response
Minev et al. Cancer vaccines: novel approaches and new promise
CA2331378A1 (fr) Strategie de vaccination permettant de prevenir et de traiter les cancers
Pietersz* et al. Generation of cellular immune responses to antigenic tumor peptides
Minev Melanoma vaccines
JP2022516639A (ja) ネオエピトープを標的とするワクチン
van Elsas et al. Transfection of IL-2 augments CTL response to human melanoma cells in vitro: immunological characterization of a melanoma vaccine
Butterfield et al. DNA and dendritic cell-based genetic immunization against cancer
MXPA98003930A (en) Vaccines against tumors and procedure for your producc
Yang et al. Peptide Vaccines
Tirosh Identification of tumor associated antigens and development of new methods for cancer immunotherapy
Bonnefoy et al. Cancer Vaccine Design: A Novel Bacterial