BG62350B2 - N-заместени производни на 3-азабицикло/3.2.0/хептан като невролептици и други - Google Patents

N-заместени производни на 3-азабицикло/3.2.0/хептан като невролептици и други Download PDF

Info

Publication number
BG62350B2
BG62350B2 BG98600A BG9860094A BG62350B2 BG 62350 B2 BG62350 B2 BG 62350B2 BG 98600 A BG98600 A BG 98600A BG 9860094 A BG9860094 A BG 9860094A BG 62350 B2 BG62350 B2 BG 62350B2
Authority
BG
Bulgaria
Prior art keywords
azabicyclo
exo
heptan
ethyl
group
Prior art date
Application number
BG98600A
Other languages
Bulgarian (bg)
English (en)
Inventor
Gerd Steiner
Liliane Unger
Berthold Behl
Hans-Juergen Teschendorf
Rainer Munschauer
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of BG62350B2 publication Critical patent/BG62350B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG98600A 1992-06-19 1994-02-28 N-заместени производни на 3-азабицикло/3.2.0/хептан като невролептици и други BG62350B2 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4219974 1992-06-19
DE4243287A DE4243287A1 (de) 1992-06-19 1992-12-21 N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
CN93114691A CN1039996C (zh) 1992-06-19 1993-12-11 N－取代氮杂双环庚烷衍生物及其用途

Publications (1)

Publication Number Publication Date
BG62350B2 true BG62350B2 (bg) 1999-08-31

Family

ID=36940125

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98600A BG62350B2 (bg) 1992-06-19 1994-02-28 N-заместени производни на 3-азабицикло/3.2.0/хептан като невролептици и други

Country Status (24)

Country Link
US (1) US5475105A (fr)
EP (1) EP0647231B1 (fr)
JP (1) JP3171258B2 (fr)
CN (2) CN1042133C (fr)
AT (1) ATE157366T1 (fr)
AU (1) AU671130B2 (fr)
BG (1) BG62350B2 (fr)
CA (1) CA2138289C (fr)
CZ (1) CZ288787B6 (fr)
DE (2) DE4243287A1 (fr)
DK (1) DK0647231T3 (fr)
ES (1) ES2107035T3 (fr)
FI (1) FI108726B (fr)
GR (1) GR3025095T3 (fr)
HU (1) HU218911B (fr)
IL (1) IL105989A (fr)
NO (1) NO305176B1 (fr)
NZ (1) NZ253121A (fr)
PH (1) PH30466A (fr)
RU (1) RU2135503C1 (fr)
SG (1) SG44782A1 (fr)
TW (1) TW408126B (fr)
WO (1) WO1994000458A1 (fr)
ZA (1) ZA934374B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4427648A1 (de) * 1994-08-04 1996-02-08 Basf Ag N-Stubstituierte 3-Azabicyclo[3,2,0,]heptan-Derivate, ihre Herstellung und Verwendung
DE4338396A1 (de) * 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4341402A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4427647A1 (de) * 1994-08-04 1996-02-08 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
US5929080A (en) * 1997-05-06 1999-07-27 American Cyanamid Company Method of treating polycystic kidney disease
US6323209B1 (en) 1997-11-06 2001-11-27 American Cyanamid Company Method of treating or inhibiting colonic polyps
DE19836404A1 (de) * 1998-08-12 2000-02-17 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE19836406A1 (de) 1998-08-12 2000-02-17 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
US6458821B1 (en) * 1998-08-12 2002-10-01 Abbott Laboratories N-substituted azabicycloheptane derivatives, production and use thereof
DE19848521A1 (de) * 1998-10-21 2000-04-27 Basf Ag Verfahren zur Herstellung von (+)-exo-6-Phenyl-3-azabicyclo-[3.2.0]heptanen
DE19960074A1 (de) * 1999-12-13 2001-06-21 Basf Ag Neues Salz von Belaperidone und dessen Modifikationen
AU2001213156A1 (en) * 2000-08-16 2002-02-25 Elena Alexandrovna Izakson Thiazine derivatives of general formula (1) having antibacterial and antiviral action
WO2006040176A1 (fr) * 2004-10-14 2006-04-20 Abbott Gmbh & Co. Kg Composes d'azabicycloheptyle destines au traitement des troubles reagissant a une modulation du recepteur de dopamine d3
US20060199768A1 (en) * 2005-03-07 2006-09-07 University Of North Carolina At Chapel Hill Inhibitors of RecA activities for control of antibiotic-resistant bacterial pathogens
EP2578216A1 (fr) 2006-11-22 2013-04-10 Seaside Therapeutics, Inc. Procédés de traitement du syndrome de l'X fragile
JP2010534647A (ja) * 2007-07-27 2010-11-11 アクテリオン ファーマシューティカルズ リミテッド ２−アザ−ビシクロ［３．３．０］オクタン誘導体
AU2015308350B2 (en) 2014-08-29 2020-03-05 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
CN112010851A (zh) * 2020-06-30 2020-12-01 浙江美诺华药物化学有限公司 一种莫西沙星盐酸盐的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155668A (en) * 1960-04-11 1964-11-03 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl)-lower-alkyl]-tertiary amines and intermediates therefor
US3328390A (en) * 1962-02-27 1967-06-27 Tri Kem Corp Certain azabicycloalkane compounds
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
DE3228303A1 (de) * 1982-07-29 1984-02-02 Robert Bosch Gmbh, 7000 Stuttgart Elektrische motorregelung
US4540318A (en) * 1982-07-29 1985-09-10 Robert Bosch, Gmbh Rotary electrical tool with speed control, especially drill
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles

Also Published As

Publication number Publication date
SG44782A1 (en) 1997-12-19
CN1105358A (zh) 1995-07-19
RU95105435A (ru) 1996-11-20
HU218911B (hu) 2000-12-28
AU671130B2 (en) 1996-08-15
CZ288787B6 (cs) 2001-09-12
EP0647231B1 (fr) 1997-08-27
WO1994000458A1 (fr) 1994-01-06
JPH07507771A (ja) 1995-08-31
DE4243287A1 (de) 1993-12-23
FI945957A0 (fi) 1994-12-19
US5475105A (en) 1995-12-12
AU4323893A (en) 1994-01-24
PH30466A (en) 1997-05-28
GR3025095T3 (en) 1998-01-30
CA2138289A1 (fr) 1994-01-06
EP0647231A1 (fr) 1995-04-12
FI108726B (fi) 2002-03-15
ZA934374B (en) 1994-12-19
FI945957A (fi) 1994-12-19
ATE157366T1 (de) 1997-09-15
NZ253121A (en) 1995-12-21
RU2135503C1 (ru) 1999-08-27
CN1042133C (zh) 1999-02-17
ES2107035T3 (es) 1997-11-16
NO944892D0 (no) 1994-12-16
DE59307217D1 (de) 1997-10-02
CN1087341A (zh) 1994-06-01
JP3171258B2 (ja) 2001-05-28
IL105989A (en) 1997-02-18
CZ323794A3 (en) 1995-05-17
HUT71351A (en) 1995-11-28
CN1039996C (zh) 1998-09-30
CA2138289C (fr) 2004-03-02
TW408126B (en) 2000-10-11
IL105989A0 (en) 1993-10-20
NO944892L (no) 1995-02-13
NO305176B1 (no) 1999-04-12
DK0647231T3 (da) 1997-09-29

Similar Documents

Publication Publication Date Title
BG62350B2 (bg) N-заместени производни на 3-азабицикло/3.2.0/хептан като невролептици и други
KR890000566B1 (ko) 1-헤테로아릴-4-[(2,5-피롤리딘디온-1-일)알킬]피페라진유도체 및 그 제조방법
JPWO2005026126A1 (ja) Ｃｒｆ拮抗剤および二環式複素環化合物
JPH0314563A (ja) 新規４―フルオロ安息香酸誘導体
JPH01249769A (ja) 向精神性ヘテロビシクロアルキルピペラジン誘導体
US5164397A (en) 2-aminopyrimidine-4-carboxamide derivatives, their preparation and their application in urinary therapeutics
AU679812B2 (en) N-substituted azabicycloheptane derivatives used, for example, as neuroleptics
US6028073A (en) N-substituted 3-azabicyclo (3.2.0)heptane derivatives useful as neuroleptics
JPH02138266A (ja) ６‐フェニル‐３‐（ピペラジニルアルキル）‐２，４（１ｈ，３ｈ）‐ピリミジンジオン誘導体
US5521209A (en) N-substituted azabicyclo[3.2.0]heptane derivatives as neuroleptics, the preparation and use thereof
JPS62135464A (ja) フエニルピペラジン誘導体
BG63632B1 (bg) N-заместени азабициклохептанови производни, приложими като невролептици
SK283489B6 (sk) Piperazinylalkyltiopyrimidínové deriváty, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
KR100254665B1 (ko) 신경이완제 등으로서 유용한 n-치환된 3-아자비시클로(3.2.0)헵탄 유도체
WO2013001498A1 (fr) Dérivés d'amidoalkylpipérazinyle pour le traitement de maladies du système nerveux central
KR100917041B1 (ko) 5-ｈｔ7 수용체에 길항작용을 갖는 신규한 화합물
SI9300625A (sl) N-substituirani derivati azabicikloheptana, njihova priprava in uporaba
HRP931499A2 (en) N-substituted azabicycloheptane derivatives, their production and use
RU2120439C1 (ru) N-замещенные производные 3-азабицикло(3,2,0)-гептана и их соли с физиологически переносимыми кислотами
TW393482B (en) N-substituted 3-azabicyclo[3.2.0]heptane derivatives, the preparation and use thereof
NZ250371A (en) N-substituted-3-azabicyclo[3.2.0]heptane derivatives, preparation and pharmaceutical compositions thereof
HRP20010181A2 (en) N-substituted azabicycloheptane derivatives, production and use thereof
SI9300628A (sl) N-substituirani derivati azabicikloheptana, njihova priprava in uporaba