BG62336B1 - Днк последователности,кодиращи нови биосинтетични предшественици на инсулин и метод за получаване на инсулин - Google Patents

Днк последователности,кодиращи нови биосинтетични предшественици на инсулин и метод за получаване на инсулин Download PDF

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Publication number
BG62336B1
BG62336B1 BG99844A BG9984495A BG62336B1 BG 62336 B1 BG62336 B1 BG 62336B1 BG 99844 A BG99844 A BG 99844A BG 9984495 A BG9984495 A BG 9984495A BG 62336 B1 BG62336 B1 BG 62336B1
Authority
BG
Bulgaria
Prior art keywords
insulin
cells
dna sequence
transformed
dna
Prior art date
Application number
BG99844A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG99844A (bg
Inventor
Silvija Mestric
Peter Punt
Radovan Valinger
Den Hondel Cees Van
Original Assignee
Pliva Farmaceutska,Kemijska,Prehrambena Ikozmeticka Industrija, Dionicko Drustvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska,Kemijska,Prehrambena Ikozmeticka Industrija, Dionicko Drustvo filed Critical Pliva Farmaceutska,Kemijska,Prehrambena Ikozmeticka Industrija, Dionicko Drustvo
Publication of BG99844A publication Critical patent/BG99844A/bg
Publication of BG62336B1 publication Critical patent/BG62336B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BG99844A 1994-08-05 1995-08-03 Днк последователности,кодиращи нови биосинтетични предшественици на инсулин и метод за получаване на инсулин BG62336B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR940432A HRP940432B1 (en) 1994-08-05 1994-08-05 Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Publications (2)

Publication Number Publication Date
BG99844A BG99844A (bg) 1996-02-28
BG62336B1 true BG62336B1 (bg) 1999-08-31

Family

ID=10946142

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99844A BG62336B1 (bg) 1994-08-05 1995-08-03 Днк последователности,кодиращи нови биосинтетични предшественици на инсулин и метод за получаване на инсулин

Country Status (13)

Country Link
EP (1) EP0704527B1 (fr)
CN (1) CN1126761A (fr)
AT (1) ATE239791T1 (fr)
BG (1) BG62336B1 (fr)
CA (1) CA2155451A1 (fr)
CZ (1) CZ199995A3 (fr)
DE (1) DE69530647T2 (fr)
ES (1) ES2198428T3 (fr)
HR (1) HRP940432B1 (fr)
PL (1) PL309882A1 (fr)
PT (1) PT704527E (fr)
SI (1) SI9500250A (fr)
SK (1) SK97195A3 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
US6403764B1 (en) 1999-01-06 2002-06-11 Genentech, Inc. Insulin-like growth factor-1 protein variants
AU5504999A (en) * 1998-07-20 2000-02-14 Frenken, Leon Gerardus Joseph Production of proteins
JP3406244B2 (ja) * 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
DE19947456A1 (de) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
WO2001072323A2 (fr) 2000-03-24 2001-10-04 Genentech, Inc. Utilisation de l'insuline pour traiter des affections des cartilages
AU2002316807A1 (en) * 2001-06-08 2002-12-23 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
WO2012015692A2 (fr) * 2010-07-28 2012-02-02 Smartcells, Inc. Polypeptides d'insuline exprimés de façon recombinante et utilisations de ceux-ci
AR087433A1 (es) * 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1260858A (fr) * 1985-03-28 1989-09-26 Lawrence S. Cousens Expression a l'aide de genes fusionnes pour l'obtention de proteines
FI872102A (fi) * 1986-06-06 1987-12-07 Panlabs Inc Expressionssystem hos filamentala fungi.
CA1340772C (fr) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression et secretion de proteines heterologues dans une levure au moyen de sequences leader tronquees du facteur alpha
DK300090D0 (da) * 1990-12-19 1990-12-19 Novo Nordisk As Fremgangsmaade til fremstilling af leadersekvenser
BR9400600A (pt) * 1994-02-17 1995-10-24 Finep Financiadora De Estudos Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos

Also Published As

Publication number Publication date
EP0704527A2 (fr) 1996-04-03
HRP940432B1 (en) 2003-10-31
CZ199995A3 (en) 1996-02-14
DE69530647T2 (de) 2004-03-11
ES2198428T3 (es) 2004-02-01
SK97195A3 (en) 1996-02-07
CN1126761A (zh) 1996-07-17
SI9500250A (en) 1996-02-29
PT704527E (pt) 2003-09-30
HRP940432A2 (en) 1997-08-31
CA2155451A1 (fr) 1996-02-06
EP0704527B1 (fr) 2003-05-07
EP0704527A3 (fr) 1997-08-27
ATE239791T1 (de) 2003-05-15
DE69530647D1 (de) 2003-06-12
BG99844A (bg) 1996-02-28
PL309882A1 (en) 1996-02-19

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