HRP940432B1 - Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin - Google Patents

Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Info

Publication number
HRP940432B1
HRP940432B1 HR940432A HRP940432A HRP940432B1 HR P940432 B1 HRP940432 B1 HR P940432B1 HR 940432 A HR940432 A HR 940432A HR P940432 A HRP940432 A HR P940432A HR P940432 B1 HRP940432 B1 HR P940432B1
Authority
HR
Croatia
Prior art keywords
insulin
dna sequences
sequences encoding
preparation
precursors
Prior art date
Application number
HR940432A
Other languages
English (en)
Inventor
Silvija Meuetri
J Peter Punt
Radovan Valinger
A M J J Cees Van Den Hondel
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Priority to HR940432A priority Critical patent/HRP940432B1/xx
Priority to SK971-95A priority patent/SK97195A3/sk
Priority to EP95112210A priority patent/EP0704527B1/en
Priority to DE69530647T priority patent/DE69530647T2/de
Priority to PT95112210T priority patent/PT704527E/pt
Priority to CZ951999A priority patent/CZ199995A3/cs
Priority to ES95112210T priority patent/ES2198428T3/es
Priority to BG99844A priority patent/BG62336B1/bg
Priority to AT95112210T priority patent/ATE239791T1/de
Priority to PL95309882A priority patent/PL309882A1/xx
Priority to CA002155451A priority patent/CA2155451A1/en
Priority to CN95115064A priority patent/CN1126761A/zh
Priority to SI9500250A priority patent/SI9500250A/sl
Publication of HRP940432A2 publication Critical patent/HRP940432A2/hr
Publication of HRP940432B1 publication Critical patent/HRP940432B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HR940432A 1994-08-05 1994-08-05 Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin HRP940432B1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
HR940432A HRP940432B1 (en) 1994-08-05 1994-08-05 Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin
SK971-95A SK97195A3 (en) 1994-08-05 1995-08-01 Dnk - sequences coding the new biosynthetic precursors of insulin and method of insuline preparation
EP95112210A EP0704527B1 (en) 1994-08-05 1995-08-03 DNA sequences encoding biosynthetic insulin precursors and process for preparation of insulin
DE69530647T DE69530647T2 (de) 1994-08-05 1995-08-03 Für biosynthetische Insulinvorstufen kodierende DNA-Sequenzen und Verfahren zur Herstellung von Insulin
PT95112210T PT704527E (pt) 1994-08-05 1995-08-03 Sequencias de adn que codificam precursores de insulina biossinteticos e processo para a preparacao de insulina
CZ951999A CZ199995A3 (en) 1994-08-05 1995-08-03 Dna sequence encoding novel insulin biosynthetic precursors and insulin preparation process
ES95112210T ES2198428T3 (es) 1994-08-05 1995-08-03 Secuencias de adn codificantes de precursores de insulina biosinteticos y procedimiento para la preparacion de insulina.
BG99844A BG62336B1 (bg) 1994-08-05 1995-08-03 Днк последователности,кодиращи нови биосинтетични предшественици на инсулин и метод за получаване на инсулин
AT95112210T ATE239791T1 (de) 1994-08-05 1995-08-03 Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin
PL95309882A PL309882A1 (en) 1994-08-05 1995-08-04 Dna sequence encoding novel biosynthetic insulin precursors and insulin obtaining method
CA002155451A CA2155451A1 (en) 1994-08-05 1995-08-04 Dna sequences encoding novel biosynthetic insulin precursors and process for preparation of insulin
CN95115064A CN1126761A (zh) 1994-08-05 1995-08-04 编码新型生物合成胰岛素前体的dna序列以及胰岛素的制备方法
SI9500250A SI9500250A (en) 1994-08-05 1995-08-04 Dna sequences encoding novel biosynthetic insulin precursors and process for preparation of insulin.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR940432A HRP940432B1 (en) 1994-08-05 1994-08-05 Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Publications (2)

Publication Number Publication Date
HRP940432A2 HRP940432A2 (en) 1997-08-31
HRP940432B1 true HRP940432B1 (en) 2003-10-31

Family

ID=10946142

Family Applications (1)

Application Number Title Priority Date Filing Date
HR940432A HRP940432B1 (en) 1994-08-05 1994-08-05 Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Country Status (13)

Country Link
EP (1) EP0704527B1 (xx)
CN (1) CN1126761A (xx)
AT (1) ATE239791T1 (xx)
BG (1) BG62336B1 (xx)
CA (1) CA2155451A1 (xx)
CZ (1) CZ199995A3 (xx)
DE (1) DE69530647T2 (xx)
ES (1) ES2198428T3 (xx)
HR (1) HRP940432B1 (xx)
PL (1) PL309882A1 (xx)
PT (1) PT704527E (xx)
SI (1) SI9500250A (xx)
SK (1) SK97195A3 (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
AU5504999A (en) * 1998-07-20 2000-02-14 Frenken, Leon Gerardus Joseph Production of proteins
DK1141014T3 (da) 1999-01-06 2005-04-11 Genentech Inc Insulinlignende vækstfaktor (IGF) i mutantvariant
JP3406244B2 (ja) * 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
DE19947456A1 (de) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
EP1265630B1 (en) 2000-03-24 2006-06-07 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
WO2002100887A2 (en) * 2001-06-08 2002-12-19 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
WO2012015692A2 (en) * 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
AR087433A1 (es) * 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE63757T1 (de) * 1985-03-28 1991-06-15 Chiron Corp Expression durch verwendung von fusionsgenen fuer proteinproduktion.
FI872102A (fi) * 1986-06-06 1987-12-07 Panlabs Inc Expressionssystem hos filamentala fungi.
CA1340772C (en) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
DK300090D0 (da) * 1990-12-19 1990-12-19 Novo Nordisk As Fremgangsmaade til fremstilling af leadersekvenser
BR9400600A (pt) * 1994-02-17 1995-10-24 Finep Financiadora De Estudos Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos

Also Published As

Publication number Publication date
PT704527E (pt) 2003-09-30
CN1126761A (zh) 1996-07-17
CZ199995A3 (en) 1996-02-14
ES2198428T3 (es) 2004-02-01
DE69530647D1 (de) 2003-06-12
SK97195A3 (en) 1996-02-07
PL309882A1 (en) 1996-02-19
SI9500250A (en) 1996-02-29
CA2155451A1 (en) 1996-02-06
ATE239791T1 (de) 2003-05-15
BG62336B1 (bg) 1999-08-31
EP0704527A3 (en) 1997-08-27
BG99844A (bg) 1996-02-28
HRP940432A2 (en) 1997-08-31
DE69530647T2 (de) 2004-03-11
EP0704527A2 (en) 1996-04-03
EP0704527B1 (en) 2003-05-07

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Legal Events

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Payment date: 20130729

Year of fee payment: 20

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Effective date: 20140815