ATE239791T1 - Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin - Google Patents

Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin

Info

Publication number
ATE239791T1
ATE239791T1 AT95112210T AT95112210T ATE239791T1 AT E239791 T1 ATE239791 T1 AT E239791T1 AT 95112210 T AT95112210 T AT 95112210T AT 95112210 T AT95112210 T AT 95112210T AT E239791 T1 ATE239791 T1 AT E239791T1
Authority
AT
Austria
Prior art keywords
insulin
dna sequences
sequences encoding
precursors
relates
Prior art date
Application number
AT95112210T
Other languages
English (en)
Inventor
Silvija Mestric
Peter J Punt
Radovan Valinger
Den Hondel Cees A M J J Van
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Application granted granted Critical
Publication of ATE239791T1 publication Critical patent/ATE239791T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT95112210T 1994-08-05 1995-08-03 Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin ATE239791T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR940432A HRP940432B1 (en) 1994-08-05 1994-08-05 Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Publications (1)

Publication Number Publication Date
ATE239791T1 true ATE239791T1 (de) 2003-05-15

Family

ID=10946142

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95112210T ATE239791T1 (de) 1994-08-05 1995-08-03 Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin

Country Status (13)

Country Link
EP (1) EP0704527B1 (de)
CN (1) CN1126761A (de)
AT (1) ATE239791T1 (de)
BG (1) BG62336B1 (de)
CA (1) CA2155451A1 (de)
CZ (1) CZ199995A3 (de)
DE (1) DE69530647T2 (de)
ES (1) ES2198428T3 (de)
HR (1) HRP940432B1 (de)
PL (1) PL309882A1 (de)
PT (1) PT704527E (de)
SI (1) SI9500250A (de)
SK (1) SK97195A3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
AU5504999A (en) * 1998-07-20 2000-02-14 Frenken, Leon Gerardus Joseph Production of proteins
JP3971108B2 (ja) 1999-01-06 2007-09-05 ジェネンテック・インコーポレーテッド インシュリン様成長因子（ｉｇｆ）ｉ突然変異体
JP3406244B2 (ja) * 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
DE19947456A1 (de) 1999-10-02 2001-04-05 Aventis Pharma Gmbh C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
DK1265630T3 (da) 2000-03-24 2006-10-09 Genentech Inc Anvendelse af insulin til behandling af brusksygdomme
WO2002100887A2 (en) * 2001-06-08 2002-12-19 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
CA2806399A1 (en) * 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
AR087433A1 (es) * 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0196056B1 (de) * 1985-03-28 1991-05-22 Chiron Corporation Expression durch Verwendung von Fusionsgenen für Proteinproduktion
FI872102A (fi) * 1986-06-06 1987-12-07 Panlabs Inc Expressionssystem hos filamentala fungi.
CA1340772C (en) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
DK300090D0 (da) * 1990-12-19 1990-12-19 Novo Nordisk As Fremgangsmaade til fremstilling af leadersekvenser
BR9400600A (pt) * 1994-02-17 1995-10-24 Finep Financiadora De Estudos Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos

Also Published As

Publication number Publication date
CA2155451A1 (en) 1996-02-06
BG99844A (bg) 1996-02-28
DE69530647T2 (de) 2004-03-11
HRP940432A2 (en) 1997-08-31
CN1126761A (zh) 1996-07-17
SI9500250A (en) 1996-02-29
EP0704527B1 (de) 2003-05-07
PT704527E (pt) 2003-09-30
DE69530647D1 (de) 2003-06-12
HRP940432B1 (en) 2003-10-31
CZ199995A3 (en) 1996-02-14
ES2198428T3 (es) 2004-02-01
EP0704527A3 (de) 1997-08-27
SK97195A3 (en) 1996-02-07
BG62336B1 (bg) 1999-08-31
EP0704527A2 (de) 1996-04-03
PL309882A1 (en) 1996-02-19

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