WO1999043834A3 - P-selectin ligand protein, including tetrameric fusion proteins - Google Patents

P-selectin ligand protein, including tetrameric fusion proteins Download PDF

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Publication number
WO1999043834A3
WO1999043834A3 PCT/US1999/004302 US9904302W WO9943834A3 WO 1999043834 A3 WO1999043834 A3 WO 1999043834A3 US 9904302 W US9904302 W US 9904302W WO 9943834 A3 WO9943834 A3 WO 9943834A3
Authority
WO
WIPO (PCT)
Prior art keywords
selectin ligand
ligand protein
selectin
disclosed
fusion proteins
Prior art date
Application number
PCT/US1999/004302
Other languages
French (fr)
Other versions
WO1999043834A2 (en
Inventor
Glenn R Larsen
Dianne S Sako
Xiao-Jia Chang
Geertruida M Veldman
Dale Cumming
Ravindra Kumar
Gray Shaw
Ray Camphausen
Monique Davis
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Priority to AU29755/99A priority Critical patent/AU2975599A/en
Publication of WO1999043834A2 publication Critical patent/WO1999043834A2/en
Publication of WO1999043834A3 publication Critical patent/WO1999043834A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
PCT/US1999/004302 1998-02-27 1999-02-25 P-selectin ligand protein, including tetrameric fusion proteins WO1999043834A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29755/99A AU2975599A (en) 1998-02-27 1999-02-25 P-selectin ligand protein including tetrameric fusion proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3208098A 1998-02-27 1998-02-27
US09/032,080 1998-02-27

Publications (2)

Publication Number Publication Date
WO1999043834A2 WO1999043834A2 (en) 1999-09-02
WO1999043834A3 true WO1999043834A3 (en) 1999-11-18

Family

ID=21862996

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004302 WO1999043834A2 (en) 1998-02-27 1999-02-25 P-selectin ligand protein, including tetrameric fusion proteins

Country Status (2)

Country Link
AU (1) AU2975599A (en)
WO (1) WO1999043834A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022820A1 (en) * 2000-09-12 2002-03-21 Genetics Institute, Llc Inhibition of stenosis or restenosis by p-selectin antagonists
US7459523B2 (en) 2003-11-12 2008-12-02 Wisconsin Alumni Research Foundation Equine P-selectin glycoprotein ligand-1 and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010309A1 (en) * 1992-10-23 1994-05-11 Genetics Institute, Inc. Novel p-selectin ligand protein
WO1994011498A1 (en) * 1992-11-16 1994-05-26 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for p-selectin and methods of use thereof
WO1995030001A2 (en) * 1994-04-28 1995-11-09 Genetics Institute, Inc. Novel p-selectin ligand protein
WO1996009309A1 (en) * 1994-09-20 1996-03-28 Pharmacia & Upjohn Company The oligosaccharide structure of a ligand for e and p selectin
WO1997000079A1 (en) * 1995-06-14 1997-01-03 The General Hospital Corporation P-selectin ligands and related molecules and methods
WO1998008949A1 (en) * 1996-08-30 1998-03-05 Genetics Institute, Inc. P-selectin ligand proteins

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010309A1 (en) * 1992-10-23 1994-05-11 Genetics Institute, Inc. Novel p-selectin ligand protein
WO1994011498A1 (en) * 1992-11-16 1994-05-26 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for p-selectin and methods of use thereof
WO1995030001A2 (en) * 1994-04-28 1995-11-09 Genetics Institute, Inc. Novel p-selectin ligand protein
WO1996009309A1 (en) * 1994-09-20 1996-03-28 Pharmacia & Upjohn Company The oligosaccharide structure of a ligand for e and p selectin
WO1997000079A1 (en) * 1995-06-14 1997-01-03 The General Hospital Corporation P-selectin ligands and related molecules and methods
WO1998008949A1 (en) * 1996-08-30 1998-03-05 Genetics Institute, Inc. P-selectin ligand proteins

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
D. SAKO ET AL.: "Expression cloning of a functional glycoprotein ligand for P-selectin.", CELL, vol. 75, 17 December 1993 (1993-12-17), pages 1179 - 1186, XP002116304 *
F. LI ET AL.: "Post-translational modifications of recombinant P-selectin glycoprotein Ligand-1 required for binding to P- and E-Selectin.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 6, 9 February 1996 (1996-02-09), pages 3255 - 3264, XP002116305 *
K. CROCE ET AL.: "Interaction between soluble P-selectin and soluble P-selectin glycoprotein ligand 1: Equilibrium Binding Analysis.", BIOCHEMISTRY, vol. 37, November 1998 (1998-11-01), pages 16472 - 16480, XP002116308 *
K.E. NORGARD ET AL.: "Characterization of a specific ligand for P-selectin on myeloid cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 17, 15 June 1993 (1993-06-15), pages 12764 - 12774, XP002116306 *
LARSEN G R ET AL: "P-SELECTIN AND E-SELECTIN. DISTINCT BUT OVERLAPPING LEUKOCYTE LIGAND SPECIFICITIES", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 16, 5 June 1992 (1992-06-05), pages 11104 - 11110, XP002067822, ISSN: 0021-9258 *
P. MEHTA ET AL.: "Affinity and kinetic analysis of P-selectin binding to P-selectin glycoprotein ligand-1", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 49, 4 December 1998 (1998-12-04), pages 32506 - 32513, XP002116307 *
W. LIU ET AL.: "Identification of N-terminal residues on P-selectin glycoprotein ligand-1 required for binding to P-selectin.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 12, 20 March 1998 (1998-03-20), pages 7078 - 7087, XP002116309 *

Also Published As

Publication number Publication date
WO1999043834A2 (en) 1999-09-02
AU2975599A (en) 1999-09-15

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